Hongzhe Duan
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View article: Protective role of overweight in Alzheimer’s disease: New findings from Mendelian randomization study
Protective role of overweight in Alzheimer’s disease: New findings from Mendelian randomization study Open
Background Weight loss has been associated with Alzheimer’s Disease (AD), suggesting the possibility that overweight may be protective against AD. Mendelian Randomization (MR) is a common method of revealing causal relationships in observa…
View article: TRAFFIC-RELATED AIR POLLUTION AND INFECTIONS JOINTLY INCREASE THE RISK OF ALZHEIMER’S DISEASE IN OLDER ADULTS
TRAFFIC-RELATED AIR POLLUTION AND INFECTIONS JOINTLY INCREASE THE RISK OF ALZHEIMER’S DISEASE IN OLDER ADULTS Open
Accumulating evidence points to a potentially major role of vulnerability to infections in Alzheimer’s disease (AD) development, although the exact mechanism is not clear. AD is a multifactorial disorder, and the presence of other risk fac…
View article: Interaction between polymorphisms in <i>MBP</i> and <i>EIF2B5</i> genes is significantly associated with Alzheimer’s disease
Interaction between polymorphisms in <i>MBP</i> and <i>EIF2B5</i> genes is significantly associated with Alzheimer’s disease Open
Background Results of recent analyses indicate that axon demyelination may play an important role in AD pathology. The MBP gene encodes a myelin basic protein involved in axon myelination in the nervous system including the central nervous…
View article: AGE-RELATED CHANGES IN BODY WEIGHT AS DETERMINANTS OF EXTREME LONGEVITY
AGE-RELATED CHANGES IN BODY WEIGHT AS DETERMINANTS OF EXTREME LONGEVITY Open
Age-related changes in body weight may mirror fundamental processes of aging and ontogeny that contribute to determining human longevity limits. We estimated the mean age trajectories of weight, along with their key characteristics, such a…
View article: THE INTERPLAY BETWEEN GENETIC VARIANTS IN MIR146A AND ABCG2 GENES IS ASSOCIATED WITH HUMAN SURVIVAL
THE INTERPLAY BETWEEN GENETIC VARIANTS IN MIR146A AND ABCG2 GENES IS ASSOCIATED WITH HUMAN SURVIVAL Open
The ABCG2 gene is well-known for its role in developing drug resistance and for its impact on the survival of cancer patients. To modulate the effects of ABCG2 on health and survival different intervention strategies were suggested. Among …
View article: Prior infections and polymorphism in NECTIN2 gene are synergistically associated with reduced hippocampal volume, a biomarker of neurodegeneration, in older women
Prior infections and polymorphism in NECTIN2 gene are synergistically associated with reduced hippocampal volume, a biomarker of neurodegeneration, in older women Open
Background A growing body of research suggests a connection between Alzheimer’s disease (AD) and prior infections, although the mechanisms are not well understood. We recently reported a significant association between a history of adult i…
View article: Is being overweight a causal factor in better survival among the oldest old? a Mendelian randomization study
Is being overweight a causal factor in better survival among the oldest old? a Mendelian randomization study Open
Overweight, defined by a body mass index (BMI) between 25 and 30, has been associated with enhanced survival among older adults in some studies. However, whether being overweight is causally linked to longevity remains unclear. To investig…
View article: Overweight as a Causal Factor Contributing to Better Survival at the Oldest Old Ages: A Mendelian Randomization Study
Overweight as a Causal Factor Contributing to Better Survival at the Oldest Old Ages: A Mendelian Randomization Study Open
Overweight, defined by a body mass index (BMI) between 25 and 30, has been associated with enhanced survival among older adults in some studies. However, whether being overweight is causally linked to longevity remains unclear. To investig…
View article: Associations of infections and vaccines with Alzheimer's disease point to a role of compromised immunity rather than specific pathogen in AD
Associations of infections and vaccines with Alzheimer's disease point to a role of compromised immunity rather than specific pathogen in AD Open
View article: How are APOE4, changes in body weight, and longevity related? Insights from a causal mediation analysis
How are APOE4, changes in body weight, and longevity related? Insights from a causal mediation analysis Open
The ε4 allele of the APOE gene ( APOE4 ) is known for its negative association with human longevity; however, the mechanism is unclear. APOE4 is also linked to changes in body weight, and the latter changes were associated with survival in…
