Skye Hsin‐Hsien Yeh
YOU?
Author Swipe
View article: One stop shop-Integrating 18F-PSMA-1007 and 11C-acetate PET with multiparametric MRI imaging for prostate cancer: A prospective study
One stop shop-Integrating 18F-PSMA-1007 and 11C-acetate PET with multiparametric MRI imaging for prostate cancer: A prospective study Open
Background: To evaluate the diagnostic performance and clinical utility of integrating 18F-PSMA-1007 PET, 11C-acetate PET, and multiparametric MRI (mpMRI) in a one-stop-shop PET/MRI protocol for intermediate- to high-risk prostate cancer s…
View article: A Landmark Multiyear Study of Alzheimer Disease: Integrating [18F]FEPPA PET Imaging With 12 Clinical Assessments for Comprehensive Disease Profiling
A Landmark Multiyear Study of Alzheimer Disease: Integrating [18F]FEPPA PET Imaging With 12 Clinical Assessments for Comprehensive Disease Profiling Open
Purpose: This multiyear study aimed to investigate the relationship between TSPO expression and cognitive decline in Alzheimer disease (AD) using [ 18 F]FEPPA PET imaging. We integrated this imaging data with 12 comprehensive clinical meas…
View article: Bao Yuan Gao vs. Calendula cream for radiotherapy-induced skin toxicity in head and neck cancer: A randomized controlled trial
Bao Yuan Gao vs. Calendula cream for radiotherapy-induced skin toxicity in head and neck cancer: A randomized controlled trial Open
Bao Yuan Gao yielded measurable skin-protective effects, suggesting potential benefits beyond Calendula. These findings, aligned with its anti-inflammatory herbal properties, support further investigation in larger, dose-controlled trials.
View article: Assessment of Vertebral Bone Marrow Perfusion, Fat/Water Content, and Trabecular Bone Changes Using Multimodal <scp>MRI</scp> and Micro‐<scp>CT</scp> in a Rat Model of Chronic Kidney Disease
Assessment of Vertebral Bone Marrow Perfusion, Fat/Water Content, and Trabecular Bone Changes Using Multimodal <span>MRI</span> and Micro‐<span>CT</span> in a Rat Model of Chronic Kidney Disease Open
Background Disturbances in calcium and phosphorus homeostasis resulting from chronic kidney disease (CKD) may lead to atherosclerotic changes in blood vessels, potentially altering bone marrow perfusion. Our study aimed to investigate vert…
View article: Pitavastatin attenuates hypercholesterolemia-induced decline in serotonin transporter availability
Pitavastatin attenuates hypercholesterolemia-induced decline in serotonin transporter availability Open
Our findings demonstrate that pitavastatin not only lowers cholesterol and reduces inflammation but also enhances SERT availability, suggesting a potential role in alleviating depressive symptoms associated with hypercholesterolemia. These…
View article: Dextromethorphan moderates reward deficiency associated with central serotonin transporter availability in 3,4-methylenedioxy-methamphetamine-treated animals
Dextromethorphan moderates reward deficiency associated with central serotonin transporter availability in 3,4-methylenedioxy-methamphetamine-treated animals Open
Background: The neurotoxicity of 3,4-methylenedioxy-methamphetamine (MDMA) to the serotonergic system is well-documented. Dextromethorphan (DM), an antitussive drug, decreased morphine- or methamphetamine (MA)-induced reward in rats and ma…
View article: Assessment of DNA/RNA Deregulation in Cancer Using <sup>99m</sup>Tc-Labeled Thiopurine
Assessment of DNA/RNA Deregulation in Cancer Using <sup>99m</sup>Tc-Labeled Thiopurine Open
Background: DNA biomarkers are useful for the assessment of tumor cell proliferation. The authors aimed to synthesize a thiopurine-based ligand for evaluation of nuclear uptake and tumor localization. Materials and Methods: A 2-hydroxyprop…
View article: Positron emission tomography (PET) imaging of neuroinflammation in healthy and Alzheimer disease participants using TSPO tracers
Positron emission tomography (PET) imaging of neuroinflammation in healthy and Alzheimer disease participants using TSPO tracers Open
Background Alzheimer’s disease (AD) is the most common type of dementia. In addition to the widely recognized accumulation of amyloid and tau protein being the core pathology of AD, neuroinflammation is another cause of brain dysfunction a…
