Yingyong Hou
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View article: Kidney, Prostate, and Bladder Cancer Burden Attributable to Tobacco Smoke Exposure in BRICS Countries from 1990 to 2021: A Systematic Analysis Based on the Global Burden of Disease Study
Kidney, Prostate, and Bladder Cancer Burden Attributable to Tobacco Smoke Exposure in BRICS Countries from 1990 to 2021: A Systematic Analysis Based on the Global Burden of Disease Study Open
Background: While tobacco smoke remains a leading modifiable risk factor for urologic cancers, comprehensive assessments in BRICS countries are scarce. We aimed to quantify the burden of kidney, prostate, and bladder cancers attributable t…
View article: Table S1 from Anlotinib plus Epirubicin Followed by Anlotinib Maintenance as First-line Treatment for Advanced Soft-tissue Sarcoma: An Open-label, Single-arm, Phase II Trial
Table S1 from Anlotinib plus Epirubicin Followed by Anlotinib Maintenance as First-line Treatment for Advanced Soft-tissue Sarcoma: An Open-label, Single-arm, Phase II Trial Open
Representativeness of Study Participants
View article: Laparoscopic resection of an incidental retroperitoneal schwannoma in a 74-year-old male: a case report and literature review
Laparoscopic resection of an incidental retroperitoneal schwannoma in a 74-year-old male: a case report and literature review Open
Background This case report highlights a rare retroperitoneal schwannoma in a 74-year-old male, discovered incidentally during a routine physical exam. Schwannomas in the retroperitoneum are uncommon and often present unique diagnostic and…
View article: CPZ promotes the proliferation of gastric cancer by activating the Wnt pathway through binding with DVL2
CPZ promotes the proliferation of gastric cancer by activating the Wnt pathway through binding with DVL2 Open
View article: High-grade uterine endometrial stromal sarcoma harboring GLI1 and MDM2/CDK4 co-amplifications
High-grade uterine endometrial stromal sarcoma harboring GLI1 and MDM2/CDK4 co-amplifications Open
GLI1 gene alterations including fusions and amplifications compromise a subset of malignant mesenchymal tumors exhibiting characteristic monomorphic nested morphology and frequent S100 positivity, which mimic glomus tumors or well differen…
View article: Diagnostic value of AHNAK2 immunohistochemical expression in papillary thyroid carcinoma: an immunohistochemical study
Diagnostic value of AHNAK2 immunohistochemical expression in papillary thyroid carcinoma: an immunohistochemical study Open
Multiple immunohistochemical markers including galectin-3 and BRAF V600E have been used to identify benign and malignant thyroid tumors. AHNAK nucleoprotein 2 (AHNAK2) is a novel oncogene that belongs to the AHNAK protein family and is upr…
View article: Adrenergic G protein-coupled receptors in liver physiology and pathology: research advances and clinical implications
Adrenergic G protein-coupled receptors in liver physiology and pathology: research advances and clinical implications Open
The liver, key for metabolism and homeostasis, sees growing focus on adrenergic GPCRs (α1/α2, β1/β2/β3; activated by adrenaline/noradrenaline). These receptors affect liver physiology/pathology and are treatment targets. This review explor…
View article: SYT4 Interacts with PSMC6 to Facilitate Malignant Progression in Gastric Carcinoma via Activating Wnt/β-catenin Signaling
SYT4 Interacts with PSMC6 to Facilitate Malignant Progression in Gastric Carcinoma via Activating Wnt/β-catenin Signaling Open
Background: Gastric cancer (GC), a prevalent and life-threatening malignancy, poses significant challenges in diagnosis and prognosis due to its complex molecular pathogenesis. Identifying novel biomarkers and therapeutic targets is…
View article: Znhit1 alleviates nitroglycerin-induced hyperalgesia in migraine mice via the inhibition of NOD-like receptor signaling pathway
Znhit1 alleviates nitroglycerin-induced hyperalgesia in migraine mice via the inhibition of NOD-like receptor signaling pathway Open
Purpose: Migraine is a neurological disorder, affecting approximately 1.16 billion individuals globally. Zinc finger HIT-type containing 1 (Znhit1), a chromatin remodeler, has exhibited a neuroprotective role. This study aims to investigat…
View article: Clinical application value of droplet digital PCR detection of Em-cfDNA in the diagnosis of hepatic alveolar echinococcosis
Clinical application value of droplet digital PCR detection of Em-cfDNA in the diagnosis of hepatic alveolar echinococcosis Open
