Hua Gu
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View article: Commentary: Blood metabolites as mediators in erectile dysfunction: insights from a multi-center proteomics and genetic study
Commentary: Blood metabolites as mediators in erectile dysfunction: insights from a multi-center proteomics and genetic study Open
View article: Design of arm joint for atmospheric diving suit
Design of arm joint for atmospheric diving suit Open
The arm of an atmospheric diving suit(ADS) is composed of various types of rotating joints and spacers connected in series. Divers complete various movements required for underwater operations by driving the rotation of various joints on t…
View article: A monolithic interdigitated PVDF transducer for structural health monitoring.
A monolithic interdigitated PVDF transducer for structural health monitoring. Open
A monolithic interdigitated PVDF transducer for structural health monitoring.
View article: Exploration and future prospects of intelligent supervision technology and system development in biological laboratories
Exploration and future prospects of intelligent supervision technology and system development in biological laboratories Open
Biological laboratories, which are crucial for research and medical trials, often face challenges such as disconnected data, fragmented systems, excessive manual processes, and insufficient smart technology. This study presents a comprehen…
View article: Identifying the genetic link between type 1 diabetes and autoimmune liver diseases
Identifying the genetic link between type 1 diabetes and autoimmune liver diseases Open
Employing two-sample MR analysis, we explored the association between T1DM and AILDs, finding that T1DM elevates the risk of AIH, PBC, and PSC. Further elucidation of the genomic landscape of T1DM and AILDs necessitates large-scale cross-d…
View article: Puncture frequency, coagulopathy, and liver injury as independent risk factors for bleeding in acute diquat poisoning after enhanced blood purification therapy
Puncture frequency, coagulopathy, and liver injury as independent risk factors for bleeding in acute diquat poisoning after enhanced blood purification therapy Open
EBPT increases bleeding risk in ADP patients, mainly due to procedural factors and organ dysfunction. Optimizing puncture techniques and closely monitoring coagulation and liver function may improve patient outcomes.
View article: On the Interplay of Clustering and Evolution in the Emergence of Epidemic Outbreaks
On the Interplay of Clustering and Evolution in the Emergence of Epidemic Outbreaks Open
In an increasingly interconnected world, a key scientific challenge is to examine mechanisms that lead to the widespread propagation of contagions, such as misinformation and pathogens, and identify risk factors that can trigger large-scal…
View article: Quality of life, sleep and anxiety status among patients with rosacea in the Yunnan plateau region: A 2‐year retrospective study
Quality of life, sleep and anxiety status among patients with rosacea in the Yunnan plateau region: A 2‐year retrospective study Open
Objective To investigate the life, sleep quality and anxiety of rosacea patients in Yunnan and the improvement of these aspects after treatment. Methods A total of 141 patients with rosacea and 123 healthy controls were included in our stu…
View article: Effect of blue light on the biological activity of human skin keratinocytes, fibroblasts and melanocytes: a preliminary study
Effect of blue light on the biological activity of human skin keratinocytes, fibroblasts and melanocytes: a preliminary study Open
摘要: 【摘要】 目的 初步探讨蓝光对人皮肤角质形成细胞、成纤维细胞与黑素细胞生物活性的影响。方法 收集2021年6月至2021年12月昆明医科大学第一附属医院10例3 ~ 12岁健康儿童包皮环切术后的废弃包皮,分离表真皮后采用选择培养基分离角质形成细胞、成纤维细胞、黑素细胞。根据预实验结果采用0、5、10、20、30、40 J/cm2剂量440 ~ 450 nm蓝光分别照射上述3种细胞,继续培养0、6、24、48 h,在各时间点采用CCK8法检测细胞增殖活力;酶联免疫吸附…
View article: Host factor TIMP1 sustains long-lasting myeloid-biased hematopoiesis after severe infection
Host factor TIMP1 sustains long-lasting myeloid-biased hematopoiesis after severe infection Open
