Hope A. Weiler
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View article: Altered sperm DNA methylation in overweight men associates transposable element regulation to paternal origins of disease risk in children
Altered sperm DNA methylation in overweight men associates transposable element regulation to paternal origins of disease risk in children Open
The occurrence of childhood neurodevelopmental disorders has been steadily increasing for decades yet we have little understanding of modes of inheritance implicated in these diseases. Epidemiology studies have revealed an association betw…
View article: Can correction of low vitamin D status in infancy program for a leaner body composition? A posttrial follow-up study of whole body lean mass in early childhood
Can correction of low vitamin D status in infancy program for a leaner body composition? A posttrial follow-up study of whole body lean mass in early childhood Open
gov/study/NCT02563015).
View article: Vitamin D Intakes of People Living in Canada: An Assessment Using Disaggregated Population Data from the 2015 Canadian Community Health Survey – Nutrition
Vitamin D Intakes of People Living in Canada: An Assessment Using Disaggregated Population Data from the 2015 Canadian Community Health Survey – Nutrition Open
In Canada, the population prevalence of inadequate vitamin D intake is high, although lower among supplement users. Since the time of this survey, dietary guidance advises vitamin D supplementation for people ≥2 y who do not consume a dail…
View article: Folic Acid-Containing Supplement Use among Females Aged 15–55 in the Canadian Community Health Survey 2015–2018
Folic Acid-Containing Supplement Use among Females Aged 15–55 in the Canadian Community Health Survey 2015–2018 Open
Although most females living in Canada reported using folic acid-containing supplements prior to and during pregnancy, use of these supplements among nonpregnant females of childbearing age is low, and sociodemographic inequalities exist.
View article: The Association Between Pregnancy Complications and Long-term Maternal Cardiometabolic Health in the MIREC Cohort Study
The Association Between Pregnancy Complications and Long-term Maternal Cardiometabolic Health in the MIREC Cohort Study Open
Context During pregnancy, women who experience certain pregnancy complications show elevations in biomarkers of inflammation and insulin resistance; however, few studies have examined these cardiometabolic biomarkers in the decade followin…
View article: Commutability assessment of new standard reference materials (SRMs) for determining serum total 25-hydroxyvitamin D using ligand binding and liquid chromatography–tandem mass spectrometry (LC–MS/MS) assays
Commutability assessment of new standard reference materials (SRMs) for determining serum total 25-hydroxyvitamin D using ligand binding and liquid chromatography–tandem mass spectrometry (LC–MS/MS) assays Open
View article: Adherence to Introduction of Iron-Rich Solid Foods Recommendations for Infants: An Analysis of Canadian Community Health Survey Data Using Cycles 2015–2018
Adherence to Introduction of Iron-Rich Solid Foods Recommendations for Infants: An Analysis of Canadian Community Health Survey Data Using Cycles 2015–2018 Open
Most infants in Canada are introduced to an iron-rich solid food first at about 6 mo of age, indicating partial adherence to the NHTI guidelines. More efforts are needed to reinforce the importance of introducing iron-rich solid foods firs…
View article: Vitamin D and Toxic Metals in Pregnancy - a Biological Perspective
Vitamin D and Toxic Metals in Pregnancy - a Biological Perspective Open
View article: Concentrations and predictors of select nutrients in Canadian human milk samples from the Maternal-Infant Research on Environmental Chemicals pregnancy cohort
Concentrations and predictors of select nutrients in Canadian human milk samples from the Maternal-Infant Research on Environmental Chemicals pregnancy cohort Open
HM mineral concentrations from this study meet the methodological inclusion criteria for updating nutrient databank values and dietary reference intakes. Consideration of factors such as diet, skin color, and BMI will be important for sele…
View article: Vitamin D and Toxic Metals in Pregnancy - a Biological Perspective
Vitamin D and Toxic Metals in Pregnancy - a Biological Perspective Open
Purpose of Review To discuss the potential biological mechanisms between vitamin D and toxic metals and summarize epidemiological studies examining this association in pregnant women. Recent Findings We identified four plausible mechanisms…
View article: Cholesterol Interference in the Assessment of Vitamin D Status: A Canadian Health Measures Survey Biobank Project
Cholesterol Interference in the Assessment of Vitamin D Status: A Canadian Health Measures Survey Biobank Project Open
Total cholesterol inversely associates with 25(OH)D, which is likely due to elevated non-HDL-cholesterol lipoprotein or triglyceride interference with the Liaison Total Assay. This is important as elevated cholesterol is common, and an und…
View article: Adherence to Vitamin D Supplementation Recommendations for Breastfed Infants and Young Children: An Analysis of Canadian Community Health Survey Data Cycles From 2015 to 2018
Adherence to Vitamin D Supplementation Recommendations for Breastfed Infants and Young Children: An Analysis of Canadian Community Health Survey Data Cycles From 2015 to 2018 Open
Adherence to providing a vitamin D supplement to breastfed infants is high in Canada. Nonetheless, we estimate that ∼27% of mothers are nonadherent to daily/almost every day administration of a vitamin D supplement and that adherence decli…
View article: In response to: How does Canada’s new vitamin D fortification policy affect the high prevalence of inadequate intake of the vitamin?
