Housam Haj Hamdo
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View article: Artificial Transcription Factors for Tuneable Gene Expression in Pichia pastoris
Artificial Transcription Factors for Tuneable Gene Expression in Pichia pastoris Open
The non-conventional yeast Pichia pastoris (syn. Komagataella phaffii ) has become a powerful eukaryotic expression platform for biopharmaceutical and biotechnological applications on both laboratory and industrial scales. Despite the fund…
View article: Liposomal FRET Assay Identifies Potent Drug‐Like Inhibitors of the Ceramide Transport Protein (CERT)
Liposomal FRET Assay Identifies Potent Drug‐Like Inhibitors of the Ceramide Transport Protein (CERT) Open
Ceramide transfer protein (CERT) mediates non‐vesicular transfer of ceramide from endoplasmic reticulum to Golgi apparatus and thus catalyzes the rate‐limiting step of sphingomyelin biosynthesis. Usually, CERT ligands are evaluated in tedi…
View article: Sphingolipid-Transporting Proteins as Cancer Therapeutic Targets
Sphingolipid-Transporting Proteins as Cancer Therapeutic Targets Open
The understanding of the role of sphingolipid metabolism in cancer has tremendously increased in the past ten years. Many tumors are characterized by imbalances in sphingolipid metabolism. In many cases, disorders of sphingolipid metabolis…