Hope E. Merens
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View article: RNA Polymerase II pausing temporally coordinates cell cycle progression and erythroid differentiation
RNA Polymerase II pausing temporally coordinates cell cycle progression and erythroid differentiation Open
Summary The controlled release of promoter-proximal paused RNA polymerase II (Pol II) into productive elongation is a major step in gene regulation. However, functional analysis of Pol II pausing is difficult because factors that regulate …
View article: Genome-wide screens for mitonuclear co-regulators uncover links between compartmentalized metabolism and mitochondrial gene expression
Genome-wide screens for mitonuclear co-regulators uncover links between compartmentalized metabolism and mitochondrial gene expression Open
Mitochondrial oxidative phosphorylation (OXPHOS) complexes are assembled from proteins encoded by both nuclear and mitochondrial DNA. These dual-origin enzymes pose a complex gene regulatory challenge for cells, in which gene expression mu…
View article: Polyphosphate initiates tau aggregation through intra- and intermolecular scaffolding
Polyphosphate initiates tau aggregation through intra- and intermolecular scaffolding Open
The aggregation and deposition of tau is a hallmark of a class of neurodegenerative diseases called tauopathies. Despite intensive study, cellular and molecular factors that trigger tau aggregation are not well understood. Here we provide …