Hongxia Duan
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View article: Harnessing dental stem cell-derived synovial cells for IBD therapy: dual modulation of gut immunity and crypt repair
Harnessing dental stem cell-derived synovial cells for IBD therapy: dual modulation of gut immunity and crypt repair Open
Supported by Beijing Natural Science Foundation (7242034, 7242092, L232077), National Natural Science Foundation of China (81870393, 81970500, 82473154, 81970500, and 82203559), and Jiangsu Province Basic Research Special Fund (BK20240117).
View article: Lipid Droplet‐Organized MDM2‐Mediated P53 Degradation: A Metabolic Switch Governing Diet‐Driven Tumor Progression
Lipid Droplet‐Organized MDM2‐Mediated P53 Degradation: A Metabolic Switch Governing Diet‐Driven Tumor Progression Open
TP53 inactivation in human cancers often results from MDM2/MDMX overexpression, yet therapeutic targeting remains challenging owing to incomplete mechanistic understanding. Lipid droplet (LD) enrichment is identified as a key trigger for M…
View article: Involvement of CD146 in the <i>Cryptococcus neoformans</i> adhesion and infection of brain endothelial cells
Involvement of CD146 in the <i>Cryptococcus neoformans</i> adhesion and infection of brain endothelial cells Open
Cryptococcal meningitis is a common and refractory central nervous system (CNS) infection with high mortality and disability. For Cryptococcus neoformans ( C. neoformans ) to penetrate the CNS, it first adheres to and breaches the blood‒br…
View article: Application of chain body temperature management checklist in robotic surgery for urology: a randomised controlled trial
Application of chain body temperature management checklist in robotic surgery for urology: a randomised controlled trial Open
Using a chain temperature management checklist in the temperature management of patients undergoing urological robotic surgery can reduce the incidence of low body temperature and shivering, decrease the rate of implementation omissions an…
View article: Canopy humidity and irrigation regimes interactively affect rice physiology, grain filling and yield during grain filling period
Canopy humidity and irrigation regimes interactively affect rice physiology, grain filling and yield during grain filling period Open
Rice growth and yield performance are closely related to climate variables and soil water regimes. Therefore, in this study, normal humidity (NH) and high humidity (HH) treatments of rice canopy were performed and combined with continuous …
View article: The impact of three thioxothiazolidin compounds on trehalase activity and development of <i>Spodoptera frugiperda</i> larvae
The impact of three thioxothiazolidin compounds on trehalase activity and development of <i>Spodoptera frugiperda</i> larvae Open
Trehalases (TREs), serving as crucial enzymes regulating trehalose and chitin metabolism in insects, represent prime targets for pest control strategies. We investigated the impact of three thioxothiazolidin compounds (1G, 2G, and 11G) on …
View article: Mcam inhibits macrophage-mediated development of mammary gland through non-canonical Wnt signaling
Mcam inhibits macrophage-mediated development of mammary gland through non-canonical Wnt signaling Open
While canonical Wnt signaling is well recognized for its crucial regulatory functions in cell fate decisions, the role of non-canonical Wnt signaling in adult stem cells remains elusive and contradictory. Here, we identified Mcam , a poten…
View article: Optimising Complex Surgical Trays Based on PDSA Cycles
Optimising Complex Surgical Trays Based on PDSA Cycles Open
Multidisciplinary collaboration offers various benefits for optimising the configuration of external device sets, such as reducing the time taken for the preoperative sorting and counting of external devices, enhancing nurses' work efficie…
View article: Water management can alleviate the deterioration of rice quality caused by high canopy humidity
Water management can alleviate the deterioration of rice quality caused by high canopy humidity Open
This study conducted a two-year field artificial intelligence (AI) greenhouse rice planting experiment with different canopy humidity (normal humidity, NH; high humidity, and HH) and irrigation regimes (continuous flooding, CF; drought cul…
View article: KCNC3 acts as a potential biomarker that is involved in the prognosis and tumor immune microenvironment in colorectal cancer
KCNC3 acts as a potential biomarker that is involved in the prognosis and tumor immune microenvironment in colorectal cancer Open
Background Colorectal cancer (CRC), the most common primary tumor in the gastrointestinal system, is a leading cause of death due to cancer worldwide. CRC is a heterogeneous disease that is associated with several genetic or somatic mutati…
View article: Potential inhibitory effects of compounds ZK-PI-5 and ZK-PI-9 on trehalose and chitin metabolism in Spodoptera frugiperda (J. E. Smith)
Potential inhibitory effects of compounds ZK-PI-5 and ZK-PI-9 on trehalose and chitin metabolism in Spodoptera frugiperda (J. E. Smith) Open
Introduction: Spodoptera frugiperda is an omnivorous agricultural pest which is great dangerous for grain output. Methods: In order to investigate the effects of potential trehalase inhibitors, ZK-PI-5 and ZK-PI-9, on the growth and develo…
View article: Effect of spray cryotherapy on respiratory function in canine models of chronic bronchitis
Effect of spray cryotherapy on respiratory function in canine models of chronic bronchitis Open
Objective: Our aim was to explore whether SCT is effective in improving respiratory function in a canine model of chronic bronchitis and to further elucidate the associated biological mechanisms. Methods: A total of ten experimental dogs w…
