Hao Yang
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View article: VTA1 and breast cancer: a potential indicator for diagnostic and prognostic evaluation
VTA1 and breast cancer: a potential indicator for diagnostic and prognostic evaluation Open
Objectives Vacuolar protein sorting-associated protein VTA1 homolog (VTA1) encodes a factor involved in multivesicular body trafficking. This investigation sought to determine if VTA1 might function as a diagnostic indicator, a standalone …
View article: Astaxanthin reverses neurodevelopmental impairment by decreasing oxidative stress-induced disruption of Maf/Bcl2 signaling in prenatal alcohol exposure
Astaxanthin reverses neurodevelopmental impairment by decreasing oxidative stress-induced disruption of Maf/Bcl2 signaling in prenatal alcohol exposure Open
Background Prenatal alcohol exposure (PAE) is recognized as the leading cause of adverse prenatal exposure disorders worldwide. The neurodevelopmental impairments resulting from PAE in offspring are classified under fetal alcohol syndrome …
View article: Efficacy of Transcutaneous Electrical Acupoint Stimulation Applied During the Post-Anesthesia Recovery Period in Improving Postoperative Recovery Quality After Gynecological Laparoscopic Surgery: A Randomized Controlled Trial
Efficacy of Transcutaneous Electrical Acupoint Stimulation Applied During the Post-Anesthesia Recovery Period in Improving Postoperative Recovery Quality After Gynecological Laparoscopic Surgery: A Randomized Controlled Trial Open
TEAS applied during the post-anesthesia recovery period significantly improves early postoperative recovery quality, reduces pain and PONV, and accelerates functional recovery in patients undergoing gynecological laparoscopic surgery.
View article: Identification of potential miRNA biomarkers for neurobrucellosis diagnosis
Identification of potential miRNA biomarkers for neurobrucellosis diagnosis Open
Background Neurobrucellosis (NB) is a rare complication of brucellosis that presentis with a variety of clinical symptoms, complicating its diagnosis. This study aimed to analyze the microRNA (miRNA) profile of cerebrospinal fluid (CSF) in…
View article: Clinical Efficacy of Ureteroscopic Pneumatic Lithotripsy and Holmium Laser Lithotripsy in Managing Ureteral Calculi: A Propensity Score Matching Analysis
Clinical Efficacy of Ureteroscopic Pneumatic Lithotripsy and Holmium Laser Lithotripsy in Managing Ureteral Calculi: A Propensity Score Matching Analysis Open
AIM: This study aims to compare the clinical efficacy of ureteroscopic pneumatic lithotripsy (URPL) and ureteroscopic holmium laser lithotripsy (URHLL) in managing ureteral calculi (UC) using the propensity score matching (PSM) method. MET…
View article: Discovery and structural studies of histone demethylases
Discovery and structural studies of histone demethylases Open
The discovery and structural elucidation of histone demethylases represent a groundbreaking advancement in the field of epigenetics. Histone methylation, a critical chromatin modification, was long regarded as irreversible until the identi…
View article: Regulatory element map of sheep reproductive tissues: functional annotation of tissue-specific strong active enhancers
Regulatory element map of sheep reproductive tissues: functional annotation of tissue-specific strong active enhancers Open
Introduction Comprehensive functional annotation of the genome is crucial for elucidating the molecular mechanisms underlying complex traits and diseases. Although functional annotation has been partially completed in sheep, a systematic a…
View article: Safe Easy Endotracheal Kit-flexible-guided endotracheal intubation reduces stress response under general anesthesia: a randomized controlled trial
Safe Easy Endotracheal Kit-flexible-guided endotracheal intubation reduces stress response under general anesthesia: a randomized controlled trial Open
SEEKflex-guided intubation, compared to the traditional tube core method, resulted in more stable hemodynamic responses and a higher first intubation success rate.
