Hong‐Yi Zheng
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View article: Correction: SARS-CoV-2-triggered mast cell rapid degranulation induces alveolar epithelial inflammation and lung injury
Correction: SARS-CoV-2-triggered mast cell rapid degranulation induces alveolar epithelial inflammation and lung injury Open
View article: Establishment and evaluation of a predictive model for immune reconstitution in people living with HIV after antiretroviral therapy
Establishment and evaluation of a predictive model for immune reconstitution in people living with HIV after antiretroviral therapy Open
This study successfully developed a prediction model with robust performance. This model has considerable potential to aid clinicians in tailoring treatment strategies, which could enhance outcomes and quality of life for PLWH.
View article: Establishment and validation of a predictive model for immune reconstitution in people with HIV after antiretroviral therapy
Establishment and validation of a predictive model for immune reconstitution in people with HIV after antiretroviral therapy Open
Background Achieving complete immune reconstitution (CIR) in people with human immunodeficiency virus (PWH) following antiretroviral therapy (ART) is essential for preventing acquired immunodeficiency syndrome (AIDS) progression and improv…
View article: Immunosenescence and its related comorbidities in older people living with HIV
Immunosenescence and its related comorbidities in older people living with HIV Open
With the aging of the global population, older people living with HIV (OPLWH) have emerged as a focal point in HIV/AIDS research. Although antiretroviral therapy has demonstrated positive effects in OPLWH, concerns persist regarding overal…
View article: Treatment outcomes amongst older people with HIV infection receiving antiretroviral therapy
Treatment outcomes amongst older people with HIV infection receiving antiretroviral therapy Open
Objectives: There is conflicting data regarding the response of older people with HIV (PWH) to antiretroviral therapy (ART). The objective of this study was to evaluate the long-term immunological and virological responses, changes in regi…
View article: Immunobiology of COVID-19: Mechanistic and therapeutic insights from animal models
Immunobiology of COVID-19: Mechanistic and therapeutic insights from animal models Open
The distribution of the immune system throughout the body complicates in vitro assessments of coronavirus disease 2019 (COVID-19) immunobiology, often resulting in a lack of reproducibility when extrapolated to the whole organism. C…
View article: Noisy Exemplars Make Large Language Models More Robust: A Domain-Agnostic Behavioral Analysis
Noisy Exemplars Make Large Language Models More Robust: A Domain-Agnostic Behavioral Analysis Open
Recent advances in prompt engineering enable large language models (LLMs) to solve multi-hop logical reasoning problems with impressive accuracy. However, there is little existing work investigating the robustness of LLMs with few-shot pro…
View article: The Efficacy and Safety of Different Noninvasive Therapies in the Treatment of Central Poststroke Pain (CPSP): A Network Meta-Analysis and Systematic Review
The Efficacy and Safety of Different Noninvasive Therapies in the Treatment of Central Poststroke Pain (CPSP): A Network Meta-Analysis and Systematic Review Open
Objective: To evaluate the efficacy and safety of noninvasive therapies in the treatment of central poststroke pain (CPSP) by network meta-analysis and to provide an evidence-based basis for clinical practice. Methods: PubMed, Cochrane Lib…
View article: Making the Most Out of the Limited Context Length: Predictive Power Varies with Clinical Note Type and Note Section
Making the Most Out of the Limited Context Length: Predictive Power Varies with Clinical Note Type and Note Section Open
Recent advances in large language models have led to renewed interest in natural language processing in healthcare using the free text of clinical notes. One distinguishing characteristic of clinical notes is their long time span over mult…
View article: Immune resilience despite inflammatory stress promotes longevity and favorable health outcomes including resistance to infection
