Hung‐Hsin Lin
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View article: Quantification of oxygen tension variation in an in vitro tumor microenvironment model based on co-culture of tumor spheroid and endothelial cells in a microfluidic device
Quantification of oxygen tension variation in an in vitro tumor microenvironment model based on co-culture of tumor spheroid and endothelial cells in a microfluidic device Open
View article: Clinical Reasoning: Flaccid Paraparesis Due to Paraneoplastic Syndrome and Depression Due to Frontal Lobe Metastasis from Adenocarcinoma Lung in a Patient with Pulmonary Tuberculosis and Benign Spindle Cell Tumor of Stomach
Clinical Reasoning: Flaccid Paraparesis Due to Paraneoplastic Syndrome and Depression Due to Frontal Lobe Metastasis from Adenocarcinoma Lung in a Patient with Pulmonary Tuberculosis and Benign Spindle Cell Tumor of Stomach Open
Middle age man had flaccid paraparesis and depression. Chest radiograph was compatible with old pulmonary tuberculosis. Non-contrast CT scan head was normal. Benign spindle cell tumor was found in gastroscopy done for hematemesis and melae…
View article: The pattern of lymph node metastasis and the outcome of high and low dissection in descending colon cancer
The pattern of lymph node metastasis and the outcome of high and low dissection in descending colon cancer Open
Background/objectives: Few studies focused on the distribution of lymph node metastasis and outcomes of different dissection levels in descending colon cancer. Ligation of the inferior mesenteric artery can sacrifice a significant length o…
View article: The Benefits of Adjuvant Chemotherapy for ypT3-4N0M0 Rectal Cancer Following Neoadjuvant Chemoradiation and Surgery
The Benefits of Adjuvant Chemotherapy for ypT3-4N0M0 Rectal Cancer Following Neoadjuvant Chemoradiation and Surgery Open
Background: Neoadjuvant chemoradiotherapy (nCRT) followed by total mesorectal excision (TME) is the current standard for locally advanced rectal cancer. This study aimed to evaluate the need for adjuvant chemotherapy and clinical outcomes …
View article: Transforming Bacterial Lower Respiratory Tract Infection Diagnosis: A Study on the Efficiency of the FilmArray Pneumonia Panel
Transforming Bacterial Lower Respiratory Tract Infection Diagnosis: A Study on the Efficiency of the FilmArray Pneumonia Panel Open
Background: Lower respiratory tract infections (LRTIs) significantly contribute to global morbidity and mortality. Conventional bacterial LRTIs diagnosis relies on microbiological methods, which are time-consuming. The Biofire ® FilmArray …
View article: Artificial intelligence-clinical decision support system for enhanced infectious disease management: Accelerating ceftazidime-avibactam resistance detection in Klebsiella pneumoniae
Artificial intelligence-clinical decision support system for enhanced infectious disease management: Accelerating ceftazidime-avibactam resistance detection in Klebsiella pneumoniae Open
The study confirms that MALDI-TOF MS, integrated with machine learning, can swiftly detect CZA resistance. Incorporating this insight into an AI-CDSS could transform clinical workflows, giving healthcare professionals immediate, crucial in…
View article: Reply to: “Does ‘the different study period’ influence outcome evaluation?”
Reply to: “Does ‘the different study period’ influence outcome evaluation?” Open
View article: Short-term outcomes of short- and long-course chemoradiotherapy before total mesorectal excision for locally advanced rectal tumors: A single-center study in Taiwan utilizing propensity score matching
Short-term outcomes of short- and long-course chemoradiotherapy before total mesorectal excision for locally advanced rectal tumors: A single-center study in Taiwan utilizing propensity score matching Open
Background: Locally advanced rectal tumors are typically treated with neoadjuvant chemoradiotherapy. Short-course chemoradiotherapy (SCRT, 2500 cGy in five fractions) is a convenient alternative to concurrent chemoradiotherapy with long-co…
View article: Innovative strategies against superbugs: Developing an AI-CDSS for precise Stenotrophomonas maltophilia treatment
Innovative strategies against superbugs: Developing an AI-CDSS for precise Stenotrophomonas maltophilia treatment Open
MALDI-TOF MS and machine learning integration into an AI-CDSS significantly improved rapid SM resistance detection. This system reduced the identification time of resistant strains from 24 h to minutes after MALDI-TOF MS identification, pr…
View article: Abdominal pain with radiation to the right thigh in a middle age woman
Abdominal pain with radiation to the right thigh in a middle age woman Open
A 43-year-old woman presented with intermittent lower abdominal sharp pain for 4 months, which radiated to her back and right thigh, especially during menstrual period. She denied fever, weight loss, and change in bowel habits, hematochezi…
View article: The alteration of fecal microbial and metabolic profile of gallstone patients in Taiwan: Single-center study
The alteration of fecal microbial and metabolic profile of gallstone patients in Taiwan: Single-center study Open
Background: Gallstone disease is a common health problem worldwide. The role of the gut microbiota in gallstone pathogenesis remains obscure. Our aim was to evaluate the association and crosstalk between gut microbiota, gut metabolomic, an…
View article: Anti-VEGF Therapy Possibly Extends Survival in Patients With Colorectal Brain Metastasis by Protecting Patients From Neurologic Disability
Anti-VEGF Therapy Possibly Extends Survival in Patients With Colorectal Brain Metastasis by Protecting Patients From Neurologic Disability Open
Anti-VEGF based systemic therapy showed favorable efficacy that was reflected in longer overall survival, iPFS and NEFS in patients with CBM.