View article: Prior infections are associated with smaller hippocampal volume in older women
Prior infections are associated with smaller hippocampal volume in older women Open
Accumulating evidence suggests that infections may play a major role in Alzheimer's disease (AD), however, mechanism is unclear, as multiple pathways may be involved. One possibility is that infections could contribute to neurodegeneration…
View article: How are<i>APOE4</i>, changes in body weight, and longevity related? Insights from a causal mediation analysis
How are<i>APOE4</i>, changes in body weight, and longevity related? Insights from a causal mediation analysis Open
The ε4 allele of the APOE gene ( APOE4) is known for its negative association with human longevity, however, the mechanism is unclear. APOE4 was also linked to changes in body weight, and the latter changes were associated with survival in…
View article: Patterns of Aging Changes in Bodyweight May Predict Alzheimer’s Disease
Patterns of Aging Changes in Bodyweight May Predict Alzheimer’s Disease Open
Relationships between patterns of aging-changes in bodyweight and AD are not fully understood. We compared mean age-trajectories of weight between those who did and did not develop late-onset-AD, and evaluated impact of age at maximum weig…
View article: Associations of infections and vaccines with Alzheimer’s disease point to a major role of compromised immunity rather than specific pathogen in AD
Associations of infections and vaccines with Alzheimer’s disease point to a major role of compromised immunity rather than specific pathogen in AD Open
INTRODUCTION Diverse pathogens (viral, bacterial, fungal) have been linked to Alzheimer’s disease (AD) indicating a possibility that the culprit may be compromised immunity rather than particular microbe. If true, then vaccines with broad …
View article: GENES FROM PEROXISOME AND INTEGRATED STRESS RESPONSE IN REGULATION OF HUMAN LONGEVITY
GENES FROM PEROXISOME AND INTEGRATED STRESS RESPONSE IN REGULATION OF HUMAN LONGEVITY Open
Dietary/caloric restriction shares pathways with peroxisome, a cellular organelle that regulates the synthesis and turnover of complex lipids. PEX3, a peroxisomal biogenesis factor involved in selective type of autophagy. EIF2AK4, a sensor…
View article: PROTECTIVE EFFECT OF SHINGLES VACCINE ON ALZHEIMER’S DISEASE CAN BE MODULATED BY RISK VARIANT OF NECTIN2 GENE
PROTECTIVE EFFECT OF SHINGLES VACCINE ON ALZHEIMER’S DISEASE CAN BE MODULATED BY RISK VARIANT OF NECTIN2 GENE Open
The aging-related decline in immune surveillance was suggested to play a major role in Alzheimer’s disease (AD). Adult vaccinations may support the aging immune system beyond prevention of the target disease, and through this provide a pro…
View article: History of infections is associated with smaller hippocampal volume in older women
History of infections is associated with smaller hippocampal volume in older women Open
Background Accumulating evidence suggests that infections can play a major role in Alzheimer’s disease (AD), however, mechanism is unclear as multiple pathways may be involved. One possibility is that infections might contribute to AD dire…
View article: A MENDELIAN RANDOMIZATION STUDY SUPPORTS CAUSAL EFFECT OF OVERWEIGHT ON LONGEVITY
A MENDELIAN RANDOMIZATION STUDY SUPPORTS CAUSAL EFFECT OF OVERWEIGHT ON LONGEVITY Open
Overweight was associated with better survival in some studies. This was termed “obesity paradox”; however, its mechanism is unclear. Mendelian Randomization (MR) is a common approach to uncovering causality in observational data using SNP…
View article: Interplay Between Genes from Peroxisome Biogenesis and Integrated Stress Response Pathways is Significantly Associated with Alzheimer’s Disease
Interplay Between Genes from Peroxisome Biogenesis and Integrated Stress Response Pathways is Significantly Associated with Alzheimer’s Disease Open
Background Peroxisomes are single‐membrane organelles involved among other things in ether‐phospholipids production that plays an important role in axon myelination in the central nervous system. Disruptions in cytosolic receptor PEX5L (in…
View article: Mendelian randomization study using paired SNPs as instruments supports casual protective effect of overweight on Alzheimer’s disease
Mendelian randomization study using paired SNPs as instruments supports casual protective effect of overweight on Alzheimer’s disease Open
Background Mendelian Randomization (MR) is a powerful method of detecting causal effects in observational studies. However, choosing an appropriate SNP as an instrumental variable ( IVar ) is challenging because of difficulties in satisfyi…
