Explanipedia

Acute kidney injury and outcomes in hospitalized children with autoimmune rheumatic disease Open

Chien‐Hung Lin, Wensheng Liu, Chuan Wan, Hsin‐Hui Wang · 2025

Predicting Learning Interest among Taiwanese Students in the Context of Big Science Issues Open

Brady Michael Jack, Chi‐Chen Chen, Hsin‐Hui Wang, Thomas J. Smith · 2024

Research shows that learning enjoyment in specific socio-scientific issues (SSI) plays an important role in predicting grade 10 students’ learning interest and learning enjoyment (i.e., genuine interest) in SSI subjects generally. However,…

Amelioration of the brain structural connectivity is accompanied with changes of gut microbiota in a tuberous sclerosis complex mouse model Open

Christine Chin‐jung Hsieh, Yu‐Chun Lo, Hsin‐Hui Wang, Hsin-Ying Shen, You‐Yin Chen , et al. · 2024

PPARγ activation ameliorates PM2.5-induced renal tubular injury by inhibiting ferroptosis and epithelial–mesenchymal transition Open

Chien‐Hung Lin, Wensheng Liu, Chuan Wan, Hsin‐Hui Wang · 2024

Exposure to fine particulate matter (PM2.5) has been associated with the development and progression of renal disease. Peroxisome proliferator-activated receptor gamma (PPARγ), a key transcription factor involved in inflammation as well as…

Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells Open

Yao-Jen Chang, Steven Lin, Zhifu Kang, Bin-Jon Shen, Wen-Hai Tsai , et al. · 2023

TRIM28/KAP1/TIF1β is a crucial epigenetic modifier. Genetic ablation of trim28 is embryonic lethal, although RNAi-mediated knockdown in somatic cells yields viable cells. Reduction in TRIM28 abundance at the cellular or organismal level re…

MEFV gene mutation spectrum in patients with familial mediterranean fever Open

Hsin‐Hui Wang · 2023

Familial Mediterranean fever (FMF) is an autosomal recessive, inherited inflammatory disease that is characterized by recurrent episodes of fever with abdominal, chest, or joint pain caused by inflammation of the serosa. FMF mainly affects…

KMT2D-related disorder with a restricted spectrum distinct from Kabuki syndrome: A rare case report describing male twins in Taiwan and a literature review Open

Jing-Er Chen, Yun‐Ru Chen, Hsin‐Hui Wang, Dau‐Ming Niu, Yen‐Fu Cheng , et al. · 2022

Kabuki syndrome is a rare congenital disorder typically characterized by facial dysmorphism, intellectual disability, developmental delay, and various congenital anomalies. Gene mutations that affect KMT2D are the main causes. Here, we rep…

Generation of TRIM28 Knockout K562 Cells by CRISPR/Cas9 Genome Editing and Characterization of TRIM28-Regulated Gene Expression in Cell Proliferation and Hemoglobin Beta Subunits Open

Yao-Jen Chang, Zhifu Kang, Jiayuan Bei, Shu‐Jen Chou, Mei‐Yeh Jade Lu , et al. · 2022

TRIM28 is a scaffold protein that interacts with DNA-binding proteins and recruits corepressor complexes to cause gene silencing. TRIM28 contributes to physiological functions such as cell growth and differentiation. In the chronic myeloid…

The role of structured inquiry, open inquiry, and epistemological beliefs in developing secondary students’ scientific and mathematical literacies Open

Hsin‐Hui Wang, Zuway‐R Hong, Hsiao‐Ching She, Thomas J. Smith, Jill Fielding-Wells , et al. · 2022

Clinical characteristics and treatment outcomes of SARS-CoV-2 delta variant outbreak, Pingtung, Taiwan, June 2021 Open

Tyng‐Yuan Jang, Hsin‐Hui Wang, Chung‐Feng Huang, Chia‐Yen Dai, Jee‐Fu Huang , et al. · 2022

We demonstrated the clinical characteristics of Delta-variant COVID-19 and treatment outcome of antiviral agents. The risk factors attributed to pneumonia were higher serum AST, ferritin, and LDH levels.