View article: Protective loop ileostomy or colostomy? A risk evaluation of all common complications
Protective loop ileostomy or colostomy? A risk evaluation of all common complications Open
Purpose: Protective ileostomy and colostomy are performed in patients undergoing low anterior resection with a high leakage risk. We aimed to compare surgical, medical, and daily care complications between these 2 ostomies in order to make…
View article: Real-World Evidence of Effectiveness and Safety of Vedolizumab for Inflammatory Bowel Disease in Taiwan: A Prospective Nationwide Registry (VIOLET) Study
Real-World Evidence of Effectiveness and Safety of Vedolizumab for Inflammatory Bowel Disease in Taiwan: A Prospective Nationwide Registry (VIOLET) Study Open
Background This nationwide prospective registry study investigated the real-world effectiveness, safety, and persistence of vedolizumab (VDZ) in inflammatory bowel disease (IBD) patients in Taiwan. Disease relapse rates after VDZ discontin…
View article: The Negative Prognostic Impact of Lymph Node Skip Metastasis in Stage III Colon Cancer With pN1 Disease: A Single-Center and Retrospective Cohort Study
The Negative Prognostic Impact of Lymph Node Skip Metastasis in Stage III Colon Cancer With pN1 Disease: A Single-Center and Retrospective Cohort Study Open
BACKGROUND: Lymph node skip metastasis is a subgroup of lymph node metastatic patterns with low incidence in node-positive colon cancer. Its clinical significance is still unclear. OBJECTIVE: This study aimed to investigate the prognostic …
View article: Perioperative optimization of Crohn's disease
Perioperative optimization of Crohn's disease Open
Crohn's disease (CD) is a chronic inflammatory disease mainly affecting the gastrointestinal tract. With the increased availability of modalities in the last two decades, the treatment of CD has advanced remarkably. Although medical treatm…
View article: A case of Pazopanib-related colon ischemia with perforation
A case of Pazopanib-related colon ischemia with perforation Open
We report a 40-year-old man who was diagnosed with myxoid liposarcoma of left thigh in 2012. Patient received adjuvant chemotherapy and radiation following postoperative tumor control; however, the disease continued to progress. Pazopanib …
View article: A Long-Term and Large-Scale Real-World Study in Taiwan: Efficacy of Target Therapy in Stage IV Colorectal Cancer
A Long-Term and Large-Scale Real-World Study in Taiwan: Efficacy of Target Therapy in Stage IV Colorectal Cancer Open
This study expands the understanding of the role of target therapy in improving survival of patients with mCRC based on real-world study results. These data represent potential survival outcomes of Taiwanese patients with mCRC in clinical …
View article: Ultrasound Calibration for Dual-Armed Surgical Navigation System
Ultrasound Calibration for Dual-Armed Surgical Navigation System Open
Ultrasound (US) imaging system is widely used in robotic systems for precision positioning in clinical applications. The US calibration is critical to minimize the difference of spatial coordinates between instruments, for minimally invasi…
View article: Preference criteria for regorafenib in treating refractory metastatic colorectal cancer are the small tumor burden, slow growth and poor/scanty spread
Preference criteria for regorafenib in treating refractory metastatic colorectal cancer are the small tumor burden, slow growth and poor/scanty spread Open
View article: The efficacy of anti-EGFR therapy in treating metastatic colorectal cancer differs between the middle/low rectum and the left-sided colon
The efficacy of anti-EGFR therapy in treating metastatic colorectal cancer differs between the middle/low rectum and the left-sided colon Open
Background Clinically, metastatic rectal cancer has been considered a subset of left-sided colon cancer. However, heterogeneity has been proposed to exist between high and middle/low rectal cancers. We aimed to examine the efficacy of anti…
View article: Three-dimensional versus conventional two-dimensional laparoscopic colectomy for colon cancer
Three-dimensional versus conventional two-dimensional laparoscopic colectomy for colon cancer Open
