Howard J. Edenberg
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View article: Integrated single-cell multiomic profiling of caudate nucleus suggests key mechanisms in alcohol use disorder
Integrated single-cell multiomic profiling of caudate nucleus suggests key mechanisms in alcohol use disorder Open
Alcohol use disorder (AUD) induces complex transcriptional and regulatory changes across multiple brain regions including the caudate nucleus, which remains understudied. Using paired single-nucleus RNA-seq and ATAC-seq on caudate samples …
View article: Genome-wide meta-analyses of cross substance use disorders in diverse populations
Genome-wide meta-analyses of cross substance use disorders in diverse populations Open
Substance use disorders (SUDs, including alcohol, cannabis, opioids, and tobacco) represent significant public health challenges. The estimated heritability of SUDs is ~50% and many individuals experience multiple SUDs concurrently. Studie…
View article: T83. DIRECT DNA SEQUENCING REVEALS ALCOHOL USE DISORDER-ASSOCIATED ALTERATIONS IN DNA METHYLATION AND HYDROXYMETHYLATION IN HUMAN CAUDATE NUCLEUS
T83. DIRECT DNA SEQUENCING REVEALS ALCOHOL USE DISORDER-ASSOCIATED ALTERATIONS IN DNA METHYLATION AND HYDROXYMETHYLATION IN HUMAN CAUDATE NUCLEUS Open
View article: Defining suicidality phenotypes for genetic studies: perspectives of the Psychiatric Genomics Consortium Suicide Working Group
Defining suicidality phenotypes for genetic studies: perspectives of the Psychiatric Genomics Consortium Suicide Working Group Open
Suicidality phenotypes, consisting of suicidal ideation (SI), suicide attempt (SA), and suicide death (SD), are all heritable but present unique challenges in genome-wide association studies (GWAS) due to their individual complexity, overl…
View article: A cross-disorder analysis of CNVs finds novel loci and dose-dependent relationships of genes to psychiatric traits
A cross-disorder analysis of CNVs finds novel loci and dose-dependent relationships of genes to psychiatric traits Open
Rare copy number variants (CNVs) are a key component of the genetic basis of psychiatric conditions, but have not been well characterized for most. We conducted a genome-wide CNV analysis across six diagnostic categories (N = 574,965): aut…
View article: Psychiatric disorders converge on common pathways but diverge in cellular context, spatial distribution, and directionality of genetic effects
Psychiatric disorders converge on common pathways but diverge in cellular context, spatial distribution, and directionality of genetic effects Open
Psychiatric conditions share common genes, but mechanisms that differentiate diagnoses remain unclear. We present a multidimensional framework for functional analysis of rare copy number variants (CNVs) across 6 diagnostic categories, incl…
View article: The Psychiatric Genomics Consortium: Discoveries and Directions
The Psychiatric Genomics Consortium: Discoveries and Directions Open
The Psychiatric Genomics Consortium (PGC) has fueled discoveries of common and rare genetic variation contributing to liability to many psychiatric and neurodevelopmental conditions. This narrative review reflects on major findings from th…
View article: The Psychiatric Genomics Consortium: Discoveries and Directions
The Psychiatric Genomics Consortium: Discoveries and Directions Open
The Psychiatric Genomics Consortium (PGC) has fueled discoveries of common and rare genetic variation contributing to liability to many psychiatric and neurodevelopmental conditions. This narrative review reflects on major findings from th…
View article: The Impact of Polygenic Risk, Parental Separation, and Parental Relationship Discord on Heavy Episodic Drinking Across Adolescence and Young Adulthood in a High-Risk Sample
The Impact of Polygenic Risk, Parental Separation, and Parental Relationship Discord on Heavy Episodic Drinking Across Adolescence and Young Adulthood in a High-Risk Sample Open
View article: Defining suicidality phenotypes for genetic studies: perspectives of the Psychiatric Genomics Consortium Suicide Working Group
Defining suicidality phenotypes for genetic studies: perspectives of the Psychiatric Genomics Consortium Suicide Working Group Open
Suicidality phenotypes, consisting of suicidal ideation (SI), suicide attempt (SA), and suicide death (SD), are all heritable but present unique challenges in genome-wide association studies (GWAS) due to their individual complexity, overl…
View article: Polygenic Scores and Mood Disorder Onsets in the Context of Family History and Early Psychopathology
Polygenic Scores and Mood Disorder Onsets in the Context of Family History and Early Psychopathology Open
Importance Bipolar disorder (BD) and major depressive disorder (MDD) aggregate within families, with risk often first manifesting as early psychopathology, including attention-deficit/hyperactivity disorder (ADHD) and anxiety disorders. Ob…
View article: Multivariate genome-wide association study (GWAS) of PTSD, Alcohol Use and Alcohol Use Disorders
Multivariate genome-wide association study (GWAS) of PTSD, Alcohol Use and Alcohol Use Disorders Open
Alcohol use disorder (AUD) commonly co-occurs with posttraumatic stress disorder (PTSD), and comorbid PTSD and AUD is associated with poorer outcomes including worse treatment outcomes and significant physical health consequences. Both PTS…
View article: Clinical, Genomic, and Neurophysiological Correlates of Lifetime Suicide Attempts among Individuals with an Alcohol Use Disorder
Clinical, Genomic, and Neurophysiological Correlates of Lifetime Suicide Attempts among Individuals with an Alcohol Use Disorder Open
Introduction: Research has identified multiple risk factors associated with suicide attempt (SA) among individuals with psychiatric illness. However, there is limited research among those with an alcohol use disorder (AUD), despite their d…
View article: Whole Genome Sequencing of Pedigrees With High Density of Substance Use and Psychiatric Disorders: A Meeting Report
Whole Genome Sequencing of Pedigrees With High Density of Substance Use and Psychiatric Disorders: A Meeting Report Open
The National Institute of Drug Abuse convened a panel of scientists with expertise in substance use disorders (SUD) and genetic methodologies primarily to determine the feasibility of performing whole genome sequencing utilizing existing p…
