Hongyue Li
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View article: Seasonal dynamics of hedgehog-borne ticks and severe fever with thrombocytopenia syndrome virus in Beijing's urban parks
Seasonal dynamics of hedgehog-borne ticks and severe fever with thrombocytopenia syndrome virus in Beijing's urban parks Open
Severe fever with thrombocytopenia syndrome virus (SFTSV), an emerging tick-borne pathogen, has caused a rising number of human cases in the urban-rural fringe of Beijing since 2021. This study explores the seasonal dynamics of hedgehog-as…
View article: Gene delivery in mosquitos with a vesicular stomatitis virus vector
Gene delivery in mosquitos with a vesicular stomatitis virus vector Open
Gain- and loss-of-function techniques are essential for comprehensive investigation of gene function. In mosquitoes, effective loss-of-function (LOF) methods such as RNA interference and gene knockout are available. However, convenient and…
View article: Structure-based engineering of the midnolin-proteasome pathway for targeted protein degradation
Structure-based engineering of the midnolin-proteasome pathway for targeted protein degradation Open
View article: Stochastic configuring networks based adaptive sliding mode control strategy to improving stability of SG-VSG paralleled microgrid
Stochastic configuring networks based adaptive sliding mode control strategy to improving stability of SG-VSG paralleled microgrid Open
This article proposes an adaptive sliding mode control (SMC) strategy based on stochastic configuring networks (SCNs) to improve the stability of synchronous generator (SG) and virtual synchronous generator (VSG) paralleled microgrid and e…
View article: Identification of hub genes and key modules in laryngeal squamous cell carcinoma
Identification of hub genes and key modules in laryngeal squamous cell carcinoma Open
We recognized the hub genes and key modules nearly associated to LSCC and these genes were validated by survival analysis and the database of Human Protein Atlas (HPA), which is of high importance for unveiling the pathogenesis of LSCC and…
View article: PA-824 inhibits porcine epidemic diarrhea virus infection <i>in vivo</i> and <i>in vitro</i> by inhibiting p53 activation
PA-824 inhibits porcine epidemic diarrhea virus infection <i>in vivo</i> and <i>in vitro</i> by inhibiting p53 activation Open
Porcine epidemic diarrhea virus (PEDV) is a type A coronavirus that causes severe watery diarrhea in piglets, resulting in severe economic losses worldwide. Therefore, new approaches to control PEDV infection are essential for a robust and…
View article: Bruceine B Displays Potent Antimyeloma Activity by Inducing the Degradation of the Transcription Factor c-Maf
Bruceine B Displays Potent Antimyeloma Activity by Inducing the Degradation of the Transcription Factor c-Maf Open
The oncogenic transcription factor c-Maf has been proposed as an ideal therapeutic target for multiple myeloma (MM), a not-yet-curable malignancy of plasma cells. In the present study, we establish a c-Maf-based luciferase screen system an…
View article: A Wireless System for Monitoring Termite Activity Using Electromagnetic Induction with Non-Looping Method
A Wireless System for Monitoring Termite Activity Using Electromagnetic Induction with Non-Looping Method Open
Termites can cause severe economic damage in households, reservoirs, agriculture, and forests. Monitoring termite activity plays an important role in integrated termite management. A device for the automatic monitoring of termites with hig…
View article: Structural insights into anion selectivity and activation mechanism of LRRC8 volume-regulated anion channels
Structural insights into anion selectivity and activation mechanism of LRRC8 volume-regulated anion channels Open
Volume-regulated anion channels (VRACs) are hexamers of LRRC8 proteins that are crucial for cell volume regulation. N termini (NTs) of the obligatory LRRC8A subunit modulate VRACs activation and ion selectivity, but the underlying mechanis…
View article: Effects of Compound Probiotics on Cecal Microbiota and Metabolome of Swine
Effects of Compound Probiotics on Cecal Microbiota and Metabolome of Swine Open
Complex probiotics are made from various single probiotics mixed in scientific formula. The long-term intake of different probiotics is beneficial to maintain the intestinal microecological balance, inhibiting harmful pathogenic flora and …
View article: Atypical Face Process in Autism Spectrum Disorder and Relevant Interventions
Atypical Face Process in Autism Spectrum Disorder and Relevant Interventions Open
The current study overviewed previous research on abnormalities in face processing in individuals with autism spectrum disorder (ASD) and concluded implications on development of relevant social skill interventions. Overall, autistic indiv…
View article: Growth, Antigenicity, and Immunogenicity of SARS-CoV-2 Spike Variants Revealed by a Live rVSV-SARS-CoV-2 Virus
Growth, Antigenicity, and Immunogenicity of SARS-CoV-2 Spike Variants Revealed by a Live rVSV-SARS-CoV-2 Virus Open
SARS-CoV-2 is an emerging coronavirus threatening human health and the economy worldwide. As an RNA virus, variants emerge during the pandemic and potentially influence the efficacy of the anti-viral drugs and vaccines. Eight spike variant…
View article: Rapid Spread of Severe Fever with Thrombocytopenia Syndrome Virus by Parthenogenetic Asian Longhorned Ticks
Rapid Spread of Severe Fever with Thrombocytopenia Syndrome Virus by Parthenogenetic Asian Longhorned Ticks Open
Severe fever with thrombocytopenia syndrome virus (SFTSV) is spreading rapidly in Asia. This virus is transmitted by the Asian longhorned tick (Haemaphysalis longicornis), which has parthenogenetically and sexually reproducing populations.…
View article: PD-L1 deficiency sensitizes tumor cells to DNA-PK inhibition and enhances cGAS-STING activation.
