Explanipedia

Serum Cystatin C and 90-Day Neurological Functional Prognosis in Acute Ischemic Stroke: Insights from a Prospective Cohort and Mendelian Randomization Open

Yongxing Deng, Qing Zhu, Jianan Wu, Jianhua Gan, Xinyi Yang , et al. · 2025

Elevated cystatin C levels demonstrated a significant association with worse 90-day functional outcome and higher mortality in these patients, partially mediated through systemic inflammation. MR findings suggested a potential causal role …

Total bilirubin modifies the relationship between obesity and stroke Open

Junqi Liao, Jingyi Chen, Lei Ji, Minghua Wu, Liu Hong-quan · 2025

Higher PHQ-9 score levels and neutrophil-to-lymphocyte ratio are associated with increased risks of stroke, all-cause mortality, and MACE in NHANES 2005–2018 Open

Junqi Liao, Aimei Zhang, Yujun Cong, Wei Peng, Xiaogang Tang , et al. · 2025

MoSec13 combined with MoGcn5b modulates MoAtg8 acetylation and regulates autophagy in <i>Magnaporthe oryzae</i> Open

Hui Qian, Minghua Wu, Wenhui Zhao, Xue‐Ming Zhu, Li‐Xiao Sun , et al. · 2025

Macroautophagy/autophagy is an evolutionarily conserved cellular degradation process that is crucial for cellular homeostasis in Magnaporthe oryzae. However, the precise regulatory mechanisms governing autophagy in this organism rem…

Zuogui Pill Promotes Neurovascular Regeneration and Corticospinal Tract Remodeling After Ischemic Stroke Open

Dan Wu, Xiaohui Yan, Shirley H. J. Mei, Hua Hao, Xiyun Fei , et al. · 2025

ZGP promotes neurovascular regeneration, CST remodeling, and neurological function recovery after ischemic stroke. The positive impacts of ZGP are linked to heightened VEGF and BDNF expression and the activation of the mTOR pathway.

U-Shaped Relationship of Serum Albumin and Neurological Functional Outcomes After Acute Ischemic Stroke: A Prospective Cohort Study Open

Yuan Zhu, Gang Xue, Shuai Xu, Qi Qin, Peian Liu , et al. · 2025

Among patients with AIS, there was a U-shaped relationship between SA levels at admission and the likelihood of poor outcomes, which was partially mediated by LDL. There is a Graphical Abstract available for this article.

Tenecteplase versus alteplase for intravenous thrombolysis of acute ischemic stroke patients with large-vessel occlusion: a systematic review and meta-analysis Open

Beibei Yao, Xintong Wang, Wu Yao, Qing Zhu, Li Li , et al. · 2025

Background Tenecteplase (TNK) was found non-inferior to alteplase (ALT) for acute ischemic stroke (AIS). We sought to further elucidate the efficacy and safety of intravenous TNK versus ALT for AIS patients with large-vessel occlusion (LVO…

Association between body roundness index and stroke results from the 1999-2018 NHANES Open

Jianhua Gan, Xinyi Yang, Jianan Wu, Pingli Mo, Yongxing Deng , et al. · 2025

There is a nonlinear positive correlation between BRI and stroke, according to this national cohort study. These results support the use of the BRI as a screening tool for assessing stroke risk; yet, because cross-sectional studies have in…

From Screens to Scenes: A Survey of Embodied AI in Healthcare Open

Yihao Liu, Xu Cao, Tingting Chen, Yankai Jiang, Jeong-Bong You , et al. · 2025

Healthcare systems worldwide face persistent challenges in efficiency, accessibility, and personalization. Powered by modern AI technologies such as multimodal large language models and world models, Embodied AI (EmAI) represents a transfo…

Combined 25-hydroxyvitamin D concentrations and physical activity on mortality in US stroke survivors: findings from the NHANES Open

Junqi Liao, Jingyi Chen, Huimin Wu, Qing Zhu, Xiaogang Tang , et al. · 2025

Mitochondria Metabolism Regulates Glucose–Lipid Homeostasis in Neurodegenerative Diseases Open

Jianliang Huang, Mingsheng Lei, Can Zhang, Cheng Zhi Huang, Yun Xiao , et al. · 2025

Neurodegenerative diseases represent a major health threat, with dysfunction in energy metabolism and imbalance in glucose–lipid homeostasis constituting key pathogenic factors. As the cell’s energy hub, mitochondria are closely associated…

From Screens to Scenes: A Survey of Embodied Ai in Healthcare Open

Yihao Liu, Xu Cao, Tingting Chen, Yankai Jiang, Jeong-Bong You , et al. · 2025

Association of phenotypic age and accelerated aging with severity and disability in patients with acute ischemic stroke Open

Yongkang Liu, Jiangchuan Wang, Zicheng Wei, Yu Wang, Minghua Wu , et al. · 2024

PhenoAge or accelerated aging is associated with stroke severity and disability even after adjusting for chronological age.

Relationship between serum glucose-potassium ratio and 90-day outcomes of patients with acute ischemic stroke Open

Xiaohui Yan, Dan Wu, Xinyu Xu, Aimei Zhang, Junqi Liao , et al. · 2024

Association of Systemic Inflammatory Response Index and Neutrophil-to-Lymphocyte Ratio on Unfavorable Functional Outcomes in Acute Ischemic Stroke Patients After Endovascular Therapy Open

Yujun Cong, Xin Xia, Junqi Liao, Aimei Zhang, Tianrui Zhang , et al. · 2024

Higher SIRI and NLR levels at admission may lead to unfavorable outcomes at 90 days for AIS patients with endovascular therapy.

