Huaiwu Lu
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View article: Single-cell and spatial transcriptomic profiling reveals distinct tumor microenvironment dynamics in cervical adenocarcinoma and squamous cell carcinoma
Single-cell and spatial transcriptomic profiling reveals distinct tumor microenvironment dynamics in cervical adenocarcinoma and squamous cell carcinoma Open
Cervical cancer (CC), a leading cause of cancer-related deaths among women worldwide, is primarily driven by high-risk human papillomavirus (HPV) infections and comprises two major histological subtypes: adenocarcinoma (AC) and squamous ce…
View article: Global, regional, and national epidemiology of cervical cancer in elderly women from 1990 to 2021 and its prediction to 2035
Global, regional, and national epidemiology of cervical cancer in elderly women from 1990 to 2021 and its prediction to 2035 Open
View article: Prognostic Significance of Complete Blood Count-Derived Inflammatory Biomarkers in Patients with Small Cell Neuroendocrine Carcinoma of the Cervix
Prognostic Significance of Complete Blood Count-Derived Inflammatory Biomarkers in Patients with Small Cell Neuroendocrine Carcinoma of the Cervix Open
Background: Small cell neuroendocrine carcinoma of the cervix (SCNEC) is a rare and highly aggressive malignancy with limited prognostic biomarkers available for clinical use. Inflammatory markers derived from complete blood count (CBC) ha…
View article: Comprehensive clinical analysis of gastric-type endocervical adenocarcinoma: a real-world multicenter study
Comprehensive clinical analysis of gastric-type endocervical adenocarcinoma: a real-world multicenter study Open
G-EAC exhibits aggressive behavior and unfavorable prognosis, with a 5-year OS of 46.1%. Multimodal treatment, particularly surgery combined with chemotherapy, remains the cornerstone of management and may improve survival. Prospective mul…
View article: Long-term efficacy and updated survival outcomes of sintilimab plus anlotinib in patients with PD-L1-positive recurrent or metastatic cervical cancer
Long-term efficacy and updated survival outcomes of sintilimab plus anlotinib in patients with PD-L1-positive recurrent or metastatic cervical cancer Open
Long-term follow-up showed persistent antitumor activity and maintained safety of sintilimab plus anlotinib in pre-treated patients with PD-L1-positive advanced cervical cancer.
View article: Serum metabolic fingerprints encode functional biomarkers for ovarian cancer diagnosis: a large-scale cohort study
Serum metabolic fingerprints encode functional biomarkers for ovarian cancer diagnosis: a large-scale cohort study Open
View article: CACA guidelines for vulvar malignancies
CACA guidelines for vulvar malignancies Open
Objective The purpose of this study is to provide reference and guidance for the clinical diagnosis and treatment of vulvar malignancies. Method This article sorts out and integrates the contents of vulvar malignancies in the field of trad…
View article: A gene-based predictive model for lymph node metastasis in cervical cancer: superior performance over imaging techniques
A gene-based predictive model for lymph node metastasis in cervical cancer: superior performance over imaging techniques Open
Objective Lymph node metastasis (LNM) critically impacts the prognosis and treatment decisions of cervical cancer patients. The accuracy and sensitivity of current imaging techniques, such as CT and MRI, are limited in assessing lymph node…
View article: Development and External Validation of a Machine Learning-Based Prognostic Model for Small Cell Neuroendocrine Cervical Carcinoma: A Multi-Center Study
Development and External Validation of a Machine Learning-Based Prognostic Model for Small Cell Neuroendocrine Cervical Carcinoma: A Multi-Center Study Open
View article: New prognostic index for neoadjuvant chemotherapy outcome in patients with advanced high-grade serous ovarian cancer
New prognostic index for neoadjuvant chemotherapy outcome in patients with advanced high-grade serous ovarian cancer Open
The ONCPI emerges as a significant prognostic marker for predicting NACT outcome in advanced HGSOC patients and holds promise for integration into clinical practice and risk-stratified trial design.
