Hongxia Dan
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Epithelial pyroptosis-induced TREM1+ macrophages activate Th17 cells to accelerate oral mucosal inflammation Open
Chronic inflammation of the oral mucosa could affect daily living and even threaten systemic health. Unlike periodontitis, oral lichen planus, a common oral chronic inflammatory disease, has diverse clinical manifestations and can progress…
A New Method for PMU Deployment Based on the Preprocessed Integer Programming Algorithm Open
To further enhance the deployment efficiency of synchronous phasor measurement units and rationally select deployment configuration schemes, an improved configuration method based on integer programming algorithms is proposed. Based on the…
Reactor Fault Diagnosis Based on CNN-LSTM Hybrid Neural Network Open
The acoustic signals generated by electrical insulation defects and mechanical failures during the operation of dry reactor contain a large amount of equipment state information, which can be used as an important feature parameter for the …
View article: New <scp>IPCL</scp> Classification Using <scp>NBI</scp> for Early Detection of <scp>OPMDs</scp> Malignant Transformation
New <span>IPCL</span> Classification Using <span>NBI</span> for Early Detection of <span>OPMDs</span> Malignant Transformation Open
Objectives Introduce a new intrapapillary capillary loop (IPCL) classification using narrow‐band imaging (NBI) to diagnose early malignant transformation in oral potentially malignant disorders (OPMDs). Methods In the exploratory phase, NB…
View article: Ferroptosis Induction Enhances Photodynamic Therapy Efficacy for OLK
Ferroptosis Induction Enhances Photodynamic Therapy Efficacy for OLK Open
Oral leukoplakia (OLK) is the most representative oral potentially malignant disorder, with a high risk of malignant transformation and unclear mechanisms of occurrence. Recently, photodynamic therapy (PDT) has exhibited great potential in…
Authors' reply: “ <span>MRTF</span> ‐A/ <span>SRF</span> signaling suppresses invasion of oral squamous cell carcinoma” Open
We would like to take this opportunity to thank Dr X for the comments on our published paper (Yang et al., 2024). And here is our response to the points raised. SRF and its co-activator MRTF-A play a vital role in the regulation of the cyt…
Single‐cell transcriptome dissecting the microenvironment remodeled by PD1 blockade combined with photodynamic therapy in a mouse model of oral carcinogenesis Open
Oral squamous cell carcinoma (OSCC) stands as a predominant and perilous malignant neoplasm globally, with the majority of cases originating from oral potential malignant disorders (OPMDs). Despite this, effective strategies to impede the …
Progress and trends in photodynamic therapy research in oral science: A bibliometric analysis Open
This research provided valuable insights into PDTOS trends and knowledge structures. These findings underscored a significant increase in the number of PDTOS publications, urging strengthened international cooperation. Emerging research ha…
Pemphigus oral lesions area index ( <span>POLAI</span> ): A new scoring scale for assessing oral pemphigus vulgaris Open
Objectives Current scales for Pemphigus vulgaris (PV) do not adequately represent the clinical variability of oral lesions. This study aimed to develop an independent scale, the Pemphigus Oral Lesions Area Index (POLAI), for assessment of …
Prediction of the short-term efficacy and recurrence of photodynamic therapy in the treatment of oral leukoplakia based on deep learning Open
ALA-PDT has excellent short-term efficacy in the management of OLK but the recurrence rate was high. Prediction model based on clinicopathological characteristics has excellent predictive effect for short-term efficacy but limited effect f…
Oral epithelial dysplasia detection and grading in oral leukoplakia using deep learning Open
Background The grading of oral epithelial dysplasia is often time-consuming for oral pathologists and the results are poorly reproducible between observers. In this study, we aimed to establish an objective, accurate and useful detection a…
Hydroxychloroquine is effective in oral lichen planus: A multicenter, randomized, controlled trial Open
Objectives This study was aimed to evaluate the safety and benefit of short‐term application of hydroxychloroquine in the management of atrophic/erosive/ulcerative oral lichen planus (OLP). Methods This multicenter, randomized, controlled,…
View article: Association between human herpes simplex virus and periodontitis: results from the continuous National Health and Nutrition Examination Survey 2009–2014
Association between human herpes simplex virus and periodontitis: results from the continuous National Health and Nutrition Examination Survey 2009–2014 Open
Background Periodontitis is a common chronic oral disease which seriously affects people's quality of life. Although human herpes simplex virus (HSV) is also found in periodontal lesions, the association between HSV infection and periodont…
CD8+ tissue-resident memory T cells induce oral lichen planus erosion via cytokine network Open
CD8 + tissue-resident memory T (CD8 + Trm) cells play key roles in many immune-inflammation-related diseases. However, their characteristics in the pathological process of oral lichen planus (OLP) remains unclear. Therefore, we investigate…
Oral Epithelial Dysplasia Detection and Grading in Oral Leukoplakia Using Deep Learning Open
BACKGROUND The grading of oral epithelial dysplasia is often time-consuming for oral pathologists and the results are poorly reproducible between observers. In this study, we aimed to establish an objective, accurate and useful detection a…
circFANCA accelerates the malignant process of OSCC by modulating miR-34a/PA28γ signaling Open
The circFANCA/miR-34a/PA28γ axis facilitates the metastasis of OSCC, and circFANCA and miR-34a have potential to serve as prognostic markers for OSCC patients.
View article: Single-cell immune profiling reveals immune responses in oral lichen planus
Single-cell immune profiling reveals immune responses in oral lichen planus Open
Introduction Oral lichen planus (OLP) is a common chronic inflammatory disorder of the oral mucosa with an unclear etiology. Several types of immune cells are involved in the pathogenesis of OLP. Methods We used single-cell RNA sequencing …
View article: World Workshop on Oral Medicine VIII: Development of a core outcome set for oral lichen planus: a consensus study
World Workshop on Oral Medicine VIII: Development of a core outcome set for oral lichen planus: a consensus study Open
The COS developed by consensus will help reduce the heterogeneity of outcomes measured in interventional trials. This will allow future pooling of outcomes and data for meta-analyses. This project showed the effectiveness of a methodology …
World Workshop on Oral Medicine VIII: Development of a core outcome set for oral lichen planus: the patient perspective Open
We have gained valuable insight into the lived experience of patients with OLP via this qualitative study. To our knowledge, this study is the first to explore the patient perspective on what should be measured in clinical trials on OLP, h…
Photodynamic therapy reduced the risk of malignant transformation of oral leukoplakia: a retrospective study in an ethnic Chinese cohort Open
Objectives: This study aimed to evaluate the effect of photodynamic therapy (PDT) on the risk of malignant transformation of oral leukoplakia (OLK). Materials and methods: This retrospective cohort study involved 370 OLK patients diagnosed…
View article: Clinical epidemiological characteristics of oral lichen planus and risk factors for erosive subtype: a multi-center cross-sectional study in China
Clinical epidemiological characteristics of oral lichen planus and risk factors for erosive subtype: a multi-center cross-sectional study in China Open
Oral lichen planus (OLP) is one of the most common oral mucosal diseases, which is often persistent and has the risk of potential malignant transformation. To explore the clinical epidemiological characteristics of OLP in China and risk fa…