PD-L1 deficiency sensitizes tumor cells to DNA-PK inhibition and enhances cGAS-STING activation. Open
Immunotherapies that block PD-L1/PD-1 immune checkpoint proteins represent a landmark breakthrough in cancer treatment. Although the role of PD-L1 in suppressing T cell activity has been extensively studied, its cancer cell-intrinsic funct…
View article: Enhanced protective immunity against SARS-CoV-2 elicited by a VSV vector expressing a chimeric spike protein
Enhanced protective immunity against SARS-CoV-2 elicited by a VSV vector expressing a chimeric spike protein Open
SARS-CoV-2 and SARS-CoV are genetically related coronavirus and share the same cellular receptor ACE2. By replacing the VSV glycoprotein with the spikes (S) of SARS-CoV-2 and SARS-CoV, we generated two replication-competent recombinant vir…
View article: Severe fever with thrombocytopenia syndrome virus and parthenogenetic Asian longhorned tick <i>Haemaphysalis longicornis</i> (Acari: Ixodidae)
Severe fever with thrombocytopenia syndrome virus and parthenogenetic Asian longhorned tick <i>Haemaphysalis longicornis</i> (Acari: Ixodidae) Open
Severe fever with thrombocytopenia syndrome virus (SFTSV) is spreading rapidly in Asia. It is transmitted by Haemaphysalis longicornis (Asian longhorned tick, ALT), which has both parthenogenetically and sexually reproducing populations. P…
View article: Patient-Derived Xenografts Are a Reliable Preclinical Model for the Personalized Treatment of Epithelial Ovarian Cancer
Patient-Derived Xenografts Are a Reliable Preclinical Model for the Personalized Treatment of Epithelial Ovarian Cancer Open
To generate robust patient-derived xenograft (PDX) models for epithelial ovarian cancer (EOC), analyze the resemblance of PDX models to the original tumors, and explore factors affecting engraftment rates, fresh cancer tissues from a conse…
View article: Genomic characterization of co-existing neoplasia and carcinoma lesions reveals distinct evolutionary paths of gallbladder cancer
Genomic characterization of co-existing neoplasia and carcinoma lesions reveals distinct evolutionary paths of gallbladder cancer Open
View article: Analysis of the genomic landscape of yolk sac tumors reveals mechanisms of evolution and chemoresistance
Analysis of the genomic landscape of yolk sac tumors reveals mechanisms of evolution and chemoresistance Open
View article: IL-37 Gene Modification Enhances the Protective Effects of Mesenchymal Stromal Cells on Intestinal Ischemia Reperfusion Injury
IL-37 Gene Modification Enhances the Protective Effects of Mesenchymal Stromal Cells on Intestinal Ischemia Reperfusion Injury Open
Background . Ischemia reperfusion injury (IRI) is the major cause of intestinal damage in clinic. Although either mesenchymal stromal cells (MSCs) or interleukin 37 (IL-37) shows some beneficial roles to ameliorate IRI, their effects are l…
View article: IL-37 Gene Modification Enhances the Protective Effects of Mesenchymal Stromal Cells on Intestinal Ischemia Reperfusion Injury
IL-37 Gene Modification Enhances the Protective Effects of Mesenchymal Stromal Cells on Intestinal Ischemia Reperfusion Injury Open
Background : Ischemia reperfusion injury (IRI) is the major cause of intestinal damage in clinic. Although either mesenchymal stromal cells (MSCs) or interleukin 37 (IL-37) showed some beneficial roles to ameliorate IRI, their effects are …
View article: IL-37 Gene Modification Enhances the Protective Effects of Mesenchymal Stromal Cells on Intestinal Ischemia Reperfusion Injury
IL-37 Gene Modification Enhances the Protective Effects of Mesenchymal Stromal Cells on Intestinal Ischemia Reperfusion Injury Open
Background: Ischemia reperfusion injury (IRI) is the major cause of intestinal damage in clinic. Although either mesenchymal stromal cells (MSCs) or interleukin 37 (IL-37) showed some beneficial roles to ameliorate IRI, their effects are l…
