Hongxia Deng
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View article: Identification of specific brain cell types associated with the interplay between inflammatory bowel diseases and neuropsychiatric disorders by Cell-Stratified Mendelian Randomisation
Identification of specific brain cell types associated with the interplay between inflammatory bowel diseases and neuropsychiatric disorders by Cell-Stratified Mendelian Randomisation Open
CZ was supported by National Key Research and Development Program of China (2023YFC2705700), and operational funds from The First Affiliated Hospital of Nanchang University (500021010). LZ was supported by National Natural Science Foundati…
View article: AndesVL Technical Report: An Efficient Mobile-side Multimodal Large Language Model
AndesVL Technical Report: An Efficient Mobile-side Multimodal Large Language Model Open
In recent years, while cloud-based MLLMs such as QwenVL, InternVL, GPT-4o, Gemini, and Claude Sonnet have demonstrated outstanding performance with enormous model sizes reaching hundreds of billions of parameters, they significantly surpas…
View article: The Mediating Role of Social Participation in the Relationship Between High-Quality Economic Development and Mental Well-being Among Chinese Elderly
The Mediating Role of Social Participation in the Relationship Between High-Quality Economic Development and Mental Well-being Among Chinese Elderly Open
This study examines social participation’s mediating role in the relationship between high-quality economic development (HQED) and Chinese elderly’s mental well-being, using data from the China Health and Retirement Longitudinal Study (12,…
View article: Spindle Cell Spindle Sarcoma Harboring a Novel <i>RECQL::ROS1</i> Gene Fusion
Spindle Cell Spindle Sarcoma Harboring a Novel <i>RECQL::ROS1</i> Gene Fusion Open
Soft tissue sarcomas are a heterogeneous group of malignancies arising from mesenchymal cells. Recent advancements in genomic profiling have identified novel gene fusions in these tumors, offering new insights into their pathogenesis and p…
View article: First Report of Tomato Necrotic Ringspot Virus and Pepper Chlorotic Spot Virus Mixed Infection in Tomato and Pepper in Laos
First Report of Tomato Necrotic Ringspot Virus and Pepper Chlorotic Spot Virus Mixed Infection in Tomato and Pepper in Laos Open
Tomato (Solanum lycopersicum L.) and chili pepper (Capsicum annuum L.), key Solanaceous crops, are susceptible to viral diseases impacting yield and quality (Shahriari et al., 2023). During October of 2024, tomato samples (YV39744, YV85813…
View article: Curcumin-based polymer prodrug nanoplatform for high-efficiency immunotherapy by synergistically suppression of head and neck cancer cell stemness
Curcumin-based polymer prodrug nanoplatform for high-efficiency immunotherapy by synergistically suppression of head and neck cancer cell stemness Open
Our prodrug nanoplatform overcomes key resistance mechanisms in HNC by coordinately targeting stemness, inducing dual apoptosis/ferroptosis, and potentiating ICD through PDT/PTT-enhanced immunomodulation. This strategy provides a potent co…
View article: Effect of marriage on overweight and obesity: evidence from China
Effect of marriage on overweight and obesity: evidence from China Open
View article: Systematic low-grade chronic inflammation and intrinsic mechanisms in polycystic ovary syndrome
Systematic low-grade chronic inflammation and intrinsic mechanisms in polycystic ovary syndrome Open
Polycystic ovary syndrome (PCOS) is a prevalent endocrine and metabolic disorder affecting 6-20% of women of childbearing age worldwide. Immune cell imbalance and dysregulation of inflammatory factors can lead to systematic low-grade chron…
View article: Comparative efficacy and safety of metformin, anti-obesity agents, and myoinositol in improving IVF/ICSI outcomes and reducing ovarian hyperstimulation syndrome in women with polycystic ovary syndrome: a systematic review and network meta-analysis
Comparative efficacy and safety of metformin, anti-obesity agents, and myoinositol in improving IVF/ICSI outcomes and reducing ovarian hyperstimulation syndrome in women with polycystic ovary syndrome: a systematic review and network meta-analysis Open
View article: Genetic diversity of highly pathogenic avian influenza H5N6 and H5N8 viruses in poultry markets in Guangdong, China, 2020-2022
