Howard Wang
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View article: RNA Binding Sensitivity of Nonstructural Protein 8 Revealed by Small-Angle Neutron Scattering and Alphafold2 Prediction
RNA Binding Sensitivity of Nonstructural Protein 8 Revealed by Small-Angle Neutron Scattering and Alphafold2 Prediction Open
The flexible structure enables nonstructural protein 8 (nsp8) to respond quickly to environmental changes, which are essential for RNA replication and transcription of SARS-CoV-2. In this work, small-angle neutron scattering and AlphaFold2…
View article: Carbon Fiber Reinforced Thermoplastics: From Materials to Manufacturing and Applications
Carbon Fiber Reinforced Thermoplastics: From Materials to Manufacturing and Applications Open
Carbon fiber reinforced thermoplastics (CFRTs) have witnessed a resurgence in recent times since their first industrial use over five decades ago, with revitalized interest from aerospace companies and other key sectors including energy an…
View article: Fucoidan for potentially treating amblyopia: Autophagy-associated targets and therapeutic mechanisms
Fucoidan for potentially treating amblyopia: Autophagy-associated targets and therapeutic mechanisms Open
Amblyopia is a pediatric disorder characterized by reduced visual acuity and remains a major pediatric health challenge. Currently, effective drug therapies for amblyopia are limited. Therefore, screening and exploring potential bioactive …
View article: Morphology of Thin-Film Nafion on Carbon as an Analogue of Fuel Cell Catalyst Layers
Morphology of Thin-Film Nafion on Carbon as an Analogue of Fuel Cell Catalyst Layers Open
Species transport in thin-film Nafion heavily influences proton-exchange membrane (PEMFC) performance, particularly in low-platinum-loaded cells. Literature suggests that phase-segregated nanostructures in hydrated Nafion thin films can re…
View article: P325: Postnatal progressive craniosynostosis: An unusual presentation leading to cascade diagnosis for multiple generations
P325: Postnatal progressive craniosynostosis: An unusual presentation leading to cascade diagnosis for multiple generations Open
NM_000141.5: FGFR2 c.1032G>A (silent) is a pathogenic variant that causes Crouzon syndrome through activation of a new donor splice site. While phenotypic variability is a known feature of Crouzon syndrome, detailed characterization of pat…
View article: Quantification and visualization of spatial distribution of dendrites in solid polymer electrolytes
Quantification and visualization of spatial distribution of dendrites in solid polymer electrolytes Open
Integrating lithium metal anodes with polymer electrolytes is a promising technology for the next generation high-energy-density rechargeable batteries. As the progress is often hindered by the dendrite growth upon cycling, quantifying thr…
View article: Concentration Scaling on Linear Viscoelastic Properties of Cellular Suspensions and Effects of Equilibrium Phase Behavior
Concentration Scaling on Linear Viscoelastic Properties of Cellular Suspensions and Effects of Equilibrium Phase Behavior Open
Concentration scaling on linear viscoelastic properties of cellular suspensions has been studied by rheometric characterisation of Phormidium suspensions and human blood in a wide range of volume fraction under small amplitude oscillatory …
View article: Multiscale characterization reveals oligomerization dependent phase separation of primer-independent RNA polymerase nsp8 from SARS-CoV-2
Multiscale characterization reveals oligomerization dependent phase separation of primer-independent RNA polymerase nsp8 from SARS-CoV-2 Open
RNA replication and transcription machinery is an important drug target for fighting against coronavirus. Non-structure protein nsp8 was proposed harboring primase activity. However, the RNA primer synthesis mechanism of nsp8 is still larg…
View article: Multiscale Characterization Reveals Oligomerization Dependent Phase Separation of Primer-independent RNA Polymerase nsp8 From SARS-CoV-2
Multiscale Characterization Reveals Oligomerization Dependent Phase Separation of Primer-independent RNA Polymerase nsp8 From SARS-CoV-2 Open
RNA replication and transcription machinery is an important drug target for fighting against coronavirus. Non-structure protein nsp8 was proposed harboring primase activity. However, the RNA primer synthesis mechanism of nsp8 is still larg…
View article: Solvent-Assisted Fractionation of Oligomeric Cellulose and Reversible Transformation of Cellulose II and IV
Solvent-Assisted Fractionation of Oligomeric Cellulose and Reversible Transformation of Cellulose II and IV Open
Oligomeric cellulose with an average degree of polymerization of 7.68 and a polydispersity of 1.04 has been fractionated using solution processes. Three fractions have been obtained through initial dissolution, subsequent crystallization, …
View article: Cellulose Nanocomposites of Cellulose Nanofibers and Molecular Coils
Cellulose Nanocomposites of Cellulose Nanofibers and Molecular Coils Open
All-cellulose nanocomposites have been produced from cellulose nanofiber (CNF) suspensions and molecular coil solutions. Morphology and small-angle neutron scattering studies show the exfoliation and dispersion of CNFs in aqueous suspensio…
View article: Flow-through Anterolateral Thigh Flaps: Report of 3 Consecutive Cases and Review of its Utility
Flow-through Anterolateral Thigh Flaps: Report of 3 Consecutive Cases and Review of its Utility Open
Summary In the field of plastic and reconstructive surgery, soft tissue reconstruction of Gustilo 3B with peripheral vascular disease or 3C fractures is a complex treatment algorithm. The concomitant issue of soft tissue coverage with vasc…
View article: Effectiveness of a Novel Dentifrice Containing Stabilized Chlorine Dioxide, Sarkosyl, and Sodium Fluoride
Effectiveness of a Novel Dentifrice Containing Stabilized Chlorine Dioxide, Sarkosyl, and Sodium Fluoride Open
This in vitro study evaluated the effectiveness of a novel dentifrice containing stabilized chlorine dioxide, sodium lauroyl sarcosinate (sarkosyl), and sodium fluoride in enhancing enamel fluoride uptake, remineralization, pellicle cleani…
View article: <p>Enhanced Efficacy of Chemically Modified Curcumin in Experimental Periodontitis: Systemic Implications [Corrigendum]</p>
Enhanced Efficacy of Chemically Modified Curcumin in Experimental Periodontitis: Systemic Implications [Corrigendum] Open
[This corrects the article DOI: 10.2147/JEP.S171119.].