Immune resilience despite inflammatory stress promotes longevity and favorable health outcomes including resistance to infection Open
View article: Genomic Evidence for the Nonpathogenic State in HIV-1–Infected Northern Pig-Tailed Macaques
Genomic Evidence for the Nonpathogenic State in HIV-1–Infected Northern Pig-Tailed Macaques Open
HIV-1 is a highly host-specific retrovirus that infects humans but not most nonhuman primates. Thus, the lack of a suitable primate model that can be directly infected with HIV-1 hinders HIV-1/AIDS research. In the previous study, we have …
View article: Extracellular vesicles mediate antibody-resistant transmission of SARS-CoV-2
Extracellular vesicles mediate antibody-resistant transmission of SARS-CoV-2 Open
View article: Noisy Exemplars Make Large Language Models More Robust: A Domain-Agnostic Behavioral Analysis
Noisy Exemplars Make Large Language Models More Robust: A Domain-Agnostic Behavioral Analysis Open
Recent advances in prompt engineering enable large language models (LLMs) to solve multi-hop logical reasoning problems with impressive accuracy. However, there is little existing work investigating the robustness of LLMs with few-shot pro…
View article: Making the Most Out of the Limited Context Length: Predictive Power Varies with Clinical Note Type and Note Section
Making the Most Out of the Limited Context Length: Predictive Power Varies with Clinical Note Type and Note Section Open
Hongyi Zheng, Yixin Zhu, Lavender Jiang, Kyunghyun Cho, Eric Oermann. Proceedings of the 61st Annual Meeting of the Association for Computational Linguistics (Volume 4: Student Research Workshop). 2023.
View article: Immunogenicity and safety of the CoronaVac inactivated SARS-CoV-2 vaccine in people with underlying medical conditions in China: a retrospective study
Immunogenicity and safety of the CoronaVac inactivated SARS-CoV-2 vaccine in people with underlying medical conditions in China: a retrospective study Open
People living with chronic disease, particularly seniors older than 60 years old, are lagging behind in the national COVID-19 vaccination campaign in China due to the uncertainty of vaccine safety and effectiveness. However, this special p…
View article: Aging induces severe SIV infection accompanied by an increase in follicular CD8+ T cells with overactive STAT3 signaling
Aging induces severe SIV infection accompanied by an increase in follicular CD8+ T cells with overactive STAT3 signaling Open
View article: Transcription Factor ZNF683 Inhibits SIV/HIV Replication through Regulating IFNγ Secretion of CD8+ T Cells
Transcription Factor ZNF683 Inhibits SIV/HIV Replication through Regulating IFNγ Secretion of CD8+ T Cells Open
Pulmonary microbial invasion frequently occurs during AIDS progression in HIV patients. Inflammatory cytokines and other immunoregulatory factors play important roles in this process. We previously established an AIDS model of SIVmac239 in…
View article: CoVac501, a self-adjuvanting peptide vaccine conjugated with TLR7 agonists, against SARS-CoV-2 induces protective immunity
CoVac501, a self-adjuvanting peptide vaccine conjugated with TLR7 agonists, against SARS-CoV-2 induces protective immunity Open
View article: Immunogenicity and Safety of the Coronavac Inactivated SARS-CoV-2 Vaccine in People with Underlying Medical Conditions: A Retrospective Study
Immunogenicity and Safety of the Coronavac Inactivated SARS-CoV-2 Vaccine in People with Underlying Medical Conditions: A Retrospective Study Open
View article: SARS-CoV-2-triggered mast cell rapid degranulation induces alveolar epithelial inflammation and lung injury
SARS-CoV-2-triggered mast cell rapid degranulation induces alveolar epithelial inflammation and lung injury Open
View article: Pro-inflammatory microenvironment and systemic accumulation of CXCR3+ cell exacerbate lung pathology of old rhesus macaques infected with SARS-CoV-2
Pro-inflammatory microenvironment and systemic accumulation of CXCR3+ cell exacerbate lung pathology of old rhesus macaques infected with SARS-CoV-2 Open
Understanding the pathological features of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in an animal model is crucial for the treatment of coronavirus disease 2019 (COVID-19). Here, we compared immunopathological …
