Hongwei Cui
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View article: Research process and hotspot prediction of deep-hole presplitting blasting technology in China’s mines
Research process and hotspot prediction of deep-hole presplitting blasting technology in China’s mines Open
The concept and mechanism of the deep-hole presplitting blasting are expounded in detail. Based on China's annual coal production data and the number of papers published on the theme of deep-hole presplitting blasting, the research process…
View article: Identification of potential molecular targets of luteolin in the treatment of hepatocellular carcinoma based on network pharmacology and transcriptome sequencing technology
Identification of potential molecular targets of luteolin in the treatment of hepatocellular carcinoma based on network pharmacology and transcriptome sequencing technology Open
LLUT suppresses HCC progression by inhibiting proliferation, regulating cell cycle and apoptosis, and blocking invasion and migration. Its therapeutic mechanisms likely involve targeting MMP9 and modulating the HIF-1α signaling pathway.
View article: Revealing the gastric protective mechanism of Physochlaina physaloides (L) G. Don. with clinical orientation: PPAR/NF-κB signalling pathway activation
Revealing the gastric protective mechanism of Physochlaina physaloides (L) G. Don. with clinical orientation: PPAR/NF-κB signalling pathway activation Open
This study provides the first evidence of the effectiveness of BPP in the prevention of gastric ulcers and treatment of chronic gastritis. We adopted a multidisciplinary approach to demonstrate that BPP and its active components, anisodami…
View article: Advances in the study of the role of gastric microbiota in the progression of gastric cancer
Advances in the study of the role of gastric microbiota in the progression of gastric cancer Open
Gastric cancer (GC) is a common malignant tumor and the third most common cancer in China in terms of mortality. Stomach microorganisms play complex roles in the development of GC. The carcinogenic mechanism of Helicobacter pylori has been…
View article: The advance of the third‑generation EGFR‑TKI in the treatment of non‑small cell lung cancer (Review)
The advance of the third‑generation EGFR‑TKI in the treatment of non‑small cell lung cancer (Review) Open
Lung cancer is currently the second most common type of cancer with the second incidence rate and the first mortality rate worldwide. Non‑small cell lung cancer (NSCLC) accounts for ~85% of the total number of cases of lung cancers. Concer…
View article: When Geoscience Meets Foundation Models: Towards General Geoscience Artificial Intelligence System
When Geoscience Meets Foundation Models: Towards General Geoscience Artificial Intelligence System Open
Artificial intelligence (AI) has significantly advanced Earth sciences, yet its full potential in to comprehensively modeling Earth's complex dynamics remains unrealized. Geoscience foundation models (GFMs) emerge as a paradigm-shifting so…
View article: Advance in vasculogenic mimicry in ovarian cancer (Review)
Advance in vasculogenic mimicry in ovarian cancer (Review) Open
Ovarian cancer (OC) is a common and highly prevalent malignant tumor in women, associated with a high mortality rate, easy recurrence and easy metastasis, which is predominantly at an advanced stage when detected in patients. This renders …
View article: Advances in the role of gut microbiota in the regulation of the tumor microenvironment (Review)
Advances in the role of gut microbiota in the regulation of the tumor microenvironment (Review) Open
As a protector of human health, the gut microbiota plays an important role in the development of the immune system during childhood, and the regulation of dietary habits, metabolism and immune system during adulthood. Dysregulated gut flor…
View article: Genome-Wide Identification and Analysis of the Maize Serine Peptidase S8 Family Genes in Response to Drought at Seedling Stage
Genome-Wide Identification and Analysis of the Maize Serine Peptidase S8 Family Genes in Response to Drought at Seedling Stage Open
Subtilisin-like proteases (subtilases) are found in almost all plant species and are involved in regulating various biotic and abiotic stresses. Although the literature on subtilases in different plant species is vast, the gene function of…
View article: Advances in the Mechanism of Luteolin against Hepatocellular Carcinoma Based on Bioinformatics and Network Pharmacology
Advances in the Mechanism of Luteolin against Hepatocellular Carcinoma Based on Bioinformatics and Network Pharmacology Open
As one of the most common malignant tumors, hepatocellular carcinoma (HCC) has a rising incidence rate and also seriously endangers human life and health. According to research reports, hepatitis B, hepatitis C, intake of aflatoxin in the …
View article: Combining Knowledge and a Data Driven Method for Identifying the Gas Kick Type in a Fractured Formation
Combining Knowledge and a Data Driven Method for Identifying the Gas Kick Type in a Fractured Formation Open
The main forms of gas kicks into the wellbore during drilling in fractured carbonate reservoirs are underbalanced pressure and gravity displacement. These two forms of gas kicks have different mechanisms of gas entry into the wellbore and …
View article: Association of rs1137101 with hypertension and type 2 diabetes mellitus of Mongolian and Han Chinese
Association of rs1137101 with hypertension and type 2 diabetes mellitus of Mongolian and Han Chinese Open
Mongolian and Han subjects from Inner Mongolia with HTN who had rs1137101 were protected against the development of T2DM. Allele A has the opposite impact on the occurrence of HTN in Mongolian and Han Chinese populations.