View article: MULTIPLE ENRICHMENT TOOLS POINT TO A CENTRAL ROLE OF CARDIAC MUSCLE IN EXTREME LONGEVITY
MULTIPLE ENRICHMENT TOOLS POINT TO A CENTRAL ROLE OF CARDIAC MUSCLE IN EXTREME LONGEVITY Open
Few genes showed consistent positive associations with extreme longevity in humans. We conducted genome-wide association study of various parental lifespans, LS (85+, 90+, 95+, 100+ vs. 75-), using UK Biobank data. At ages 100+, the negati…
View article: Gene‐level Association Study of Alzheimer’s Disease on CHS and FRAM cohorts
Gene‐level Association Study of Alzheimer’s Disease on CHS and FRAM cohorts Open
Background Experimental, clinical, and genetic epidemiological studies continue clarifying important aspects of Alzheimer’s disease (AD) pathological development. Despite this progress the genetic mechanisms of AD regulation remain unclear…
View article: Interactions between genes involved in physiological dysregulation and axon guidance: role in Alzheimer’s disease
Interactions between genes involved in physiological dysregulation and axon guidance: role in Alzheimer’s disease Open
Dysregulation of physiological processes may contribute to Alzheimer’s disease (AD) development. We previously found that an increase in the level of physiological dysregulation (PD) in the aging body is associated with declining resilienc…
View article: Understanding Alzheimer’s disease in the context of aging: Findings from applications of stochastic process models to the Health and Retirement Study
Understanding Alzheimer’s disease in the context of aging: Findings from applications of stochastic process models to the Health and Retirement Study Open
There is growing literature on applications of biodemographic models, including stochastic process models (SPM), to studying regularities of age dynamics of biological variables in relation to aging and disease development. Alzheimer's dis…
View article: ADULT INFECTIONS ARE ASSOCIATED WITH HIGHER RISK OF ALZHEIMER’S DISEASE BUT LOWER RISK OF CANCER
ADULT INFECTIONS ARE ASSOCIATED WITH HIGHER RISK OF ALZHEIMER’S DISEASE BUT LOWER RISK OF CANCER Open
Growing evidence suggests that infections may promote Alzheimer’s disease (AD). Chronic infections have also been linked to several cancers. However, there is evidence that acute febrile infections may treat some cancers, suggesting that a…
View article: ALZHEIMER’S DISEASE AND COMORBIDITIES: A COMPLEX INTERPLAY IN THE CONTEXT OF AGING
ALZHEIMER’S DISEASE AND COMORBIDITIES: A COMPLEX INTERPLAY IN THE CONTEXT OF AGING Open
There is evidence on high prevalence of comorbidity in people with dementia and on associations between comorbidities and progression of Alzheimer’s disease (AD). Comorbidities accumulate with age and age is also a major risk factor for AD…
View article: PATTERNS OF AGING CHANGES IN BODY WEIGHT AND BMI MAY PREDICT CHANCES OF ALZHEIMER'S DISEASE AND LONGEVITY
PATTERNS OF AGING CHANGES IN BODY WEIGHT AND BMI MAY PREDICT CHANCES OF ALZHEIMER'S DISEASE AND LONGEVITY Open
Background Lower bodyweight/BMI was previously linked to AD and frailty; however, the role of long-term changes in the bodyweight/BMI in both AD and longevity is not well understood, as is the role of APOE polymorphism in such changes. Met…
View article: Genes Involved in Physiological Dysregulation and Decline in Resilience: Role in Alzheimer’s Disease
Genes Involved in Physiological Dysregulation and Decline in Resilience: Role in Alzheimer’s Disease Open
Our recent GWAS of a composite measure of physiological dysregulation (PD) in the Long Life Family Study (LLFS) found that the top genes associated with age-related changes in PD are involved in biological pathways relevant to maintaining …
View article: Applications of Stochastic Process Models to Constructing Predictive Models of Alzheimer’s Disease
Applications of Stochastic Process Models to Constructing Predictive Models of Alzheimer’s Disease Open
Large-scale population-based data collecting repeated measures of biomarkers, follow-up data on events (incidence of diseases and mortality), and extensive genetic data provide excellent opportunities for applying statistical models for jo…
View article: Interactions Between Genes From Aging Pathways Significantly Influence Risk of Alzheimer’s Disease
Interactions Between Genes From Aging Pathways Significantly Influence Risk of Alzheimer’s Disease Open
Age is major risk factor for AD; however, relationships between aging and AD are not well understood. Decline in physiological resilience is universal feature of human aging that may also play role in AD. Aging-related pathways (such as IG…