Background: Three-dimensional (3D) laparoscopy was developed to overcome the drawbacks of two-dimensional (2D) laparoscopy, namely lack of depth perception. However, the benefit of 3D laparoscopy in colorectal surgery is inconclusive. Here…
View article: Clinicopathological and Molecular Features of Patients with Early and Late Recurrence after Curative Surgery for Colorectal Cancer
Clinicopathological and Molecular Features of Patients with Early and Late Recurrence after Curative Surgery for Colorectal Cancer Open
Background: Few reports have investigated genetic alterations between patients with early and late recurrence following curative surgery for colorectal cancer (CRC). Methods: A total of 1227 stage I–III CRC patients who underwent curative …
View article: The microRNA-210-Stathmin1 Axis Decreases Cell Stiffness to Facilitate the Invasiveness of Colorectal Cancer Stem Cells
The microRNA-210-Stathmin1 Axis Decreases Cell Stiffness to Facilitate the Invasiveness of Colorectal Cancer Stem Cells Open
Cell migration is critical for regional dissemination and distal metastasis of cancer cells, which remain the major causes of poor prognosis and death in patients with colorectal cancer (CRC). Although cytoskeletal dynamics and cellular de…
View article: Differences in intestinal microbiota profiling after upper and lower gastrointestinal surgery
Differences in intestinal microbiota profiling after upper and lower gastrointestinal surgery Open
Background: We aimed to investigate the long-term effects of metabolic profiles and microbiota status in patients after upper gastrointestinal (GI) surgery and lower GI surgery and compared them with a control group. Methods: In this cross…
View article: Clinicopathological and Molecular Features of Colorectal Cancer Patients With Mucinous and Non-Mucinous Adenocarcinoma
Clinicopathological and Molecular Features of Colorectal Cancer Patients With Mucinous and Non-Mucinous Adenocarcinoma Open
Background The prognosis of mucinous adenocarcinoma (MAC) and non-mucinous adenocarcinoma (NMAC) in colorectal cancer (CRC) is controversial, and the molecular differences between them are unclear. Methods Between 2000 and 2010, a total of…
View article: Clinicopathological and molecular features between synchronous and metachronous metastases in colorectal cancer.
Clinicopathological and molecular features between synchronous and metachronous metastases in colorectal cancer. Open
The molecular difference between synchronous and metachronous metastases in colorectal cancer (CRC) remains unclear. Between 2000 and 2010, a total of 492 CRC patients were enrolled, including 280 with synchronous metastasis and 212 with m…
View article: Clinicopathological and Molecular Profiles of Sporadic Microsatellite Unstable Colorectal Cancer with or without the CpG Island Methylator Phenotype (CIMP)
Clinicopathological and Molecular Profiles of Sporadic Microsatellite Unstable Colorectal Cancer with or without the CpG Island Methylator Phenotype (CIMP) Open
Background: The 5’-C-phosphate-G-3’ island methylator phenotype (CIMP) is a specific phenotype of colorectal cancer (CRC) associated with microsatellite instability-high (MSI-high) tumors. Methods: In this study, we determined the CIMP sta…
View article: Risk factors for delayed perineal wound healing and its impact on prolonged hospital stay after abdominoperineal resection
Risk factors for delayed perineal wound healing and its impact on prolonged hospital stay after abdominoperineal resection Open
View article: Combined Microsatellite Instability and Elevated Microsatellite Alterations at Selected Tetranucleotide Repeats (EMAST) Might Be a More Promising Immune Biomarker in Colorectal Cancer
Combined Microsatellite Instability and Elevated Microsatellite Alterations at Selected Tetranucleotide Repeats (EMAST) Might Be a More Promising Immune Biomarker in Colorectal Cancer Open
Background The form of microsatellite instability (MSI) affecting tetranucleotide repeats known as elevated microsatellite alterations at selected tetranucleotide repeats (EMAST) has emerged as a new potential biomarker in multiple cancers…