In response to: How does Canada’s new vitamin D fortification policy affect the high prevalence of inadequate intake of the vitamin? Open
View article: A phase II dose evaluation pilot feasibility randomized controlled trial of cholecalciferol in critically ill children with vitamin D deficiency (VITdAL-PICU study)
A phase II dose evaluation pilot feasibility randomized controlled trial of cholecalciferol in critically ill children with vitamin D deficiency (VITdAL-PICU study) Open
Background Vitamin D deficiency (VDD) is highly prevalent in the pediatric intensive care unit (ICU) and associated with worse clinical course. Trials in adult ICU demonstrate rapid restoration of vitamin D status using an enteral loading …
View article: A phase II dose evaluation pilot feasibility randomized controlled trial of cholecalciferol in critically ill children with vitamin D deficiency (VITdAL-PICU study)
A phase II dose evaluation pilot feasibility randomized controlled trial of cholecalciferol in critically ill children with vitamin D deficiency (VITdAL-PICU study) Open
Background: Vitamin D deficiency (VDD) is highly prevalent in the pediatric intensive care unit (ICU) and associated with worse clinical course. Trials in adult ICU demonstrate rapid restoration of vitamin D status using an enteral loading…
View article: Population Iron Status in Canada: Results from the Canadian Health Measures Survey 2012–2019
Population Iron Status in Canada: Results from the Canadian Health Measures Survey 2012–2019 Open
Correction methods for estimating population iron status need further research. Considering the fundamental drawbacks of each method, uncorrected and regression-corrected estimates provide a reasonable range for ID in the Canadian populati…
View article: Association between toxic metals, vitamin D and preterm birth in the<scp>Maternal–Infant</scp>research on environmental chemicals study
Association between toxic metals, vitamin D and preterm birth in the<span>Maternal–Infant</span>research on environmental chemicals study Open
Background Toxic metals, like lead, are risk factors for preterm birth (PTB), but few studies have examined low levels found in most Canadians. Vitamin D, which may have antioxidant activity, protects against PTB. Objectives In this study,…
View article: Vitamin D Status of People 3 to 79 Years of Age from the Canadian Health Measures Survey 2012–2019
Vitamin D Status of People 3 to 79 Years of Age from the Canadian Health Measures Survey 2012–2019 Open
Most people in Canada have adequate vitamin D status; nonetheless, racialized groups have an elevated prevalence of inadequacy. Further research is required to evaluate if current strategies to improve vitamin D status, including increasin…
View article: Effect of Vitamin D Supplementation on Bone Mass in Infants With 25-Hydroxyvitamin D Concentrations Less Than 50 nmol/L
Effect of Vitamin D Supplementation on Bone Mass in Infants With 25-Hydroxyvitamin D Concentrations Less Than 50 nmol/L Open
Importance The dose of supplemental vitamin D needed in infants born with serum 25-hydroxyvitamin D (25[OH]D) concentrations less than 50 nmol/L (ie, 20 ng/mL) is unclear. Objective To determine whether a higher dose (1000 IU vs 400 IU per…
View article: Vitamin D Status of Infants of Mothers with Gestational Diabetes: Status at Birth and a Randomized Controlled Trial of Vitamin D Supplementation across Infancy
Vitamin D Status of Infants of Mothers with Gestational Diabetes: Status at Birth and a Randomized Controlled Trial of Vitamin D Supplementation across Infancy Open
View article: The association between metals, vitamin D and preterm birth in the MIREC Cohort Study
The association between metals, vitamin D and preterm birth in the MIREC Cohort Study Open
BACKGROUND Toxic metals, like lead, are risk factors for preterm birth (PTB), but few studies have explored this association at the low levels currently found in the Canadian population. Conversely, studies suggest that vitamin D may have …
