Horacio Cabral
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View article: Antiemesis Corticosteroids Potentiate Checkpoint Blockade Efficacy by Normalizing the Immune Microenvironment in Metastatic Murine Breast Cancer
Antiemesis Corticosteroids Potentiate Checkpoint Blockade Efficacy by Normalizing the Immune Microenvironment in Metastatic Murine Breast Cancer Open
Glucocorticoid steroids are widely prescribed in oncology for managing treatment‐related side effects, though their use is discouraged in patients undergoing immune checkpoint blockade (ICB). Given the crucial role of steroids in supportiv…
View article: Collagen Signaling via DDR1 Exacerbates Barriers to Macromolecular Drug Delivery in a 3D Model of Pancreatic Cancer Fibrosis
Collagen Signaling via DDR1 Exacerbates Barriers to Macromolecular Drug Delivery in a 3D Model of Pancreatic Cancer Fibrosis Open
Fibrosis is a significant barrier to drug delivery in pancreatic ductal adenocarcinoma (PDAC) and contributes to its dismal prognosis. Pancreatic stellate cells (PSCs) drive fibrosis by excessively secreting extracellular matrix proteins s…
View article: New Advances in Biomedical Application of Polymeric Micelles
New Advances in Biomedical Application of Polymeric Micelles Open
In the last decade, nanomedicine has arisen as an emergent area of medicine, which studies nanometric systems, namely polymeric micelles (PMs), that increase the solubility and the stability of the encapsulated drugs. Furthermore, their ap…
View article: Glycoliposomes target lymphatic dendritic cells in a size-dependent manner to activate natural killer T cells against breast tumors
Glycoliposomes target lymphatic dendritic cells in a size-dependent manner to activate natural killer T cells against breast tumors Open
Glycolipids have high potential for activating natural killer T (NKT) cells to mediate robust antitumor responses. However, critical challenges, such as low baseline NKT cell counts and the risk of unintentionally engaging immunosuppressiv…
View article: Optoregulated mRNA Delivery Controls Pleiotropic Immune Signaling for Tumor‐Targeted Therapy
Optoregulated mRNA Delivery Controls Pleiotropic Immune Signaling for Tumor‐Targeted Therapy Open
Spatiotemporal control of protein expression remains a critical challenge in messenger RNA (mRNA) therapeutics, particularly for tumor‐targeted therapy. Here, we introduce a Light‐Induced Transfection System (LITS) leveraging photosensitiz…
View article: Optoregulated mRNA Delivery Controls Pleiotropic Immune Signaling for Tumor‐Targeted Therapy
Optoregulated mRNA Delivery Controls Pleiotropic Immune Signaling for Tumor‐Targeted Therapy Open
Spatiotemporal control of protein expression remains a critical challenge in messenger RNA (mRNA) therapeutics, particularly for tumor‐targeted therapy. Here, we introduce a Light‐Induced Transfection System (LITS) leveraging photosensitiz…
View article: Artificial Intelligence Approach in Machine Learning-Based Modeling and Networking of the Coronavirus Pathogenesis Pathway
Artificial Intelligence Approach in Machine Learning-Based Modeling and Networking of the Coronavirus Pathogenesis Pathway Open
The coronavirus pathogenesis pathway, which consists of severe acute respiratory syndrome (SARS) coronavirus infection and signaling pathways, including the interferon pathway, the transforming growth factor beta pathway, the mitogen-activ…
View article: Triblock Polyampholyte‐Based Nanovesicles for Targeted Spleen Delivery
Triblock Polyampholyte‐Based Nanovesicles for Targeted Spleen Delivery Open
Polymeric vesicles are a promising platform for targeted drug delivery. In this study, nanovesicles are developed using triblock polyampholytes composed of neutral poly(ethylene glycol), cationic poly(L‐lysine), and anionic poly(α,β‐aspart…
View article: Artificial Intelligence Approach in Machine Learning-Based Modeling and Networking of the Coronavirus Pathogenesis Pathway
Artificial Intelligence Approach in Machine Learning-Based Modeling and Networking of the Coronavirus Pathogenesis Pathway Open
The coronavirus pathogenesis pathway, which consists of severe acute respiratory syndrome (SARS) coronavirus infection and signaling pathways, including the interferon pathway, the transforming growth factor beta pathway, the mitogen-activ…
View article: Bone marrow vessels are hyperpermeable to macromolecules and nanoscale medicine in a size-dependent manner
Bone marrow vessels are hyperpermeable to macromolecules and nanoscale medicine in a size-dependent manner Open
Bone marrow (BM) has roles in health and disease, so systemically administered nanocarriers (NCs) targeting or avoiding BM are desirable. While the hydrodynamic diameter of NCs can be tuned to target or avoid various organs, the size depen…
View article: Dual-labelled polymeric micelles for singlet oxygen reporting in biological systems
Dual-labelled polymeric micelles for singlet oxygen reporting in biological systems Open
Dually-labelled polymeric micelles allowed tracing both the probe location and the levels of singlet oxygen ( 1 O 2 ) in biological systems.