ddPCR is characterized by its ease of operation and cost-effectiveness. It also holds significant value for screening in resource-limited areas, thereby helping to improve early diagnosis rates for HAE and enhance patient prognosis. Subseq…
View article: Obstructive jaundice with duodenal biliary fistula: diagnostic and therapeutic challenges, case report, and literature review
Obstructive jaundice with duodenal biliary fistula: diagnostic and therapeutic challenges, case report, and literature review Open
Background This case presents a 56-year-old male with obstructive jaundice, complicated by bile duct stones, bile duct dilation, and a possible biliary-enteric fistula. This case contributes to the literature by highlighting the complexiti…
View article: Case Report and Literature Review: Intrathyroid Thymic Carcinoma
Case Report and Literature Review: Intrathyroid Thymic Carcinoma Open
This case report details a case of intrathyroid thymic carcinoma (ITTC). ITTC is extremely rare with few reports. Diagnosis is difficult due to a lack of specific features and depends on pathology. A 36‐year‐old male was diagnosed. His con…
View article: Subacute liver failure caused by hyperthyroidism and complicated by drugs: a case report and review of the literature
Subacute liver failure caused by hyperthyroidism and complicated by drugs: a case report and review of the literature Open
Background Severe liver dysfunction due to concurrent hyperthyroidism and drug-induced liver injury (DILI) is exceedingly rare, posing significant diagnostic and therapeutic challenges. This case report highlights the complexity of managin…
View article: CD103<sup>+</sup>CD8<sup>+</sup> tissue‐resident memory T lymphocytes of melanoma boost anti‐tumour immunity and predict immunotherapy outcomes
CD103<sup>+</sup>CD8<sup>+</sup> tissue‐resident memory T lymphocytes of melanoma boost anti‐tumour immunity and predict immunotherapy outcomes Open
Background Immunotherapy has revolutionised melanoma treatment, providing significant clinical benefits by reactivating the anti‐tumour immune system. CD8 + tissue‐resident memory T lymphocytes (CD8 + TRM) have emerged as crucial mediators…
View article: The triple realm of AI-enabled education: from instrumental rationality to value reconstruction
The triple realm of AI-enabled education: from instrumental rationality to value reconstruction Open
Artificial Intelligence (AI) is reshaping the education ecosystem, and its development presents the triple realm of "instrumental rationality - integration rationality - value rationality". The instrumental rationality stage optimises teac…
View article: Risk factors for post-endoscopic retrograde cholangiopancreatography pancreatitis in the Chinese population: a systematic review and meta-analysis
Risk factors for post-endoscopic retrograde cholangiopancreatography pancreatitis in the Chinese population: a systematic review and meta-analysis Open
Aim: To systematically identify and evaluate key risk factors for post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis in the Chinese population, providing evidence-based guidance to inform clinical practice, particularl…
View article: Case Report: A rare case of hepatic undifferentiated pleomorphic sarcoma: diagnostic dilemmas and multidisciplinary management strategies
Case Report: A rare case of hepatic undifferentiated pleomorphic sarcoma: diagnostic dilemmas and multidisciplinary management strategies Open
Undifferentiated pleomorphic sarcoma of the liver is an extremely rare mesenchymal malignancy, and there is limited literature on its clinical manifestations, diagnostic challenges, and therapeutic strategies. The case is unique due to its…
View article: Age-related incidence of mismatch repair deficiency (dMMR) and its prognostic role in BRAF-mutant colorectal cancer
Age-related incidence of mismatch repair deficiency (dMMR) and its prognostic role in BRAF-mutant colorectal cancer Open
Background The incidence of BRAF mutation and defective mismatch repair (dMMR) in colorectal cancer (CRC) is low. While dMMR is closely related to BRAF mutation, its prognostic significance in BRAF-mutant CRC remains unclear. Methods We co…
View article: Auxiliary liver transplantation using otherwise-discarded liver allograft combined with associating liver partition and portal vein ligation for staged hepatectomy for unresectable colorectal liver metastases
Auxiliary liver transplantation using otherwise-discarded liver allograft combined with associating liver partition and portal vein ligation for staged hepatectomy for unresectable colorectal liver metastases Open