Genetic diversity of highly pathogenic avian influenza H5N6 and H5N8 viruses in poultry markets in Guangdong, China, 2020-2022 Open
H5 highly pathogenic avian influenza (HPAI) viruses of the A/Goose/Guangdong/1/96 (Gs/Gd) lineage continue to evolve and cause outbreaks in domestic poultry and wild birds, with sporadic spillover infections in mammals. The global spread o…
View article: Global epidemiological profile in nasopharyngeal carcinoma: a prediction study
Global epidemiological profile in nasopharyngeal carcinoma: a prediction study Open
Objectives This study delineates the global nasopharyngeal carcinoma’s (NPC) incidence and mortality across 185 countries in 2020 and projects the disease’s burden by 2040. Design A prediction study. Setting Countries within the 20 world r…
View article: Characterization of Cancer Stem Cells in Laryngeal Squamous Cell Carcinoma by Single-cell RNA Sequencing
Characterization of Cancer Stem Cells in Laryngeal Squamous Cell Carcinoma by Single-cell RNA Sequencing Open
Cancer stem cells (CSCs) constitute a pivotal element within the tumor microenvironment (TME), driving the initiation and progression of cancer. However, the identification of CSCs and their underlying molecular mechanisms in laryngeal squ…
View article: mTORC2-driven chromatin cGAS mediates chemoresistance through epigenetic reprogramming in colorectal cancer
mTORC2-driven chromatin cGAS mediates chemoresistance through epigenetic reprogramming in colorectal cancer Open
Cyclic GMP–AMP synthase (cGAS), a cytosolic DNA sensor that initiates a STING-dependent innate immune response, binds tightly to chromatin, where its catalytic activity is inhibited; however, mechanisms underlying cGAS recruitment to chrom…
View article: Irisin alleviated the reproductive endocrinal disorders of PCOS mice accompanied by changes in gut microbiota and metabolomic characteristics
Irisin alleviated the reproductive endocrinal disorders of PCOS mice accompanied by changes in gut microbiota and metabolomic characteristics Open
Introduction Folliculogenesis and oligo/anovulation are common pathophysiological characteristics in polycystic ovary syndrome (PCOS) patients, and it is also accompanied by gut microbiota dysbiosis. It is known that physical activity has …
View article: Autophagy-targeting modulation to promote peripheral nerve regeneration
Autophagy-targeting modulation to promote peripheral nerve regeneration Open
Nerve regeneration following traumatic peripheral nerve injuries and neuropathies is a complex process modulated by diverse factors and intricate molecular mechanisms. Past studies have focused on factors that stimulate axonal outgrowth an…
View article: Identification of a disulfidptosis-related lncRNA signature for the prognostic and immune landscape prediction in head and neck squamous cell carcinoma
Identification of a disulfidptosis-related lncRNA signature for the prognostic and immune landscape prediction in head and neck squamous cell carcinoma Open
View article: Injuries of Different Surgical Instruments on the Vocal Folds of Dogs
Injuries of Different Surgical Instruments on the Vocal Folds of Dogs Open
Compared with the CO2 laser, the electrotome and steel knife showed less damage and better healing, while the plasma radiofrequency ablation showed the most obvious thermal burns to laryngeal and vocal tissues during surgery, wi…
View article: Characterization of Cancer Stem Cells in Laryngeal Squamous Cell Carcinoma by Single-Cell RNA Sequencing
Characterization of Cancer Stem Cells in Laryngeal Squamous Cell Carcinoma by Single-Cell RNA Sequencing Open
Cancer stem cells (CSCs) constitute a pivotal element within the tumor microenvironment (TME), driving the initiation and progression of cancer. However, the identification of CSCs and their underlying molecular mechanisms in laryngeal squ…
View article: Predicting the prognosis, immune response, and immunotherapy in head and neck squamous cell carcinoma using a novel risk model based on anoikis-related lncRNAs
Predicting the prognosis, immune response, and immunotherapy in head and neck squamous cell carcinoma using a novel risk model based on anoikis-related lncRNAs Open
View article: Author Correction: Disordered metabolism in mice lacking irisin
Author Correction: Disordered metabolism in mice lacking irisin Open
1, where the value of 'iBAT ratio (%)' was erroneously stated as 'Liver ratio (%)' and 'Spleen ratio (%)' in the column 'WT' .The correct and incorrect values appear below.
