Huaichen Li
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View article: Toxin-antitoxin system gene mutations driving Mycobacterium tuberculosis transmission revealed by whole genome sequencing
Toxin-antitoxin system gene mutations driving Mycobacterium tuberculosis transmission revealed by whole genome sequencing Open
Background The toxin-antitoxin (TA) system plays a vital role in the virulence and pathogenicity of Mycobacterium tuberculosis ( M. tuberculosis ). However, the regulatory mechanisms and the impact of gene mutations on M. tuberculosis tran…
View article: Trends in the Notification Rates and Treatment Outcome of Tuberculosis in Shandong Province, China, 2005–2021
Trends in the Notification Rates and Treatment Outcome of Tuberculosis in Shandong Province, China, 2005–2021 Open
After unremitting efforts to fight against TB, the notification rates of registered TB and bacteriologically confirmed TB declined in Shandong Province. The rate of poor outcomes remained stable during 2008-2019, then rise significantly af…
View article: The influence of pyrazinamide resistant associated gene mutations on multidrug-resistant mycobacterium tuberculosis in China
The influence of pyrazinamide resistant associated gene mutations on multidrug-resistant mycobacterium tuberculosis in China Open
Background Pyrazinamide (PZA) is essential for the treatment of drug-susceptible and drug-resistant tuberculosis (TB), especially multidrug-resistant (MDR) TB, but the condition of PZA resistance (PZA-R) across China is unknown. Our aim is…
View article: Multidrug-resistant Mycobacterium tuberculosis transmission in Shandong, China
Multidrug-resistant Mycobacterium tuberculosis transmission in Shandong, China Open
Multidrug-resistant tuberculosis (MDR-TB) has imposed a significant economic and health burden worldwide, notably in China. Using whole genome sequence, we sought to understand the mutation and transmission of MDR-TB in Shandong. A retrosp…
View article: Polyketide synthases mutation in tuberculosis transmission revealed by whole genomic sequence, China, 2011–2019
Polyketide synthases mutation in tuberculosis transmission revealed by whole genomic sequence, China, 2011–2019 Open
Introduction: Tuberculosis (TB) is an infectious disease caused by a bacterium called Mycobacterium tuberculosis ( Mtb ). Previous studies have primarily focused on the transmissibility of multidrug-resistant (MDR) or extensively drug-resi…
View article: Genomic analysis of lineage-specific transmission of multidrug resistance tuberculosis in China
Genomic analysis of lineage-specific transmission of multidrug resistance tuberculosis in China Open
MDR-TB epidemic in China is predominantly driven by the spread of highly transmissible Beijing strains. A range of drug-resistance mutations of L2 MDR-TB strains displayed minimal fitness costs and may facilitate their transmission.
View article: Transmission dynamics and phylogeography of Mycobacterium tuberculosis in China based on whole-genome phylogenetic analysis
Transmission dynamics and phylogeography of Mycobacterium tuberculosis in China based on whole-genome phylogenetic analysis Open
The present study provides insights into the different transmission and migration patterns of the major M. tuberculosis lineages in China and highlights that transmissible L2.2.1 is a threat to tuberculosis control.