Association Apo B/Apo a-1 Ratio and Prognostic Nutritional Index with 90-Day Outcomes of Acute Ischemic Stroke Open

Junqi Liao, Yuan Zhu, Aimei Zhang, Dan Wu, Xiaohui Yan , et al. · 2024

The Apo B/Apo A-1 ratio is a risk factor for poor AIS outcomes, whereas PNI acts as a protective factor. The association between the ApoB/ApoA-1 ratio and poor AIS outcomes was partially mediated by PNI.

Antioxidants and Fertility in Women with Ovarian Aging: A Systematic Review and Meta-Analysis Open

Yujie Shang, Nannan Song, Ruohan He, Minghua Wu · 2024

Ovarian aging is a major factor for female subfertility. Multiple antioxidants have been applied in different clinical scenarios, but their effects on fertility in women with ovarian aging are still unclear. To address this, a meta-analysi…

Potential value and research frontiers of virus in neuroinflammation: a bibliometric and visualized analysis Open

Danyang Li, Minghua Wu · 2024

Background Neuroinflammation represents the immune response of the central nervous system to nerve injury, infection, toxin stimulation, or autoimmunity and is implicated in a wide range of neurological disorders. Viruses play a pivotal ro…

Antioxidants Improve Reproductive Health in Women With Ovarian Aging Open

Yujie Shang, Minghua Wu, Ruohan He · 2024

Objectives: Ovarian aging is a major factor for female subfertility. Multiple antioxidants have been applied in different clinical scenarios to delay aging, but their effects in the ovarian aging are still unclear. Therefore, we performed …

The Association of Systemic Inflammatory Response Index and Neutrophil-to-High-Density Lipoprotein Ratio Mediated by Fasting Blood Glucose with 90-Day Prognosis in Acute Ischemic Stroke Patients Open

Aimei Zhang, Yuan Zhu, Junqi Liao, Dan Wu, Xiaohui Yan , et al. · 2024

Introduction: The contribution of individual and combined inflammatory markers for the prognosis of acute ischemic stroke (AIS) remains elusive. This study investigated the effect of systemic inflammatory response index (SIRI…

Causal relationship between inflammatory proteins and glioblastoma: a two-sample bi‑directional mendelian randomization study Open

Xiang Lin, Wei Gao, Chen Huang, Minghua Wu, Xiaoling She · 2024

Background: Observational studies have indicated a potential correlation between glioblastoma and circulating inflammatory proteins. Further investigation is required to establish a causal relationship between these two factors. Methods: W…

Integrated single-cell and spatial transcriptomic analysis reveals YBX1 drives immune regulation in GBM progression Open

Yanshan Ge, Huiting Weng, Yingnan Sun, Minghua Wu · 2024

Correlation of Peripheral Blood Inflammatory Indicators to Prognosis After Intravenous Thrombolysis in Acute Ischemic Stroke: A Retrospective Study Open

Tianrui Zhang, Sha Fu, Xiao-Feng Cao, Yangjingyi Xia, Manyan Hu , et al. · 2024

C-NLR and C-LMR can be used as biomarkers to predict prognosis of AIS patients treated with early intravenous thrombolysis.

Chronic stress as an emerging risk factor for the development and progression of glioma Open

Yi Lan, Xiang Lin, Xiaoling She, Wei Gao, Minghua Wu · 2024

Gliomas tend to have a poor prognosis and are the most common primary malignant tumors of the central nervous system. Compared with patients with other cancers, glioma patients often suffer from increased levels of psychological stress, su…

Predictive Panel for Immunotherapy in Low-Grade Glioma Open

Qingqing Lv, Zhaoyu Zhang, Haijuan Fu, Danyang Li, Yihao Liu , et al. · 2024

We obtained 3 reliable immune subtypes, and patients with the IS2 subtype are suitable for immunotherapy, in which NAMPT, SLC11A1, TNC, VIM, and SPP1 are predictive panel markers for ICB in the LGG group. Our findings provide a rationale f…

New insight on microglia activation in neurodegenerative diseases and therapeutics Open

Yucong Xu, Wei Gao, Yingnan Sun, Minghua Wu · 2023

Microglia are immune cells within the central nervous system (CNS) closely linked to brain health and neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. In response to changes in the surrounding environment, mi…

Association of fasting blood glucose level with 90-day unfavorable outcome in acute ischemic stroke patients Open

Yangjingyi Xia, Li Li, Yunze Li, Manyan Hu, Tianrui Zhang , et al. · 2023

FBG is an independent predictor of 90-day unfavorable outcome after stroke in AIS patients. When FBG ≥ 5.5 mmol/L, the risk of 90-day unfavorable outcome increases significantly.

Association of Plasma Lipids with White Matter Hyperintensities in Patients with Acute Ischemic Stroke Open

Yongkang Liu, Cuiping Yuan, Xiaohong Chen, Xiaokun Fang, Jingru Hao , et al. · 2023

Serum lipid levels were not associated with the presence of any type of WMH in patients with AIS.

Association of Immune-inflammation-based prognostic index with depression: A cross-sectional analysis of NHANES data Open

Li Li, Kailin Yin, Xintong Wang, Yawei Zheng, Minghua Wu , et al. · 2023

Background: Immune-inflammatory mediators might modulate a wide range of immune and inflammatory processes，resulting in an increased risk of depression. The objective of this study was to assess the association between Systemic Immune-infl…

The relationship between systemic inflammation index, systemic immune-inflammatory index, and inflammatory prognostic index and 90-day outcomes in acute ischemic stroke patients treated with intravenous thrombolysis Open

Fei Ma, Lulu Li, Liang Xu, Jiacheng Wu, Aimei Zhang , et al. · 2023

Background and purpose To explore the association of systemic inflammatory index (SIRI), systemic immune-inflammatory index (SII) and inflammatory prognosis index (IPI) with 90d outcomes in patients with acute ischemic stroke (AIS) after i…

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