Hossein Ameri
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View article: Persistent disparities in diabetic retinopathy outcomes among socially deprived individuals despite treatment adherence
Persistent disparities in diabetic retinopathy outcomes among socially deprived individuals despite treatment adherence Open
Objective To evaluate the long-term impact of social determinants of health on diabetic retinopathy (DR) incidence, complications, and management in patients with type 2 diabetes mellitus (T2DM), with emphasis on disparities among treatmen…
View article: Developing Laterality-Specific Computable Phenotypes from Electronic Health Record Data, Employing Treatment-Warranted Diabetic Macular Edema as a Use Case
Developing Laterality-Specific Computable Phenotypes from Electronic Health Record Data, Employing Treatment-Warranted Diabetic Macular Edema as a Use Case Open
Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
View article: Loss of Peripheral Retinal Vessels in Retinitis Pigmentosa
Loss of Peripheral Retinal Vessels in Retinitis Pigmentosa Open
Objective Retinitis pigmentosa (RP) is the most common inherited retinal disease and a major cause of irreversible vision loss. The purpose of this study was to assess peripheral retinal vessels in RP. Design Cross-sectional study Subjects…
View article: Visual Cortical Thickness Increases with Prolonged Artificial Vision Restoration
Visual Cortical Thickness Increases with Prolonged Artificial Vision Restoration Open
The Argus II retinal prosthesis restores visual perception to late blind patients. It has been shown that structural changes occur in the brain due to late-onset blindness, including cortical thinning in visual regions of the brain. Follow…
View article: <i>Mycobacterium</i> dormancy and antibiotic tolerance within the retinal pigment epithelium of ocular tuberculosis
<i>Mycobacterium</i> dormancy and antibiotic tolerance within the retinal pigment epithelium of ocular tuberculosis Open
Tuberculosis (TB) is a leading cause of death among infectious diseases worldwide due to latent TB infection, which is the critical step for the successful pathogenic cycle. In this stage , Mycobacterium tuberculosis resides inside the hos…
View article: Comparison of The Results of Sponsored Genetic Testing Panels for Inherited Retinal Diseases
Comparison of The Results of Sponsored Genetic Testing Panels for Inherited Retinal Diseases Open
Background/Objectives: Gene therapy’s emergence has made molecular diagnosis for inherited retinal diseases clinically significant. Free genetic testing panels have improved testing access in clinical practice, yet the interpretation of re…
View article: Retinal Cell Biology in Health and Disease
Retinal Cell Biology in Health and Disease Open
The intricate network of cells and processes that govern retinal health has long been a subject of fascination and intensive study within the scientific community [...]
View article: Comparison of Retinal Metabolic Activity and Structural Development between rd10 Mice and Normal Mice Using Multiphoton Fluorescence Lifetime Imaging Microscopy
Comparison of Retinal Metabolic Activity and Structural Development between rd10 Mice and Normal Mice Using Multiphoton Fluorescence Lifetime Imaging Microscopy Open
Fluorescence lifetime imaging microscopy (FLIM) is a technique that analyzes the metabolic state of tissues based on the spatial distribution of fluorescence lifetimes of certain interacting molecules. We used multiphoton FLIM to study the…
View article: Frequency and Pattern of Worldwide Ocular Gene Therapy Clinical Trials up to 2022
Frequency and Pattern of Worldwide Ocular Gene Therapy Clinical Trials up to 2022 Open
The purpose of this study is to describe worldwide gene therapy clinical trials aimed at treating ophthalmic disorders. Information regarding all worldwide clinical trials was collected through 15 different sources, including ClinicalTrial…
View article: Effects of Smoothing and Adaptive Filtering in Multifocal Electroretinography (mfERG)
Effects of Smoothing and Adaptive Filtering in Multifocal Electroretinography (mfERG) Open
(1) Background: mfERG testing is used to study the function of cone photoreceptors in the central retina. Various filters including “smoothing” (Smooth) and “adaptive data filtering” (Adapt) are used to simplify raw data. This study will s…
View article: The Impact of Vision Restoration on Visual Cortical Structure
The Impact of Vision Restoration on Visual Cortical Structure Open
The Argus II retinal prosthesis restores low-resolution visual perception to late blind patients. It has been shown that structural changes occur in the brain due to late-onset blindness, including cortical thinning in visual regions of th…
View article: Vogt-Koyanagi-Harada-like Syndrome and Electronegative Electroretinogram after Nivolumab Therapy for Metastatic Cutaneous Melanoma: A Case Report
Vogt-Koyanagi-Harada-like Syndrome and Electronegative Electroretinogram after Nivolumab Therapy for Metastatic Cutaneous Melanoma: A Case Report Open
Background: Vogt-Koyanagi-Harada-like (VKH) syndrome or electronegative electroretinograms (ERG) have both been described before or after immunotherapy for metastatic cutaneous melanoma, but they have not been described occurring together.…
View article: Optical coherence tomography in healthy human subjects in the setting of prolonged dark adaptation
Optical coherence tomography in healthy human subjects in the setting of prolonged dark adaptation Open
Human studies have established that short periods of dark adaptation can induce outer retinal thinning and various band intensity changes that can be detected with Optical Coherence Tomography (OCT). Similar findings were observed in mice,…
View article: Recurrent Uveitis-Glaucoma-Hyphema Syndrome Due to Positional Pupillary Capture after Sutureless Scleral-Fixated Secondary Intraocular Lens Placement
