Hsu‐Lei Lee
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View article: Multiparametric Dynamic Contrast Imaging for Voxelwise Quantitative Assessment of Brain Tumors
Multiparametric Dynamic Contrast Imaging for Voxelwise Quantitative Assessment of Brain Tumors Open
A multiparametric dynamic contrast imaging technique was developed to simultaneously quantify brain tissue perfusion, microvasculature permeability, transmembrane water efflux, and susceptibility with a single scan and a single-dose contra…
View article: Retrospectively Quantified T2 Improves Detection of Clinically Significant Peripheral Zone Prostate Cancer
Retrospectively Quantified T2 Improves Detection of Clinically Significant Peripheral Zone Prostate Cancer Open
Background: Multiparametric MRI (mpMRI) as a non-invasive imaging tool is important in prostate cancer (PCa) detection and localization. Combined with radiomics analysis, features extracted from mpMRI have been utilized to predict PCa aggr…
View article: Generalizable, sequence‐invariant deep learning image reconstruction for subspace‐constrained quantitative <scp>MRI</scp>
Generalizable, sequence‐invariant deep learning image reconstruction for subspace‐constrained quantitative <span>MRI</span> Open
Purpose To develop a deep subspace learning network that can function across different pulse sequences. Methods A contrast‐invariant component‐by‐component (CBC) network structure was developed and compared against previously reported spat…
View article: Accelerated <scp>CEST</scp> imaging through deep learning quantification from reduced frequency offsets
Accelerated <span>CEST</span> imaging through deep learning quantification from reduced frequency offsets Open
Purpose To shorten CEST acquisition time by leveraging Z‐spectrum undersampling combined with deep learning for CEST map construction from undersampled Z‐spectra. Methods Fisher information gain analysis identified optimal frequency offset…
View article: Ferumoxytol‐Enhanced <scp>5D</scp> Multiphase Steady‐State Imaging Using Rotating Cartesian K‐Space With Low‐Rank Reconstruction for Pediatric Congenital Heart Disease
Ferumoxytol‐Enhanced <span>5D</span> Multiphase Steady‐State Imaging Using Rotating Cartesian K‐Space With Low‐Rank Reconstruction for Pediatric Congenital Heart Disease Open
Background The rotating Cartesian k‐space multiphase steady‐state imaging with contrast (ROCK‐MUSIC) pulse sequence enables acquisition of whole‐heart, cardiac phase‐resolved images in pediatric congenital heart disease (CHD) without relia…
View article: Coronary Plaque Characterization with T1-weighted MRI and Near-Infrared Spectroscopy to Predict Periprocedural Myocardial Injury.
Coronary Plaque Characterization with T1-weighted MRI and Near-Infrared Spectroscopy to Predict Periprocedural Myocardial Injury. Open
Purpose To clarify the predominant causative plaque constituent for periprocedural myocardial injury (PMI) following percutaneous coronary intervention: (a) erythrocyte-derived materials, indicated by a high plaque-to-myocardium signal int…
View article: Motion-compensated T1 mapping in cardiovascular magnetic resonance imaging: a technical review
Motion-compensated T1 mapping in cardiovascular magnetic resonance imaging: a technical review Open
mapping is becoming a staple magnetic resonance imaging method for diagnosing myocardial diseases such as ischemic cardiomyopathy, hypertrophic cardiomyopathy, myocarditis, and more. Clinically, most mapping sequences acquire a single sl…
View article: Free‐breathing 3D CEST MRI of human liver at 3.0 T
Free‐breathing 3D CEST MRI of human liver at 3.0 T Open
Purpose To develop a novel 3D abdominal CEST MRI technique at 3 T using MR multitasking, which enables entire‐liver coverage with free‐breathing acquisition. Methods k‐Space data were continuously acquired with repetitive steady‐state CEST…
View article: Free‐breathing, non‐<scp>ECG</scp>, simultaneous myocardial <scp>T<sub>1</sub></scp>, <scp>T<sub>2</sub></scp>, <scp>T<sub>2</sub></scp>*, and fat‐fraction mapping with motion‐resolved cardiovascular MR multitasking
Free‐breathing, non‐<span>ECG</span>, simultaneous myocardial <span>T<sub>1</sub></span>, <span>T<sub>2</sub></span>, <span>T<sub>2</sub></span>*, and fat‐fraction mapping with motion‐resolved cardiovascular MR multitasking Open
Purpose To develop a free‐breathing, non‐electrocardiogram technique for simultaneous myocardial T 1 , T 2 , T 2 *, and fat‐fraction (FF) mapping in a single scan. Methods The MR Multitasking framework is adapted to quantify T 1 , T 2 , T …
View article: Locating causal hubs of memory consolidation in spontaneous brain network
Locating causal hubs of memory consolidation in spontaneous brain network Open
SUMMARY Memory consolidation after learning involves spontaneous, brain-wide network reorganization during rest and sleep, but how this is achieved is still poorly understood. Current theory suggests that the hippocampus is pivotal for res…
View article: Simultaneous Multi-Slice Cardiac MR Multitasking for Motion-Resolved, Non-ECG, Free-Breathing T1–T2 Mapping
Simultaneous Multi-Slice Cardiac MR Multitasking for Motion-Resolved, Non-ECG, Free-Breathing T1–T2 Mapping Open
The aim of this study is to simultaneously quantify T1/T2 across three slices of the left-ventricular myocardium without breath-holds or ECG monitoring, all within a 3 min scan. Radial simultaneous multi-slice (SMS) encoding, self-gating, …
View article: Whole‐brain steady‐state CEST at 3 T using MR Multitasking
Whole‐brain steady‐state CEST at 3 T using MR Multitasking Open
Purpose To perform fast 3D steady‐state CEST (ss‐CEST) imaging using MR Multitasking. Methods A continuous acquisition sequence with repetitive ss‐CEST modules was developed. Each ss‐CEST module contains a single‐lobe Gaussian saturation p…
View article: Remodeling of Sensorimotor Brain Connectivity in <i>Gpr88</i> -Deficient Mice
Remodeling of Sensorimotor Brain Connectivity in <i>Gpr88</i> -Deficient Mice Open
Recent studies have demonstrated that orchestrated gene activity and expression support synchronous activity of brain networks. However, there is a paucity of information on the consequences of single gene function on overall brain functio…
View article: Enhanced subject-specific resting-state network detection and extraction with fast fMRI
Enhanced subject-specific resting-state network detection and extraction with fast fMRI Open
Resting‐state networks have become an important tool for the study of brain function. An ultra‐fast imaging technique that allows to measure brain function, called Magnetic Resonance Encephalography (MREG), achieves an order of magnitude h…
View article: Deletion of the mu opioid receptor gene in mice reshapes the reward–aversion connectome
Deletion of the mu opioid receptor gene in mice reshapes the reward–aversion connectome Open
Significance Mice manipulated by targeted deletion of a specific brain gene show diverse pathological phenotypes, apparent, for example, in behavioral experiments. To explain observed findings, connectome genetics attempts to uncover how b…