Huafu Chen
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View article: Mother-child dyadic interactions shape the developing social brain and Theory of Mind in young children
Mother-child dyadic interactions shape the developing social brain and Theory of Mind in young children Open
Social cognition develops through a complex interplay between neural maturation and environmental factors, yet the neurobehavioral mechanisms underlying this process remain unclear. Using a naturalistic fMRI paradigm, we investigated the e…
View article: Choroid plexus enlargement correlated with motor dysfunction in spinocerebellar ataxia type 3
Choroid plexus enlargement correlated with motor dysfunction in spinocerebellar ataxia type 3 Open
gov], identifier [ChiCTR1800019901].
View article: Individualized structural network deviations predict surgical outcome in mesial temporal lobe epilepsy: a multicenter validation study
Individualized structural network deviations predict surgical outcome in mesial temporal lobe epilepsy: a multicenter validation study Open
Background: Surgical resection is an effective treatment for medically refractory mesial temporal lobe epilepsy (mTLE), however, more than one-third of patients fail to achieve seizure freedom after surgery. This study aimed to evaluate pr…
View article: A Cerebellar Partitioning Method Using Spectral Clustering With Optimized Nonlinear Functional Connectivity
A Cerebellar Partitioning Method Using Spectral Clustering With Optimized Nonlinear Functional Connectivity Open
Cerebellum has a stronger individual specificity of functional signals than the brain and is associated with a variety of neuropsychiatric disorders, and increasing attention is being paid to neuropsychiatric symptoms caused by cerebellar …
View article: Population-specific brain charts reveal Chinese-Western differences in neurodevelopmental trajectories
Population-specific brain charts reveal Chinese-Western differences in neurodevelopmental trajectories Open
Human brain charts provide unprecedented opportunities for decoding neurodevelopmental milestones and establishing clinical benchmarks for precision brain medicine 1-7 . However, current lifespan brain charts are primarily derived from Eur…
View article: Mother-child dyadic interactions shape children’s social brain and theory of mind
Mother-child dyadic interactions shape children’s social brain and theory of mind Open
Social cognition develops through a complex interplay between neural maturation and environmental factors, yet the neurobehavioral mechanisms underlying this process remain unclear. Using a naturalistic fMRI paradigm, we investigated the e…
View article: Charting Brain Growth in Chinese Children with Autism
Charting Brain Growth in Chinese Children with Autism Open
Autism Spectrum Disorder (ASD) is a lifelong neurodevelopmental condition characterized by atypical brain growth. While advances in neuroimaging and openly sharing large-sample datasets such as the Autism Brain Imaging Data Exchange (ABIDE…
View article: Common neuroanatomical differential factors underlying heterogeneous gray matter volume variations in five common psychiatric disorders
Common neuroanatomical differential factors underlying heterogeneous gray matter volume variations in five common psychiatric disorders Open
Multifaceted evidence has shown that psychiatric disorders share common neurobiological mechanisms. However, the tremendous inter-individual heterogeneity among patients with psychiatric disorders limits trans-diagnostic studies with case-…
View article: Effects of trace element dysregulation on brain structure and function in spinocerebellar Ataxia type 3
Effects of trace element dysregulation on brain structure and function in spinocerebellar Ataxia type 3 Open
Spinocerebellar ataxia type 3 (SCA3), a neurodegenerative disorder caused by excess CAG repeats in the ATXN3 gene, leads to progressive cerebellar ataxia and other symptoms. The results of previous studies suggest that trace element dysreg…
View article: Medulla oblongata dominated synaptic density network degeneration in amyotrophic lateral sclerosis
Medulla oblongata dominated synaptic density network degeneration in amyotrophic lateral sclerosis Open
These findings suggest that synaptic density network degeneration in ALS may follow a bottom-up transmission pattern, primarily involving in the medulla oblongata-striatum-neocortex network, which have the potential to capture new network-…
View article: Similar trajectories of psychological states predict marital satisfaction
Similar trajectories of psychological states predict marital satisfaction Open
Modern mate selection theories suggest that people are more likely to marry someone similar to themselves in terms of numerous attributes. Recent research has demonstrated a positive relationship between marital satisfaction and inter-subj…
View article: Neurodevelopmental deviations in schizophrenia: Evidences from multimodal connectome-based brain ages