Pentraxin 3 Mediates Early Inflammatory Response and EMT Process in Human Tubule Epithelial Cells Induced by PM <sub>2.5</sub> Open

Chien Hung Lin, Wensheng Liu, Chuan Wan, Hsin‐Hui Wang · 2022

PM2.5 Induces Early Epithelial Mesenchymal Transition in Human Proximal Tubular Epithelial Cells through Activation of IL-6/STAT3 Pathway Open

Chien‐Hung Lin, Chuan Wan, Wensheng Liu, Hsin‐Hui Wang · 2021

Particulate matter exposure has been known as a potential risk for the global burden of disease, such as respiratory and cardiovascular diseases. Accumulating evidence suggests that PM2.5 (particulate matter with a diameter less than 2.5 μ…

The functional characterization of phosphorylation of tristetraprolin at C-terminal NOT1-binding domain Open

H. J. Hsieh, Yenan Chen, Yao-Jen Chang, Hsin‐Hui Wang, Yahan Yu , et al. · 2021

Background Tristetraprolin (TTP) family proteins contain conserved tandem CCCH zinc-finger binding to AU-rich elements and C-terminal NOT1-binding domain. TTP is phosphorylated extensively in cells, and its mRNA destabilization activity is…

New Era of Immunotherapy in Pediatric Brain Tumors: Chimeric Antigen Receptor T-Cell Therapy Open

Wan-Tai Wu, Wen‐Ying Lin, Yi‐Wei Chen, Chun‐Fu Lin, Hsin‐Hui Wang , et al. · 2021

Immunotherapy, including chimeric antigen receptor (CAR) T-cell therapy, immune checkpoint inhibitors, cancer vaccines, and dendritic cell therapy, has been incorporated as a fifth modality of modern cancer care, along with surgery, radiat…

A Comparison of the Effectiveness of Share Decision Making and Standard Education for Cardiac Catheterization: A Pilot Study Open

Hsiao-Hui Chiu, Hsiao-Jung Cheng, Hsin‐Hui Wang, Hsiao-Fen Hsu, Chih-Yi Lee , et al. · 2021

Background: Cardiovascular diseases are the second leading cause of death in the top ten leading causes of death in 2018 in Taiwan, and coronary artery disease is one of the main causes.Aim: To compare whether there are differences in pati…

Apical microsurgery of C-shaped maxillary first molar: A case report Open

Chih-Hsin Liu, Sung‐Chih Hsieh, Hsin‐Hui Wang · 2020

Gene Modified CAR-T Cellular Therapy for Hematologic Malignancies Open

Wen‐Ying Lin, Hsin‐Hui Wang, Yi‐Wei Chen, Chun‐Fu Lin, Hueng‐Chuen Fan , et al. · 2020

With advances in the understanding of characteristics of molecules, specific antigens on the surface of hematological malignant cells were identified and multiple therapies targeting these antigens as neoplasm treatments were developed. Am…

2,3,5,4′-tetrahydroxystilbene-2-O-b-D-glucoside triggers the pluripotent-like possibility of dental pulp stem cells by activating the JAK2/STAT3 axis: Preliminary observations Open

Yen-Wen Huang, Chi-Yu Lin, Yu‐Tang Chin, Po‐Jan Kuo, Yen‐Wen Wu , et al. · 2020

Mutation of TRIM28-Lys304 to Gln Attenuates its Interaction with KRAB-ZNFs and Promotes Differentiation of Erythroleukemic K562 Cells Open

Y. L. Chang, Steven Lin, Zhifu Kang, Bin-Jon Shen, Wen-Hai Tsai , et al. · 2020

BackgroundTRIM28/KAP1/TIF1β is a key epigenetic modifier. Genetic ablation of trim28 is embryonic lethal although RNAi-mediated knockdown in somatic cells yields viable cells. Reduction in TRIM28 abundance at the cellular or organismal lev…

TRIM28 Regulates Dlk1 Expression in Adipogenesis Open

Hsin-Pin Lu, Chieh-Ju Lin, Wen‐Ching Chen, Yao-Jen Chang, Sheng‐Wei Lin , et al. · 2020

The tripartite motif-containing protein 28 (TRIM28) is a transcription corepressor, interacting with histone deacetylase and methyltransferase complexes. TRIM28 is a crucial regulator in development and differentiation. We would like to in…

The Functional Characterization of Phosphorylation of Tristetraprolin at C-Terminal NOT1-binding Domain Open

Hsin-Hui Hsieh, Yenan Chen, Yao‐Jen Chang, Hsin‐Hui Wang, Yahan Yu , et al. · 2020

Backgound : Tristetraprolin (TTP) family proteins contain conserved tandem CCCH zinc-finger binding to AU-rich elements and C-terminal NOT1-binding domain. TTP is phosphorylated extensively in cells and its mRNA destabilization activity is…

Involvement of MicroRNA-296 in the Inhibitory Effect of Epigallocatechin Gallate against the Migratory Properties of Anoikis-Resistant Nasopharyngeal Carcinoma Cells Open