Recurrent Uveitis-Glaucoma-Hyphema Syndrome Due to Positional Pupillary Capture after Sutureless Scleral-Fixated Secondary Intraocular Lens Placement Open
Here, we present a case of floppy iris leading to positional pupillary capture by a sutureless, scleral-fixated intraocular lens (IOL) causing recurrent uveitis-glaucoma-hyphema (UGH) syndrome. The patient developed recurrent episodes of U…
View article: Macular hole reopening after inverted internal limiting membrane flap
Macular hole reopening after inverted internal limiting membrane flap Open
Introduction: Here, we present a case of macular hole (MH) reopening after an initial successful closure with an inverted internal limiting membrane (ILM) flap procedure. Case Report: The patient was a 72-year-old Hispanic male who present…
View article: Hypertension
Hypertension Open
Purpose: To describe the case of a 67-year-old female with proliferative retinopathy secondary to uncontrolled hypertension. Methods: Retrospective case report including multimodal imaging. Results: A 67-year-old female presented with mild…
View article: Sight restoration reverses blindness-induced cross-modal functional connectivity changes between the visual and somatosensory cortex at rest
Sight restoration reverses blindness-induced cross-modal functional connectivity changes between the visual and somatosensory cortex at rest Open
Resting-state functional connectivity (rsFC) has been used to assess the effect of vision loss on brain plasticity. With the emergence of vision restoration therapies, rsFC analysis provides a means to assess the functional changes followi…
View article: Insights into Metabolic Activity and Structure of the Retina through Multiphoton Fluorescence Lifetime Imaging Microscopy in Mice
Insights into Metabolic Activity and Structure of the Retina through Multiphoton Fluorescence Lifetime Imaging Microscopy in Mice Open
Fluorescence lifetime imaging microscopy (FLIM) evaluates the metabolic state of tissue based on reduced nicotinamide adenine dinucleotide (NAD(P)H) and flavin adenine dinucleotide (FAD). Fluorescence lifetime imaging ophthalmoscopy (FLIO)…
View article: Insights into Metabolic Activity and Structure of the Retina through Multiphoton Fluorescence Lifetime Imaging Microscopy in Mice
Insights into Metabolic Activity and Structure of the Retina through Multiphoton Fluorescence Lifetime Imaging Microscopy in Mice Open
Fluorescence lifetime imaging microscopy (FLIM) evaluates the metabolic state of tissue based on reduced nicotinamide adenine dinucleotide (NAD(P)H) and flavin adenine dinucleotide (FAD). Fluorescence lifetime imaging ophthalmoscopy (FLIO…
View article: Capillary density and caliber as assessed by optical coherence tomography angiography may be significant predictors of diabetic retinopathy severity
Capillary density and caliber as assessed by optical coherence tomography angiography may be significant predictors of diabetic retinopathy severity Open
Purpose To validate retinal capillary density and caliber associations with diabetic retinopathy (DR) severity in different clinical settings. Methods This cross-sectional study assessed retinal capillary density and caliber in the superfi…
View article: Ischemic index and distribution of retinal capillary non-perfusion in neovascular glaucoma
Ischemic index and distribution of retinal capillary non-perfusion in neovascular glaucoma Open
Introduction: Neovascular Glaucoma (NVG) is a condition normally caused by hypoxic posterior ocular disease, which produces angiogenic factors such as vascular endothelial growth factor (VEGF) that stimulate new vessel proliferation of the…
View article: Acquired Vitelliform Macular Degeneration: Characteristics and Challenges of Managing Subretinal Fluid
Acquired Vitelliform Macular Degeneration: Characteristics and Challenges of Managing Subretinal Fluid Open
Purpose: To highlight diagnostic challenges in patients with acquired vitelliform macular degeneration (AVMD) with subretinal fluid (SRF) and to examine the characteristics of image findings in patients with AVMD. Methods: In this retrospe…
View article: Fundus Autofluorescence and Clinical Applications
Fundus Autofluorescence and Clinical Applications Open
Fundus autofluorescence (FAF) has allowed in vivo mapping of retinal metabolic derangements and structural changes not possible with conventional color imaging. Incident light is absorbed by molecules in the fundus, which are excited and i…
View article: Relating Retinal Vascular Oxygen Saturation and Microvasculature Morphology at Progressive Stages of Diabetic Retinopathy
Relating Retinal Vascular Oxygen Saturation and Microvasculature Morphology at Progressive Stages of Diabetic Retinopathy Open
The findings of this study have the potential to improve clinical management of DR by providing better understanding of human disease pathophysiology and propelling future studies to identify multiple image-based biomarkers for improved di…
View article: Ischemic Index and Distribution of Retinal Capillary Non-perfusion in Neovascular Glaucoma: a Retrospective Study
Ischemic Index and Distribution of Retinal Capillary Non-perfusion in Neovascular Glaucoma: a Retrospective Study Open
Purpose: To evaluate the pattern of retinal ischemia in newly diagnosed neovascular glaucoma (NVG).Methods: This is a retrospective single-center cross-sectional study of patients seen at LAC+USC Medical Center from January 2015 to April 2…
View article: Electroretinogram and Visual Field Correlation in Birdshot Chorioretinopathy
Electroretinogram and Visual Field Correlation in Birdshot Chorioretinopathy Open
In this study, the largest isopter of Glodmann visual field showed a strong positive correlation with all standard ERG amplitudes in BCR. This novel finding underscores the role of ERG as an objective visual function test in monitoring the…