View article: CD146 Associates with Gp130 to Control a Macrophage Pro‐inflammatory Program That Regulates the Metabolic Response to Obesity
CD146 Associates with Gp130 to Control a Macrophage Pro‐inflammatory Program That Regulates the Metabolic Response to Obesity Open
The mechanism of obesity‐related metabolic dysfunction involves the development of systemic inflammation, largely mediated by macrophages. Switching of M1‐like adipose tissue macrophages (ATMs) to M2‐like ATMs, a population of macrophages …
View article: Prognostic Significance of Circadian Gene Expression in Lung Cancer
Prognostic Significance of Circadian Gene Expression in Lung Cancer Open
Objective To explore the expression and prognostic significance of circadian genes (PER1, PER2, PER3, CRY1, CRY2, CLOCK and BMAL1) in lung cancer. Methods mRNA expressions of circadian rhythm genes in lung cancer and normal tissues were an…
View article: Phosphorylation of CAP1 regulates lung cancer proliferation, migration, and invasion
Phosphorylation of CAP1 regulates lung cancer proliferation, migration, and invasion Open
Purpose Cyclase-associated protein 1 (CAP1) is a ubiquitous protein which regulates actin dynamics. Previous studies have shown that S308 and S310 are the two major phosphorylated sites in human CAP1. In the present study, we aimed to inve…
View article: Effects of bronchial thermoplasty and cryoablation on airway smooth muscle
Effects of bronchial thermoplasty and cryoablation on airway smooth muscle Open
Background: The effectiveness of bronchial thermoplasty (BT) has been reported in patients with severe asthma. This study compared the effects of BT and cryoballoon ablation (CBA) therapy on the airway smooth muscle (ASM). Methods: Eight h…
View article: CD146 bound to LCK promotes T cell receptor signaling and antitumor immune responses in mice
CD146 bound to LCK promotes T cell receptor signaling and antitumor immune responses in mice Open
Initiation of T cell receptor (TCR) signaling involves the activation of the tyrosine kinase LCK; however, it is currently unclear how LCK is recruited and activated. Here, we have identified the membrane protein CD146 as an essential memb…
View article: TiO2 supported single Ag atoms nanozyme for elimination of SARS-CoV2
TiO2 supported single Ag atoms nanozyme for elimination of SARS-CoV2 Open
The outbreak of SARS-coronavirus 2 (SARS-CoV2) has become a global health emergency. Although enormous efforts have been made, there is still no effective treatment against the new virus. Herein, a TiO2 supported single-atom nanozyme conta…
View article: Phosphorylation of CAP1 Regulates Lung Cancer Proliferation, Migration and Invasion
Phosphorylation of CAP1 Regulates Lung Cancer Proliferation, Migration and Invasion Open
Purpose : Cyclase-associated protein 1 (CAP1) is a ubiquitous protein which regulates actin dynamics. Comprehensive bioinformatics analysis showed CAP1 is a type of cancer-related protein. Previous studies have shown that the protein CAP1 …
View article: Structure basis for AA98 inhibition on the activation of endothelial cells mediated by CD146
Structure basis for AA98 inhibition on the activation of endothelial cells mediated by CD146 Open
CD146 is an adhesion molecule that plays important roles in angiogenesis, cancer metastasis, and immune response. It exists as a monomer or dimer on the cell surface. AA98 is a monoclonal antibody that binds to CD146, which abrogates the a…
View article: CD146 is a Novel ANGPTL2 Receptor that Promotes Obesity by Manipulating Lipid Metabolism and Energy Expenditure
CD146 is a Novel ANGPTL2 Receptor that Promotes Obesity by Manipulating Lipid Metabolism and Energy Expenditure Open
Obesity and its related complications pose an increasing threat to human health; however, targetable obesity‐related membrane receptors are not yet elucidated. Here, the membrane receptor CD146 is demonstrated to play an essential role in …
View article: The diagnostic value of metagenomic next⁃generation sequencing in infectious diseases
The diagnostic value of metagenomic next⁃generation sequencing in infectious diseases Open
Background: Although traditional diagnostic techniques of infection are mature and price favorable at present, most of them are time-consuming and with a low positivity. Metagenomic next⁃generation sequencing (mNGS) was studied widely beca…
View article: Review and prospect of CD146 research
Review and prospect of CD146 research Open
CD146 was initially identified as a marker of melanoma in 1987. The research history of more than 30 years revealed its physiological functions in early development, immune response, metabolism, and pathological functions in inflammation…
View article: The diagnostic value of metagenomic next⁃generation sequencing in infectious diseases
The diagnostic value of metagenomic next⁃generation sequencing in infectious diseases Open
Background: Although traditional diagnostic techniques of infection are mature and price favorable at present, most of them are time-consuming and with a low positivity. Metagenomic next⁃generation sequencing (mNGS) was studied widely beca…
View article: The prognostic value of immune infiltration signature and its potential mechanism in gastric cancer
The prognostic value of immune infiltration signature and its potential mechanism in gastric cancer Open
The development of gastric cancer (GC) is closely associated with tumor microenvironment. Tumor infiltrating immune cells (TIICs), as a significant component of the tumor microenvironment, not only dominates the immune response of tumors, …