Chien-Hung Lin, Hsin‐Hui Wang, Tsung‐Hsien Chen, Tony F. Chan, Peir‐Haur Hung , et al. · 2020

Short noncoding endogenous RNAs, including microRNAs (miRNAs), are associated with the development and metastasis of multiple cancers. Epigallocatechin gallate (EGCG), the most active and abundant polyphenol in green tea, plays a crucial r…

Thermal behavior and viscoelastic properties of gutta-percha used for back-filling the root canal Open

Yung-Hao Hsu, Hsin‐Hui Wang, Yung‐Kang Shen, James L. Gutmann, Sung‐Chih Hsieh · 2019

The soft type gutta-percha underwent significant crystallization during cooling, and therefore exhibited pronounced volume shrinkage. Furthermore, the soft type gutta-percha underwent a greater rate of change in viscoelasticity under cooli…

Wasted Ganoderma tsugae Derived Chitosans for Smear Layer Removal in Endodontic Treatment Open

Sheng‐Tung Huang, Nai‐Chia Teng, Hsin‐Hui Wang, Sung‐Chih Hsieh, Jen‐Chang Yang · 2019

The objective of this study is to investigate the synergistic effects of acid etching and metal-ion chelation in dental smear layer removal using wasted Ganoderma tsugae derived chitosans. The wasted Ganoderma tsugae fruiting body was used…

Microbiology of peritoneal dialysis-related infection and factors of refractory peritoneal dialysis related peritonitis: A ten-year single-center study in Taiwan Open

Hsin‐Hui Wang, Chung‐Hao Huang, Mei‐Chuan Kuo, Shang‐Yi Lin, Chin-Huei Hsu , et al. · 2019

Gram-positive organisms remained major cause of PD-related peritonitis. About three quarters of causative pathogens were susceptible to the recommended empirical treatment for PD-related peritonitis. Baseline hyponatremia (<130 mmol/L) was…

臺灣公民科技素養、科學興趣及科學參與之探討 Exploring Taiwan Citizens’ Scientific Literacy, Interest in, and Engagement in Learning Science Open

Hsin‐Hui Wang, 林煥祥 Huann-Shyang Lin, 洪瑞兒 Zuway-R Hong · 2018

本研究目的在探討臺灣公民科技素養、科學興趣和科學參與之交互作用，並以分層隨機抽樣選取年滿18～70 歲公民共計1,831 人為研究樣本，填答信度與效度良好之公民科技素養試題。為瞭解臺灣民眾科技素養及科學興趣狀況，首先以極端組群法將公民的科技素養及科學興趣依據分數高低區分為四類組：「高科技素養、高科學興趣組」、「高科技素養、低科學興趣組」、「低科技素養、高科學興趣組」及「低科技素養、低科學興趣組」。再以百分比同質性檢定比較不同性別、年齡層及學歷在這四組的分布差異，發現「高科技…

Mortality Risks among Various Primary Renal Diseases in Children and Adolescents on Chronic Dialysis Open

Hsin‐Hsu Chou, Yuan‐Yow Chiou, Yee‐Hsuan Chiou, You‐Lin Tain, Hsin‐Hui Wang , et al. · 2018

There is little information available on the association between primary renal disease (PRD) and long-term mortality in the pediatric dialysis population. The objective of this study was to explore mortality risks in children and adolescen…

The Impact of Socio-scientific Issue Discussions on Student Environmentalism Open

Huann‐shyang Lin, Hsin‐Hui Wang, Zuway‐R Hong, Shu‐Chiu Liu · 2018

A one group pretest-posttest design of study was used to investigate the impact of Socio-Scientific Issue (SSI) discussion on college students’ awareness of and self-efficacy toward environmental issues, responsibility for sustainable deve…

Smear layer and debris removal from dentinal tubules using different irrigation protocols: scanning electron microscopic evaluation, an in vitro study Open

Hsin‐Hui Wang, Daniel Sanabria-Liviac, Philippe Sleiman, Samuel O. Dorn, David E. Jaramillo · 2017

Background This study investigated the ability of different irrigation protocols to keep dentinal tubules (DT) open and avoid their blockage by the smear layer (SL) during the cleaning and shaping procedure (CSP). Methods Twenty-five extra…

Etiology and pediatric chronic kidney disease progression: Taiwan Pediatric Renal Collaborative Study Open

Yuan‐Yow Chiou, Ching-Yuang Lin, Mei-Ju Chen, Yee-Hsuan Chiou, Yi-Fan Wang , et al. · 2015

CKD etiology affects disease progression. Careful monitoring and treatment of anemia and elevated blood pressure in children with CKD may slow disease progression.

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