View article: Nanoenabled IL-15 Superagonist via Conditionally Stabilized Protein–Protein Interactions Eradicates Solid Tumors by Precise Immunomodulation
Nanoenabled IL-15 Superagonist via Conditionally Stabilized Protein–Protein Interactions Eradicates Solid Tumors by Precise Immunomodulation Open
Protein complexes are crucial structures that control many biological processes. Harnessing these structures could be valuable for therapeutic therapy. However, their instability and short lifespans need to be addressed for effective use. …
View article: Master Regulators of Causal Networks in Intestinal- and Diffuse-Type Gastric Cancer and the Relation to the RNA Virus Infection Pathway
Master Regulators of Causal Networks in Intestinal- and Diffuse-Type Gastric Cancer and the Relation to the RNA Virus Infection Pathway Open
Causal networks are important for understanding disease signaling alterations. To reveal the network pathways affected in the epithelial–mesenchymal transition (EMT) and cancer stem cells (CSCs), which are related to the poor prognosis of …
View article: Master Regulators of Causal Networks in Intestinal- and Diffuse-Type Gastric Cancer and the Relation to RNA Virus Infection Pathway
Master Regulators of Causal Networks in Intestinal- and Diffuse-Type Gastric Cancer and the Relation to RNA Virus Infection Pathway Open
The causal networks are important for understanding the signaling alterations in diseases. To reveal the network pathways affected in epithelial-mesenchymal transition (EMT) and cancer stem cells (CSCs), which are related to poor prognosis…
View article: The Pathway Flow Starting From Chronic Reactive Oxygen Species Leading to Human Treatment-Resistant Gastric Cancer
The Pathway Flow Starting From Chronic Reactive Oxygen Species Leading to Human Treatment-Resistant Gastric Cancer Open
The injury causes resistance in human gastric cancer (GC). This Adverse Outcome Pathway (AOP) entitled “Increases in cellular reactive oxygen species (ROS) and chronic ROS leading to human treatment-resistant gastric cancer (GC)” consists …
View article: Supplementary Figure S3 from Stabilizing Tumor-Resident Mast Cells Restores T-Cell Infiltration and Sensitizes Sarcomas to PD-L1 Inhibition
Supplementary Figure S3 from Stabilizing Tumor-Resident Mast Cells Restores T-Cell Infiltration and Sensitizes Sarcomas to PD-L1 Inhibition Open
Ketotifen monotherapy does not affect tumor growth.
View article: Supplementary Table S2 from Stabilizing Tumor-Resident Mast Cells Restores T-Cell Infiltration and Sensitizes Sarcomas to PD-L1 Inhibition
Supplementary Table S2 from Stabilizing Tumor-Resident Mast Cells Restores T-Cell Infiltration and Sensitizes Sarcomas to PD-L1 Inhibition Open
ANOVA test for the coefficients of the model. P-values less than 0.05 indicate that the coefficients of the model are significantly different than zero.
