Hsiao‐Sheng Liu
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View article: Gut microbial metabolites in cancer immunomodulation
Gut microbial metabolites in cancer immunomodulation Open
Gut microbiota–derived metabolites are emerging as systemic “remote immunoregulators” that shape tumor immunity across tissues. Integrating evidence across short-chain fatty acids, tryptophan derivatives, secondary bile acids, polyamines a…
View article: Repurposing Doxycycline to Overcome High‐Glucose–Induced Mitochondrial Biogenesis–Mediated Chemoresistance in Colorectal Cancer Cells
Repurposing Doxycycline to Overcome High‐Glucose–Induced Mitochondrial Biogenesis–Mediated Chemoresistance in Colorectal Cancer Cells Open
Chemoresistance is a major contributor to treatment failure in most patients with cancer. Hyperglycaemia enhances chemoresistance in stage III colorectal cancer (CRC) patients, potentially through a mechanism involving c‐Myc. Phospho‐PGC‐1…
View article: Effect of feeding programme on the metabolisable energy of feed for broilers: starvation-feeding-starvation vs ad libitum feeding
Effect of feeding programme on the metabolisable energy of feed for broilers: starvation-feeding-starvation vs ad libitum feeding Open
The determination of metabolisable energy (ME) in feed ingredients is essential for accurate diet formulation and growth management in broiler. However, the precision of ME determination may be influenced by the choice of feeding programme…
View article: Using Integrated Bioinformatics Analysis to Identify Saponin Formosanin C as a Ferroptosis Inducer in Colorectal Cancer with p53 and Oncogenic KRAS
Using Integrated Bioinformatics Analysis to Identify Saponin Formosanin C as a Ferroptosis Inducer in Colorectal Cancer with p53 and Oncogenic KRAS Open
Ferroptosis, a form of cell death, is characterized by lipid peroxidation and is dependent on iron and reactive oxygen species (ROS). Here, through bioinformatics analysis, formosanin C was predicted to be a ferroptosis inducer in colorect…
View article: Recommendation for immune prophylaxis of respiratory syncytial virus infection in children
Recommendation for immune prophylaxis of respiratory syncytial virus infection in children Open
Respiratory syncytial virus (RSV) is the most common pathogen for young children hospitalized with bronchiolitis and pneumonia. Most infections occur below 1 year of age, and almost all children have been infected before 2 years of age. Mo…
View article: Recommendation for the use of respiratory syncytial virus vaccines
Recommendation for the use of respiratory syncytial virus vaccines Open
Respiratory syncytial virus (RSV) is the most common pathogen for young children hospitalized with bronchiolitis and pneumonia. Most infections occur below 1 year of age. RSV is also a significant viral pathogen for adults with respiratory…
View article: Increased autophagy activity suppresses hyperglycemia-related colorectal cancer tumorigenesis both in vitro and in vivo
Increased autophagy activity suppresses hyperglycemia-related colorectal cancer tumorigenesis both in vitro and in vivo Open
Hyperglycemia contributes to recurrence, poor survival, and drug resistance in colorectal cancer (CRC) patients. Overexpression of G9a (euchromatic histone-lysine N-methyltransferase 2, EHMT2), together with decreased autophagy activity, h…
View article: Dehydroepiandrosterone suppresses human colorectal cancer progression through ER stress-mediated autophagy and apoptosis in a p53-independent manner
Dehydroepiandrosterone suppresses human colorectal cancer progression through ER stress-mediated autophagy and apoptosis in a p53-independent manner Open
Colorectal cancer (CRC) is one of the primary contributors to cancer-related fatalities, with up to 80% of advanced CRC cases exhibiting mutations in the p53 gene. Unfortunately, the development of new compounds targeting mutant p53 is qui…
View article: The role of <i>Atg5</i> gene in tumorigenesis under autophagy deficiency conditions
The role of <i>Atg5</i> gene in tumorigenesis under autophagy deficiency conditions Open
Autophagy is a self‐recycling machinery to maintain cellular homeostasis by degrading harmful materials in the cell. Autophagy‐related gene 5 ( Atg5 ) is required for autophagosome maturation. However, the role of Atg5 in tumorigenesis und…
View article: Revealing potential Rab proteins participate in regulation of secretory autophagy machinery
Revealing potential Rab proteins participate in regulation of secretory autophagy machinery Open
Autophagy can be classified as degradative and secretory based on distinct functions. The small GTPase proteins Rab8a and Rab37 are responsible for secretory autophagy‐mediated exocytosis of IL‐1β, insulin, and TIMP1 (tissue inhibitor of 5…
View article: Repurposing pitavastatin and atorvastatin to overcome chemoresistance of metastatic colorectal cancer under high glucose conditions
Repurposing pitavastatin and atorvastatin to overcome chemoresistance of metastatic colorectal cancer under high glucose conditions Open
Background Colorectal cancer (CRC) poses a significant clinical challenge because of drug resistance, which can adversely impact patient outcomes. Recent research has shown that abnormalities within the tumor microenvironment, especially h…
