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View article: Structure of the N-RNA/P interface reveals mode of L/P attachment to the nucleocapsid of human metapneumovirus
Structure of the N-RNA/P interface reveals mode of L/P attachment to the nucleocapsid of human metapneumovirus Open
Human metapneumovirus (HMPV) is a major cause of respiratory illness in young children. The polymerase complex of HMPV consists of two obligate components, the L polymerase and its cofactor, the phosphoprotein P. During replication and tra…
View article: Interactions between the Nucleoprotein and the Phosphoprotein of Pneumoviruses: Structural Insight for Rational Design of Antivirals
Interactions between the Nucleoprotein and the Phosphoprotein of Pneumoviruses: Structural Insight for Rational Design of Antivirals Open
Pneumoviruses include pathogenic human and animal viruses, the most known and studied being the human respiratory syncytial virus (hRSV) and the metapneumovirus (hMPV), which are the major cause of severe acute respiratory tract illness in…
View article: Characterization of the interaction domains between the phosphoprotein and the nucleocapsid of human Metapneumovirus
Characterization of the interaction domains between the phosphoprotein and the nucleocapsid of human Metapneumovirus Open
Human metapneumovirus (HMPV) causes severe respiratory diseases in young children. The HMPV RNA genome is encapsidated by the viral nucleoprotein, forming an RNA-N complex (N Nuc ), which serves as template for genome replication and mRNA …