View article: Research on Pore Pressure Detection While Drilling Based on Mechanical Specific Energy
Research on Pore Pressure Detection While Drilling Based on Mechanical Specific Energy Open
The detection of the formation of pore pressure while drilling is of great importance to ensure safe drilling operations. At present, the dc-exponent concept is mainly used to detect pore pressure while drilling. The dc-exponent concept is…
View article: Role of Metabolic Reprogramming of Long non-coding RNA in Clear Cell Renal Cell Carcinoma
Role of Metabolic Reprogramming of Long non-coding RNA in Clear Cell Renal Cell Carcinoma Open
Renal cell carcinoma (RCC), one of the most frequent cancers, is a "classical" malignancy characterized by metabolic reprogramming. Clear cell renal cell carcinoma (ccRCC) is its most common histopathological subtype. Long-stranded non-cod…
View article: The prognostic value and multiomic features of m6A-related risk signature in lung adenocarcinoma.
The prognostic value and multiomic features of m6A-related risk signature in lung adenocarcinoma. Open
The prognostic signature based on m6A regulators might provide novel insights into prognostic assessment and individualized treatment for patients with LUAD.
View article: Design of transceiver based on functional programming
Design of transceiver based on functional programming Open
This paper discusses the setting of transceiver based on functional programming, and decouples the differences between communication protocol and network transmission protocol from the specific business implementation. In the actual applic…
View article: Research Progress of CircRNAs Regulating Biological Behavior of Clear Cell Renal Cell Carcinoma
Research Progress of CircRNAs Regulating Biological Behavior of Clear Cell Renal Cell Carcinoma Open
Renal cell carcinoma is one of the ten multiple cancers, and its incidence rate and mortality rate have been increasing in more than 20 years. Clear cell renal cell carcinoma (ccRCC) is the most common histopathological subtype. Cyclic rib…
View article: Heterologous Expression of Three Ammopiptanthus mongolicus Dehydrin Genes Confers Abiotic Stress Tolerance in Arabidopsis thaliana
Heterologous Expression of Three Ammopiptanthus mongolicus Dehydrin Genes Confers Abiotic Stress Tolerance in Arabidopsis thaliana Open
Ammopiptanthus mongolicus, a xerophyte plant that belongs to the family Leguminosae, adapts to extremely arid, hot, and cold environments, making it an excellent woody plant to study the molecular mechanisms underlying abiotic stress toler…
View article: Role of MicroRNA-30c in cancer progression
Role of MicroRNA-30c in cancer progression Open
MicroRNAs (miRNAs or miRs) is a non-coding small RNA of a type of 18~24 nucleotide-regulated gene that has been discovered in recent years. It mainly degrades the target gene mRNA or inhibits its translation process through the complete or…
View article: Knockdown of long noncoding RNA DLEU1 suppresses the progression of renal cell carcinoma by downregulating the Akt pathway
Knockdown of long noncoding RNA DLEU1 suppresses the progression of renal cell carcinoma by downregulating the Akt pathway Open
Increasing evidence has indicated that long noncoding RNAs (lncRNAs) are involved in the tumorigenesis and progression of various types of cancer. The lncRNA deleted in lymphocytic leukemia 1 (DLEU1) has been reported to be dysregulated in…
View article: Combination of quercetin and Adriamycin effectively suppresses the growth of refractory acute leukemia
Combination of quercetin and Adriamycin effectively suppresses the growth of refractory acute leukemia Open
The present study aimed to investigate the effect of combined treatment with quercetin and Adriamycin (doxorubicin) on the development of refractory acute leukemia. Primary leukemic cells were isolated from patients with refractory drug-re…
View article: Advances in the Regulatory Effects of Bioactive Peptides on Metabolic Signaling Pathways in Tumor Cells
Advances in the Regulatory Effects of Bioactive Peptides on Metabolic Signaling Pathways in Tumor Cells Open
Changes in cell metabolism are an important feature of tumors that has always been an intense topic of study, particularly in regard to whether metabolic disorders are a cause or an effect of tumorigenesis. Studies have shown that the proc…
View article: Association between LCE gene polymorphisms and psoriasis vulgaris among Mongolians from Inner Mongolia
Association between LCE gene polymorphisms and psoriasis vulgaris among Mongolians from Inner Mongolia Open
The late cornified envelope (LCE) gene cluster is located on chromosome 1q21, including LCE1-LCE6. Several single nucleotide polymorphisms (SNPs) in the LCE cluster were associated with susceptibility to psoriasis in Chinese population. Ho…
View article: Effect of T helper cell 1/T helper cell 2 balance and nuclear factor-κB on white matter injury in premature neonates
Effect of T helper cell 1/T helper cell 2 balance and nuclear factor-κB on white matter injury in premature neonates Open
Incidence of white matter injury (WMI), which is featured as softening of white matter tissues, has recently increased. Previous studies have demonstrated a close correlation between T helper cell 1 and T helper cell 2 (Th1/Th2) imbalance …