Hrant Hovhannisyan
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View article: Genome-wide Discovery of lncRNAs in Mucorales Reveals Essential Roles in Development and Fungal Biology
Genome-wide Discovery of lncRNAs in Mucorales Reveals Essential Roles in Development and Fungal Biology Open
Long non-coding RNAs (lncRNAs) emerged as key regulators across eukaryotes, yet their functions in early-diverging fungal (EDF) pathogens remain largely unknown. Here, we provide the first comprehensive identification and characterization …
View article: A multidimensional assessment of in-host fitness costs of drug resistance in the opportunistic fungal pathogen <i>Candida glabrata</i>
A multidimensional assessment of in-host fitness costs of drug resistance in the opportunistic fungal pathogen <i>Candida glabrata</i> Open
Drug-resistant microbes typically carry mutations in genes involved in critical cellular functions and may therefore be less fit under drug-free conditions than susceptible strains. Candida glabrata is a prevalent opportunistic yeast patho…
View article: Overlooked <i>Candida glabrata</i> petites are echinocandin tolerant, induce host inflammatory responses, and display poor <i>in vivo</i> fitness
Overlooked <i>Candida glabrata</i> petites are echinocandin tolerant, induce host inflammatory responses, and display poor <i>in vivo</i> fitness Open
Small colony variants are relatively common among some bacterial species and are associated with poor prognosis and recalcitrant infections. Similarly, Candida glabrata— a major intracellular fungal pathogen—produces small and slow-growing…
View article: A multidimensional assessment of in-host fitness costs of drug resistance in the opportunistic fungal pathogen<i>Candida glabrata</i>
A multidimensional assessment of in-host fitness costs of drug resistance in the opportunistic fungal pathogen<i>Candida glabrata</i> Open
The global rise of antimicrobial resistance poses a serious threat to public health. Because drug-resistant (DR) pathogens typically carry mutations in genes involved in critical cellular functions, they may be less fit under drug-free con…
View article: Overlooked<i>Candida glabrata</i>petites are echinocandin tolerant, induce host inflammatory responses, and display poor<i>in vivo</i>fitness
Overlooked<i>Candida glabrata</i>petites are echinocandin tolerant, induce host inflammatory responses, and display poor<i>in vivo</i>fitness Open
Small colony variants (SCVs) are relatively common among some bacterial species and are associated with poor prognosis and recalcitrant infections. Similarly, Candida glabrata – a major intracellular fungal pathogen – produces small and sl…
View article: Multiplexed target enrichment of coding and non-coding transcriptomes enables studying Candida spp. infections from human derived samples
Multiplexed target enrichment of coding and non-coding transcriptomes enables studying Candida spp. infections from human derived samples Open
The study of transcriptomic interactions between host and pathogens in in vivo conditions is challenged by the low relative amounts of the pathogen RNA. Yeast opportunistic pathogens of the genus Candida can cause life-threatening systemic…
View article: Human albumin enhances the pathogenic potential of Candida glabrata on vaginal epithelial cells
Human albumin enhances the pathogenic potential of Candida glabrata on vaginal epithelial cells Open
The opportunistic pathogen Candida glabrata is the second most frequent causative agent of vulvovaginal candidiasis (VVC), a disease that affects 70–75% of women at least once during their life. However, C . glabrata is almost avirulent in…
View article: Human albumin enhances the pathogenic potential of Candida glabrata on vaginal epithelial cells
Human albumin enhances the pathogenic potential of Candida glabrata on vaginal epithelial cells Open
The opportunistic pathogen Candida glabrata is the second most frequent causative agent of vulvovaginal candidiasis (VVC), a disease that affects 70–75% of women at least once during their life. However, C. glabrata is almost avirulent in …
View article: Target Enrichment Enables the Discovery of lncRNAs with Somatic Mutations or Altered Expression in Paraffin-Embedded Colorectal Cancer Samples
Target Enrichment Enables the Discovery of lncRNAs with Somatic Mutations or Altered Expression in Paraffin-Embedded Colorectal Cancer Samples Open
Long non-coding RNAs (lncRNAs) play important roles in cancer and are potential new biomarkers or targets for therapy. However, given the low and tissue-specific expression of lncRNAs, linking these molecules to particular cancer types and…
View article: Integrative Omics Analysis Reveals a Limited Transcriptional Shock After Yeast Interspecies Hybridization
Integrative Omics Analysis Reveals a Limited Transcriptional Shock After Yeast Interspecies Hybridization Open
The formation of interspecific hybrids results in the coexistence of two diverged genomes within the same nucleus. It has been hypothesized that negative epistatic interactions and regulatory interferences between the two sub-genomes may e…
View article: The Transcriptional Aftermath in Two Independently Formed Hybrids of the Opportunistic Pathogen Candida orthopsilosis
The Transcriptional Aftermath in Two Independently Formed Hybrids of the Opportunistic Pathogen Candida orthopsilosis Open
How new pathogens emerge is an important question that remains largely unanswered. Some emerging yeast pathogens are hybrids originated through the crossing of two different species, but how hybridization contributes to higher virulence is…
View article: The transcriptional aftermath in two independently formed hybrids of the opportunistic pathogen<i>Candida orthopsilosis</i>
The transcriptional aftermath in two independently formed hybrids of the opportunistic pathogen<i>Candida orthopsilosis</i> Open
Interspecific hybridization can drive evolutionary adaptation to novel environments. The Saccharomycotina clade of budding yeasts includes many hybrid lineages, and hybridization has been proposed as a source for new pathogenic species. Ca…
View article: CROSSMAPPER: estimating cross-mapping rates and optimizing experimental design in multi-species sequencing studies
CROSSMAPPER: estimating cross-mapping rates and optimizing experimental design in multi-species sequencing studies Open
Motivation Numerous sequencing studies, including transcriptomics of host-pathogen systems, sequencing of hybrid genomes, xenografts, mixed species systems, metagenomics and meta-transcriptomics, involve samples containing genetic material…
View article: Recent trends in molecular diagnostics of yeast infections: from PCR to NGS
Recent trends in molecular diagnostics of yeast infections: from PCR to NGS Open
The incidence of opportunistic yeast infections in humans has been increasing over recent years. These infections are difficult to treat and diagnose, in part due to the large number and broad diversity of species that can underlie the inf…
View article: Investigation of the Candida–host interaction using dual RNA-seq
Investigation of the Candida–host interaction using dual RNA-seq Open
Candida species are commensal yeasts but are also responsible of life-threatening infection in at-risk populations, like new-born or immunocompromised patients. Candida albicans is the most common causative species, and the most studied. M…