Hsin‐Hui Shen
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View article: Prediction of liquid–liquid phase separation proteins based on protein language model
Prediction of liquid–liquid phase separation proteins based on protein language model Open
Liquid–liquid phase separation (LLPS) enables biomolecules to form membraneless condensates critical for cellular functions like RNA metabolism and protein synthesis. Identifying LLPS-associated proteins is essential for understanding thei…
View article: Daptomycin-Loaded Nanocarriers Facilitate Synergistic Killing of Methicillin-Resistant <i>Staphylococcus aureus</i> via Lipid-Mediated Interactions and Targeting
Daptomycin-Loaded Nanocarriers Facilitate Synergistic Killing of Methicillin-Resistant <i>Staphylococcus aureus</i> via Lipid-Mediated Interactions and Targeting Open
Preservation and augmentation of existing antimicrobials is crucial in combating antimicrobial resistance. Gram-positive bacteria, exemplified by Staphylococcus aureus, are among the most common human bacterial pathogens, with methicillin-…
View article: Advancement of technology towards developing perovskite-based solar cells for renewable energy harvesting and energy transformation applications
Advancement of technology towards developing perovskite-based solar cells for renewable energy harvesting and energy transformation applications Open
This review comprehensively examines the latest strategies for developing high-performance perovskite solar cells (PSCs) including lead-free PSCs, lead-based PSCs (covering power-conversion-efficiencies (PCEs) : >26%; Stability: >8 months;…
View article: Enhanced Antibacterial Properties of Lyotropic Liquid Crystalline Nanoparticles via Curvature Modulation
Enhanced Antibacterial Properties of Lyotropic Liquid Crystalline Nanoparticles via Curvature Modulation Open
Lyotropic liquid crystalline nanoparticles (LCNPs) have shown significant potential as nanocarriers for antibiotic delivery and as an alternative polytherapy strategy with antibiotics. Mechanistic studies indicate that these nanoparticles …
View article: Multimodal geometric learning for antimicrobial peptide identification by leveraging alphafold2-predicted structures and surface features
Multimodal geometric learning for antimicrobial peptide identification by leveraging alphafold2-predicted structures and surface features Open
Antimicrobial peptides (AMPs) are short peptides that play critical roles in diverse biological processes and exhibit functional activities against target organisms. While numerous methods have demonstrated the effectiveness of deep neural…
View article: Staphylococcal toxin PVL ruptures model membranes under acidic conditions through interactions with cardiolipin and phosphatidic acid
Staphylococcal toxin PVL ruptures model membranes under acidic conditions through interactions with cardiolipin and phosphatidic acid Open
Panton-Valentine leukocidin (PVL) is a pore-forming toxin secreted by Staphylococcus aureus strains that cause severe infections. Bicomponent PVL kills phagocytes depending on cell surface receptors, such as complement 5a receptor 1 (C5aR1…
View article: Cholic-Acid Derived, Guanidine-Functionalized Polymers as Broad-Spectrum Antimicrobial Agents
Cholic-Acid Derived, Guanidine-Functionalized Polymers as Broad-Spectrum Antimicrobial Agents Open
In this study, we report the design of a new guanylated, cholic-acid-based monomer (GM) to combat antimicrobial resistance. The microbial activity stems from the interfacial amphiphilicity of cholic acid, while guanidine shows a strong ass…
View article: Unlocking Interfacial Interactions of In Situ Grown Multidimensional Bismuth‐Based Perovskite Heterostructures for Photocatalytic Hydrogen Evolution
Unlocking Interfacial Interactions of In Situ Grown Multidimensional Bismuth‐Based Perovskite Heterostructures for Photocatalytic Hydrogen Evolution Open
To combat the energy crisis and environmental pollution, developing renewable energy technology such as hydrogen (H 2 ) production is necessary. The sulfur–iodine thermochemical cycle has high commercial potential in conducting hydrogen io…
View article: Enhanced Nitric Oxide Delivery Through Self‐Assembling Nanoparticles for Eradicating Gram‐Negative Bacteria
Enhanced Nitric Oxide Delivery Through Self‐Assembling Nanoparticles for Eradicating Gram‐Negative Bacteria Open