View article: Deeper Siamese Network With Stronger Feature Representation for Visual Tracking
Deeper Siamese Network With Stronger Feature Representation for Visual Tracking Open
Siamese network based visual tracking has drawn considerable attention recently due to the balanced accuracy and speed. This type of method mostly trains a relatively shallow twin network offline, and measures the similarity online using c…
View article: Understanding the Aryl Hydrocarbon Receptor(AhR)-mediated generation of the intraepithelial lymphocytes
Understanding the Aryl Hydrocarbon Receptor(AhR)-mediated generation of the intraepithelial lymphocytes Open
Mature T cells are divided into two distinct major subsets: CD4 helper T (Th) cells and CD8 cytotoxic T (Tc) cells. Th cells essentially regulate immune responses by mediating the activation and controlling the function of other immune cel…
View article: Abstract 129: Molecular and Genetic Characterization of Functional Schwann-Cell Like Cells (iMDSCs) Transformed from Muscle Derived Stem Cells
Abstract 129: Molecular and Genetic Characterization of Functional Schwann-Cell Like Cells (iMDSCs) Transformed from Muscle Derived Stem Cells Open
PURPOSE: Current microsurgical techniques do not address the atrophy and loss of Schwann cells (SCs) after peripheral nerve trauma. SCs are the principal glial cells that are known to facilitate axonal regeneration through cytokine signali…
View article: <p>Enhanced efficacy of chemically modified curcumin in experimental periodontitis: systemic implications</p>
Enhanced efficacy of chemically modified curcumin in experimental periodontitis: systemic implications Open
These data, plus that from previous studies, support the therapeutic potential of CMC 2.24 in the management of inflammatory periodontal disease and its ability to reduce the risk of associated systemic diseases. The current study also ind…
View article: Correction: Author Correction: Attenuation of RNA polymerase II pausing mitigates BRCA1-associated R-loop accumulation and tumorigenesis
Correction: Author Correction: Attenuation of RNA polymerase II pausing mitigates BRCA1-associated R-loop accumulation and tumorigenesis Open
Nature Communications 8: Article number: 15908 (2017); Published 26 June 2017; Updated 30 March 2018 The original version of this Article omitted the following from the Acknowledgements: ‘The work was also supported by a grant to Y.H. from…
View article: Attenuation of RNA polymerase II pausing mitigates BRCA1-associated R-loop accumulation and tumorigenesis
Attenuation of RNA polymerase II pausing mitigates BRCA1-associated R-loop accumulation and tumorigenesis Open
Most BRCA1 -associated breast tumours are basal-like yet originate from luminal progenitors. BRCA1 is best known for its functions in double-strand break repair and resolution of DNA replication stress. However, it is unclear whether loss …
View article: Controlled Heat Stress Promotes Myofibrillogenesis during Myogenesis
Controlled Heat Stress Promotes Myofibrillogenesis during Myogenesis Open
Hyperthermia therapy has recently emerged as a clinical modality used to finely tune heat stress inside the human body for various biomedical applications. Nevertheless, little is known regarding the optimal timing or temperature of heat s…
View article: 2553: Measuring functional recovery after chronic denervation of peripheral nerves: A novel rat forelimb model
2553: Measuring functional recovery after chronic denervation of peripheral nerves: A novel rat forelimb model Open
BackgroundFunctional outcomes after vascularized composite allotransplantation (VCA) depend on nerve regeneration. After transplantation, the recipient peripheral nerve axons slowly grow and reinne...