Xiao Hu
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View article: NSUNs-driven dysregulation: the next frontier in targeted cancer therapy?
NSUNs-driven dysregulation: the next frontier in targeted cancer therapy? Open
Epitranscriptomic modifications represent a fundamental regulatory layer in cancer biology, with RNA methylation emerging as a pivotal mechanism governing transcriptomic dynamics. Among these, 5-methylcytosine (m 5 C) RNA methylation—a ubi…
View article: Discovery of a β-arrestin-biased CCKBR agonist that blocks CCKBR-dependent long-term potentiation
Discovery of a β-arrestin-biased CCKBR agonist that blocks CCKBR-dependent long-term potentiation Open
The CCKBR agonists induce neocortical long-term potentiation of excitatory synaptic transmission and enhance memory formation, while its antagonists weaken the potentiation in the amygdala and alleviate depression-like behaviors. However, …
View article: Mechanisms and toxicity of plasma-induced antibiotic degradation: advances in synergistic strategies and computational evaluation
Mechanisms and toxicity of plasma-induced antibiotic degradation: advances in synergistic strategies and computational evaluation Open
The widespread use of antibiotics has raised environmental and health concerns, leading to the adoption of plasma technology for antibiotic degradation. This review, based on Google Scholar and Connected Papers, covers recent methods, incl…
View article: Novel MAFG-METTL14-SCD1 axis regulates lipid metabolism mediating choroidal melanoma distant metastasis
Novel MAFG-METTL14-SCD1 axis regulates lipid metabolism mediating choroidal melanoma distant metastasis Open
Background Tumor invasion and metastasis are strongly influenced by cell membrane fluidity, regulated by lipid metabolism. In choroidal melanoma (CM), a highly metastatic cancer, the relationship between lipid metabolism, membrane fluidity…
View article: Flexibility Incentive Market Mechanism for Combined Frequency Regulation and Electricity Markets for the Power System with Distributed Energy Resources Aggregators via Modified Leiden Algorithm
Flexibility Incentive Market Mechanism for Combined Frequency Regulation and Electricity Markets for the Power System with Distributed Energy Resources Aggregators via Modified Leiden Algorithm Open
Distributed energy resources provide local power as a supplement on the customer side. Recent rapid development of the distributed energy source enhances the clear energy production at the terminal of the power system. Whereas the small ca…
View article: Multilevel Barriers to Perianal Condyloma Care Among Men Who Have Sex With Men in Northeast China
Multilevel Barriers to Perianal Condyloma Care Among Men Who Have Sex With Men in Northeast China Open
Importance Men who have sex with men (MSM) with perianal condyloma face compounded health care challenges within structural inequities. Current research poorly characterizes their medical experiences, including barriers to care, psychosoci…
View article: 6 kW near single-mode monolithic fiber laser oscillator based on a core NA design of confined ytterbium-doped fiber
6 kW near single-mode monolithic fiber laser oscillator based on a core NA design of confined ytterbium-doped fiber Open
In this article, we presented an investigation on the combination of the low-NA and confined doped design in Yb-doped fiber for gain filtering in the fiber laser oscillator. Theoretical simulations showed that for a ytterbium-doped fiber w…
View article: Ambient blade-coated perovskite solar cells with high reverse bias stability enabled by polymeric hole transporter design
Ambient blade-coated perovskite solar cells with high reverse bias stability enabled by polymeric hole transporter design Open
Reverse bias stability remains a critical challenge for inverted perovskite solar cells (PSCs). While self-assembled monolayers (SAMs) boost efficiency, their low breakdown voltages limit device reliability. Thick PTAA layer improves break…
View article: Short-term risks of influenza and COVID-19 following influenza infection: A self-controlled case series study
Short-term risks of influenza and COVID-19 following influenza infection: A self-controlled case series study Open
Influenza infection may temporarily increase susceptibility to COVID-19 while reducing the risk of influenza reinfection. These findings highlight the importance of targeted surveillance and preventive strategies during influenza peaks to …
View article: A Nested DUAL-axis Accelerometer with Enhanced Temperature Robustness for Testing Across the Entire Operational Temperature Range
A Nested DUAL-axis Accelerometer with Enhanced Temperature Robustness for Testing Across the Entire Operational Temperature Range Open
This paper investigates a nested biaxial micro-electro-mechanical systems (MEMS) accelerometer with low coupling error, derives the kinetic model equations of the accelerometer, and performs finite element simulations of the operating mode…
View article: Effects of Functional Foods and Dietary Bioactives on Human Health
Effects of Functional Foods and Dietary Bioactives on Human Health Open
Functional foods and dietary bioactives are moving from discovery to translation because we can now engineer structure and exposure together—the two levers that largely determine real-world efficacy [...]
