Huaibin M. Ko
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View article: Clearance of amyloid plaque via focused ultrasonication in a mouse model of Alzheimer's disease
Clearance of amyloid plaque via focused ultrasonication in a mouse model of Alzheimer's disease Open
View article: 452 EBER-Positive Intramucosal Carcinoma Arising in Gastric Foveolar Dysplasia Without Intestinal Metaplasia: A Rare Case Expanding EBV-Driven Tumorigenesis
452 EBER-Positive Intramucosal Carcinoma Arising in Gastric Foveolar Dysplasia Without Intestinal Metaplasia: A Rare Case Expanding EBV-Driven Tumorigenesis Open
Introduction/Objective Epstein-Barr virus-associated gastric carcinoma (EBVaGC) typically arises in intestinalized mucosa, with EBV infection considered a late event. Its role in precursor lesions remains poorly understood. Methods/Case Re…
View article: Management of Ileal Pouch Cancer in Patients With Inflammatory Bowel Disease
Management of Ileal Pouch Cancer in Patients With Inflammatory Bowel Disease Open
View article: Featured Cover
Featured Cover Open
View article: Hemorrhagic pouchitis after bowel preparation with sodium phosphate—based enema: a case report
Hemorrhagic pouchitis after bowel preparation with sodium phosphate—based enema: a case report Open
View article: Claudin 18 immunohistochemistry in cholangiocarcinoma
Claudin 18 immunohistochemistry in cholangiocarcinoma Open
Given the poor prognosis and current lack of therapeutic options, trials of anti-CLDN18.2 inhibitors could be considered in patients with CCA and high expression of CLDN18 by immunohistochemistry.
View article: Inflammatory bowel disease‐associated serrated lesions with dysplasia are frequently associated with advanced neoplasia: supporting a unified classification approach
Inflammatory bowel disease‐associated serrated lesions with dysplasia are frequently associated with advanced neoplasia: supporting a unified classification approach Open
Aims Inflammatory bowel disease (IBD)‐associated serrated lesions are categorized into three distinct subtypes: traditional serrated adenoma (TSA)‐like lesion, sessile serrated lesion (SSL)‐like lesion, and serrated lesion, not otherwise s…
View article: Resolution of cuffitis after removal surgical staple from ileal pouch-anal anastomosis
Resolution of cuffitis after removal surgical staple from ileal pouch-anal anastomosis Open
View article: Goblet Cell Loss Linked to NOD2 and Secondary Resection in Crohn’s Disease Is Induced by Dysbiosis and Epithelial MyD88
Goblet Cell Loss Linked to NOD2 and Secondary Resection in Crohn’s Disease Is Induced by Dysbiosis and Epithelial MyD88 Open
View article: Epstein-Barr Virus–Associated B-Cell Lymphoproliferative Disorder Involving the Adrenal Gland in Granulomatosis With Polyangiitis
Epstein-Barr Virus–Associated B-Cell Lymphoproliferative Disorder Involving the Adrenal Gland in Granulomatosis With Polyangiitis Open
Epstein-Barr virus (EBV)–associated lymphoproliferative disorders (LPDs) are rare conditions. Immunomodulatory therapies impair T-cell–mediated immune responses to latent EBV-infected memory B cells, promoting their reactivation and leadin…
View article: Successful treatment of ileocolonic anastomotic stricture with ustekinumab in Crohn’s disease: a case report
Successful treatment of ileocolonic anastomotic stricture with ustekinumab in Crohn’s disease: a case report Open
View article: Extraskeletal Ewing Sarcoma of the Gastrointestinal and Hepatobiliary Tract
Extraskeletal Ewing Sarcoma of the Gastrointestinal and Hepatobiliary Tract Open
Ewing sarcoma (ES) is an uncommon mesenchymal neoplasm that typically develops as a bone mass, although up to 30% arise in extraskeletal sites. ES of the gastrointestinal (GI) and hepatobiliary tract is rare and may be misdiagnosed as othe…
View article: Gut-associated lymphoid tissue attrition associates with response to anti-α4β7 therapy in ulcerative colitis
Gut-associated lymphoid tissue attrition associates with response to anti-α4β7 therapy in ulcerative colitis Open
Vedolizumab (VDZ) is a first-line treatment in ulcerative colitis (UC) that targets the α4β7- mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1) axis. To determine the mechanisms of action of VDZ, we examined five distinct coho…
View article: Solitary pouch ulcer syndrome—a newly recognized phenotype of the ileal pouch disorders
Solitary pouch ulcer syndrome—a newly recognized phenotype of the ileal pouch disorders Open
View article: Plasticity of intragraft alloreactive T cell clones in human gut correlates with transplant outcomes
Plasticity of intragraft alloreactive T cell clones in human gut correlates with transplant outcomes Open
The site of transition between tissue-resident memory (TRM) and circulating phenotypes of T cells is unknown. We integrated clonotype, alloreactivity, and gene expression profiles of graft-repopulating recipient T cells in the intestinal m…
View article: Myeloid cell influx into the colonic epithelium is associated with disease severity and non-response to anti-Tumor Necrosis Factor Therapy in patients with Ulcerative Colitis