In the current battle against antibiotic resistance, the resilience of Gram‐negative bacteria against traditional antibiotics is due not only to their protective outer membranes but also to mechanisms like efflux pumps and enzymatic degrad…
View article: Deep learning approaches for non-coding genetic variant effect prediction: current progress and future prospects
Deep learning approaches for non-coding genetic variant effect prediction: current progress and future prospects Open
Recent advancements in high-throughput sequencing technologies have significantly enhanced our ability to unravel the intricacies of gene regulatory processes. A critical challenge in this endeavor is the identification of variant effects,…
View article: Cardiac-targeted delivery of a novel Drp1 inhibitor for acute cardioprotection
Cardiac-targeted delivery of a novel Drp1 inhibitor for acute cardioprotection Open
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View article: Scalable Fabrication Methods of Large‐Area (n‐<i>i</i>‐p) Perovskite Solar Panels
Scalable Fabrication Methods of Large‐Area (n‐<i>i</i>‐p) Perovskite Solar Panels Open
Organometal halide perovskite photovoltaic (PV) cells have achieved power conversion efficiencies (PCEs) comparable to the leading crystalline silicon (c‐Si) PV technology. However, despite their exceptional performance, these perovskite s…
View article: Dual recognition of multiple signals in bacterial outer membrane proteins enhances assembly and maintains membrane integrity
Dual recognition of multiple signals in bacterial outer membrane proteins enhances assembly and maintains membrane integrity Open
Outer membrane proteins (OMPs) are essential components of the outer membrane of Gram-negative bacteria. In terms of protein targeting and assembly, the current dogma holds that a ‘β-signal’ imprinted in the final β-strand of the OMP engag…
View article: Author Response: Dual recognition of multiple signals in bacterial outer membrane proteins enhances assembly and maintains membrane integrity
Author Response: Dual recognition of multiple signals in bacterial outer membrane proteins enhances assembly and maintains membrane integrity Open
Full text Figures and data Side by side Abstract eLife assessment Introduction Results Discussion Materials and methods Data availability References Peer review Author response Article and author information Abstract Outer membrane protein…
View article: Dual Recognition of Multiple Signals in Bacterial Outer Membrane Proteins Enhance Assembly and Maintain Membrane Integrity
Dual Recognition of Multiple Signals in Bacterial Outer Membrane Proteins Enhance Assembly and Maintain Membrane Integrity Open
Outer membrane proteins (OMPs) are essential components of the outer membrane of Gram-negative bacteria. In terms of protein targeting and assembly, the current dogma holds that a “β-signal” imprinted in the final β-strand of the OMP engag…
View article: Joint Public Review: Dual Recognition of Multiple Signals in Bacterial Outer Membrane Proteins Enhance Assembly and Maintain Membrane Integrity
Joint Public Review: Dual Recognition of Multiple Signals in Bacterial Outer Membrane Proteins Enhance Assembly and Maintain Membrane Integrity Open
Outer membrane proteins (OMPs) are essential components of the outer membrane of Gram-negative bacteria. In terms of protein targeting and assembly, the current dogma holds that a "β-signal" imprinted in the final β-strand of the OMP engag…
View article: Author Response: Dual Recognition of Multiple Signals in Bacterial Outer Membrane Proteins Enhance Assembly and Maintain Membrane Integrity
Author Response: Dual Recognition of Multiple Signals in Bacterial Outer Membrane Proteins Enhance Assembly and Maintain Membrane Integrity Open
Outer membrane proteins (OMPs) are essential components of the outer membrane of Gram-negative bacteria. In terms of protein targeting and assembly, the current dogma holds that a “β-signal” imprinted in the final β-strand of the OMP engag…
View article: Polysaccharide‐Targeting Lipid Nanoparticles to Kill Gram‐Negative Bacteria
Polysaccharide‐Targeting Lipid Nanoparticles to Kill Gram‐Negative Bacteria Open
The rapid increase and spread of Gram‐negative bacteria resistant to many or all existing treatments threaten a return to the preantibiotic era. The presence of bacterial polysaccharides that impede the penetration of many antimicrobials a…
View article: Reviewer #2 (Public Review): Simultaneous Recognition of Multiple Signals in Bacterial Outer Membrane Proteins Enhance Assembly and Maintain Membrane Integrity
