Zhenlin Hu
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View article: Petroselinum sativum (Parsley) extract suppresses oxidative stress and inflammatory responses in human keratinocytes and reduces atopic dermatitis symptoms in mouse skin
Petroselinum sativum (Parsley) extract suppresses oxidative stress and inflammatory responses in human keratinocytes and reduces atopic dermatitis symptoms in mouse skin Open
Petroselinum crispum (Mill.) Fuss (parsley), a traditional botanical drug used for treating skin conditions including atopic dermatitis (AD), has unclear effects on epidermal keratinocytes. This study investigated the antioxidant and anti-…
View article: Research Progress on Aging Detection of Composite Insulators Based on Spectroscopy
Research Progress on Aging Detection of Composite Insulators Based on Spectroscopy Open
The safety of composite insulators in high-voltage transmission lines is directly related to the stable operation of the power system, which is a fundamental condition for the normal functioning of people’s lives and industrial production.…
View article: Rapid High-Accuracy Quantitative Analysis of Water Hardness by Combination of One-Point Calibration Laser-Induced Breakdown Spectroscopy and Aerosolization
Rapid High-Accuracy Quantitative Analysis of Water Hardness by Combination of One-Point Calibration Laser-Induced Breakdown Spectroscopy and Aerosolization Open
Water quality should be tested to ensure it is acceptable for the healthy growth of plants and animals, and water hardness is one of the important testing indexes. Herein, a novel approach was proposed to achieve high accuracy and rapid qu…
View article: A Systematic Review of Nanoparticle-Mediated Ferroptosis in Glioma Therapy
A Systematic Review of Nanoparticle-Mediated Ferroptosis in Glioma Therapy Open
Glioma, a highly malignant central nervous system tumor, exhibits aggressive invasiveness, extensive infiltration, and poor prognosis. Conventional treatments such as surgery, radiotherapy, and chemotherapy are hindered by limitations incl…
View article: Nerol enhances lipid synthesis in human sebocytes via cannabinoid receptor-2-mediated MAPK signaling
Nerol enhances lipid synthesis in human sebocytes via cannabinoid receptor-2-mediated MAPK signaling Open
Collectively, our findings show that nerol exerts a lipogenic effect on human sebocytes in a CB2-dependent manner through the activation of MAPK pathway, suggesting the therapeutic potential of this monoterpene in controlling cutaneous dis…
View article: α-ionone promotes keratinocyte functions and accelerates epidermal barrier recovery
α-ionone promotes keratinocyte functions and accelerates epidermal barrier recovery Open
These results demonstrated the role of α-ionone in the improvement of keratinocyte functions and the epidermal barrier recovery. These findings suggest possible therapeutic application of α-ionone in the treatment of skin barrier disruptio…
View article: Role of Omega-Hydroxy Ceramides in Epidermis: Biosynthesis, Barrier Integrity and Analyzing Method
Role of Omega-Hydroxy Ceramides in Epidermis: Biosynthesis, Barrier Integrity and Analyzing Method Open
Attached to the outer surface of the corneocyte lipid envelope (CLE), omega-hydroxy ceramides (ω-OH-Cer) link to involucrin and function as lipid components of the stratum corneum (SC). The integrity of the skin barrier is highly dependent…
View article: Protective effect of Saussurea involucrata polysaccharide against skin dryness induced by ultraviolet radiation
Protective effect of Saussurea involucrata polysaccharide against skin dryness induced by ultraviolet radiation Open
Background: Exposure to ultraviolet B (UVB) radiation can damage the epidermis barrier function and eventually result in skin dryness. At present, little work is being devoted to skin dryness. Searching for active ingredients that can prot…
View article: Time-Resolved Laser-Induced Breakdown Spectroscopy for Accurate Qualitative and Quantitative Analysis of Brown Rice Flour Adulteration
Time-Resolved Laser-Induced Breakdown Spectroscopy for Accurate Qualitative and Quantitative Analysis of Brown Rice Flour Adulteration Open
To solve the adulteration problem of brown rice flour in the commodity market, a novel, accurate, and stable detection method based on time-resolved laser-induced breakdown spectroscopy (TR-LIBS) is proposed. Qualitative and quantitative a…
View article: Cryptotanshinone protects skin cells from ultraviolet radiation-induced photoaging via its antioxidant effect and by reducing mitochondrial dysfunction and inhibiting apoptosis
