Hoonkyo Suh
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View article: The<i>Mef2c</i>Gene Dose-Dependently Controls Hippocampal Neurogenesis and the Expression of Autism-Like Behaviors
The<i>Mef2c</i>Gene Dose-Dependently Controls Hippocampal Neurogenesis and the Expression of Autism-Like Behaviors Open
Mutations in the activity-dependent transcription factor MEF2C have been associated with several neuropsychiatric disorders. Among these, autism spectrum disorder (ASD)-related behavioral deficits are manifested. Multiple animal models tha…
View article: Augmenting neurogenesis rescues memory impairments in Alzheimer’s disease by restoring the memory-storing neurons
Augmenting neurogenesis rescues memory impairments in Alzheimer’s disease by restoring the memory-storing neurons Open
Hippocampal neurogenesis is impaired in Alzheimer’s disease (AD) patients and familial Alzheimer’s disease (FAD) mouse models. However, it is unknown whether new neurons play a causative role in memory deficits. Here, we show that immature…
View article: Augmenting Neurogenesis Rescues Memory Impairments in Alzheimer's Disease by Restoring the Engram
Augmenting Neurogenesis Rescues Memory Impairments in Alzheimer's Disease by Restoring the Engram Open
View article: Role of Hippocampal Neurogenesis in Alcohol Withdrawal Seizures
Role of Hippocampal Neurogenesis in Alcohol Withdrawal Seizures Open
Chronic alcohol consumption results in alcohol use disorder (AUD). Interestingly, however, sudden alcohol withdrawal (AW) after chronic alcohol exposure also leads to a devastating series of symptoms, referred to as alcohol withdrawal synd…
View article: Hippocampal Neurogenesis and Neural Circuit Formation in a Cuprizone-Induced Multiple Sclerosis Mouse Model
Hippocampal Neurogenesis and Neural Circuit Formation in a Cuprizone-Induced Multiple Sclerosis Mouse Model Open
Cognitive impairments are key features in multiple sclerosis (MS), a progressive disorder characterized by neuroinflammation-induced demyelination in the central nervous system. To understand the neural substrates that link demyelination t…
View article: Activity of hippocampal adult-born neurons regulates alcohol withdrawal seizures
Activity of hippocampal adult-born neurons regulates alcohol withdrawal seizures Open
Alcohol withdrawal (AW) after chronic alcohol exposure produces a series of symptoms, with AW-associated seizures being among the most serious and dangerous. However, the mechanism underlying AW seizures has yet to be established. In our m…
View article: Setd5 haploinsufficiency alters neuronal network connectivity and leads to autistic-like behaviors in mice
Setd5 haploinsufficiency alters neuronal network connectivity and leads to autistic-like behaviors in mice Open
View article: Chemogenetic silencing of hippocampal neurons suppresses epileptic neural circuits
Chemogenetic silencing of hippocampal neurons suppresses epileptic neural circuits Open
We investigated how pathological changes in newborn hippocampal dentate granule cells (DGCs) lead to epilepsy. Using a rabies virus-mediated retrograde tracing system and a designer receptors exclusively activated by designer drugs (DREADD…
View article: Long-Term Labeling of Hippocampal Neural Stem Cells by a Lentiviral Vector
Long-Term Labeling of Hippocampal Neural Stem Cells by a Lentiviral Vector Open
Using a lentivirus-mediated labeling method, we investigated whether the adult hippocampus retains long-lasting, self-renewing neural stem cells (NSCs). We first showed that a single injection of a lentiviral vector expressing a green fluo…
View article: Growth Associated Protein 43 (GAP-43) as a Novel Target for the Diagnosis, Treatment and Prevention of Epileptogenesis
Growth Associated Protein 43 (GAP-43) as a Novel Target for the Diagnosis, Treatment and Prevention of Epileptogenesis Open
We previously showed increased growth associated protein 43 (GAP-43) expression in brain samples resected from patients with cortical dysplasia (CD), which was correlated with duration of epilepsy. Here, we used a rat model of CD to examin…
View article: Hippocampal TERT Regulates Spatial Memory Formation through Modulation of Neural Development
Hippocampal TERT Regulates Spatial Memory Formation through Modulation of Neural Development Open
View article: BACE1 Deficiency Causes Abnormal Neuronal Clustering in the Dentate Gyrus
BACE1 Deficiency Causes Abnormal Neuronal Clustering in the Dentate Gyrus Open
BACE1 is validated as Alzheimer's β-secretase and a therapeutic target for Alzheimer's disease. In examining BACE1-null mice, we discovered that BACE1 deficiency develops abnormal clusters of immature neurons, forming doublecortin-positive…
View article: Regional-specific effect of fluoxetine on rapidly dividing progenitors along the dorsoventral axis of the hippocampus
Regional-specific effect of fluoxetine on rapidly dividing progenitors along the dorsoventral axis of the hippocampus Open
View article: Reactivation of Tert in the medial prefrontal cortex and hippocampus rescues aggression and depression of Tert−/− mice
Reactivation of Tert in the medial prefrontal cortex and hippocampus rescues aggression and depression of Tert−/− mice Open
View article: High concentration of glucocorticoids in the hippocampus plays opposite roles in acute and chronic phase in regulating HPA axis activity.
High concentration of glucocorticoids in the hippocampus plays opposite roles in acute and chronic phase in regulating HPA axis activity. Open
(A) Western blotting showing CRF protein expression in the hypothalamus 2 hours after the infusion of CORT (10 µM, 2 µl) into the DG regions. n = 3 for each group. Arrow heads indicate the location of nearest band in the ladder. (B) The CO…
View article: NO mediates the different roles of glucocorticoids in hippocampus and hypothalamus in regulating HPA axis activity.
NO mediates the different roles of glucocorticoids in hippocampus and hypothalamus in regulating HPA axis activity. Open
Representative imaging of nNOS-positive cells in the hippocampus (left column) and in the PVN regions of the hypothalamus (right column) after 28 days CORT (40 mg/kg, s.c.) or DMSO treatment (A) and the number of nNOS-positive cells (B), n…
View article: Selective infusion of CORT into the hypothalamus increases the level of CORT in the hypothalamus persistently.
Selective infusion of CORT into the hypothalamus increases the level of CORT in the hypothalamus persistently. Open
(A) Representative photo indicated the target of the infusion (the left PVN region of the hypothalamus). 3V: third ventricle. (B) The concentration of CORT in the whole hypothalamus 24 h after infusion of CORT. n = 3 for each group. (C) Th…
View article: High concentration of glucocorticoids is sufficient to induce depressive behaviors and hyperactivity of HPA axis.
High concentration of glucocorticoids is sufficient to induce depressive behaviors and hyperactivity of HPA axis. Open
(A) Immobility time in the TST after 28 days CORT treatment (40 mg/kg/d, s.c.) (n = 14 for each group). (B) Immobility time in the FST 28 days CORT treatment (40 mg/kg/d, s.c.) (n = 14 for each group). (C) Sucrose preference of mice 28 day…
View article: Chronic Alcohol Exposure is Associated with Decreased Neurogenesis, Aberrant Integration of Newborn Neurons, and Cognitive Dysfunction in Female Mice
Chronic Alcohol Exposure is Associated with Decreased Neurogenesis, Aberrant Integration of Newborn Neurons, and Cognitive Dysfunction in Female Mice Open
Our study revealed that chronic alcohol exposure disrupted multiple steps of neurogenesis, including the production and development of newborn neurons. In addition, chronic alcohol exposure altered connectivity of newborn neurons with othe…