View article: Biological function and clinical application prospect of tsRNAs in digestive system biology and pathology
Biological function and clinical application prospect of tsRNAs in digestive system biology and pathology Open
tsRNAs are small non-coding RNAs originating from tRNA that play important roles in a variety of physiological activities such as RNA silencing, ribosome biogenesis, retrotransposition, and epigenetic inheritance, as well as involvement in…
View article: Identification and validation of a novel signature based on T cell marker genes to predict prognosis, immunotherapy response and chemotherapy sensitivity in head and neck squamous carcinoma by integrated analysis of single-cell and bulk RNA-sequencing
Identification and validation of a novel signature based on T cell marker genes to predict prognosis, immunotherapy response and chemotherapy sensitivity in head and neck squamous carcinoma by integrated analysis of single-cell and bulk RNA-sequencing Open
View article: 1310P Loratadine: A potential game-changer in lung cancer treatment with improved survival outcomes
1310P Loratadine: A potential game-changer in lung cancer treatment with improved survival outcomes Open
View article: Neddylation inhibitor MLN4924 sensitizes head and neck squamous carcinoma cells to (S)-10-hydroxycamptothecin
Neddylation inhibitor MLN4924 sensitizes head and neck squamous carcinoma cells to (S)-10-hydroxycamptothecin Open
View article: Identification of a new anoikis-related gene signature for prognostic significance in head and neck squamous carcinomas
Identification of a new anoikis-related gene signature for prognostic significance in head and neck squamous carcinomas Open
Anoikis, a mode of programmed cell death, is essential for normal development and homeostasis in the organism and plays an important role in the onset and progression of cancers. The authors of this research sought to establish a gene sign…
View article: The influence of embryo stage on obstetric complications and perinatal outcomes following programmed compared to natural frozen-thawed embryo transfer cycles: a systematic review and meta-analysis
The influence of embryo stage on obstetric complications and perinatal outcomes following programmed compared to natural frozen-thawed embryo transfer cycles: a systematic review and meta-analysis Open
Objective To investigate the effect of embryo stage at the time of transfer on obstetric and perinatal outcomes in programmed frozen-thawed embryo transfer (FET) versus natural FET cycles. Design Systematic review and meta-analysis. Settin…
View article: Spatial metabolomics in head and neck tumors: a review
Spatial metabolomics in head and neck tumors: a review Open
The joint analysis of single-cell transcriptomics, proteomics, lipidomics, metabolomics and spatial metabolomics is continually transforming our understanding of the mechanisms of metabolic reprogramming in tumor cells. Since head and neck…
View article: Association between long-term exposure to air pollution and the risk of incident laryngeal cancer: a longitudinal UK Biobank-based study
Association between long-term exposure to air pollution and the risk of incident laryngeal cancer: a longitudinal UK Biobank-based study Open
View article: The influence of embryo stage on obstetric complications and perinatal outcomes following programmed compared to natural frozen-thawed embryo transfer cycles: A systematic review and meta-analysis
The influence of embryo stage on obstetric complications and perinatal outcomes following programmed compared to natural frozen-thawed embryo transfer cycles: A systematic review and meta-analysis Open
Background Recent literature has reported that the higher obstetric and perinatal complications in FET may be associated with endometrial preparation protocols. To date, the specific mechanism behind these higher complications is unknown a…
View article: Establishment and validation of a redox-related long non-coding RNAs prognostic signature in head and neck squamous cell carcinoma
Establishment and validation of a redox-related long non-coding RNAs prognostic signature in head and neck squamous cell carcinoma Open
Reduction and oxidation (redox) reactions occur in living organisms as part of normal cellular metabolism. Here, we established a novel redox-related long non-coding RNAs (rrlncRNAs) signature to predict the prognosis and therapeutic respo…