Huajiang Liu
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View article: Dissecting T Cell Exhaustion in Non-Small Cell Lung Cancer: Single-Cell and Spatial Transcriptomics Reveal Prognostic Signatures and Therapeutic Implications
Dissecting T Cell Exhaustion in Non-Small Cell Lung Cancer: Single-Cell and Spatial Transcriptomics Reveal Prognostic Signatures and Therapeutic Implications Open
Background: Non-small cell lung cancer (NSCLC) represents 85% of lung cancers and remains a leading cause of cancer death. Immunotherapy advancements have improved treatment, but many patients develop resistance due to T cell exhaustion. U…
View article: Comparison of the Construction Methods of Parathyroid Organoids and Functional Influence of Calcium on Organoids
Comparison of the Construction Methods of Parathyroid Organoids and Functional Influence of Calcium on Organoids Open
Objective This study aimed to determine the more suitable method for constructing parathyroid organoids. Methods Parathyroid organoids were established using two different culture conditions, and organoid morphology and ATP activity were a…
View article: The Cardioprotective Effects and Mechanisms of Astragalus-Safflower Herb Pairs on Coronary Heart Disease Identified by Network Pharmacology and Experimental Verification
The Cardioprotective Effects and Mechanisms of Astragalus-Safflower Herb Pairs on Coronary Heart Disease Identified by Network Pharmacology and Experimental Verification Open
Background: Huang Qi (HQ, Astragalus) and Hong Hua (HH, Safflower), two Chinese herbal remedies, are widely used to treat coronary heart disease (CHD). However, the underlying mechanisms of this herb pair remain unclear. The aim of this st…
View article: Advances in immunotherapy modalities for atherosclerosis
Advances in immunotherapy modalities for atherosclerosis Open
Cardiovascular disease (CVD) is one of the leading causes of death worldwide. Atherosclerosis is the pathological basis of atherosclerotic cardiovascular disease (ASCVD). Atherosclerosis is now understood to be a long-term immune-mediated …
View article: Role of ferroptosis-related genes in coronary atherosclerosis and identification of key genes: integration of bioinformatics analysis and experimental validation
Role of ferroptosis-related genes in coronary atherosclerosis and identification of key genes: integration of bioinformatics analysis and experimental validation Open
Background Coronary atherosclerosis (CA) is the most common type of atherosclerosis. However, the inherent pathogenesis and mechanisms of CA are unclear, and the relationship with ferroptosis-related genes (FRGs) has not been reported. The…
View article: Fulvestrant, an estrogen receptor inhibitor, relieves postoperative hemorrhoid edema via up-regulation of miR- 424-5p
Fulvestrant, an estrogen receptor inhibitor, relieves postoperative hemorrhoid edema via up-regulation of miR- 424-5p Open
Purpose: To investigate estrogen receptor (ER) expression in postoperative hemorrhoid edema tissues, and the likely mechanism involved in fulvestrant-mediated reduction of postoperative hemorrhoid edema.Methods: One hundred and eighty-five…
View article: A Network Pharmacology Study to Explore the Underlying Mechanism of Safflower (Carthamus tinctorius L.) in the Treatment of Coronary Heart Disease
A Network Pharmacology Study to Explore the Underlying Mechanism of Safflower (Carthamus tinctorius L.) in the Treatment of Coronary Heart Disease Open
Safflower has long been used to treat coronary heart disease (CHD). However, the underlying mechanism remains unclear. The goal of this study was to predict the therapeutic effect of safflower against CHD using a network pharmacology and t…
View article: A Network Pharmacology Study to Explore the Underlying Mechanism of Safflower (Carthamus Tinctorius L.) in the Treatment of Coronary Heart Disease
A Network Pharmacology Study to Explore the Underlying Mechanism of Safflower (Carthamus Tinctorius L.) in the Treatment of Coronary Heart Disease Open
Background: Safflower has long been used to treat coronary heart disease (CHD). However, the underlying mechanism remains unclear. The goal of this study was to predict the therapeutic effect of safflower against CHD using a network pharma…
View article: Additional file 2 of Role of ferroptosis-related genes in coronary atherosclerosis and identification of key genes: integration of bioinformatics analysis and experimental validation
Additional file 2 of Role of ferroptosis-related genes in coronary atherosclerosis and identification of key genes: integration of bioinformatics analysis and experimental validation Open
Additional file 2: Table S3. Raw data on the correlation of overlapping genes and FRG.
View article: Establishment and characterization of organoids from a patient with adenomyoepithelioma of the breast
Establishment and characterization of organoids from a patient with adenomyoepithelioma of the breast Open
Adenomyoepithelioma (AME) of the breast is a rare tumor that is composed of proliferating epithelial and myoepithelial cells. The pathogenesis of AME remains unclear, and no breast cancer cells have been identified in such tumor tissues. I…
View article: Circulating tumor DNA as a potential prognostic and predictive biomarker during interventional therapy of unresectable primary liver cancer
Circulating tumor DNA as a potential prognostic and predictive biomarker during interventional therapy of unresectable primary liver cancer Open
ctDNA was a reliable biomarker to assist in diagnosis and evaluation of prognosis and treatment efficacy in advanced liver cancer. Considering that biopsy is unnecessary when advanced liver cancer is diagnosed, ctDNA may be an ideal biomar…
View article: IQ Motif Containing GTPase-Activating Protein 3 (IQGAP3) Inhibits Kaempferol-Induced Apoptosis in Breast Cancer Cells by Extracellular Signal-Regulated Kinases 1/2 (ERK1/2) Signaling Activation
IQ Motif Containing GTPase-Activating Protein 3 (IQGAP3) Inhibits Kaempferol-Induced Apoptosis in Breast Cancer Cells by Extracellular Signal-Regulated Kinases 1/2 (ERK1/2) Signaling Activation Open
BACKGROUND Breast cancer (BC), a prevalent and heterogeneous disease of glandular breast tissue, is the most common cancer in women. The interaction between Kaempferol and IQ motif containing GTPase-activating protein 3 (IQGAP3) in BC and …