Houman Goudarzi
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View article: High Airway‐To‐Vessel Volume Ratio and Visual Bronchiectasis Are Associated With Exacerbations in <scp>COPD</scp>
High Airway‐To‐Vessel Volume Ratio and Visual Bronchiectasis Are Associated With Exacerbations in <span>COPD</span> Open
Background and Objective The effects of the volume mismatch between the airway and lung vasculature on exacerbation in chronic obstructive pulmonary disease (COPD) is uncertain. We aimed to examine the association between an increased volu…
View article: Determinants of airway morphology in asthma: Inflammatory and noninflammatory factors
Determinants of airway morphology in asthma: Inflammatory and noninflammatory factors Open
View article: Association of Phthalate Exposure with Respiratory and Allergic Symptoms and Type 2 and Non-Type 2 Inflammation: The Hokkaido Study
Association of Phthalate Exposure with Respiratory and Allergic Symptoms and Type 2 and Non-Type 2 Inflammation: The Hokkaido Study Open
Phthalate exposure is linked to asthma and allergic symptoms, yet their individual and combined effects on symptoms and inflammatory biomarkers, type 2 (T2) and non-T2, remain unexplored. This study examined the association of phthalate me…
View article: Prevalence and clinical impact of asthma-COPD overlap in severe asthma
Prevalence and clinical impact of asthma-COPD overlap in severe asthma Open
The prevalence of ACO in our multicenter cohort study on severe asthma was approximately 30 %. The presence of ACO was not an independent risk for exacerbations or decline in FEV1.
View article: Impact of wheat sensitization on wheeze and T2 phenotypes in general population of children
Impact of wheat sensitization on wheeze and T2 phenotypes in general population of children Open
View article: Increased adiposity-to-muscle ratio and severity of sinusitis affect quality of life in asthma: Computed tomographic analysis
Increased adiposity-to-muscle ratio and severity of sinusitis affect quality of life in asthma: Computed tomographic analysis Open
Increased VF relative to ESM mass and high LMS may deteriorate asthma-related quality of life, regardless of presence of intrapulmonary disease.
View article: Impact of the Covid-19 pandemic and ensuing online teaching on pre-clinical medical education
Impact of the Covid-19 pandemic and ensuing online teaching on pre-clinical medical education Open
View article: Organophosphate Flame Retardants Associated with Increased Oxidative Stress Biomarkers and Elevated Feno Levels in General Population of Children: The Hokkaido Study
Organophosphate Flame Retardants Associated with Increased Oxidative Stress Biomarkers and Elevated Feno Levels in General Population of Children: The Hokkaido Study Open
View article: Serum 5-S-cysteinyldopa as a predictive biomarker for stem cell transplantation-related complications in children and young adults
Serum 5-S-cysteinyldopa as a predictive biomarker for stem cell transplantation-related complications in children and young adults Open
Diffuse hyperpigmentation is common in patients who undergo chemotherapy or stem cell transplantation (SCT). However, only a few studies have reported the relation between skin reactions and SCT-related complications. Serum 5-S-cysteinyldo…
View article: Referee report. For: Medical students' perspective on the United States Medical Licensing Examination (USMLE) Step 1 transition to Pass/Fail [version 2; peer review: 5 approved with reservations, 1 not approved]
Referee report. For: Medical students' perspective on the United States Medical Licensing Examination (USMLE) Step 1 transition to Pass/Fail [version 2; peer review: 5 approved with reservations, 1 not approved] Open
View article: Exposure to organophosphate flame retardants and plasticizers is positively associated with wheeze and FeNO and eosinophil levels among school-aged children: The Hokkaido study
Exposure to organophosphate flame retardants and plasticizers is positively associated with wheeze and FeNO and eosinophil levels among school-aged children: The Hokkaido study Open
Exposure to organophosphate flame retardants and plasticizers (PFRs) increases the risk of asthma and allergies. However, little is known about its association with type 2 inflammation (T2) biomarkers used in the management of allergies. T…
View article: Organophosphate Flame Retardants Mixture associated with Increased Urinary Oxidative Stress Biomarkers among School Children: The Hokkaido Study
Organophosphate Flame Retardants Mixture associated with Increased Urinary Oxidative Stress Biomarkers among School Children: The Hokkaido Study Open
BACKGROUND AND AIM: Exposure to organophosphate flame retardants (PFRs) has been reported to be associated with increased risks of asthma and allergies. Oxidative stress contributes to the development of asthma, allergic diseases and infla…
View article: Higher Levels of Organophosphate Flame Retardants and Plasticizers Showed Positive Associations with Wheeze, Feno and Peripheral Blood Eosinophil Levels Among School Children: The Hokkaido Study
Higher Levels of Organophosphate Flame Retardants and Plasticizers Showed Positive Associations with Wheeze, Feno and Peripheral Blood Eosinophil Levels Among School Children: The Hokkaido Study Open
View article: Blood eosinophil count variability in chronic obstructive pulmonary disease and severe asthma
Blood eosinophil count variability in chronic obstructive pulmonary disease and severe asthma Open
We identified variations in the blood eosinophil counts and their contributing factors in patients with COPD and severe asthma.
View article: Differential role of mucus plugs in asthma: Effects of smoking and association with airway inflammation
Differential role of mucus plugs in asthma: Effects of smoking and association with airway inflammation Open
The association of mucus plug score with exacerbation frequency and reduced lung function may vary due to airway inflammatory profile and smoking status in asthma.
