Hongxuan Feng
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View article: Cerebrovascular compromise and cognitive decline driven by chronic heart failure
Cerebrovascular compromise and cognitive decline driven by chronic heart failure Open
Objective This study investigated the effects of chronic heart failure with decreased LVEF on small cerebral vascular disease (CSVD) and associated cognitive impairment. Methods This study encompassed a cohort of 73 patients diagnosed with…
View article: Intestinal Microbiota, Metabolites and Brain Network Structure Changes in Polycystic Ovary Syndrome patients
Intestinal Microbiota, Metabolites and Brain Network Structure Changes in Polycystic Ovary Syndrome patients Open
Background Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting reproductive-aged women. We investigated gut microbiota and brain network alterations in PCOS patients. Methods We enrolled 26 PCOS patients and 20 health…
View article: Functional MRI study of neurovascular coupling in patients with non-lesional epilepsy
Functional MRI study of neurovascular coupling in patients with non-lesional epilepsy Open
Objective The diagnosis of patients with non-lesional epilepsy (NLE) is relatively challenging because of the absence of a clear focus on imaging, and the underlying pathological mechanism remains unclear. The neuronal activity and functio…
View article: Euthyroid sick syndrome predicts the risk of ischemic stroke-associated pneumonia in the acute stage of ischemic stroke: a nested case-control study
Euthyroid sick syndrome predicts the risk of ischemic stroke-associated pneumonia in the acute stage of ischemic stroke: a nested case-control study Open
Objective Ischemic stroke-associated pneumonia (iSAP) affects about 10% of acute ischemic stroke patients during hospitalization. Current prediction scales for iSAP are insufficient. Identifying early biomarkers for stroke-associated pneum…
View article: Relationship of Glymphatic Function with Cognitive Impairment, Sleep Disorders, Anxiety and Depression in Patients with Parkinson’s Disease
Relationship of Glymphatic Function with Cognitive Impairment, Sleep Disorders, Anxiety and Depression in Patients with Parkinson’s Disease Open
Glymphatic function is closely associated with cognition and sleep of PD patients.
View article: Serum biomarkers in patients with drug-resistant epilepsy: a proteomics-based analysis
Serum biomarkers in patients with drug-resistant epilepsy: a proteomics-based analysis Open
Objective To investigate the serum biomarkers in patients with drug-resistant epilepsy (DRE). Methods A total of 9 DRE patients and 9 controls were enrolled. Serum from DRE patients was prospectively collected and analyzed for potential se…
View article: Brain diffusion tensor imaging reveals altered connections and networks in epilepsy patients
Brain diffusion tensor imaging reveals altered connections and networks in epilepsy patients Open
Introduction Accumulating evidence shows that epilepsy is a disease caused by brain network dysfunction. This study explored changes in brain network structure in epilepsy patients based on graph analysis of diffusion tensor imaging data. …
View article: Study of brain network alternations in non-lesional epilepsy patients by BOLD-fMRI
Study of brain network alternations in non-lesional epilepsy patients by BOLD-fMRI Open
Objective To investigate the changes of brain network in epilepsy patients without intracranial lesions under resting conditions. Methods Twenty-six non-lesional epileptic patients and 42 normal controls were enrolled for BOLD-fMRI examina…
View article: A tract-based spatial statistics study of white matter integrity in epilepsy
A tract-based spatial statistics study of white matter integrity in epilepsy Open
Objective To investigate the changes of cerebral white matter diffusion tensor in epilepsy patients based on the method of tract-based spatial statistics (TBSS). Methods Twenty-six patients with epilepsy and 42 healthy volunteers matched f…
View article: Effect of cognitive behavioral intervention on anxiety, depression, and quality of life in patients with epilepsy.
Effect of cognitive behavioral intervention on anxiety, depression, and quality of life in patients with epilepsy. Open
Increases in overall scores, seizure worry, cognitive functioning, and medication effect were better in the CBT group. CBT can improve anxiety, depression, and quality of life in patients with epilepsy. Women and combined-drug patients wit…
View article: The Relationship Between Serum YKL-40 Levels on Admission and Stroke-Associated Pneumonia in Patients with Acute Ischemic Stroke
The Relationship Between Serum YKL-40 Levels on Admission and Stroke-Associated Pneumonia in Patients with Acute Ischemic Stroke Open
Our study demonstrated that YKL-40 might be considered as a useful biomarker to predict SAP in AIS patients.
