Hongwei Geng
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View article: Radiotherapy combined with anti-PD-1 immunotherapy promotes ferroptosis-driven control of hepatocellular carcinoma
Radiotherapy combined with anti-PD-1 immunotherapy promotes ferroptosis-driven control of hepatocellular carcinoma Open
Combination of radiotherapy (RT) and anti-PD-1 immunotherapy (IO) has shown significant efficacy in treating hepatocellular carcinoma (HCC). Nevertheless, yet the underlying mechanisms remain incompletely understood. A Hepa1-6 mouse HCC mo…
View article: Phosphoglycerate kinase 1 as a potential prognostic biomarker in papillary thyroid carcinoma
Phosphoglycerate kinase 1 as a potential prognostic biomarker in papillary thyroid carcinoma Open
Backgroud Papillary thyroid carcinoma (PTC) represents a malignant epithelial tumor characterized with a preference for younger individuals. Despite its generally favorable prognosis, PTC still poses considerable challenges, particularly i…
View article: The Institutional Evolution of Chinese University Data Governance: An Analytical Framework Based on Historical Institutionalism
The Institutional Evolution of Chinese University Data Governance: An Analytical Framework Based on Historical Institutionalism Open
This article examines the institutional evolution of university data governance in China through the lens of historical institutionalism, offering a novel perspective on this critical topic. This framework provides a structured approach to…
View article: Genetic identification and characterization of a novel locus for wheat kernel length
Genetic identification and characterization of a novel locus for wheat kernel length Open
View article: Identification of quantitative trait loci and candidate genes for grain superoxide dismutase activity in wheat
Identification of quantitative trait loci and candidate genes for grain superoxide dismutase activity in wheat Open
Background Superoxide dismutase (SOD) can greatly scavenge reactive oxygen species (ROS) in plants. SOD activity is highly related to plant stress tolerance that can be improved by overexpression of SOD genes. Identification of SOD activit…
View article: Impact of Drought Stress on Yield-Related Agronomic Traits of Different Genotypes in Spring Wheat
Impact of Drought Stress on Yield-Related Agronomic Traits of Different Genotypes in Spring Wheat Open
Drought stress is one of the major abiotic stresses to wheat worldwide, with negative effects on wheat growth and yield. Assessing genetic variation and drought stress tolerance of key agronomic and physiological traits of spring wheat and…
View article: Single-cell RNA sequencing and m6A RNA methylation sequencing and reveal cellular and molecular mechanisms of radiation combined with PD-1 blockade in NSCLC
Single-cell RNA sequencing and m6A RNA methylation sequencing and reveal cellular and molecular mechanisms of radiation combined with PD-1 blockade in NSCLC Open
Background : Lung cancer is the leading cause of cancer-related mortality, and more than 85% of lung cancer cases are non-small cell lung cancer (NSCLC). The heterogeneity and molecular basis of this disease remain incompletely understood.…
View article: Quantitative Trait Locus (QTL) Mapping for Common Wheat Plant Heights Based on Unmanned Aerial Vehicle Images
Quantitative Trait Locus (QTL) Mapping for Common Wheat Plant Heights Based on Unmanned Aerial Vehicle Images Open
The application of unmanned aerial vehicle (UAV) remote sensing technology for high-throughput acquisition of phenotypic values of field plant height is of great significance in plant height monitoring of wheat varieties (lines). Based on …
View article: QTL mapping of drought tolerance at germination stage in wheat using the 50 K SNP array
QTL mapping of drought tolerance at germination stage in wheat using the 50 K SNP array Open
Drought is a major concern among abiotic stresses in wheat ( Triticum aestivum L.) production. Breeding resistant cultivars are the most effective means to manage drought stress. F 6 recombinant inbred lines (RIL) derived from the cross of…
View article: Butyrate Suppresses Glucose Metabolism of Colorectal Cancer Cells via GPR109a-AKT Signaling Pathway and Enhances Chemotherapy
Butyrate Suppresses Glucose Metabolism of Colorectal Cancer Cells via GPR109a-AKT Signaling Pathway and Enhances Chemotherapy Open
Glycolysis inhibitors are promising therapeutic drugs for tumor treatment, which target the uniquely elevated glucose metabolism of cancer cells. Butyrate is a critical product of beneficial microbes in the colon, which exerts extraordinar…
View article: Annealing-Induced Grain Refinement and Hardening in Ultrafine-Grained Al and Al-Mg Alloys
Annealing-Induced Grain Refinement and Hardening in Ultrafine-Grained Al and Al-Mg Alloys Open
View article: Synonymous Mutations of Porcine Igf1r Extracellular Domain Affect Differentiation and Mineralization in MC3T3-E1 Cells
Synonymous Mutations of Porcine Igf1r Extracellular Domain Affect Differentiation and Mineralization in MC3T3-E1 Cells Open