View article: Mechanism of indoleamine 2, 3‐dioxygenase inhibiting cardiac allograft rejection in mice
Mechanism of indoleamine 2, 3‐dioxygenase inhibiting cardiac allograft rejection in mice Open
Indoleamine 2, 3‐dioxygenase (IDO)‐mediated regulation of tryptophan metabolism plays an important role in immune tolerance in transplantation, but it has not been elucidated which mechanism specifically induces the occurrence of immune to…
View article: Establishment of replication-competent vesicular stomatitis virus-based recombinant viruses suitable for SARS-CoV-2 entry and neutralization assays
Establishment of replication-competent vesicular stomatitis virus-based recombinant viruses suitable for SARS-CoV-2 entry and neutralization assays Open
Replication-competent vesicular stomatitis virus (VSV)-based recombinant viruses are useful tools for studying emerging and highly pathogenic enveloped viruses in level 2 biosafety facilities. Here, we used a replication-competent recombin…
View article: SDF-1/CXCR4 axis enhances the immunomodulation of human endometrial regenerative cells in alleviating experimental colitis
SDF-1/CXCR4 axis enhances the immunomodulation of human endometrial regenerative cells in alleviating experimental colitis Open
View article: Complete genome sequence and comparative genomics of the golden pompano ( <i>Trachinotus ovatus</i> ) pathogen, V <i>ibrio harveyi</i> strain QT520
Complete genome sequence and comparative genomics of the golden pompano ( <i>Trachinotus ovatus</i> ) pathogen, V <i>ibrio harveyi</i> strain QT520 Open
Vibrio harveyi is a Gram-negative, halophilic bacterium that is an opportunistic pathogen of commercially farmed marine vertebrate species. To understand the pathogenicity of this species, the genome of V. harveyi QT520 was analyzed and co…
View article: Peer Review #1 of "Complete genome sequence and comparative genomics of the golden pompano (Trachinotus ovatus) pathogen, Vibrio harveyi strain QT520 (v0.1)"
Peer Review #1 of "Complete genome sequence and comparative genomics of the golden pompano (Trachinotus ovatus) pathogen, Vibrio harveyi strain QT520 (v0.1)" Open
Vibrio harveyi is a Gram-negative, halophilic bacterium that is an opportunistic pathogen of commercially farmed marine vertebrate species.To understand the pathogenicity of this species, the genome of V. harveyi QT520 was analyzed and com…
View article: Peer Review #1 of "Complete genome sequence and comparative genomics of the golden pompano (Trachinotus ovatus) pathogen, Vibrio harveyi strain QT520 (v0.2)"
Peer Review #1 of "Complete genome sequence and comparative genomics of the golden pompano (Trachinotus ovatus) pathogen, Vibrio harveyi strain QT520 (v0.2)" Open
Vibrio harveyi is a Gram-negative, halophilic bacterium that is an opportunistic pathogen of commercially farmed marine vertebrate species.To understand the pathogenicity of this species, the genome of V. harveyi QT520 was analyzed and com…
View article: Peer Review #2 of "Complete genome sequence and comparative genomics of the golden pompano (Trachinotus ovatus) pathogen, Vibrio harveyi strain QT520 (v0.1)"
Peer Review #2 of "Complete genome sequence and comparative genomics of the golden pompano (Trachinotus ovatus) pathogen, Vibrio harveyi strain QT520 (v0.1)" Open
Vibrio harveyi is a Gram-negative, halophilic bacterium that is an opportunistic pathogen of commercially farmed marine vertebrate species.To understand the pathogenicity of this species, the genome of V. harveyi QT520 was analyzed and com…
View article: A Method for Determining the Content of Glycoproteins in Biological Samples
A Method for Determining the Content of Glycoproteins in Biological Samples Open
The glycoprotein purified from the mycelium extract of Tremella fuciformis was marked with iodine through the iodine substitution reaction. The content of iodine, which is indicative of the amount of the marked tremella glycoprotein (ITG),…