View article: Annotated test-retest dataset of lung cancer CT scan images reconstructed at multiple imaging parameters
Annotated test-retest dataset of lung cancer CT scan images reconstructed at multiple imaging parameters Open
Quantitative imaging biomarkers (QIB) are increasingly used in clinical research to advance precision medicine approaches in oncology. Computed tomography (CT) is a modality of choice for cancer diagnosis, prognosis, and response assessmen…
View article: The reproducibility and predictivity of radiomic features extracted from dynamic contrast-enhanced computed tomography of hepatocellular carcinoma
The reproducibility and predictivity of radiomic features extracted from dynamic contrast-enhanced computed tomography of hepatocellular carcinoma Open
Purpose To assess the reproducibility of radiomic features (RFs) extracted from dynamic contrast-enhanced computed tomography (DCE-CT) scans of patients diagnosed with hepatocellular carcinoma (HCC) with regards to inter-observer variabili…
View article: Machine learning-based identification of contrast-enhancement phase of computed tomography scans
Machine learning-based identification of contrast-enhancement phase of computed tomography scans Open
Contrast-enhanced computed tomography scans (CECT) are routinely used in the evaluation of different clinical scenarios, including the detection and characterization of hepatocellular carcinoma (HCC). Quantitative medical image analysis ha…
View article: Molecular mechanisms of pancreatic cancer liver metastasis: the role of PAK2
Molecular mechanisms of pancreatic cancer liver metastasis: the role of PAK2 Open
Background Pancreatic cancer remains an extremely malignant digestive tract tumor, posing a significant global public health burden. Patients with pancreatic cancer, once metastasis occurs, lose all hope of cure, and prognosis is extremely…
View article: Risk factors associated with postoperative respiratory failure after esophagectomy for esophageal cancer
Risk factors associated with postoperative respiratory failure after esophagectomy for esophageal cancer Open
Aim: Respiratory failure is common after esophagectomy for esophageal cancer (EC). This study aimed to identify the risk factors associated with postoperative respiratory failure following esophagectomy for EC. Methods: A single-center obs…
View article: Development of a prognostic model based on anoikis-related genes for predicting clinical prognosis and immunotherapy of hepatocellular carcinoma
Development of a prognostic model based on anoikis-related genes for predicting clinical prognosis and immunotherapy of hepatocellular carcinoma Open
Hepatocellular Carcinoma (HCC) is the predominant cause of cancer-related mortality worldwide. The majority of HCC patients are diagnosed at advanced stages of the disease, with a high likelihood of metastasis and unfavorable prognosis. An…
View article: Modeling Tumor Growth Using Partly Conditional Survival Models: A Case Study in Colorectal Cancer
Modeling Tumor Growth Using Partly Conditional Survival Models: A Case Study in Colorectal Cancer Open
PURPOSE There are multiple approaches to modeling the relationship between longitudinal tumor measurements obtained from serial imaging and overall survival. Many require strong assumptions that are untestable and debatable. We illustrate …
View article: Germline <i>EGFR</i> Mutations and Familial Lung Cancer
Germline <i>EGFR</i> Mutations and Familial Lung Cancer Open
PURPOSE The genomic underpinnings of inherited lung cancer risk are poorly understood. This prospective study characterized the clinical phenotype of patients and families with germline EGFR pathogenic variants (PVs). METHODS The Investiga…
View article: Clinical efficacy of thermal ablation for the treatment of pulmonary carcinoid tumor: a propensity-matched analysis
Clinical efficacy of thermal ablation for the treatment of pulmonary carcinoid tumor: a propensity-matched analysis Open
To investigate the clinical efficacy of thermal ablation in the treatment of pulmonary carcinoid (PC) tumor. Data of patients with inoperable PC diagnosed from 2000 to 2019 were obtained from the SEER database and analyzed according to dif…
View article: Development and validation of nomograms for predicting overall survival and cancer-specific survival in elderly patients with locally advanced gastric cancer: a population-based study
Development and validation of nomograms for predicting overall survival and cancer-specific survival in elderly patients with locally advanced gastric cancer: a population-based study Open
Objective To evaluate the multiple factors influencing the survival of elderly patients with locally advanced gastric cancer (LAGC) and develop and validate the novel nomograms for predicting the survival. Methods The clinical features of …
View article: Intraoperative performance and outcomes of robotic and laparoscopic total gastrectomy for gastric cancer: A high‐volume center retrospective propensity score matching study
Intraoperative performance and outcomes of robotic and laparoscopic total gastrectomy for gastric cancer: A high‐volume center retrospective propensity score matching study Open
Background Studies on robotic total gastrectomy (RTG) are currently limited. This study aimed to compare the intraoperative performance as well as short‐ and long‐term outcomes of RTG and laparoscopic total gastrectomy (LTG). Methods A tot…
View article: Baseline Radiomic Signature to Estimate Overall Survival in Patients With NSCLC
Baseline Radiomic Signature to Estimate Overall Survival in Patients With NSCLC Open
The radiomic signature provides an early readout of the anticipated OS in patients with NSCLC treated with nivolumab or chemotherapy. This could provide important prognostic information and may support risk stratification in clinical trial…