View article: Identifying optimal first-line immune checkpoint inhibitors based regiments for advanced non-small cell lung cancer without oncogenic driver mutations: A systematic review and network meta-analysis
Identifying optimal first-line immune checkpoint inhibitors based regiments for advanced non-small cell lung cancer without oncogenic driver mutations: A systematic review and network meta-analysis Open
Background Immune checkpoint inhibitors (ICIs) have changed the treatment pattern of advanced and metastatic NSCLC. A series of ICI based therapies have emerged in the first-line treatment field, but the comparative efficacy was unclear. M…
View article: Additional file 1 of Association between two-component systems gene mutation and Mycobacterium tuberculosis transmission revealed by whole genome sequencing
Additional file 1 of Association between two-component systems gene mutation and Mycobacterium tuberculosis transmission revealed by whole genome sequencing Open
Supplementary Material 1: Additional file 2: Tables S1–S3
View article: Disseminated Strongyloidiasis Misdiagnosed as Guillain-Barré Syndrome: The Value of High-Throughput Genetic Sequencing of Pathogenic Microorganisms in Parasitic Infections
Disseminated Strongyloidiasis Misdiagnosed as Guillain-Barré Syndrome: The Value of High-Throughput Genetic Sequencing of Pathogenic Microorganisms in Parasitic Infections Open
This case highlights the combined application of mNGS and traditional testing in the clinical diagnosis of difficult and critical parasitic infections in immunocompromised patients. mNGS is a new, adjunct diagnostic method to rapidly scree…
View article: Twice evasions of Omicron variants explain the temporal patterns in six Asia and Oceania countries
Twice evasions of Omicron variants explain the temporal patterns in six Asia and Oceania countries Open
Background: The ongoing Coronavirus 2019 (COVID-19) pandemic has emerged and caused multiple pandemic waves in the following six countries: India, Indonesia, Nepal, Malaysia, Bangladesh and Myanmar. Some of the countries had been much less…
View article: Impact of alcohol drinking and tobacco smoking on the drug-resistance of newly diagnosed tuberculosis: a retrospective cohort study in Shandong, China, during 2004–2020
Impact of alcohol drinking and tobacco smoking on the drug-resistance of newly diagnosed tuberculosis: a retrospective cohort study in Shandong, China, during 2004–2020 Open
Objectives To investigate the independent and collective impact of alcohol drinking and tobacco smoking on the drug-resistance of newly diagnosed tuberculosis (TB). Design This was a retrospective cohort study. Setting Shandong, China. Par…
View article: Changing Epidemiology of TB in Shandong, China Driven by Demographic Changes
Changing Epidemiology of TB in Shandong, China Driven by Demographic Changes Open
Tuberculosis (TB) incidence has been in steady decline in China over the last few decades. However, ongoing demographic transition, fueled by aging, and massive internal migration could have important implications for TB control in the fut…
View article: An Ecological Study of Tuberculosis Incidence in China, From 2002 to 2018
An Ecological Study of Tuberculosis Incidence in China, From 2002 to 2018 Open
Introduction Tuberculosis is one of the main infectious diseases threatening global health, which is also the main cause of death from a single source of infection (above HIV/AIDS). China is a country with a high burden of tuberculosis in …
View article: Use of <scp>PD</scp>‐1 inhibitor tislelizumab in the treatment of advanced pulmonary sarcomatoid carcinoma: A case report
Use of <span>PD</span>‐1 inhibitor tislelizumab in the treatment of advanced pulmonary sarcomatoid carcinoma: A case report Open
Pulmonary sarcomatoid carcinoma (PSC), characterized by poor differentiation, aggressive progression, and early metastasis, is a rare type of non‐small cell lung carcinoma (NSCLC), which shows a low response rate to conventional antitumor …
View article: COVID-19 and Tuberculosis Coinfection: An Overview of Case Reports/Case Series and Meta-Analysis
COVID-19 and Tuberculosis Coinfection: An Overview of Case Reports/Case Series and Meta-Analysis Open
Background: Coronavirus disease 2019 (COVID-19) and tuberculosis (TB) are two major infectious diseases posing significant public health threats, and their coinfection (aptly abbreviated COVID-TB) makes the situation worse. This study aime…
View article: Drug-Resistant Tuberculosis Among Children: A Systematic Review and Meta-Analysis
Drug-Resistant Tuberculosis Among Children: A Systematic Review and Meta-Analysis Open
Background: Drug-resistant tuberculosis (DR-TB), especially multidrug-resistant tuberculosis (MDR-TB) is a public health threat. Little is known about estimates of different profiles and rates of DR-TB among children globally. Methods: We …