View article: Perspective: Human Milk Composition and Related Data for National Health and Nutrition Monitoring and Related Research
Perspective: Human Milk Composition and Related Data for National Health and Nutrition Monitoring and Related Research Open
View article: Associations between Body Composition and Vitamin D Status in Children with Overweight and Obesity Participating in a 1-Year Lifestyle Intervention
Associations between Body Composition and Vitamin D Status in Children with Overweight and Obesity Participating in a 1-Year Lifestyle Intervention Open
Background: To examine associations between body composition and vitamin D status in children participating in a lifestyle intervention. Methods: Children (6–12 y, n = 101) with a body mass index (BMI)-for-age >85th percentile were randomi…
View article: Vitamin D supplementation and gross motor development: A 3-year follow-up of a randomized trial
Vitamin D supplementation and gross motor development: A 3-year follow-up of a randomized trial Open
GMD in young children who received 400 IU/d of supplemental vitamin D in infancy is not influenced by season-at-birth. This dose of vitamin D of 400 IU/d as recommended in North America adequately supports GMD. The modest enhancement in GM…
View article: Maternal Android Adiposity and Vitamin D Status in Lactation Are Positive Predictors of Child Adiposity and Vitamin D Status at 2 Years of Age: A Follow-Up Study From Montréal
Maternal Android Adiposity and Vitamin D Status in Lactation Are Positive Predictors of Child Adiposity and Vitamin D Status at 2 Years of Age: A Follow-Up Study From Montréal Open
Recent evidence suggests that fetal exposure to both maternal excess adiposity and low maternal vitamin D status is associated with body composition of the children. The objective was to explore whether maternal android adiposity and mater…
View article: Correction of neonatal vitamin D status using 1000 IU vitamin D/d increased lean body mass by 12 months of age compared with 400 IU/d: a randomized controlled trial
Correction of neonatal vitamin D status using 1000 IU vitamin D/d increased lean body mass by 12 months of age compared with 400 IU/d: a randomized controlled trial Open
View article: Blood metals and vitamin D status in a pregnancy cohort: A bidirectional biomarker analysis
Blood metals and vitamin D status in a pregnancy cohort: A bidirectional biomarker analysis Open
Low 25-hydroxyvitamin D (25OHD), a biomarker of vitamin D status, is associated with reduced immune function and adverse pregnancy outcomes, such as preterm birth. Observational studies indicate that long-term, high level exposure to metal…
View article: Iodine Status of Mother-Infant Dyads from Montréal, Canada: Secondary Analyses of a Vitamin D Supplementation Trial in Breastfed Infants
Iodine Status of Mother-Infant Dyads from Montréal, Canada: Secondary Analyses of a Vitamin D Supplementation Trial in Breastfed Infants Open
View article: Maternal excess adiposity and serum 25-hydroxyvitamin D < 50 nmol/L are associated with elevated whole body fat mass in healthy breastfed neonates
Maternal excess adiposity and serum 25-hydroxyvitamin D < 50 nmol/L are associated with elevated whole body fat mass in healthy breastfed neonates Open
View article: Maternal Vitamin D Status and Gestational Weight Gain as Correlates of Neonatal Bone Mass in Healthy Term Breastfed Young Infants from Montreal, Canada
Maternal Vitamin D Status and Gestational Weight Gain as Correlates of Neonatal Bone Mass in Healthy Term Breastfed Young Infants from Montreal, Canada Open
The implications of maternal gestational weight gain (GWG) and vitamin D status to neonatal bone health are unclear. We tested whether maternal 25-hydroxyvitamin D (25(OH)D) and GWG relate to neonatal bone mineral content (BMC) and bone mi…