View article: A Hybrid G-Quadruplex Structure Formed by a Sequence from the MAX Gene
A Hybrid G-Quadruplex Structure Formed by a Sequence from the MAX Gene Open
Here, we report the NMR solution structure of the G-quadruplex (G4) folded by the 24-nt guanine-rich DNA sequence d-[AG3AG4A2G4TGA2G4A]. The sequence is originated from the first intron of the MAX gene, which encodes the transcription fact…
View article: An induced pluripotent stem cell-based chemical genetic approach for studying spinal muscular atrophy
An induced pluripotent stem cell-based chemical genetic approach for studying spinal muscular atrophy Open
Spinal muscular atrophy (SMA) is a genetic disease characterized by degeneration of spinal cord motor neurons and neuromuscular junctions. Despite recent development in therapies for SMA, treatment efficacy largely relies on administration…
View article: A novel long-acting C5a-blocking cyclic peptide prevents sepsis-induced organ dysfunction via effective blockade of the inflammatory cascade
A novel long-acting C5a-blocking cyclic peptide prevents sepsis-induced organ dysfunction via effective blockade of the inflammatory cascade Open
Sepsis is a life-threatening syndrome characterized by dysregulated host responses to infection, leading to severe organ dysfunction and a high mortality rate. Reducing the incidence of sepsis is of paramount importance. Given that sepsis-…
View article: Temporal Evolution and Numerical Simulation of Water-Sensitive Reservoirs During Long-Term Waterflooding: A Case Study of the North 31 Wutonggou Formation
Temporal Evolution and Numerical Simulation of Water-Sensitive Reservoirs During Long-Term Waterflooding: A Case Study of the North 31 Wutonggou Formation Open
This study addresses the challenges of uneven recovery in strongly water-sensitive reservoirs through the development of a time-dependent two-phase flow model capturing the dynamic evolution of permeability and relative permeability. Based…
View article: Aortobronchial Fistula: A Case Report and Literature Review
Aortobronchial Fistula: A Case Report and Literature Review Open
This report details the urgent management of a life‐threatening aortobronchial fistula (ABF) in a 61‐year‐old male with a history of esophageal cancer surgery, who presented with massive hemoptysis, underscoring the critical role of rapid …
View article: Postoperative kinesiophobia in elderly patients with femoral neck fractures: a prospective study of psychological and social determinants
Postoperative kinesiophobia in elderly patients with femoral neck fractures: a prospective study of psychological and social determinants Open
Objectives This study examined the psychosocial correlates of postoperative kinesiophobia in elderly patients with femoral neck fractures, with a focus on the roles of psychological resilience and social support in mitigating movement-rela…
View article: Cultural Sustainability Through Heritage-Led Underground Development: The Case Study
Cultural Sustainability Through Heritage-Led Underground Development: The Case Study Open
The integration of cultural heritage into sustainable urban development has garnered increasing attention, with a growing recognition of its role in fostering resilient, inclusive, and identity-rich cities. While surface-level monuments of…
View article: Cellular angiofibroma of the inguinal scrotal region: A rare case report
Cellular angiofibroma of the inguinal scrotal region: A rare case report Open
Rationale: Cellular angiofibroma (CAF) is a rare benign mesenchymal tumor, which is difficult to diagnose due to its lack of specificity in clinical and imaging manifestations. This case highlights the challenges in the preoperative diagno…
View article: Blood pressure levels and risk of intracerebral hemorrhage in the general population: evidence from a large prospective cohort study
Blood pressure levels and risk of intracerebral hemorrhage in the general population: evidence from a large prospective cohort study Open
In this large cohort of adults without baseline stroke and coronary heart disease, moderately lower BP levels were associated with reduced risk of incident ICH. These findings may help refine our understanding of BP thresholds relevant to …