Hsiaopei Mok
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View article: Perioperative corticosteroids for reducing postoperative complications following esophagectomy: an updated systematic review and meta-analysis
Perioperative corticosteroids for reducing postoperative complications following esophagectomy: an updated systematic review and meta-analysis Open
View article: Genomic alteration profile and <scp>PD‐L1</scp> expression among different breast cancer subtypes in Chinese population and their correlations
Genomic alteration profile and <span>PD‐L1</span> expression among different breast cancer subtypes in Chinese population and their correlations Open
Backgroud There were limitations existing in programmed cell‐death ligand 1 (PD‐L1) as predictive biomarkers for breast cancer (BC), hence exploring the correlation between PD‐L1 levels and other biomarkers in BC may become a very useful t…
View article: Distinct clinical and somatic mutational features of breast tumors with high-, low-, or non-expressing human epidermal growth factor receptor 2 status
Distinct clinical and somatic mutational features of breast tumors with high-, low-, or non-expressing human epidermal growth factor receptor 2 status Open
View article: Clinicopathologic and Genomic Features in Triple-Negative Breast Cancer Between Special and No-Special Morphologic Pattern
Clinicopathologic and Genomic Features in Triple-Negative Breast Cancer Between Special and No-Special Morphologic Pattern Open
Background Triple-negative breast cancer (TNBC) is refractory and heterogeneous, comprising various entities with divergent phenotype, biology, and clinical presentation. As an aggressive subtype, Chinese TNBC patients with special morphol…
View article: Accumulated Epinephrine Dose is Associated With Acute Kidney Injury Following Resuscitation in Adult Cardiac Arrest Patients
Accumulated Epinephrine Dose is Associated With Acute Kidney Injury Following Resuscitation in Adult Cardiac Arrest Patients Open
The goal of this study was to investigate the association between total epinephrine dosage during resuscitation and acute kidney injury after return of spontaneous circulation in patients with cardiac arrest. We performed a secondary analy…
View article: Spectrum of <i>MAP3K1</i> mutations in breast cancer is luminal subtype‑predominant and related to prognosis
Spectrum of <i>MAP3K1</i> mutations in breast cancer is luminal subtype‑predominant and related to prognosis Open
MAP3K1 is a MAPK family serine-threonine kinase that is frequently mutated in human cancer. The association between mutations in the MAP3K1 gene and the clinicopathological characteristics and prognosis of patients with breast cance…
View article: Heterogenous and Low Expression of HER2 in Breast Cancer Overcome by DS-8201a in a Heavily Treated Patient: Case Report and Review of the Literature
Heterogenous and Low Expression of HER2 in Breast Cancer Overcome by DS-8201a in a Heavily Treated Patient: Case Report and Review of the Literature Open
Breast cancer is highly heterogenous with temporal and spatial heterogeneity making it necessary for rebiopsy. DS-8201a, a new potential therapy for human epidermal growth factor receptor 2 (HER2) low expression breast cancer, had been pro…
View article: 3D-bioprinted vascular scaffold with tunable mechanical properties for simulating and promoting neo-vascularization
3D-bioprinted vascular scaffold with tunable mechanical properties for simulating and promoting neo-vascularization Open
Alternative artificial vessels with tissue-matching mechanical and biological performance have been continuously taking great attention in bioengineering. However, it is challenging to take into account both mechanical and biological prope…
View article: CDKN1C as a prognostic biomarker correlated with immune infiltrates and therapeutic responses in breast cancer patients
CDKN1C as a prognostic biomarker correlated with immune infiltrates and therapeutic responses in breast cancer patients Open
Breast cancer (BC) prognosis and therapeutic sensitivity could not be predicted efficiently. Previous evidence have shown the vital roles of CDKN1C in BC. Therefore, we aimed to construct a CDKN1C‐based model to accurately predicting overa…
View article: Genetic and immune characteristics of sentinel lymph node metastases and multiple lymph node metastases compared to their matched primary breast tumours
Genetic and immune characteristics of sentinel lymph node metastases and multiple lymph node metastases compared to their matched primary breast tumours Open
This work was supported by funds from High-level Hospital Construction Project (DFJH201921), the National Natural Science Foundation of China (81902828 and 82002928), the Fundamental Research Funds for the Central Universities (y2syD219223…
View article: Characterization of AKT Somatic Mutations in Chinese Breast Cancer Patients
Characterization of AKT Somatic Mutations in Chinese Breast Cancer Patients Open
Patients in the GDPH cohort had lower rates of AKT and AKT3 mutation and higher AKT1 mutation rate than those in the TCGA cohort, while harboring missense mutations detected predominantly as E17K mutation in AKT1. In GDPH cohort, there wer…
View article: Association of Body Mass Index With Somatic Mutations in Breast Cancer
Association of Body Mass Index With Somatic Mutations in Breast Cancer Open