View article: Deficiency of IL-20 receptor subunit A decreases enterovirus A71 lethality of mice with enhanced M1 macrophage polarization and cytokine
Deficiency of IL-20 receptor subunit A decreases enterovirus A71 lethality of mice with enhanced M1 macrophage polarization and cytokine Open
Enterovirus A71 (EV-A71) can cause fatality in patients with increases of cytokines, IL-10, IL-12, and IFN-γ, which are mutually regulated. IFN-γ is induced and protects the host from EV-A71 in a murine infection model. IFN-γ and IL-10 pro…
View article: Engineered extracellular vesicles carrying let-7a-5p for alleviating inflammation in acute lung injury
Engineered extracellular vesicles carrying let-7a-5p for alleviating inflammation in acute lung injury Open
Background Acute lung injury (ALI) is a life-threatening respiratory condition characterized by severe inflammation and lung tissue damage, frequently causing rapid respiratory failure and long-term complications. The microRNA let-7a-5p is…
View article: Degradative autophagy regulates the homeostasis of miRnas to control cancer development
Degradative autophagy regulates the homeostasis of miRnas to control cancer development Open
Macroautophagy/autophagy acts as an anti-tumor mechanism in early cancer stages but promotes growth in established tumors. Similarly, miRNAs function as tumor suppressors or oncogenes, depending on their target genes. This reciprocal relat…
View article: Age and prior vaccination determine the antibody level in children with primary SARS-CoV-2 Omicron infection
Age and prior vaccination determine the antibody level in children with primary SARS-CoV-2 Omicron infection Open
In our study, children aged 6 months to 2 years have the highest antibody responses to SARS-CoV-2 Omicron variant infection. Age and prior vaccination are the main factors influencing the immunogenicity of SARS-CoV-2 infection.
View article: High G9a Expression in DLBCL and Its Inhibition by Niclosamide to Induce Autophagy as a Therapeutic Approach
High G9a Expression in DLBCL and Its Inhibition by Niclosamide to Induce Autophagy as a Therapeutic Approach Open
Background: Diffuse large B-cell lymphoma (DLBCL) is a malignant lymphoid tumor disease that is characterized by heterogeneity, but current treatment does not benefit all patients, which highlights the need to identify oncogenic genes and …
View article: Secretory autophagy-promoted cargo exocytosis requires active RAB37
Secretory autophagy-promoted cargo exocytosis requires active RAB37 Open
RAB37 GTPase regulates cargo exocytosis by cycling between an inactive GDP-bound form and an active GTP-bound form. We reveal that RAB37 simultaneously regulates autophagy activation and tissue inhibitor of metalloproteinase 1 (TIMP1) secr…
View article: Supplementary Table 2 from SH3BGRL3 Protein as a Potential Prognostic Biomarker for Urothelial Carcinoma: A Novel Binding Partner of Epidermal Growth Factor Receptor
Supplementary Table 2 from SH3BGRL3 Protein as a Potential Prognostic Biomarker for Urothelial Carcinoma: A Novel Binding Partner of Epidermal Growth Factor Receptor Open
Protein identification of urine from patients with BPH.
View article: Supplementary Figure Legend, Supplementary materials and methods from SH3BGRL3 Protein as a Potential Prognostic Biomarker for Urothelial Carcinoma: A Novel Binding Partner of Epidermal Growth Factor Receptor
Supplementary Figure Legend, Supplementary materials and methods from SH3BGRL3 Protein as a Potential Prognostic Biomarker for Urothelial Carcinoma: A Novel Binding Partner of Epidermal Growth Factor Receptor Open
Supplementary Figure legend, Supplementary materials and methods
View article: Data from SH3BGRL3 Protein as a Potential Prognostic Biomarker for Urothelial Carcinoma: A Novel Binding Partner of Epidermal Growth Factor Receptor
Data from SH3BGRL3 Protein as a Potential Prognostic Biomarker for Urothelial Carcinoma: A Novel Binding Partner of Epidermal Growth Factor Receptor Open
Purpose: Mass spectrometry–based biomarker discovery has clinical benefit. To identify novel biomarkers for urothelial carcinoma, we performed quantitative proteomics on pooled urine pairs from patients with and without urothelial carcinom…
View article: Supplementary Figure 4 from SH3BGRL3 Protein as a Potential Prognostic Biomarker for Urothelial Carcinoma: A Novel Binding Partner of Epidermal Growth Factor Receptor
Supplementary Figure 4 from SH3BGRL3 Protein as a Potential Prognostic Biomarker for Urothelial Carcinoma: A Novel Binding Partner of Epidermal Growth Factor Receptor Open
Involvement of SH3BGRL3 in nuclear translocation of beta-catenin, phosphorylation status of Raf-1 after EGF treatment and sensitivity of gefitinib
View article: Supplementary Table 1 from SH3BGRL3 Protein as a Potential Prognostic Biomarker for Urothelial Carcinoma: A Novel Binding Partner of Epidermal Growth Factor Receptor
Supplementary Table 1 from SH3BGRL3 Protein as a Potential Prognostic Biomarker for Urothelial Carcinoma: A Novel Binding Partner of Epidermal Growth Factor Receptor Open
Protein identification of urine from 3 pair of patients with UC.