Cryptotanshinone protects skin cells from ultraviolet radiation-induced photoaging via its antioxidant effect and by reducing mitochondrial dysfunction and inhibiting apoptosis Open
The integrity of skin tissue structure and function plays an important role in maintaining skin rejuvenation. Ultraviolet (UV) radiation is the main environmental factor that causes skin aging through photodamage of the skin tissue. Crypto…
View article: Cucurbitacin promotes hair growth in mice by inhibiting the expression of fibroblast growth factor 18
Cucurbitacin promotes hair growth in mice by inhibiting the expression of fibroblast growth factor 18 Open
Cucurbitacin significantly reduced the levels of FGF18 mRNA and protein in the dorsal skin of mice to accelerate the HFs to enter the anagen phase earlier, thereby promoting the regeneration of hair. Thus, cucurbitacin can be considered a …
View article: Identification of different colored plastics by laser-induced breakdown spectroscopy combined with neighborhood component analysis and support vector machine
Identification of different colored plastics by laser-induced breakdown spectroscopy combined with neighborhood component analysis and support vector machine Open
Plastic recycling is an effective strategy to solve the shortage of national resources and improve the ecological environment. Herein, a novel approach was proposed to identify different colored plastics using laser-induced breakdown spect…
View article: Suppression of FGF5 and FGF18 Expression by Cholesterol-Modified siRNAs Promotes Hair Growth in Mice
Suppression of FGF5 and FGF18 Expression by Cholesterol-Modified siRNAs Promotes Hair Growth in Mice Open
FGF5 and FGF18 are key factors in the regulation of the hair follicle cycle. FGF5 is overexpressed during the late anagen phase and serves as a crucial regulatory factor that promotes the anagen-to-catagen transition in the hair follicle c…
View article: Keratinocyte Growth Factor 2 Ameliorates UVB-Induced Skin Damage via Activating the AhR/Nrf2 Signaling Pathway
Keratinocyte Growth Factor 2 Ameliorates UVB-Induced Skin Damage via Activating the AhR/Nrf2 Signaling Pathway Open
Objective: Exposure to ultraviolet B (UVB) can cause skin damage through oxidative stress, DNA damage, and apoptosis. Keratinocyte growth factor (KGF) has been shown to reduce the content of intracellular reactive oxygen species (ROS) foll…
View article: Carnosine Stimulates Macrophage-Mediated Clearance of Senescent Skin Cells Through Activation of the AKT2 Signaling Pathway by CD36 and RAGE
Carnosine Stimulates Macrophage-Mediated Clearance of Senescent Skin Cells Through Activation of the AKT2 Signaling Pathway by CD36 and RAGE Open
Background: Macrophages can selectively recognize and eliminate senescent cells, but this function is impaired with age, resulting in excessive accumulation of senescent cells in the skin, which ultimately causes skin aging. Therefore, enh…
View article: Simultaneous Compositional and Grain Size Measurements Using Laser Opto-Ultrasonic Dual Detection for Additive Manufacturing
Simultaneous Compositional and Grain Size Measurements Using Laser Opto-Ultrasonic Dual Detection for Additive Manufacturing Open
Metal-based additive manufacturing (AM) is a disruptive technique with great potential across multiple industries; however, its manufacturing quality is unstable, leading to an urgent requirement for component properties detection. The dis…
View article: Cytoprotective Effects Evaluation of a Novel Danshensu Derivative DEX-018 against Oxidative Stress Injury in HUVECs
Cytoprotective Effects Evaluation of a Novel Danshensu Derivative DEX-018 against Oxidative Stress Injury in HUVECs Open
Ischemic heart disease (IHD) is one of the most common cardiovascular diseases with high morbidity and mortality. Danshensu (DSS) is widely used in the treatment of coronary heart disease. In this study, the carboxy group of DSS was esteri…
View article: Fucoidan from Undaria pinnatifida Ameliorates Epidermal Barrier Disruption via Keratinocyte Differentiation and CaSR Level Regulation
Fucoidan from Undaria pinnatifida Ameliorates Epidermal Barrier Disruption via Keratinocyte Differentiation and CaSR Level Regulation Open
The epidermal barrier acts as a line of defense against external agents as well as helps to maintain body homeostasis. The calcium concentration gradient across the epidermal barrier is closely related to the proliferation and differentiat…
View article: Determination of trace heavy metal elements in aqueous solution using surface-enhanced laser-induced breakdown spectroscopy