View article: Radiation issue in clinical nuclear molecular imaging
Radiation issue in clinical nuclear molecular imaging Open
Radiation is ubiquitous in nature, and radiation is also widely used in various fields of medicine, agriculture, and industry. Current biological doses below 100 mSv are called low-dose radiation (LDR). Scientists have no consensus of effe…
View article: Increased Cerebral Blood Flow Following L110 Acupuncture in Healthy Volunteers Observed with 99mTc-Ethyl Cysteine Dimer Single-Photon Emission Computed Tomography
Increased Cerebral Blood Flow Following L110 Acupuncture in Healthy Volunteers Observed with 99mTc-Ethyl Cysteine Dimer Single-Photon Emission Computed Tomography Open
Background:: Ischemic stroke is the second most common cause of death and a major cause of disability worldwide. Acupuncture is frequently advocated as an alternative treatment during stroke rehabilitation. Aim: The purpose of this study w…
View article: Assessment of the anti-nociceptive effects of fetal ventral mesencephalic tissue allografts in a rat model of hemi-Parkinson’s disease using fMRI
Assessment of the anti-nociceptive effects of fetal ventral mesencephalic tissue allografts in a rat model of hemi-Parkinson’s disease using fMRI Open
Extensive studies showed increased subjective pain sensitivity in Parkinson’s disease (PD), which appeared to be partially reversed by dopaminergic (DA) treatment. Although cell replacement represents an attractive therapeutic strategy, it…
View article: Multi-Modal Synergistic 99mTc-TRODAT-1 SPECT and MRI for Evaluation of the Efficacy of Hyperbaric Oxygen Therapy in CO-Induced Delayed Parkinsonian and Non-Parkinsonian Syndromes
Multi-Modal Synergistic 99mTc-TRODAT-1 SPECT and MRI for Evaluation of the Efficacy of Hyperbaric Oxygen Therapy in CO-Induced Delayed Parkinsonian and Non-Parkinsonian Syndromes Open
Background: Delayed neuropsychiatric syndrome (DNS) is characterized by motor dysfunction after acute carbon monoxide (CO) poisoning. We examined the relationship between dopamine transporter (DAT) loss using kit-based Tc-99m-TRODAT-1 (DAT…
View article: Amitriptyline Accelerates SERT Binding Recovery in a Rat 3,4-Methylenedioxymethamphetamine (MDMA) Model: In Vivo 4-[18F]-ADAM PET Imaging
Amitriptyline Accelerates SERT Binding Recovery in a Rat 3,4-Methylenedioxymethamphetamine (MDMA) Model: In Vivo 4-[18F]-ADAM PET Imaging Open
Numerous studies have confirmed that 3,4-Methylenedioxymethamphetamine (MDMA) produces long-lasting changes to the density of the serotonin reuptake transporter (SERT). Amitriptyline (AMI) has been shown to exert neuroprotective properties…
View article: Preliminary Results on the Long-Term Effects of Dextromethorphan on MDMA-Mediated Serotonergic Deficiency and Volumetric Changes in Primates Based on 4-[18F]-ADAM PET/MRI
Preliminary Results on the Long-Term Effects of Dextromethorphan on MDMA-Mediated Serotonergic Deficiency and Volumetric Changes in Primates Based on 4-[18F]-ADAM PET/MRI Open
Alterations to the serotonergic system due to 3,4-methylenedioxymethamphetamine (MDMA) (ecstasy) consumption have been extensively documented. However, knowledge of the reversibility of these neurotoxic effects based on in vivo evaluations…
View article: Design and In Vivo Evaluation of a Novel Transdermal Hydrogen/Oxygen-Generating Patch
Design and In Vivo Evaluation of a Novel Transdermal Hydrogen/Oxygen-Generating Patch Open
Hydrogen/oxygen-generating biomaterials, a new trend in regenerative medicine, generate and supply hydrogen/oxygen to increase the local levels of hydrogen/oxygen to support tissue healing and regeneration. In this study, we carefully defi…
View article: Amitriptyline Accelerates SERT Binding Recovery Rate in MDMA-Induced Rat Model: In Vivo 4-[18F]-ADAM PET Imaging
Amitriptyline Accelerates SERT Binding Recovery Rate in MDMA-Induced Rat Model: In Vivo 4-[18F]-ADAM PET Imaging Open
Background Numerous studies have confirmed that 3, 4-Methylenedioxymethamphetamine (MDMA) produces long-lasting changes to the serotonergic system and decreases the density of the serotonin reuptake transporter (SERT). However, amitriptyli…
View article: Automated Synthesis and Initial Evaluation of (4′-Amino-5′,8′-difluoro-1′H-spiro[piperidine-4,2′-quinazolin]-1-yl)(4-[<sup>18</sup>F]fluorophenyl)methanone for PET/MR Imaging of Inducible Nitric Oxide Synthase