View article: Supplementary Figure S8 from Stabilizing Tumor-Resident Mast Cells Restores T-Cell Infiltration and Sensitizes Sarcomas to PD-L1 Inhibition
Supplementary Figure S8 from Stabilizing Tumor-Resident Mast Cells Restores T-Cell Infiltration and Sensitizes Sarcomas to PD-L1 Inhibition Open
Ketotifen mechanotherapeutic enhances the neoadjuvant treatment by reducing the recruitment of immunosuppressive cell populations.
View article: Supplementary Figure S7 from Stabilizing Tumor-Resident Mast Cells Restores T-Cell Infiltration and Sensitizes Sarcomas to PD-L1 Inhibition
Supplementary Figure S7 from Stabilizing Tumor-Resident Mast Cells Restores T-Cell Infiltration and Sensitizes Sarcomas to PD-L1 Inhibition Open
Ketotifen alleviates hypoxia and restores intratumoral T cell infiltration by upregulating immune cell adhesion to blood vessels.
View article: Supplementary Figure S3 from Stabilizing Tumor-Resident Mast Cells Restores T-Cell Infiltration and Sensitizes Sarcomas to PD-L1 Inhibition
Supplementary Figure S3 from Stabilizing Tumor-Resident Mast Cells Restores T-Cell Infiltration and Sensitizes Sarcomas to PD-L1 Inhibition Open
Ketotifen monotherapy does not affect tumor growth.
View article: Data from Stabilizing Tumor-Resident Mast Cells Restores T-Cell Infiltration and Sensitizes Sarcomas to PD-L1 Inhibition
Data from Stabilizing Tumor-Resident Mast Cells Restores T-Cell Infiltration and Sensitizes Sarcomas to PD-L1 Inhibition Open
Purpose:To explore the cellular cross-talk of tumor-resident mast cells (MC) in controlling the activity of cancer-associated fibroblasts (CAF) to overcome tumor microenvironment (TME) abnormalities, enhancing the efficacy of immune-checkp…
View article: Supplementary Table S1 from Stabilizing Tumor-Resident Mast Cells Restores T-Cell Infiltration and Sensitizes Sarcomas to PD-L1 Inhibition
Supplementary Table S1 from Stabilizing Tumor-Resident Mast Cells Restores T-Cell Infiltration and Sensitizes Sarcomas to PD-L1 Inhibition Open
The parameters of the model that predict the tumor growth rate after treatment (V_r=a E+b V_0+c E V_0+d). The predicted values are presented in Fig. 6C.
View article: Supplementary Figure S2 from Stabilizing Tumor-Resident Mast Cells Restores T-Cell Infiltration and Sensitizes Sarcomas to PD-L1 Inhibition
Supplementary Figure S2 from Stabilizing Tumor-Resident Mast Cells Restores T-Cell Infiltration and Sensitizes Sarcomas to PD-L1 Inhibition Open
In vitro assessment of MC/9 cells.
View article: Supplementary Figure S6 from Stabilizing Tumor-Resident Mast Cells Restores T-Cell Infiltration and Sensitizes Sarcomas to PD-L1 Inhibition
Supplementary Figure S6 from Stabilizing Tumor-Resident Mast Cells Restores T-Cell Infiltration and Sensitizes Sarcomas to PD-L1 Inhibition Open
Expression of PD-L1 in sarcoma tumors.
View article: Data from Stabilizing Tumor-Resident Mast Cells Restores T-Cell Infiltration and Sensitizes Sarcomas to PD-L1 Inhibition
Data from Stabilizing Tumor-Resident Mast Cells Restores T-Cell Infiltration and Sensitizes Sarcomas to PD-L1 Inhibition Open
Purpose:To explore the cellular cross-talk of tumor-resident mast cells (MC) in controlling the activity of cancer-associated fibroblasts (CAF) to overcome tumor microenvironment (TME) abnormalities, enhancing the efficacy of immune-checkp…
View article: Supplementary Figure S4 from Stabilizing Tumor-Resident Mast Cells Restores T-Cell Infiltration and Sensitizes Sarcomas to PD-L1 Inhibition
Supplementary Figure S4 from Stabilizing Tumor-Resident Mast Cells Restores T-Cell Infiltration and Sensitizes Sarcomas to PD-L1 Inhibition Open
10 mg/kg ketotifen dose is tolerable.