Neurodevelopmental deviations in schizophrenia: Evidences from multimodal connectome-based brain ages Open
Background Pathologic schizophrenia process originate early in brain development, leading to detectable brain alterations via structural and functional magnetic resonance imaging (MRI). Recent MRI studies have sought to characterize diseas…
View article: Similarity or complementarity? Understanding marital relationships in terms of sexual dimorphism in brain morphometry and gender roles
Similarity or complementarity? Understanding marital relationships in terms of sexual dimorphism in brain morphometry and gender roles Open
"Birds of a feather flock together" and "opposites attract" are two contrasting statements regarding interpersonal relationships. Sex differences provide a theoretical integration of these two conflicting statements. Here, we explored the …
View article: Unraveling Integration-Segregation Imbalances in Schizophrenia Through Topological High-Order Functional Connectivity
Unraveling Integration-Segregation Imbalances in Schizophrenia Through Topological High-Order Functional Connectivity Open
Background The occurrence of brain disorders correlates with detectable dysfunctions in the specialization of brain connectomics. While extensive research has explored this relationship, there is a lack of studies specifically examining th…
View article: Exploring functional and structural connectivity disruptions in spinocerebellar ataxia type 3: Insights from gradient analysis
Exploring functional and structural connectivity disruptions in spinocerebellar ataxia type 3: Insights from gradient analysis Open
Aims Spinocerebellar Ataxia Type 3 (SCA3) is a rare genetic ataxia that impacts the entire brain and is characterized as a neurodegenerative disorder affecting the neural network. This study explores how alterations in the functional hiera…
View article: Imbalanced optimal feedback motor control system in spinocerebellar ataxia type 3
Imbalanced optimal feedback motor control system in spinocerebellar ataxia type 3 Open
Background and purpose Human motor planning and control depend highly on optimal feedback control systems, such as the neocortex–cerebellum circuit. Here, diffusion tensor imaging was used to verify the disruption of the neocortex–cerebell…
View article: Morphometric brain organization across the human lifespan reveals increased dispersion linked to cognitive performance
Morphometric brain organization across the human lifespan reveals increased dispersion linked to cognitive performance Open
The human brain is organized as segregation and integration units and follows complex developmental trajectories throughout life. The cortical manifold provides a new means of studying the brain’s organization in a multidimensional connect…
View article: Individualized Structural Perturbations on Normative Brain Connectome Restrict Deep Brain Stimulation Outcomes in Parkinson's Disease
Individualized Structural Perturbations on Normative Brain Connectome Restrict Deep Brain Stimulation Outcomes in Parkinson's Disease Open
Background Patients with Parkinson's disease (PD) respond to deep brain stimulation (DBS) variably. However, how brain substrates restrict DBS outcomes remains unclear. Objective In this article, we aim to identify prognostic brain signatu…
View article: From Sight to Insight: A Multi-task Approach with the Visual Language Decoding Model
From Sight to Insight: A Multi-task Approach with the Visual Language Decoding Model Open
Visual neural decoding aims to unlock the mysteries of how the human brain interprets the visual world. While early studies made some progress in decoding visual activity for singular type of information, they failed to concurrently reveal…
View article: Compressed cerebellar functional connectome hierarchy in spinocerebellar ataxia type 3
Compressed cerebellar functional connectome hierarchy in spinocerebellar ataxia type 3 Open
Spinocerebellar ataxia type 3 (SCA3) is an inherited movement disorder characterized by a progressive decline in motor coordination. Despite the extensive functional connectivity (FC) alterations reported in previous SCA3 studies in the ce…
View article: Divergent suicidal symptomatic activations converge on somato-cognitive action network in depression
Divergent suicidal symptomatic activations converge on somato-cognitive action network in depression Open
Individuals with depression have the highest lifetime prevalence of suicide attempts (SA) among mental illnesses. Numerous neuroimaging studies have developed biomarkers from task-related neural activation in depressive patients with SA, b…
View article: Chemoarchitectural Signatures of Subcortical Shape Alterations in Generalized Epilepsy
Chemoarchitectural Signatures of Subcortical Shape Alterations in Generalized Epilepsy Open
Genetic generalized epilepsies (GGE) exhibit widespread morphometric alterations in the subcortical structures. Subcortical nuclei are essential for understanding GGE pathophysiology, but their fine-grained morphological diversity has yet …