View article: Advances in management algorithm in clear cell carcinoma of cervix
Advances in management algorithm in clear cell carcinoma of cervix Open
This comprehensive review critically assesses tailored management strategies for clear cell carcinoma of the cervix (cCCC), an uncommon subtype of cervical adenocarcinomas. A globally prevalent condition, cCCC affects individuals across di…
View article: HNRNPC mediates lymphatic metastasis of cervical cancer through m6A-dependent alternative splicing of FOXM1
HNRNPC mediates lymphatic metastasis of cervical cancer through m6A-dependent alternative splicing of FOXM1 Open
View article: Research progress of antibody–drug conjugates in gynecologic cancer
Research progress of antibody–drug conjugates in gynecologic cancer Open
Gynecologic cancer is a critical concern in the field of women’s health, and traditional treatment methods have demonstrated limited efficacy for certain advanced and recurrent gynecologic cancers. In recent years, antibody–drug conjugate …
View article: Treatment patterns and prognosis of patients with clear cell adenocarcinoma of the cervix: a population-based cohort study
Treatment patterns and prognosis of patients with clear cell adenocarcinoma of the cervix: a population-based cohort study Open
Objectives: To describe treatment patterns and prognoses for clear cell adenocarcinoma of the cervix (CCAC), a poorly understood rare tumor. Methods: A retrospective case–control study was conducted using the Surveillance, Epidemiology, an…
View article: Feasibility of the “cuff-sleeve” suture method in improving the uterine blood supply after radical trachelectomy: A retrospective analysis
Feasibility of the “cuff-sleeve” suture method in improving the uterine blood supply after radical trachelectomy: A retrospective analysis Open
The "cuff-sleeve" suture method was associated with increased diameter of the uterine and ovarian vessels and may be a feasible method to improve the uterine blood supply and pregnancy rate after radical trachelectomy. It still warrants fu…
View article: Long‐term survival outcomes and immune checkpoint inhibitor retreatment in patients with advanced cervical cancer treated with camrelizumab plus apatinib in the phase II CLAP study
Long‐term survival outcomes and immune checkpoint inhibitor retreatment in patients with advanced cervical cancer treated with camrelizumab plus apatinib in the phase II CLAP study Open
Background Camrelizumab plus apatinib have demonstrated robust antitumor activity and safety in patients with advanced cervical cancer (CLAP study; NCT03816553). We herein present the updated long‐term results of the CLAP study and explore…
View article: Metastatic pericardial mass and cardiophrenic lymph nodes resection in ovarian cancer
Metastatic pericardial mass and cardiophrenic lymph nodes resection in ovarian cancer Open
We demonstrate that advanced ovarian cancer with extra-abdominal diseases, such as bulky pericardial mass and cardiophrenic lymph nodes, should not be an absolute contraindication to a planned complete debulking surgery. Based on our growi…
View article: The Evaluation of Endometrial Sampler SAP-1 in Screening Patients With General Risk of Endometrial Cancer: A Diagnostic Test Study
The Evaluation of Endometrial Sampler SAP-1 in Screening Patients With General Risk of Endometrial Cancer: A Diagnostic Test Study Open
Objectives: In recent years, early screening for endometrial cancer (EC) has received increasing attention. EC screening is recommended to be conducted among high-risk and risk-increasing populations, while the general-risk population, eve…
View article: New Prognostic Index for Neoadjuvant Chemotherapy Outcomes in Patients with Advanced High-Grade Serous Ovarian Cancer
New Prognostic Index for Neoadjuvant Chemotherapy Outcomes in Patients with Advanced High-Grade Serous Ovarian Cancer Open
Background: A prognostic index validated for the outcomes of advanced high-grade serous ovarian cancer (HGSOC) patients with neoadjuvant chemotherapy (NACT) is still lacking. We therefore developed an ovarian neoadjuvant chemotherapy progn…
View article: An analysis of clinical characteristics and prognosis of endometrioid ovarian cancer based on the SEER database and two centers in China
An analysis of clinical characteristics and prognosis of endometrioid ovarian cancer based on the SEER database and two centers in China Open
