Howard Eichenbaum
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View article: Correlates of hippocampal complex-spike cell activity in rats performing a nonspatial radial maze task
Correlates of hippocampal complex-spike cell activity in rats performing a nonspatial radial maze task Open
The observation of hippocampal place cells forms a major line of evidence supporting the view that the hippocampus is dedicated to spatial processing. However, most studies demonstrating the spatial properties of hippocampal unit activity …
View article: Brain Aging: Changes in the Nature of Information Coding by the Hippocampus
Brain Aging: Changes in the Nature of Information Coding by the Hippocampus Open
Advanced age in rats is associated with a decline in spatial memory capacities dependent on hippocampal processing. As yet, however, little is known about the nature of age-related alterations in the information encoded by the hippocampus.…
View article: Memory Representation within the Parahippocampal Region
Memory Representation within the Parahippocampal Region Open
The activity of 378 single neurons was recorded from areas of the parahippocampal region (PHR), including the perirhinal and lateral entorhinal cortex, as well as the subiculum, in rats performing an odor-guided delayed nonmatching-to-samp…
View article: Cognitive decline associated with normal aging in rats: a neuropsychological approach.
Cognitive decline associated with normal aging in rats: a neuropsychological approach. Open
The effects of aging on cognitive capacities were examined by comparing the performance of young and old rats on tasks characterized as dependent on different brain systems. This neuropsychological approach was employed to determine the ex…
View article: Reactivation of time cell sequences in the hippocampus
Reactivation of time cell sequences in the hippocampus Open
The temporal order of an experience is a fundamental property of episodic memories, yet the mechanism for the consolidation of temporal sequences in long-term memory is still unknown. A potential mechanism for memory consolidation depends …
View article: Memory creation and modification: Enhancing the treatment of psychological disorders.
Memory creation and modification: Enhancing the treatment of psychological disorders. Open
Modification of the ongoing influence of maladaptive cognitive, emotional, and behavioral patterns is a fundamental feature of many psychological treatments. Accordingly, a clear understanding of the nature of memory adaptation and accommo…
View article: Temporal binding function of dorsal CA1 is critical for declarative memory formation
Temporal binding function of dorsal CA1 is critical for declarative memory formation Open
Significance Our ability to form declarative memories depends on the hippocampus, and this capacity degrades with age. To identify the critical determinants of this age-associated memory loss, we explored the relationships between two func…
View article: The role of the hippocampus in navigation is memory
The role of the hippocampus in navigation is memory Open
There is considerable research on the neurobiological mechanisms within the hippocampal system that support spatial navigation. In this article I review the literature on navigational strategies in humans and animals, observations on hippo…
View article: Memory: Organization and Control
Memory: Organization and Control Open
A major goal of memory research is to understand how cognitive processes in memory are supported at the level of brain systems and network representations. Especially promising in this direction are new findings in humans and animals that …
View article: Cover Image, Volume 26, Issue 10
Cover Image, Volume 26, Issue 10 Open
This cover image corresponds to the commentary Hippocampus 25 by Howard Eichenbaum et al., DOI: 10.1002/hipo.22616. Design Credit: Jarret Frank.
View article: Time Cells in Hippocampal Area CA3
Time Cells in Hippocampal Area CA3 Open
Hippocampal "time cells" that fire at specific moments in a temporally structured memory task have so far been observed only in area CA1, and some studies have suggested that temporal coding within the hippocampus is exclusive to CA1. Here…
View article: Hippocampus at 25
Hippocampus at 25 Open
The journal Hippocampus has passed the milestone of 25 years of publications on the topic of a highly studied brain structure, and its closely associated brain areas. In a recent celebration of this event, a Boston memory group invited 16 …
View article: Complementary Functional Organization of Neuronal Activity Patterns in the Perirhinal, Lateral Entorhinal, and Medial Entorhinal Cortices
Complementary Functional Organization of Neuronal Activity Patterns in the Perirhinal, Lateral Entorhinal, and Medial Entorhinal Cortices Open
It is commonly conceived that the cortical areas of the hippocampal region are functionally divided into the perirhinal cortex (PRC) and the lateral entorhinal cortex (LEC), which selectively process object information; and the medial ento…
View article: Rhythmic coordination of hippocampal neurons during associative memory processing
Rhythmic coordination of hippocampal neurons during associative memory processing Open
Hippocampal oscillations are dynamic, with unique oscillatory frequencies present during different behavioral states. To examine the extent to which these oscillations reflect neuron engagement in distinct local circuit processes that are …
View article: Author response: Rhythmic coordination of hippocampal neurons during associative memory processing
Author response: Rhythmic coordination of hippocampal neurons during associative memory processing Open
Full text Figures and data Side by side Abstract eLife digest Introduction Results Discussion Materials and methods References Decision letter Author response Article and author information Metrics Abstract Hippocampal oscillations are dyn…
View article: Memory and Space: Towards an Understanding of the Cognitive Map
Memory and Space: Towards an Understanding of the Cognitive Map Open
More than 50 years of research have led to the general agreement that the hippocampus contributes to memory, but there has been a major schism among theories of hippocampal function over this time. Some researchers argue that the hippocamp…
View article: Transient optogenetic inactivation of the medial entorhinal cortex biases the active population of hippocampal neurons
Transient optogenetic inactivation of the medial entorhinal cortex biases the active population of hippocampal neurons Open
The mechanisms that enable the hippocampal network to express the appropriate spatial representation for a particular circumstance are not well understood. Previous studies suggest that the medial entorhinal cortex (MEC) may have a role in…