View article: Multi-ancestral genome-wide association study of clinically defined nicotine dependence reveals strong genetic correlations with other substance use disorders and health-related traits
Multi-ancestral genome-wide association study of clinically defined nicotine dependence reveals strong genetic correlations with other substance use disorders and health-related traits Open
Genetic research on nicotine dependence has utilized multiple assessments that are in weak agreement. We conducted a genome-wide association study of nicotine dependence defined using the Diagnostic and Statistical Manual of Mental Disorde…
View article: The Psychiatric Genomics Consortium: Discoveries and Directions
The Psychiatric Genomics Consortium: Discoveries and Directions Open
The Psychiatric Genomics Consortium (PGC) has fueled discoveries of common and rare genetic variation contributing to liability to many psychiatric and neurodevelopmental conditions. This narrative review reflects on major findings from th…
View article: The Psychiatric Genomics Consortium: Discoveries and Directions
The Psychiatric Genomics Consortium: Discoveries and Directions Open
The Psychiatric Genomics Consortium (PGC) has fueled discoveries of common and rare genetic variation contributing to liability to 13 psychiatric and neurodevelopmental conditions. This narrative review reflects on major findings from the …
View article: Correction: Assessment and ascertainment in psychiatric molecular genetics: challenges and opportunities for cross-disorder research
Correction: Assessment and ascertainment in psychiatric molecular genetics: challenges and opportunities for cross-disorder research Open
View article: The Landscape of Shared and Divergent Genetic Influences across 14 Psychiatric Disorders
The Landscape of Shared and Divergent Genetic Influences across 14 Psychiatric Disorders Open
Psychiatric disorders display high levels of comorbidity and genetic overlap 1,2 . Genomic methods have shown that even for schizophrenia and bipolar disorder, two disorders long-thought to be etiologically distinct 3 , the majority of gen…
View article: Utility of Candidate Genes From an Algorithm Designed to Predict Genetic Risk for Opioid Use Disorder
Utility of Candidate Genes From an Algorithm Designed to Predict Genetic Risk for Opioid Use Disorder Open
Importance Recently, the US Food and Drug Administration gave premarketing approval to an algorithm based on its purported ability to identify individuals at genetic risk for opioid use disorder (OUD). However, the clinical utility of the …
View article: Identification of risk variants and cross-disorder pleiotropy through multi-ancestry genome-wide analysis of alcohol use disorder
Identification of risk variants and cross-disorder pleiotropy through multi-ancestry genome-wide analysis of alcohol use disorder Open
View article: Multi-ancestral genome-wide association study of clinically defined nicotine dependence reveals strong genetic correlations with other substance use disorders and health-related traits
Multi-ancestral genome-wide association study of clinically defined nicotine dependence reveals strong genetic correlations with other substance use disorders and health-related traits Open
Background Genetic research on nicotine dependence has utilized multiple assessments that are in weak agreement. Methods We conducted a genome-wide association study (GWAS) of nicotine dependence defined using the Diagnostic and Statistica…
View article: Assessment and ascertainment in psychiatric molecular genetics: challenges and opportunities for cross-disorder research
Assessment and ascertainment in psychiatric molecular genetics: challenges and opportunities for cross-disorder research Open
Psychiatric disorders are highly comorbid, heritable, and genetically correlated [1–4]. The primary objective of cross-disorder psychiatric genetics research is to identify and characterize both the shared genetic factors that contribute t…
View article: Author Correction: Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction
Author Correction: Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction Open
View article: Polygenic risk for alcohol use disorder affects cellular responses to ethanol exposure in a human microglial cell model
Polygenic risk for alcohol use disorder affects cellular responses to ethanol exposure in a human microglial cell model Open
Polygenic risk scores (PRSs) assess genetic susceptibility to alcohol use disorder (AUD), yet their molecular implications remain underexplored. Neuroimmune interactions, particularly in microglia, are recognized as notable contributors to…
View article: Concerns about genetic risk testing for opioid use disorder
Concerns about genetic risk testing for opioid use disorder Open
View article: The impact of polygenic risk, parental separation, and parental relationship discord on heavy episodic drinking across adolescence and young adulthood in a high-risk sample
The impact of polygenic risk, parental separation, and parental relationship discord on heavy episodic drinking across adolescence and young adulthood in a high-risk sample Open
Objective. Parental separation and parental relationship discord are cross-sectionally associated with alcohol use behaviors in youth and adults, but less is known about whether and how parental separation and discord are associated with t…
View article: Correction: Principal Component Analysis Reduces Collider Bias in Polygenic Score Effect Size Estimation
Correction: Principal Component Analysis Reduces Collider Bias in Polygenic Score Effect Size Estimation Open
View article: Integrated Single-Cell Multiomic Profiling of Caudate Nucleus Suggests Key Mechanisms in Alcohol Use Disorder
Integrated Single-Cell Multiomic Profiling of Caudate Nucleus Suggests Key Mechanisms in Alcohol Use Disorder Open
Alcohol use disorder (AUD) induces complex transcriptional and regulatory changes across multiple brain regions including the caudate nucleus, which remains understudied. Using paired single-nucleus RNA-seq and ATAC-seq on caudate samples …
View article: Genome-wide meta-analyses of cross substance use disorders in European, African, and Latino ancestry populations
Genome-wide meta-analyses of cross substance use disorders in European, African, and Latino ancestry populations Open