View article: Future career plans of medical students and the <scp>COVID</scp>‐19 pandemic: Time to recover?
Future career plans of medical students and the <span>COVID</span>‐19 pandemic: Time to recover? Open
In 2019 and before the COVID-19 pandemic, about 68% of our medical students in Japan wished to engage in academic activities abroad. However, in 2020 and during the pandemic, this percentage fell to 35%. We found a significant increase in …
View article: Mixture exposure to plastic-related short half-life chemicals and associations with childhood asthma and allergies: The Hokkaido Study
Mixture exposure to plastic-related short half-life chemicals and associations with childhood asthma and allergies: The Hokkaido Study Open
In recent years, exposure to environmental chemicals is thought to be one of the factors contributing to allergies. However, studies examining the effects of mixture chemical exposures on allergies are limited. The aim of this study is to …
View article: Potential determinants of T helper 2 markers and their distribution in school-aged children
Potential determinants of T helper 2 markers and their distribution in school-aged children Open
In addition to wheezing and rhinitis, eczema and secondhand smoke exposure are independent factors for Th2 biomarker interpretation in children. Furthermore, the typical values and cutoff values of blood eosinophils in adults may not be ap…
View article: Effects of obesity on CC16 and their potential role in overweight/obese asthma
Effects of obesity on CC16 and their potential role in overweight/obese asthma Open
Introduction Club cell secretory protein-16 (CC16) is a major anti-inflammatory protein expressed in the airway; however, the potential role of CC16 on overweight/obese asthma has not been assessed. In this study, we examined whether obesi…
View article: Impact of COVID-19 on international medical education and the future plans of medical students in Japan
Impact of COVID-19 on international medical education and the future plans of medical students in Japan Open
Background: The aim of this study was to assess the impact of the coronavirus disease 2019 (COVID-19) pandemic on the current study methods and future plans of medical students compared to those in the pre-pandemic period. Methods: Second-…
View article: Measuring the availability of human resources for health and its relationship to universal health coverage for 204 countries and territories from 1990 to 2019: a systematic analysis for the Global Burden of Disease Study 2019
Measuring the availability of human resources for health and its relationship to universal health coverage for 204 countries and territories from 1990 to 2019: a systematic analysis for the Global Burden of Disease Study 2019 Open
Bill & Melinda Gates Foundation.
View article: Further evidence for association of YKL-40 with severe asthma airway remodeling
Further evidence for association of YKL-40 with severe asthma airway remodeling Open
View article: Impact of COVID-19 on international medical education and the future plans of medical students in Japan
Impact of COVID-19 on international medical education and the future plans of medical students in Japan Open
Background: The aim of this study was to assess the impact of the coronavirus disease 2019 (COVID-19) pandemic on the current study methods and future plans of medical students compared to those in the pre-pandemic period. Methods: Second-…
View article: Impact of Covid-19 pandemic and consequent online teaching on medical education: subjective and objective assessment
Impact of Covid-19 pandemic and consequent online teaching on medical education: subjective and objective assessment Open
In the current study, we examined the impact of the COVID-19 pandemic and online education on the academic performance of medical students; face-to-face (2019), fully online (2020), and a combination of these methods (2021), collecting dat…
View article: Relationships between maternal perfluoroalkyl substance levels, polymorphisms of receptor genes, and adverse birth outcomes in the Hokkaido birth cohort study, Japan
Relationships between maternal perfluoroalkyl substance levels, polymorphisms of receptor genes, and adverse birth outcomes in the Hokkaido birth cohort study, Japan Open
View article: The association between prenatal perfluoroalkyl substance exposure and symptoms of attention-deficit/hyperactivity disorder in 8-year-old children and the mediating role of thyroid hormones in the Hokkaido study
The association between prenatal perfluoroalkyl substance exposure and symptoms of attention-deficit/hyperactivity disorder in 8-year-old children and the mediating role of thyroid hormones in the Hokkaido study Open
Higher PFAS levels in maternal serum during pregnancy were associated with lower risks of ADHD symptoms at 8 years of age. The association was stronger among first-born children in relation to hyperactivity-impulsivity than with regard to …
View article: Associations between maternal mono-(2-ethylhexyl) phthalate levels, nuclear receptor gene polymorphisms, and fatty acid levels in pregnant Japanese women in the Hokkaido study
Associations between maternal mono-(2-ethylhexyl) phthalate levels, nuclear receptor gene polymorphisms, and fatty acid levels in pregnant Japanese women in the Hokkaido study Open
View article: Tetracycline Treatment for COVID-19
Tetracycline Treatment for COVID-19 Open
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak that originated in late 2019 has become a serious global threat to human health. Presently, there are no drugs approved to combat the disease (COVID-19). Therefore, …
View article: Association of abdominal visceral adiposity with sputum IL-5 levels in asthma
Association of abdominal visceral adiposity with sputum IL-5 levels in asthma Open
View article: Associations among maternal perfluoroalkyl substance levels, fetal sex-hormone enzymatic gene polymorphisms, and fetal sex hormone levels in the Hokkaido study
Associations among maternal perfluoroalkyl substance levels, fetal sex-hormone enzymatic gene polymorphisms, and fetal sex hormone levels in the Hokkaido study Open