Explanipedia

Remote communications for caries prevention counseling among Pediatric Dentists in the United States Open

Burton L. Edelstein, Raynika Trent, Patricia Zybert, Randi L. Wolf, Pamela Koch , et al. · 2025

Multi-population genome-wide association study identifies multiple novel loci associated with asymptomatic intracranial large artery stenosis Open

Minghua Liu, Farid Khasiyev, Antonio Spagnolo‐Allende, Danurys Sanchez, Howard Andrews , et al. · 2025

Introduction: Intracranial large artery stenosis (ILAS) is one of the most common causes of stroke worldwide and is associated with the risk for future vascular events. Asymptomatic ILAS is a frequent finding on neuroimaging and shares man…

Brain Abnormalities in Children Exposed Prenatally to the Pesticide Chlorpyrifos Open

Bradley S. Peterson, Sahar Delavari, Ravi Bansal, Siddhant Sawardekar, Chaitanya Gupte , et al. · 2025

Importance Chlorpyrifos (CPF) is one of the most widely used insecticides throughout the world. Preclinical and clinical studies have suggested that prenatal CPF exposure is neurotoxic, but its effects on the human brain are unknown. Objec…

Preliminary Investigation of Obstructive Sleep Apnea and Alzheimer’s Disease in Down Syndrome Open

Dasoo Milton Yoon, David T. Plante, Victoria Fleming, Benjamin L. Handen, Patrick J. Lao , et al. · 2025

This study provided a preliminary examination of indices of obstructive sleep apnea (OSA) and sleep disruptions in adults with Down syndrome (DS), and their associations with Alzheimer’s disease (AD) pathology and symptomatology. Ninety-th…

Placebo‐Controlled, Randomized Double‐Blind N‐Of‐1 Trial to Study Safety and Potential Efficacy of <span>TJ</span>‐68 for Improving Muscle Cramps in Patients With Amyotrophic Lateral Sclerosis: A Pilot Study Open

Hiroshi Mitsumoto, Ken Cheung, Björn Oskarsson, Grace E. Jang, Howard Andrews , et al. · 2025

Introduction/Aims Muscle cramps are a common symptom in amyotrophic lateral sclerosis (ALS). Ameliorating muscle cramps may improve quality of life in devastating diseases like ALS. A traditional Japanese medicine (Kampo, TJ‐68) is widely …

Multi-population Genome-Wide Association Study Identifies Multiple Novel Loci associated with Asymptomatic Intracranial Large Artery Stenosis Open

Minghua Liu, Farid Khasiyev, Antonio Spagnolo‐Allende, Danurys Sanchez, Howard Andrews , et al. · 2025

Background Intracranial large artery stenosis (ILAS) is one of the most common causes of stroke worldwide and is associated with the risk for future vascular events. Asymptomatic ILAS is a frequent finding on neuroimaging and shares many r…

The Alzheimer's Biomarker Consortium–Down Syndrome (ABC‐DS): A 10‐year report Open

Benjamin L. Handen, Mark Mapstone, Sigan L. Hartley, Howard Andrews, Brad T. Christian , et al. · 2025

INTRODUCTION Virtually all adults with Down syndrome (DS) will accumulate the neuropathologies associated with Alzheimer's disease (AD) by age 40, with the majority having a clinical dementia diagnosis by their middle 50s. METHODS This pap…

Crossword puzzle training and neuroplasticity in mild cognitive impairment (COGIT-2): 78-week, multi-site, randomized controlled trial with cognitive, functional, imaging and biomarker outcomes Open

Li Wang, Terry E. Goldberg, Philip D. Harvey, Angela J. Hanson, Jeffrey N. Motter , et al. · 2025

Background: Cognitive training represents an important potential therapeutic strategy for mild cognitive impairment (MCI). In our recently completed trial, crossword puzzles were superior to computerized cognitive training on Alzheimer's d…

Correlating hippocampal and amygdala volumes with neuropathological burden in Down syndrome and Alzheimer’s disease and related neurodegenerative pathologies using 7T postmortem MRI Open

Jr‐Jiun Liou, Jinghang Li, Jacob Berardinelli, Hecheng Jin, Tales Santini , et al. · 2025

Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC), is common in elderly brains and often seen in conjunction with Alzheimer’s disease neuropathologic change (ADNC). LATE-NC typically begins in the amygda…