Determination of trace heavy metal elements in aqueous solution using surface-enhanced laser-induced breakdown spectroscopy Open
Heavy metal pollution is one of the main problems in water pollution, which is harmful to humans. Surface-enhanced laser-induced breakdown spectroscopy (SENLIBS) has been applied to detect trace amounts of heavy metal elements in aqueous s…
View article: Investigation of the self-absorption effect using time-resolved laser-induced breakdown spectroscopy
Investigation of the self-absorption effect using time-resolved laser-induced breakdown spectroscopy Open
Self-absorption seriously affects the accuracy and stability of quantitative analysis in laser-induced breakdown spectroscopy (LIBS). To reduce the effect of self-absorption, we investigated the temporal evolution of the self-absorption ef…
View article: OP07.10: Placenta reperfusion in monochorionic twin pregnant cases with intrauterine demise of one fetus
OP07.10: Placenta reperfusion in monochorionic twin pregnant cases with intrauterine demise of one fetus Open
To illuminate the monochorionic twin placental perfusion changes after intrauterine demise of one fetus and its mechanism. Monochorionic (MC) twin cases with spontaneous and post-laser fetal demise or fetal reduction by radiofrequency abla…
View article: Schisandrin B protects human keratinocyte-derived HaCaT�cells from tert-butyl hydroperoxide-induced oxidative damage through activating the Nrf2 signaling pathway
Schisandrin B protects human keratinocyte-derived HaCaT�cells from tert-butyl hydroperoxide-induced oxidative damage through activating the Nrf2 signaling pathway Open
Schisandrin B (Sch B), an active extract of Schisandra chinensis, has demonstrated antioxidant activity in a number of in vitro and in vivo models. In the present study, the capacity of Sch B to protect against oxidative injury in keratino…
View article: Discovery of Potent Small-Molecule Inhibitors of Ubiquitin-Conjugating Enzyme UbcH5c from α-Santonin Derivatives
Discovery of Potent Small-Molecule Inhibitors of Ubiquitin-Conjugating Enzyme UbcH5c from α-Santonin Derivatives Open
As a therapeutic target for antitumor necrosis factor (TNF)-α interventions, UbcH5c is one of the key ubiquitin-conjugating enzymes catalyzing ubiquitination during TNF-α-triggered nuclear factor kappa B (NF-κB) activation. In the present …
View article: Correction: Corrigendum: Screening of an anti-inflammatory peptide from Hydrophis cyanocinctus and analysis of its activities and mechanism in DSS-induced acute colitis
Correction: Corrigendum: Screening of an anti-inflammatory peptide from Hydrophis cyanocinctus and analysis of its activities and mechanism in DSS-induced acute colitis Open
Scientific Reports 6: Article number: 25672; published online: 09 May 2016; updated: 25 August 2016 This Article contains errors. In the Results section under subheading ‘H. cyanocinctus venom gland T7 phage display library construction an…
View article: MASM, a Matrine Derivative, Offers Radioprotection by Modulating Lethal Total-Body Irradiation-Induced Multiple Signaling Pathways in Wistar Rats
MASM, a Matrine Derivative, Offers Radioprotection by Modulating Lethal Total-Body Irradiation-Induced Multiple Signaling Pathways in Wistar Rats Open
Matrine is an alkaloid extracted from Sophora flavescens Ait and has many biological activities, such as anti-inflammatory, antitumor, anti-fibrosis, and immunosuppressive properties. In our previous studies, the matrine derivative MASM wa…
View article: Screening of an anti-inflammatory peptide from Hydrophis cyanocinctus and analysis of its activities and mechanism in DSS-induced acute colitis
Screening of an anti-inflammatory peptide from Hydrophis cyanocinctus and analysis of its activities and mechanism in DSS-induced acute colitis Open
Snake has been used for centuries as a traditional Chinese medicine, especially for therapeutic treatment for inflammatory diseases; however, its mechanisms of action and active constituents remain controversial. In our study, a tumor necr…
View article: The Mixture of Salvianolic Acids from Salvia miltiorrhiza and Total Flavonoids from Anemarrhena asphodeloides Attenuate Sulfur Mustard-Induced Injury
The Mixture of Salvianolic Acids from Salvia miltiorrhiza and Total Flavonoids from Anemarrhena asphodeloides Attenuate Sulfur Mustard-Induced Injury Open
Sulfur mustard (SM) is a vesicating chemical warfare agent used in numerous military conflicts and remains a potential chemical threat to the present day. Exposure to SM causes the depletion of cellular antioxidant thiols, mainly glutathio…