Purpose To assess the clinical characteristics and the risk factors related to the unfavorable prognosis of endometrioid ovarian carcinoma (EOVC) based on data from the Surveillance, Epidemiology, and End Results (SEER) database and two cl…
View article: APOBEC3B stratifies ovarian clear cell carcinoma with distinct immunophenotype and prognosis
APOBEC3B stratifies ovarian clear cell carcinoma with distinct immunophenotype and prognosis Open
View article: Development and external validation of nomograms for predicting individual survival in patients with ovarian clear cell carcinoma
Development and external validation of nomograms for predicting individual survival in patients with ovarian clear cell carcinoma Open
Purpose Ovarian clear cell carcinoma (OCCC) is a distinct and highly malignant subtype of ovarian cancer with high individual heterogeneity in survival that requires specific prognostic predictive tools. Thus, this study aimed to construct…
View article: Additional file 2 of An analysis of clinical characteristics and prognosis of endometrioid ovarian cancer based on the SEER database and two centers in China
Additional file 2 of An analysis of clinical characteristics and prognosis of endometrioid ovarian cancer based on the SEER database and two centers in China Open
Additional file 2: Figure S1. Flowchart of the selection for patients with endometrioid ovarian carcinoma. Figure S2. The calibration curves of one-year, three-year and five-year overall survival of the nomogram. Figure S3. Distribution of…
View article: Additional file 1 of An analysis of clinical characteristics and prognosis of endometrioid ovarian cancer based on the SEER database and two centers in China
Additional file 1 of An analysis of clinical characteristics and prognosis of endometrioid ovarian cancer based on the SEER database and two centers in China Open
Additional file 1: Table S1. FIGO and AJCC staging system for epithelial ovarian carcinoma. Table S2. Surgical procedures and clinical outcomes of 87 patients with EOVC. Table S3. Comparison of EOVC patients with/without endometriosis in t…
View article: SF002/#87 Single-site laparoscopic radical trachelectomy without a uterine manipulator
SF002/#87 Single-site laparoscopic radical trachelectomy without a uterine manipulator Open
Introduction Report regarding single-site laparoscopic radical trachelectomy (RT) is still absent at the present stage, for which the feasibility and safety of this surgery remains a question. We herein introduce the single-site laparoscop…
View article: Novel prognostic nomograms in cervical cancer based on analysis of 1075 patients
Novel prognostic nomograms in cervical cancer based on analysis of 1075 patients Open
Objective To explore the factors affecting the prognosis of cervical cancer (CC), and to construct and evaluate predictive nomograms to guide individualized clinical treatment. Methods The clinicopathological and follow‐up data of CC patie…
View article: PARP inhibitor resistance in breast and gynecological cancer: Resistance mechanisms and combination therapy strategies
PARP inhibitor resistance in breast and gynecological cancer: Resistance mechanisms and combination therapy strategies Open
Breast cancer and gynecological tumors seriously endanger women’s physical and mental health, fertility, and quality of life. Due to standardized surgical treatment, chemotherapy, and radiotherapy, the prognosis and overall survival of can…
View article: PRKCI Mediates Radiosensitivity via the Hedgehog/GLI1 Pathway in Cervical Cancer
PRKCI Mediates Radiosensitivity via the Hedgehog/GLI1 Pathway in Cervical Cancer Open
Objective Insensitivity to radiotherapy accounts for the majority of therapeutic failures in cervical cancer (CC) patients who undergo radical radiotherapy. We aimed to elucidate the molecular mechanisms underlying radiosensitivity to iden…
View article: Detection of ovarian cancer using plasma cell-free DNA methylomes
Detection of ovarian cancer using plasma cell-free DNA methylomes Open
Background Ovarian cancer (OC) is a highly lethal gynecologic cancer, and it is hard to diagnose at an early stage. Clinically, there are no ovarian cancer-specific markers for early detection. Here, we demonstrate the use of cell-free DNA…
View article: Additional file 2 of Detection of ovarian cancer using plasma cell-free DNA methylomes
Additional file 2 of Detection of ovarian cancer using plasma cell-free DNA methylomes Open
Additional file 2. Supplementary tables of the article.