View article: SARS-CoV-2-Triggered Mast Cell Rapid Degranulation Induces Alveolar Epithelial Inflammation and Lung Injury
SARS-CoV-2-Triggered Mast Cell Rapid Degranulation Induces Alveolar Epithelial Inflammation and Lung Injury Open
SARS-CoV-2 infection-induced hyper-inflammation links to the acute lung injury and COVID-19 severity. Identifying the primary mediators that initiate the uncontrolled hypercytokinemia is essential for treatments. Mast cells (MCs) are strat…
View article: Gastrodin Exerts Cardioprotective Action via Inhibition of Insulin-Like Growth Factor Type 2/Insulin-Like Growth Factor Type 2 Receptor Expression in Cardiac Hypertrophy
Gastrodin Exerts Cardioprotective Action via Inhibition of Insulin-Like Growth Factor Type 2/Insulin-Like Growth Factor Type 2 Receptor Expression in Cardiac Hypertrophy Open
Pathological cardiac hypertrophy is commonly associated with an upregulation of fetal genes, fibrosis, cardiac dysfunction, and heart failure. Previous studies have demonstrated that gastrodin (GAS) exerts cardioprotective action in the tr…
View article: Tree Shrew Cells Transduced with Human CD4 and CCR5 Support Early Steps of HIV-1 Replication, but Viral Infectivity Is Restricted by APOBEC3
Tree Shrew Cells Transduced with Human CD4 and CCR5 Support Early Steps of HIV-1 Replication, but Viral Infectivity Is Restricted by APOBEC3 Open
The development of animal models is critical for studying human diseases and their pathogenesis and for evaluating drug and vaccine efficacy. For improved AIDS research, the ideal animal model of HIV-1 infection should be a small laborator…
View article: Northern pig-tailed macaques (<i>Macaca leonina</i>) infected with SARS-CoV-2 show rapid viral clearance and persistent immune response
Northern pig-tailed macaques (<i>Macaca leonina</i>) infected with SARS-CoV-2 show rapid viral clearance and persistent immune response Open
Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2), has become an unprecedented global health emergency. At present, SARS-CoV-2-infected nonhuman primates are considered the g…
View article: A cross-talk between epithelium and endothelium mediates human alveolar–capillary injury during SARS-CoV-2 infection
A cross-talk between epithelium and endothelium mediates human alveolar–capillary injury during SARS-CoV-2 infection Open
View article: Elevated exhaustion levels and reduced functional diversity of T cells in peripheral blood may predict severe progression in COVID-19 patients
Elevated exhaustion levels and reduced functional diversity of T cells in peripheral blood may predict severe progression in COVID-19 patients Open
View article: Delayed severe cytokine storm and immune cell infiltration in SARS-CoV-2-infected aged Chinese rhesus macaques
Delayed severe cytokine storm and immune cell infiltration in SARS-CoV-2-infected aged Chinese rhesus macaques Open
As of June 2020, Coronavirus Disease 2019 (COVID-19) has killed an estimated 440 000 people worldwide, 74% of whom were aged ≥65 years, making age the most significant risk factor for death caused by severe acute respiratory syndrome coron…
View article: Superior intestinal integrity and limited microbial translocation are associated with lower immune activation in SIVmac239-infected northern pig-tailed macaques (<em>Macaca leonina</em>)
Superior intestinal integrity and limited microbial translocation are associated with lower immune activation in SIVmac239-infected northern pig-tailed macaques (<em>Macaca leonina</em>) Open
Microbial translocation is a cause of systemic immune activation in HIV/SIV infection. In the present study, we found a lower CD8+ T cell activation level in Macaca leonina (northern pig-tailed macaques, NPMs) than in …
View article: Host Restriction Factors APOBEC3G/3F and Other Interferon-Related Gene Expressions Affect Early HIV-1 Infection in Northern Pig-Tailed Macaque (Macaca leonina)
Host Restriction Factors APOBEC3G/3F and Other Interferon-Related Gene Expressions Affect Early HIV-1 Infection in Northern Pig-Tailed Macaque (Macaca leonina) Open
The northern pig-tailed macaques (NPMs) lack TRIM5α, an antiviral restriction factor, and instead have TRIM5-CypA. In our previous study, we demonstrated that HIV-1NL4-3 successfully infected NPMs and formed a long-term viral re…