View article: Regional and whole-brain neurofunctional alterations during pain empathic processing of physical but not affective pain in migraine patients
Regional and whole-brain neurofunctional alterations during pain empathic processing of physical but not affective pain in migraine patients Open
View article: Crystal-storing histiocytosis associated with MALT Lymphoma: a case report and literature review
Crystal-storing histiocytosis associated with MALT Lymphoma: a case report and literature review Open
Introduction and importance: Crystal-storing histiocytosis (CSH) is a rare, non-neoplastic histiocytic proliferation that often complicates underlying lymphoproliferative or plasma cell disorders. The respiratory system is uncommonly invol…
View article: Mirizzi syndrome masquerading as gallbladder carcinoma: a case report on diagnostic challenges and multidisciplinary management
Mirizzi syndrome masquerading as gallbladder carcinoma: a case report on diagnostic challenges and multidisciplinary management Open
Background Mirizzi syndrome is a rare condition that is frequently misdiagnosed as gallbladder cancer due to overlapping clinical and imaging features. This case underscores the diagnostic challenge of differentiating these two conditions …
View article: 753 | FINAL ANALYSIS OF CONCORDANCE STUDY OF IMMUNOHISTOCHEMICAL CD30 EXPRESSION DETECTED BY NINE ASSAYS AND THE VENTANA CD30 ASSAY IN CHINESE LYMPHOMA PATIENTS (CREDIT STUDY)
753 | FINAL ANALYSIS OF CONCORDANCE STUDY OF IMMUNOHISTOCHEMICAL CD30 EXPRESSION DETECTED BY NINE ASSAYS AND THE VENTANA CD30 ASSAY IN CHINESE LYMPHOMA PATIENTS (CREDIT STUDY) Open
View article: 762 | ARTIFICIAL INTELLIGENCE‐ASSISTED QUANTITATIVE ANALYSIS FOR THE IMMUNOHISTOCHEMICAL EXPRESSION OF CD30 IN LYMPHOMAS
762 | ARTIFICIAL INTELLIGENCE‐ASSISTED QUANTITATIVE ANALYSIS FOR THE IMMUNOHISTOCHEMICAL EXPRESSION OF CD30 IN LYMPHOMAS Open
View article: The prognostic and immune significance of fibronectin type III domain-containing 1 gene in pan-cancer and its relationship with proliferation and migration of stomach adenocarcinoma
The prognostic and immune significance of fibronectin type III domain-containing 1 gene in pan-cancer and its relationship with proliferation and migration of stomach adenocarcinoma Open
FNDC1 is highly expressed in various tumor tissues and may serve as a potential prognostic biomarker and immunotherapy target in cancer. It plays a crucial role in proliferation, migration and invasion of STAD.
View article: FGFR2 fusion/rearrangement analysis in intrahepatic cholangiocarcinoma using DNA/RNA-based NGS and FISH
FGFR2 fusion/rearrangement analysis in intrahepatic cholangiocarcinoma using DNA/RNA-based NGS and FISH Open
Patients with intrahepatic cholangiocarcinoma (iCCA) harboring FGFR2 fusion/rearrangement benefit from targeted therapies, highlighting the need for reliable testing strategies to identify FGFR2 alterations. We assessed 226 iCCA cases usin…
View article: A case of quadruple wild-type gastrointestinal stromal tumor with CDC42BPB::NTRK3 fusion and abundant lymphoid infiltration
A case of quadruple wild-type gastrointestinal stromal tumor with CDC42BPB::NTRK3 fusion and abundant lymphoid infiltration Open
View article: Ultrasonography for Rare Lumbar Hernia Diagnosis: Multimodal Imaging Insights
Ultrasonography for Rare Lumbar Hernia Diagnosis: Multimodal Imaging Insights Open
This case report highlights the role of ultrasonography in diagnosing a rare right lumbar hernia in a 57‐year‐old male presenting with a painless lumbar mass. Ultrasound revealed a hypoechoic mass with disrupted fascial continuity. CT imag…
View article: Case Report: BRCA1 and BRCA2 loss in a young man with primary cutaneous extraskeletal osteosarcoma
Case Report: BRCA1 and BRCA2 loss in a young man with primary cutaneous extraskeletal osteosarcoma Open
Background Extraskeletal osteosarcoma is an uncommon and high-grade soft tissue malignancy. The incidence is even lower when the skin is the primary site. To the best of our knowledge, the primary cutaneous osteosarcoma has fewer than 30 r…
View article: Colonoscopy Uptake in First-Degree Relatives of CRC Patients: Challenges and Intervention Strategies
Colonoscopy Uptake in First-Degree Relatives of CRC Patients: Challenges and Intervention Strategies Open
This study provides references for domestic research on the willingness of first-degree relatives for colonoscopy, provide new ideas for formulating intervention methods more suitable for first-degree relatives for colonoscopy, and promote…