Reviewer #2 (Public Review): Simultaneous Recognition of Multiple Signals in Bacterial Outer Membrane Proteins Enhance Assembly and Maintain Membrane Integrity Open
Outer membrane proteins (OMPs) are essential components of the outer membrane of Gram-negative bacteria. In terms of protein targeting and assembly, the current dogma holds that a "β-signal" imprinted in the final β-strand of the OMP engag…
View article: Simultaneous Recognition of Multiple Signals in Bacterial Outer Membrane Proteins Enhance Assembly and Maintain Membrane Integrity
Simultaneous Recognition of Multiple Signals in Bacterial Outer Membrane Proteins Enhance Assembly and Maintain Membrane Integrity Open
Outer membrane proteins (OMPs) are essential components of the outer membrane of Gram-negative bacteria. In terms of protein targeting and assembly, the current dogma holds that a “β-signal” imprinted in the final β-strand of the OMP engag…
View article: Reviewer #1 (Public Review): Simultaneous Recognition of Multiple Signals in Bacterial Outer Membrane Proteins Enhance Assembly and Maintain Membrane Integrity
Reviewer #1 (Public Review): Simultaneous Recognition of Multiple Signals in Bacterial Outer Membrane Proteins Enhance Assembly and Maintain Membrane Integrity Open
Outer membrane proteins (OMPs) are essential components of the outer membrane of Gram-negative bacteria. In terms of protein targeting and assembly, the current dogma holds that a “β-signal” imprinted in the final β-strand of the OMP engag…
View article: Dual recognition of multiple signals in bacterial outer membrane proteins enhances assembly and maintains membrane integrity
Dual recognition of multiple signals in bacterial outer membrane proteins enhances assembly and maintains membrane integrity Open
Outer membrane proteins (OMPs) are essential components of the outer membrane of Gram-negative bacteria. In terms of protein targeting and assembly, the current dogma holds that a ‘β-signal’ imprinted in the final β-strand of the OMP engag…
View article: One-Pot Synthesis of Ultra-Small Pt Nanoparticles-Loaded Nitrogen-Doped Mesoporous Carbon Nanotube for Efficient Catalytic Reaction
One-Pot Synthesis of Ultra-Small Pt Nanoparticles-Loaded Nitrogen-Doped Mesoporous Carbon Nanotube for Efficient Catalytic Reaction Open
In this study, Pt nanoparticles-loaded nitrogen-doped mesoporous carbon nanotube (Pt/NMCT) was successfully synthesized through a polydopamine-mediated “one-pot” co-deposition strategy. The Pt source was introduced during the co-deposition…
View article: iAMPCN: a deep-learning approach for identifying antimicrobial peptides and their functional activities
iAMPCN: a deep-learning approach for identifying antimicrobial peptides and their functional activities Open
Antimicrobial peptides (AMPs) are short peptides that play crucial roles in diverse biological processes and have various functional activities against target organisms. Due to the abuse of chemical antibiotics and microbial pathogens’ inc…
View article: An Ultrastable Self‐Assembled Antibacterial Nanospears Made of Protein
An Ultrastable Self‐Assembled Antibacterial Nanospears Made of Protein Open
Protein‐based nanomaterials have broad applications in the biomedical and bionanotechnological sectors owing to their outstanding properties such as high biocompatibility and biodegradability, structural stability, sophisticated functional…
View article: Recent Progress of 2D Layered Materials in Water-in-Salt/Deep Eutectic Solvent-Based Liquid Electrolytes for Supercapacitors
Recent Progress of 2D Layered Materials in Water-in-Salt/Deep Eutectic Solvent-Based Liquid Electrolytes for Supercapacitors Open
Supercapacitors are candidates with the greatest potential for use in sustainable energy resources. Extensive research is being carried out to improve the performances of state-of-art supercapacitors to meet our increased energy demands be…
View article: Urea-Based Deep Eutectic Solvent with Magnesium/Lithium Dual Ions as an Aqueous Electrolyte for High-Performance Battery-Supercapacitor Hybrid Devices
Urea-Based Deep Eutectic Solvent with Magnesium/Lithium Dual Ions as an Aqueous Electrolyte for High-Performance Battery-Supercapacitor Hybrid Devices Open
A new deep eutectic solvent (DES) made from urea, magnesium chloride, lithium perchlorate and water has been developed as the electrolyte for battery-supercapacitor hybrid devices. The physicochemical characteristics of DES electrolytes an…