Hossein Daghagh
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View article: Superior efficacy and persistence of Orca-T-allogeneic CAR19/22 versus autologous CAR19/22 in high-risk adult B-ALL
Superior efficacy and persistence of Orca-T-allogeneic CAR19/22 versus autologous CAR19/22 in high-risk adult B-ALL Open
Background: Adults with high-risk (HR), relapsed/refractory (r/r) B-ALL who receive CAR-T often require consolidative allogeneic HCT to achieve long-term remission. Emerging data suggests that adult B-ALL patients (pts) with prior HCT have…
View article: CTIM-05. HUMANIZED ANTI-CAR ANTIBODIES AFFECT DURABLE RESPONSE TO GD2-CAR T-CELLS IN DIFFUSE MIDLINE GLIOMA
CTIM-05. HUMANIZED ANTI-CAR ANTIBODIES AFFECT DURABLE RESPONSE TO GD2-CAR T-CELLS IN DIFFUSE MIDLINE GLIOMA Open
H3K27M-mutated diffuse midline gliomas (DMGs) are universally lethal cancers in children and young adults. Our team previously demonstrated efficacy of GD2-targeting chimeric antigen receptor (GD2-CAR) T-cells in preclinical models of DMG …
View article: Homozygous mutation in <i>CSF1R </i>causes brain abnormalities, neurodegeneration, and dysosteosclerosis (BANDDOS)
Homozygous mutation in <i>CSF1R </i>causes brain abnormalities, neurodegeneration, and dysosteosclerosis (BANDDOS) Open
Introduction: The CSF1R gene encodes the receptor for colony-stimulating factor-1, the macrophage, and monocyte-specific growth factor. Mutations in this gene cause hereditary diffuse leukoencephalopathy with spheroids (HDLS) with autosoma…