Classifying COVID-19 hospitalizations in epidemiology cohort studies: The C4R study Open

Elizabeth C. Oelsner, Akshaya Krishnaswamy, Rafail Rustamov, Pallavi Balte, Tauqeer Ali , et al. · 2025

RATIONALE: Robust COVID-19 outcomes classification is important for ongoing epidemiology research on acute and post-acute COVID-19 conditions. Protocolized medical record review is an established method to validate endpoints for clinical t…

Crisis Intervention Team Mental Health Training for Law Enforcement Officers: Protocol for a Multi‐Site, Randomized, Controlled Trial Open

Michael T. Compton, Elisabeth Jackson, En Fu, Howard Andrews, R. Bruno , et al. · 2025

The multi-site RCT will yield generalizable, high-impact findings to inform policy and practice, addressing critical gaps in research on CIT training.

Classifying COVID-19 hospitalizations in epidemiology cohort studies: The C4R study Open

Elizabeth C. Oelsner, Akshaya Krishnaswamy, Rafail Rustamov, Pallavi Balte, Tauqeer Ali , et al. · 2025

Rationale Robust COVID-19 outcomes classification is important for ongoing epidemiology research on acute and post-acute COVID-19 conditions. Protocolized medical record review is an established method to validate endpoints for clinical tr…

Prenatal exposure to polycyclic aromatic hydrocarbons, reduced hippocampal subfield volumes, and word reading Open

H. J. Yang, Jonathan D. Cohen, David Pagliaccio, Bruce Ramphal, Virginia Rauh , et al. · 2025

Chronic Disease Management of Early Childhood Dental Caries: Practices of US Pediatric Dentists Open

Burton L. Edelstein, Charles E. Basch, Patricia Zybert, Randi L. Wolf, Christie L. Custodio‐Lumsden , et al. · 2025

Except for pharmacologic treatments and despite professional guidelines, CDM approaches are underused. We posit that CDM approaches hold strong promise to enhance oral health equity as value-based care arrangements expand in dentistry.

Preliminary investigation of obstructive sleep apnea and Alzheimer’s disease in down syndrome Open

Dasoo Milton Yoon, David T. Plante, Victoria Fleming, Benjamin L. Handen, Patrick J. Lao , et al. · 2025

This study provided a preliminary examination of indices of obstructive sleep apsnea (OSA) and sleep disruptions in adults with Down syndrome (DS), and their associations with Alzheimer’s disease (AD) pathology and symptomatology. A total …

A comparison of multiple amyloid PET radiotracers for Down syndrome clinical trials Open

Matthew Zammit, Julie C. Price, Bradley T. Christian, Michael S. Rafii, Beau M. Ances , et al. · 2025

Adults with Down syndrome carry high risk of developing Alzheimer’s disease and efforts to include this population in clinical trials remain limited. A barrier to recruitment for anti-amyloid trials includes the availability of the same am…

The role of the hippocampus in working memory and word reading: Novel neural correlates of reading among youth living in the context of economic disadvantage Open

Enitan T. Marcelle, H. J. Yang, J Cohen, Bruce Ramphal, David Pagliaccio , et al. · 2024

A left-lateralized cortical reading circuit underlies successful reading and fails to engage in individuals with reading problems. Studies identifying this circuit included youth from economically advantaged backgrounds and focused on cort…

Precision Medicine for Treating Alzheimer’s Disease in Down Syndrome Open

Sonal Sukreet, Elise K Kim, Melissa Petersen, Fan Zhang, Mary Sano , et al. · 2024

Background Individuals with Down Syndrome (DS) exhibit a genetic form of Alzheimer's disease (AD). In this study, we leveraged biobanked plasma samples from a completed clinical trial focused on anti‐inflammatory treatment, Vitamin E, for …

Ethnic and Racial Disparities in Self-Reported Personal Protective Equipment Shortages Among New York Healthcare Workers During the COVID-19 Pandemic Open

Armaan Sodhi, Stanford Chihuri, Christina W. Hoven, Ezra Susser, Charles DiMaggio , et al. · 2024

Healthcare workers of racial and ethnic minority status in New York experienced more pervasive personal protective equipment shortages than their non-Hispanic White counterparts during the COVID-19 pandemic.

