Hope Lu
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View article: Selective Biological Responses of Phagocytes and Lungs to Purified Histones
Selective Biological Responses of Phagocytes and Lungs to Purified Histones Open
Histones invoke strong proinflammatory responses in many different organs and cells. We assessed biological responses to purified or recombinant histones, using human and murine phagocytes and mouse lungs. H1 had the strongest ability in v…
View article: Complement Destabilizes Cardiomyocyte Function In Vivo after Polymicrobial Sepsis and In Vitro
Complement Destabilizes Cardiomyocyte Function In Vivo after Polymicrobial Sepsis and In Vitro Open
There is accumulating evidence during sepsis that cardiomyocyte (CM) homeostasis is compromised, resulting in cardiac dysfunction. An important role for complement in these outcomes is now demonstrated. Addition of C5a to electrically pace…