Automated Synthesis and Initial Evaluation of (4′-Amino-5′,8′-difluoro-1′H-spiro[piperidine-4,2′-quinazolin]-1-yl)(4-[<sup>18</sup>F]fluorophenyl)methanone for PET/MR Imaging of Inducible Nitric Oxide Synthase Open
Background. Inducible nitric oxide synthase (iNOS) plays a crucial role in neuroinflammation, especially microglial activity, and may potentially represent a useful biomarker of neuroinflammation. In this study, we carefully defined a stra…
View article: <i>In Vivo</i> Evaluation of the Combined Anticancer Effects of Cisplatin and SAHA in Nonsmall Cell Lung Carcinoma Using [<sup>18</sup>F]FAHA and [<sup>18</sup>F]FDG PET/CT Imaging
<i>In Vivo</i> Evaluation of the Combined Anticancer Effects of Cisplatin and SAHA in Nonsmall Cell Lung Carcinoma Using [<sup>18</sup>F]FAHA and [<sup>18</sup>F]FDG PET/CT Imaging Open
Combining standard drugs with low doses of histone deacetylase inhibitors (HDACIs) is a promising strategy to increase the efficacy of chemotherapy. The ability of well-tolerated doses of HDACIs that act as chemosensitizers for platinum-ba…
View article: GMP-compliant fully automated radiosynthesis of [18F]FEPPA for PET/MRI imaging of regional brain TSPO expression
GMP-compliant fully automated radiosynthesis of [18F]FEPPA for PET/MRI imaging of regional brain TSPO expression Open
View article: In Vivo Brain Region-specific TSPO&nbsp;Imaging by PET/MRI [18F]FEPPA
In Vivo Brain Region-specific TSPO Imaging by PET/MRI [18F]FEPPA Open
Background: Expression of translocator protein (TSPO) on the outer mitochondrial membrane of activated microglia is strongly associated with neuroinflammation. The second-generation PET ligand [18F]FEPPA specifically binds TSPO …
View article: A high-sucrose diet aggravates Alzheimer's disease pathology, attenuates hypothalamic leptin signaling, and impairs food-anticipatory activity in APPswe/PS1dE9 mice
A high-sucrose diet aggravates Alzheimer's disease pathology, attenuates hypothalamic leptin signaling, and impairs food-anticipatory activity in APPswe/PS1dE9 mice Open
High-fat and high-sugar diets contribute to the prevalence of type 2 diabetes and Alzheimer's disease (AD). Although the impact of high-fat diets on AD pathogenesis has been established, the effect of high-sucrose diets (HSDs) on AD pathog…
View article: In vivo long-lasting alterations of central serotonin transporter activity and associated dopamine synthesis after acute repeated administration of methamphetamine
In vivo long-lasting alterations of central serotonin transporter activity and associated dopamine synthesis after acute repeated administration of methamphetamine Open
Background Methamphetamine (METH)-associated alterations in the striatal dopamine (DA) system or dopamine transport (DAT) have been identified in clinical and preclinical studies with positron emission tomography (PET) imaging but have not…
View article: Emergent Techniques for Transporter and Receptor-Based Imaging and Interventional Molecular Imaging
Emergent Techniques for Transporter and Receptor-Based Imaging and Interventional Molecular Imaging Open
View article: Augmented Insulin and Leptin Resistance of High Fat Diet-Fed APPswe/PS1dE9 Transgenic Mice Exacerbate Obesity and Glycemic Dysregulation
Augmented Insulin and Leptin Resistance of High Fat Diet-Fed APPswe/PS1dE9 Transgenic Mice Exacerbate Obesity and Glycemic Dysregulation Open
Alzheimer’s disease (AD), a progressive neurodegenerative disease is highly associated with metabolic syndromes. We previously demonstrated that glycemic dysregulation and obesity are augmented in high fat diet (HFD)-treated APPswe/PS1dE9 …
View article: <i>In Vivo</i>6-([<sup>18</sup>F]Fluoroacetamido)-1-hexanoicanilide PET Imaging of Altered Histone Deacetylase Activity in Chemotherapy-Induced Neurotoxicity
<i>In Vivo</i>6-([<sup>18</sup>F]Fluoroacetamido)-1-hexanoicanilide PET Imaging of Altered Histone Deacetylase Activity in Chemotherapy-Induced Neurotoxicity Open
Background . Histone deacetylases (HDACs) regulate gene expression by changing histone deacetylation status. Neurotoxicity is one of the major side effects of cisplatin, which reacts with deoxyribonucleic acid (DNA) and has excellent antit…