Epidemiologic Features of Recovery From SARS-CoV-2 Infection Open

Elizabeth C. Oelsner, Yifei Sun, Pallavi Balte, Norrina B. Allen, Howard Andrews , et al. · 2024

Importance: Persistent symptoms and disability following SARS-CoV-2 infection, known as post-COVID-19 condition or "long COVID," are frequently reported and pose a substantial personal and societal burden. Objective: To determine time to r…

Novel measures of cognition and function for the AD spectrum in the Novel Measures for Alzheimer's Disease Prevention Trials (NoMAD) project: Psychometric properties, convergent validation, and contrasts with established measures Open

Hyun Kim, Seonjoo Lee, Alina Levine, Benjamin Huber, Howard Andrews , et al. · 2024

INTRODUCTION This study derived composite scores for two novel cognitive measures, the No Practice Effect (NPE) battery and the Miami Computerized Functional Skills Assessment and Training system for use in early‐stage Alzheimer's disease …

Rare variant analyses validate known ALS genes in a multi-ethnic population and identifies ANTXR2 as a candidate in PLS Open

Tess D. Pottinger, Joshua E. Motelow, Gundula Povysil, Cristiane Araújo Martins Moreno, Zhong Ren , et al. · 2024

COVID-19 vaccine attitudes among mental health professionals in the WHO’s global clinical practice network Open

Cary S. Kogan, Dan J. Stein, José Ángel García‐Pacheco, Tahilia J. Rebello, Madeline I. Montoya , et al. · 2024

Although COVID-19 vaccines have demonstrated efficacy, there is variability in health professionals’ attitudes towards these agents. Factors associated with mental health professionals’ attitudes towards COVID-19 vaccination are not well u…

Examining the Impact of the Innovative Opioid Court Model on Treatment Access and Court Outcomes for Court Participants Open

Katherine S. Elkington, Margaret E. Ryan, Cale Basaraba, Renald Dambreville, Dan Alschuler , et al. · 2024

Objective The opioid intervention court (OIC) is an innovative, pre-plea treatment court to facilitate rapid linkage to medications for opioid use disorder (MOUD) for people at risk of overdose. This study compares participants in OIC and …

Epidemiologic Features of Recovery From SARS-CoV-2 Infection Open

Elizabeth C. Oelsner, Yifei Sun, Pallavi Balte, Norrina B. Allen, Howard Andrews , et al. · 2024

Importance Persistent symptoms and disability following SARS-CoV-2 infection, known as post–COVID-19 condition or “long COVID,” are frequently reported and pose a substantial personal and societal burden. Objective To determine time to rec…

Diabetes mellitus and hard braking events in older adult drivers Open

Difei Liu, Stanford Chihuri, Howard Andrews, Marian E. Betz, Carolyn DiGuiseppi , et al. · 2024

Frailty and poor physical functioning as risk factors for driving cessation Open

Thelma J. Mielenz, Haomiao Jia, Carolyn DiGuiseppi, David Strogatz, Howard Andrews , et al. · 2024

Introduction Frailty and low physical performance are modifiable factors and, therefore, targets for interventions aimed at delaying driving cessation (DC). The objective was to determine the impact of frailty and physical performance on D…

Sleep–wake behavior, perceived fatigability, and cognitive reserve in older adults Open

Nancy Kerner, Terry E. Goldberg, Hannah Cohen, Julia G. Phillips, Daniel E. Cohen , et al. · 2024

INTRODUCTION The effects of sleep–wake behavior on perceived fatigability and cognitive abilities when performing daily activities have not been investigated across levels of cognitive reserve (CR). METHODS CR Index Questionnaire (CRIq) da…

Comparison of tau spread in people with Down syndrome versus autosomal-dominant Alzheimer's disease: a cross-sectional study Open

Julie K. Wisch, Nicole S. McKay, Anna H. Boerwinkle, James L. Kennedy, Shaney Flores , et al. · 2024

Collaborative Cohort of Cohorts for COVID-19 Research (C4R) Study: Study Design Open

E.C. Oelsner, Amar Krishnaswamy, P.P Balte, Nicholas B. Allen, Tamara Ali , et al. · 2024

The Collaborative Cohort of Cohorts for COVID-19 Research (C4R) is a national prospective study of adults comprising 14 established US prospective cohort studies. Starting as early as 1971, investigators in the C4R cohort studies have coll…

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