Owing to the wide application of miniature pigs in biomedicine, the formation mechanism of its short stature must be elucidated. The insulin-like growth factor 1 receptor (IGF-1R), which receives signals through the extracellular domain (E…
View article: MicroRNA 322 Aggravates Dexamethasone-Induced Muscle Atrophy by Targeting IGF1R and INSR
MicroRNA 322 Aggravates Dexamethasone-Induced Muscle Atrophy by Targeting IGF1R and INSR Open
Dexamethasone (Dex) has been widely used as a potent anti-inflammatory, antishock, and immunosuppressive agent. However, high dose or long-term use of Dex is accompanied by side effects including skeletal muscle atrophy, whose underlying m…
View article: miR-140 inhibits porcine fetal fibroblasts proliferation by directly targeting type 1 insulin-like growth factor receptor and indirectly inhibiting type 1 insulin-like growth factor receptor expression via SRY-box 4
miR-140 inhibits porcine fetal fibroblasts proliferation by directly targeting type 1 insulin-like growth factor receptor and indirectly inhibiting type 1 insulin-like growth factor receptor expression via SRY-box 4 Open
Objective: This study aimed to elucidate the effect of miR-140 on the proliferation of porcine fetal fibroblasts (PFFs) and identify the target genes of miR-140 in PFFs.Methods: In this study, bioinformatics software was used to predict an…
View article: Resveratrol Reverses Cigarette Smoke-Induced Urocystic Epithelial–Mesenchymal Transition via Suppression of STAT3 Phosphorylation in SV-HUC-1-Immortalized Human Urothelial Cells
Resveratrol Reverses Cigarette Smoke-Induced Urocystic Epithelial–Mesenchymal Transition via Suppression of STAT3 Phosphorylation in SV-HUC-1-Immortalized Human Urothelial Cells Open
Hongliang Sun, Zhiqiang Zhang, Taotao Zhang, Hao Geng, Dongdong Xie, Yi Wang, Demao Ding, Tao Zhang, Dexin Yu Department of Urology, The Second Affiliated Hospital of Anhui Medical University, Hefei 230032, People’s Republic of China…
View article: Novel alternative splice variant of IGF-1R and its mRNA expression patterns in BaMa and Landrace pigs
Novel alternative splice variant of IGF-1R and its mRNA expression patterns in BaMa and Landrace pigs Open
The transcript variants of Insulin-like growth factor 1 receptor (IGF-1R) and their expression profiles had never been illuminated in pigs until now. Herein, we identified IGF-1R AS02 as a novel splice variant of IGF-1R gene by RT-PCR and …
View article: Physical Mapping of Peroxidase Genes and Development of Functional Markers for TaPod-D1 on Bread Wheat Chromosome 7D
Physical Mapping of Peroxidase Genes and Development of Functional Markers for TaPod-D1 on Bread Wheat Chromosome 7D Open
Peroxidase (POD) activity in wheat (Triticum aestivum L.) grain influences natural carotenoid pigment content and is associated with the color of flour, and processing and product quality. Here, we report the molecular characterizat…
View article: GWAS Analysis and QTL Identification of Fiber Quality Traits and Yield Components in Upland Cotton Using Enriched High-Density SNP Markers
GWAS Analysis and QTL Identification of Fiber Quality Traits and Yield Components in Upland Cotton Using Enriched High-Density SNP Markers Open
It is of great importance to identify quantitative trait loci (QTL) controlling fiber quality traits and yield components for future marker-assisted selection (MAS) and candidate gene function identifications. In this study, two kinds of t…
View article: A high-density genetic map of extra-long staple cotton (Gossypium barbadense) constructed using genotyping-by-sequencing based single nucleotide polymorphic markers and identification of fiber traits-related QTL in a recombinant inbred line population
A high-density genetic map of extra-long staple cotton (Gossypium barbadense) constructed using genotyping-by-sequencing based single nucleotide polymorphic markers and identification of fiber traits-related QTL in a recombinant inbred line population Open
This study represents one of the first genetic mapping studies on the fiber quality and lint yield traits in a RIL population of G. barbadense using GBS-SNPs. The results provide important information for the subsequent fine mapping of QTL…
View article: High temperature stabilization of a nanostructured Cu-Y2O3 composite through microalloying with Ti
High temperature stabilization of a nanostructured Cu-Y2O3 composite through microalloying with Ti Open
View article: Genome-wide identification and analysis of the MADS-box gene family in bread wheat (Triticum aestivum L.)
Genome-wide identification and analysis of the MADS-box gene family in bread wheat (Triticum aestivum L.) Open
The MADS-box genes encode transcription factors with key roles in plant growth and development. A comprehensive analysis of the MADS-box gene family in bread wheat (Triticum aestivum) has not yet been conducted, and our understanding of th…
View article: Genome-Wide Association of Stem Water Soluble Carbohydrates in Bread Wheat
Genome-Wide Association of Stem Water Soluble Carbohydrates in Bread Wheat Open
Water soluble carbohydrates (WSC) in stems play an important role in buffering grain yield in wheat against biotic and abiotic stresses; however, knowledge of genes controlling WSC is very limited. We conducted a genome-wide association st…