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View article: Second messengers involved in the mechanism of action of bradykinin in sensory neurons in culture
Second messengers involved in the mechanism of action of bradykinin in sensory neurons in culture Open
Application of bradykinin to neonatal rat dorsal root ganglion neurons caused a depolarization associated with an inward current and an increase in membrane conductance that was probably due to the opening of sodium channels. No hyperpolar…
View article: Capsaicin-induced ion fluxes in dorsal root ganglion cells in culture
Capsaicin-induced ion fluxes in dorsal root ganglion cells in culture Open
Capsaicin is a pungent pain-producing compound found in plants of the capsicum family; it exerts excitatory, desensitizing, and toxic effects on a subset of sensory neurons, including the polymodal nociceptor population. We have carried ou…
View article: Nicotinic receptors of frog ganglia resemble pharmacologically those of skeletal muscle
Nicotinic receptors of frog ganglia resemble pharmacologically those of skeletal muscle Open
The actions of ACh antagonists were studied on synaptic currents of autonomic ganglia of the frog. Fast excitatory synaptic currents (ESCs) were recorded from cardiac and paravertebral neurons with the use of the 2-microelectrode voltage-c…
View article: Depolarization of nonmyelinated fibers of the rat vagus nerve produced by activation of protein kinase C
Depolarization of nonmyelinated fibers of the rat vagus nerve produced by activation of protein kinase C Open
The effect of activation of protein kinase C by phorbol esters has been studied on the nonmyelinated (C) fibers of the rat vagus nerve. Grease- gap recording at room temperature was used to monitor changes in the resting and action potenti…