Howard M. Johnson
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MicroRNAs secreted by the parasitic nematode Brugia malayi disrupt lymphatic endothelial cell integrity Open
Lymphatic filariasis (LF) is a neglected tropical disease affecting over 51 million people in 72 endemic countries. Causative agents of LF are mosquito-borne parasitic nematodes Wuchereria bancrofti , Brugia malayi , and Brugia timori . Th…
View article: Corneal application of SOCS1/3 peptides for the treatment of eye diseases mediated by inflammation and oxidative stress
Corneal application of SOCS1/3 peptides for the treatment of eye diseases mediated by inflammation and oxidative stress Open
Several blinding diseases affecting the retina and optic nerve are exacerbated by or caused by dysregulated inflammation and oxidative stress. These diseases include uveitis, age related macular degeneration, diabetic retinopathy and glauc…
Disparate viral pandemics from COVID19 to monkeypox and beyond: a simple, effective and universal therapeutic approach hiding in plain sight Open
The field of antiviral therapeutics is fixated on COVID19 and rightly so as the fatalities at the height of the pandemic in the United States were almost 1,000,000 in a twelve month period spanning parts of 2020/2021. A coronavirus called …
View article: Suppressor of Cytokine Signaling 3 Derived Peptide as a Therapeutic for Inflammatory, and Oxidative Stress Induced Damage to the Retina
Suppressor of Cytokine Signaling 3 Derived Peptide as a Therapeutic for Inflammatory, and Oxidative Stress Induced Damage to the Retina Open
Purpose Inflammation and oxidative stress are contributing factors to age-related macular degeneration (AMD) and other retinal diseases. We tested a cell penetrating peptide from the kinase inhibitory region of intracellular checkpoint inh…
View article: Individual and Synergistic Anti-Coronavirus Activities of SOCS1/3 Antagonist and Interferon α1 Peptides
Individual and Synergistic Anti-Coronavirus Activities of SOCS1/3 Antagonist and Interferon α1 Peptides Open
Suppressors of Cytokine Signaling (SOCS) are intracellular proteins that negatively regulate the induction of cytokines. Amongst these, SOCS1 and SOCS3 are particularly involved in inhibition of various interferons. Several viruses have hi…
1404 A peptide mimetic of the kinase inhibitory region of suppressor of cytokine signaling-1 attenuates lymphocyte activation and lupus progression in MRL/Lpr lupus model Open
Background Lupus progression is driven by the aberrant activation of T and B lymphocytes which promote a dysregulated cytokine milieu and produce pathogenic antibodies. Many cytokines, including interferon gamma (IFN-γ), utilize the janus …
View article: Corneal Application of R9-SOCS1-KIR Peptide Alleviates Endotoxin-Induced Uveitis
Corneal Application of R9-SOCS1-KIR Peptide Alleviates Endotoxin-Induced Uveitis Open
Topical delivery of R9-SOCS1-KIR peptide allows the patient to self-administer the drug, while preventing any systemic effects on unrelated organs.
View article: SOCS, Intrinsic Virulence Factors, and Treatment of COVID-19
SOCS, Intrinsic Virulence Factors, and Treatment of COVID-19 Open
The suppressor of cytokine signaling (SOCS) family of intracellular checkpoint inhibitors has received little recognition compared to other checkpoint inhibitors. Two members of this family, SOCS1 and SOCS3, are indispensable, since SOCS1 …
View article: A C-terminal peptide from type I interferon protects the retina in a mouse model of autoimmune uveitis
A C-terminal peptide from type I interferon protects the retina in a mouse model of autoimmune uveitis Open
Experimental autoimmune uveitis (EAU) in rodents recapitulates many features of the disease in humans and has served as a useful tool for the development of therapeutics. A peptide from C-terminus of interferon α1, conjugated to palmitoyl-…
A Cell Penetrating Peptide from Type I Interferon Protects the Retina in a Mouse Model of Autoimmune Uveitis Open
Experimental autoimmune uveitis (EAU) in rodents recapitulates many features of the disease in humans and has served as a useful tool for the development of therapeutics. A peptide from C-terminus of interferon α1, conjugated to palmitoyl-…
Noncanonical IFN Signaling, Steroids, and STATs: A Probable Role of V-ATPase Open
A small group of only seven transcription factors known as STATs (signal transducer and activator of transcription) are considered to be canonical determinants of specific gene activation for a plethora of ligand/receptor systems. The acti…
Temporal trends in acute kidney injury across health care settings in the Irish health system: a cohort study Open
Background.Complete ascertainment of the true rates of acute kidney injury (AKI) and emerging trends are essential for planning of preventive strategies within health systems.Methods.We conducted a retrospective cohort study from 2005 to 2…
View article: A Cell Penetrating Peptide from SOCS-1 Prevents Ocular Damage in Experimental Autoimmune Uveitis
A Cell Penetrating Peptide from SOCS-1 Prevents Ocular Damage in Experimental Autoimmune Uveitis Open
We describe an immunosuppressive peptide corresponding to the kinase inhibitory region (KIR) of the intracellular checkpoint protein suppressor of cytokine signaling 1 (SOCS-1) that binds to the phospho-tyrosine containing regions of the t…
Editorial: The Dynamic Role of Suppressor of Cytokine Signaling Proteins in the Regulation of Immune and Autoimmune Responses Open
EDITORIAL article Front. Immunol., 17 July 2017Sec. Inflammation Volume 8 - 2017 | https://doi.org/10.3389/fimmu.2017.00825
Noncanonical IFN Signaling: Mechanistic Linkage of Genetic and Epigenetic Events Open
The canonical model of cytokine signaling via the JAK/STAT pathway dominates our view of signal transduction but provides no insight into the significance of the simultaneous presence of activated JAKs and STATs in the nucleus of cells tre…