Myeloid cell influx into the colonic epithelium is associated with disease severity and non-response to anti-Tumor Necrosis Factor Therapy in patients with Ulcerative Colitis Open
Ulcerative colitis (UC) is an idiopathic chronic inflammatory disease of the colon with sharply rising global prevalence. Dysfunctional epithelial compartment (EC) dynamics are implicated in UC pathogenesis although EC-specific studies are…
View article: Density of Biopsy Sampling Required to Ensure Accurate Histological Assessment of Inflammation in Active Ulcerative Colitis
Density of Biopsy Sampling Required to Ensure Accurate Histological Assessment of Inflammation in Active Ulcerative Colitis Open
Background Histological response to treatment is an important outcome in patients with ulcerative colitis (UC). The accuracy of biopsy-based measurements of inflammation may be limited by error imposed by natural microscopic heterogeneity …
View article: Gut-associated lymphoid tissue attrition associates with response to anti-α4β7 therapy in ulcerative colitis
Gut-associated lymphoid tissue attrition associates with response to anti-α4β7 therapy in ulcerative colitis Open
Targeting the α4β7-MAdCAM-1 axis with vedolizumab (VDZ) is a front-line therapeutic paradigm in ulcerative colitis (UC). However, mechanism(s) of action (MOA) of VDZ remain relatively undefined. Here, we examined three distinct cohorts of …
View article: NOX1 is essential for TNFα-induced intestinal epithelial ROS secretion and inhibits M cell signatures
NOX1 is essential for TNFα-induced intestinal epithelial ROS secretion and inhibits M cell signatures Open
Objective Loss-of-function mutations in genes generating reactive oxygen species (ROS), such as NOX1 , are associated with IBD. Mechanisms whereby loss of ROS drive IBD are incompletely defined. Design ROS measurements and single-cell tran…
View article: Genomic characterization of lymphomas in patients with inborn errors of immunity
Genomic characterization of lymphomas in patients with inborn errors of immunity Open
Patients with inborn errors of immunity (IEI) have a higher risk of developing cancer, especially lymphoma. However, the molecular basis for IEI-related lymphoma is complex and remains elusive. Here, we perform an in-depth analysis of lymp…
View article: Non-esophageal eosinophilic gastrointestinal disorders
Non-esophageal eosinophilic gastrointestinal disorders Open
View article: Ulcerative colitis is characterized by a plasmablast-skewed humoral response associated with disease activity
Ulcerative colitis is characterized by a plasmablast-skewed humoral response associated with disease activity Open
View article: Enhanced virtual crossmatch in intestinal transplantation: association with outcomes and application in practice
Enhanced virtual crossmatch in intestinal transplantation: association with outcomes and application in practice Open
This enhanced virtual cross match more effectively predicts high-risk intestinal transplantation and is a better substitute for physical cross-match than the current virtual cross match. It also helps to avoid ill-considered abandonment of…
View article: Convergence of cytokine dysregulation and antibody deficiency in common variable immunodeficiency with inflammatory complications
Convergence of cytokine dysregulation and antibody deficiency in common variable immunodeficiency with inflammatory complications Open
View article: A myeloid–stromal niche and gp130 rescue in NOD2-driven Crohn’s disease
A myeloid–stromal niche and gp130 rescue in NOD2-driven Crohn’s disease Open
View article: Intestinal Host Response to SARS-CoV-2 Infection and COVID-19 Outcomes in Patients With Gastrointestinal Symptoms
Intestinal Host Response to SARS-CoV-2 Infection and COVID-19 Outcomes in Patients With Gastrointestinal Symptoms Open
View article: Gastrointestinal Manifestations of a Rare Lipid Storage Disorder
Gastrointestinal Manifestations of a Rare Lipid Storage Disorder Open
View article: Intestinal Inflammation Modulates the Expression of ACE2 and TMPRSS2 and Potentially Overlaps With the Pathogenesis of SARS-CoV-2–related Disease
Intestinal Inflammation Modulates the Expression of ACE2 and TMPRSS2 and Potentially Overlaps With the Pathogenesis of SARS-CoV-2–related Disease Open
View article: Gastrointestinal involvement attenuates COVID-19 severity and mortality
Gastrointestinal involvement attenuates COVID-19 severity and mortality Open
Given that gastrointestinal (GI) symptoms are a prominent extrapulmonary manifestation of coronavirus disease 2019 (COVID-19), we investigated the impact of GI infection on disease pathogenesis in three large cohorts of patients in the Uni…
View article: Malakoplakia of the gastrointestinal tract: clinicopathologic analysis of 23 cases
Malakoplakia of the gastrointestinal tract: clinicopathologic analysis of 23 cases Open
Background Malakoplakia is an uncommon, tumor-like inflammatory disease characterized by impaired histiocytes that are unable to completely digest phagocytized bacteria. The genitourinary tract is the most common site of involvement, howev…