Background The relationship between body mass index (BMI) and the prognosis or treatment response in patients with breast cancer has been demonstrated in previous studies, but the somatic mutation profiles in breast cancer patients with di…
View article: Inflammatory indicator levels in patients undergoing aortic valve replacement via median sternotomy with preoperative anxiety and postoperative complications: a prospective cohort study
Inflammatory indicator levels in patients undergoing aortic valve replacement via median sternotomy with preoperative anxiety and postoperative complications: a prospective cohort study Open
Objective This study was performed to evaluate the association of preoperative anxiety with inflammatory indicators and postoperative complications in patients undergoing scheduled aortic valve replacement surgery. Methods A prospective co…
View article: PIK3CA somatic alterations in invasive breast cancers: different spectrum from Caucasians to Chinese detected by next generation sequencing
PIK3CA somatic alterations in invasive breast cancers: different spectrum from Caucasians to Chinese detected by next generation sequencing Open
Purpose Somatic alteration of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) is a crucial therapeutic target in breast cancer (BC) and PI3Kα-specific inhibitor Alpelisib has been used in clinics. This study…
View article: Molecular characterization of breast cancer: a potential novel immune-related lncRNAs signature
Molecular characterization of breast cancer: a potential novel immune-related lncRNAs signature Open
Background Accumulating evidence has demonstrated that immune-related lncRNAs (IRLs) are commonly aberrantly expressed in breast cancer (BC). Thus, we aimed to establish an IRL-based tool to improve prognosis prediction in BC patients. Met…
View article: Genetic mutation profile of Chinese HER2-positive breast cancers and genetic predictors of responses to Neoadjuvant anti-HER2 therapy
Genetic mutation profile of Chinese HER2-positive breast cancers and genetic predictors of responses to Neoadjuvant anti-HER2 therapy Open
Purpose Despite the therapeutic success of existing HER2-targeted therapies, tumors respond quite differently to them. This study aimed at figuring out genetic mutation profile of Chinese HER2-positive patients and investigating predictive…
View article: Comprehensive analysis of autophagy‐related prognostic genes in breast cancer
Comprehensive analysis of autophagy‐related prognostic genes in breast cancer Open
Accumulating evidence revealed that autophagy played vital roles in breast cancer (BC) progression. Thus, the aim of this study was to investigate the prognostic value of autophagy‐related genes (ARGs) and develop a ARG‐based model to eval…
View article: Comparison of BRCA versus non-BRCA germline mutations and associated somatic mutation profiles in patients with unselected breast cancer
Comparison of BRCA versus non-BRCA germline mutations and associated somatic mutation profiles in patients with unselected breast cancer Open
The data on the phenotypes associated with some rare germline mutations in Chinese breast cancer patients are limited. The difference in somatic mutation profiles in breast cancer patients with germline BRCA and non-BRCA mutations remains …
View article: Heterogeneity of genomic profile in patients with HER2-positive breast cancer
Heterogeneity of genomic profile in patients with HER2-positive breast cancer Open
HER2-positive breast cancer is a biologically and clinically heterogeneous disease. Based on the expression of hormone receptors (HR), breast tumors can be further categorized into HR positive and HR negative. Here, we elucidated the compr…
View article: Secreted modular calcium-binding proteins in pathophysiological processes and embryonic development
Secreted modular calcium-binding proteins in pathophysiological processes and embryonic development Open
SMOC1 and SMOC2 are critical regulators of many cell biological processes and potential therapeutic targets for the control of human cancers and birth defects.
View article: Frequency of germline mutations in women’s cancer susceptibility genes in a large cohort of Chinese breast cancer patients
Frequency of germline mutations in women’s cancer susceptibility genes in a large cohort of Chinese breast cancer patients Open
View article: Identification of a novel microRNA recurrence-related signature and risk stratification system in breast cancer
Identification of a novel microRNA recurrence-related signature and risk stratification system in breast cancer Open
Increasing evidence has revealed that microRNAs (miRNAs) play vital roles in breast cancer (BC) prognosis. Thus, we aimed to identify recurrence-related miRNAs and establish accurate risk stratification system in BC patients. A total of 38…
View article: Characterization of frequently mutated cancer genes in Chinese breast tumors: a comparison of Chinese and TCGA cohorts
Characterization of frequently mutated cancer genes in Chinese breast tumors: a comparison of Chinese and TCGA cohorts Open
We elucidated the mutational landscape of cancer genes in Chinese breast cancer and further identified significant genomic differences between Asian and Caucasian patients. These results should improve our understanding of pathogenesis and…