Infection is able to promote innate immunity by enhancing a long-term myeloid output even after the inciting infectious agent has been cleared. However, the mechanisms underlying such a regulation are not fully understood. Using a mouse po…
View article: PB0267 High-Dose Dexamethasone Corrects the Elevated TCRαβ+ Double-Negative T Cells in Pediatric Patients with Primary Immune Thrombocytopenia
PB0267 High-Dose Dexamethasone Corrects the Elevated TCRαβ+ Double-Negative T Cells in Pediatric Patients with Primary Immune Thrombocytopenia Open
View article: Ubiquitin Ligases CBL and CBL-B Maintain the Homeostasis and Immune Quiescence of Dendritic Cells
Ubiquitin Ligases CBL and CBL-B Maintain the Homeostasis and Immune Quiescence of Dendritic Cells Open
Dendritic cells (DCs) are composed of multiple lineages of hematopoietic cells and orchestrate immune responses upon detecting the danger and inflammatory signals associated with pathogen and damaged tissues. Under steady-state, DCs are ma…
View article: Consensus on the Diagnosis and Treatment of Melasma in China (2021 Version)#
Consensus on the Diagnosis and Treatment of Melasma in China (2021 Version)# Open
The pathogenesis of melasma is believed to be related to heredity, sun exposure, sex hormones, and other factors. The mechanisms underlying the development of melasma include increased melanin synthesis, vascular proliferation within the s…
View article: The magnitude of germinal center reactions is restricted by a fixed number of preexisting niches
The magnitude of germinal center reactions is restricted by a fixed number of preexisting niches Open
Significance The germinal center (GC) reaction generates high-affinity antibody–producing plasma cells and memory B cells that are pivotal for immune responses against pathogens and effective vaccination. However, it remains a challenging …
View article: Cbl and Cbl-b control the germinal center reaction by facilitating naive B cell antigen processing
Cbl and Cbl-b control the germinal center reaction by facilitating naive B cell antigen processing Open
Antigen uptake and presentation by naive and germinal center (GC) B cells are different, with the former expressing even low-affinity BCRs efficiently capture and present sufficient antigen to T cells, whereas the latter do so more efficie…
View article: SINS model in the management of biosafety level 2 laboratories: exploration and practice
SINS model in the management of biosafety level 2 laboratories: exploration and practice Open
View article: Hippo Pathway Kinase Mst1 Is Required for Long-Lived Humoral Immunity
Hippo Pathway Kinase Mst1 Is Required for Long-Lived Humoral Immunity Open
The protein kinase Mst1 is a key component of the evolutionarily conserved Hippo pathway that regulates cell survival, proliferation, differentiation, and migration. In humans, Mst1 deficiency causes primary immunodeficiency. Patients with…
View article: Cbl Ubiquitin Ligases Control B Cell Exit from the Germinal-Center Reaction
Cbl Ubiquitin Ligases Control B Cell Exit from the Germinal-Center Reaction Open
View article: Correlation between prefrontal-striatal pathway impairment and cognitive impairment in patients with leukoaraiosis
Correlation between prefrontal-striatal pathway impairment and cognitive impairment in patients with leukoaraiosis Open
Our study aimed to investigate the changes of white matter microstructure of cortico-subcortical pathways using diffusion tensor imaging (DTI), and to explore the relationship between abnormal parameters of DTI and cognitive function under…
View article: The Csk-Associated Adaptor PAG Inhibits Effector T Cell Activation in Cooperation with Phosphatase PTPN22 and Dok Adaptors
The Csk-Associated Adaptor PAG Inhibits Effector T Cell Activation in Cooperation with Phosphatase PTPN22 and Dok Adaptors Open
View article: The Csk-Associated Adaptor PAG Inhibits Effector T Cell Activation in Cooperation with Phosphatase PTPN22 and Dok Adaptors
The Csk-Associated Adaptor PAG Inhibits Effector T Cell Activation in Cooperation with Phosphatase PTPN22 and Dok Adaptors Open