View article: <i>RNA toxicity and perturbation of</i>rRNA processing in spinocerebellar ataxia type 2
<i>RNA toxicity and perturbation of</i>rRNA processing in spinocerebellar ataxia type 2 Open
BACKGROUND Spinocerebellar ataxia type 2 (SCA2) is a neurodegenerative disease caused by expansion of a CAG repeat in Ataxin-2 ( ATXN2 ) gene. The mutant ATXN2 protein with a polyglutamine tract is known to be toxic and contributes to the …
View article: Generation of a human induced pluripotent stem cell line JHUi003-A with homozygous mutation for spinocerebellar ataxia type 12 using genome editing
Generation of a human induced pluripotent stem cell line JHUi003-A with homozygous mutation for spinocerebellar ataxia type 12 using genome editing Open
Spinocerebellar ataxia type 12 (SCA12) is caused by a CAG expansion mutation in PPP2R2B, a gene encoding a brain-specific regulatory unit of protein phosphatase 2A (PP2A); while normal alleles carry 4 to 31 triplets, the disease alleles ca…
View article: Correction to: Protective Effects of 28-O-Cafeoyl Betulin (B-CA) on the Cerebral Cortex of Ischemic Rats Revealed by a NMR-Based Metabolomics Analysis
Correction to: Protective Effects of 28-O-Cafeoyl Betulin (B-CA) on the Cerebral Cortex of Ischemic Rats Revealed by a NMR-Based Metabolomics Analysis Open
View article: Dynamic Change of Eosinophil and Acute Ischemic Stroke
Dynamic Change of Eosinophil and Acute Ischemic Stroke Open
Background: Eosinopenia has been shown to be a predicative factor for the infection and mortality in ischemic stroke patients which mainly focused on static eosinophil count. This study aimed to explore the relationship between dynamic cha…
View article: Significant reduction in the LDL cholesterol increases the risk of intracerebral hemorrhage: a systematic review and meta-analysis of 33 randomized controlled trials.
Significant reduction in the LDL cholesterol increases the risk of intracerebral hemorrhage: a systematic review and meta-analysis of 33 randomized controlled trials. Open
The dose-dependent pleiotropic effects of statin therapy may have unwanted side effects such as increasing the risk of intracerebral hemorrhage (ICH). The relationships among statin therapy, LDL-cholesterol levels, and ICH risk remain cont…
View article: Long-noncoding RNA Peg13 alleviates epilepsy progression in mice via the miR-490-3p/Psmd11 axis to inactivate the Wnt/β-catenin pathway.
Long-noncoding RNA Peg13 alleviates epilepsy progression in mice via the miR-490-3p/Psmd11 axis to inactivate the Wnt/β-catenin pathway. Open
Epilepsy, one of the most common neurological diseases with spontaneous recurrent seizures, is a severe health problem globally. The present study aimed to study the role and upstream mechanism of 26S proteasome non-ATPase regulatory subun…
View article: A11, a novel diaryl acylhydrazone derivative, exerts neuroprotection against ischemic injury in vitro and in vivo
A11, a novel diaryl acylhydrazone derivative, exerts neuroprotection against ischemic injury in vitro and in vivo Open
View article: T-lymphocyte subsets as a predictive biomarker for stroke-associated pneumonia.
T-lymphocyte subsets as a predictive biomarker for stroke-associated pneumonia. Open
The aim of this study was to facilitate the clinical treatment and prognosis of stroke-associated pneumonia (SAP) by examining changes in T-lymphocyte subsets. Stroke patients admitted in Suzhou Hospital between 2014 and 2016 participated …
View article: Dual anti-ischemic effects of rosmarinic acid n-butyl ester via alleviation of DAPK-p53-mediated neuronal damage and microglial inflammation
Dual anti-ischemic effects of rosmarinic acid n-butyl ester via alleviation of DAPK-p53-mediated neuronal damage and microglial inflammation Open
View article: Influence of renal function on the association between homocysteine level and risk of ischemic stroke.
Influence of renal function on the association between homocysteine level and risk of ischemic stroke. Open
We examined whether the association between total homocysteine (tHCY) and risk of ischemic stroke (IS) varies depending on renal function to gain insight into why tHCY-lowering vitamins do not reduce the incidence of cardiovascular disease…