Hualin Zhang
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View article: Initial experience of spatially fractionated lattice radiation therapy for palliative treatment of pediatric bulky tumors
Initial experience of spatially fractionated lattice radiation therapy for palliative treatment of pediatric bulky tumors Open
Purpose Spatially fractionated radiation therapy (SFRT) has demonstrated high clinical response rates with minimal toxicity in adult patients with bulky tumors, including radioresistant histologies. However, there is limited clinical data …
View article: P12.27.B A PHASE 0/1 STUDY OF PRMT5 INHIBITOR BMS-986504 IN RECURRENT GLIOBLASTOMA PARTICIPANTS WITH MTAP DELETED TUMORS.
P12.27.B A PHASE 0/1 STUDY OF PRMT5 INHIBITOR BMS-986504 IN RECURRENT GLIOBLASTOMA PARTICIPANTS WITH MTAP DELETED TUMORS. Open
BACKGROUND Methylthioadenosine phosphorylase (MTAP) deletions occur in approximately 40% of glioblastoma (GBM) tumors, leading to accumulation of methylthioadenosine and rendering tumor cells selectively vulnerable to inhibition of protein…
View article: Stereotactic core ablative radiation therapy for small hypoxic tumors: impact of dosimetric approaches and consequent optimization strategy in the context of spatially fractionated radiation therapy
Stereotactic core ablative radiation therapy for small hypoxic tumors: impact of dosimetric approaches and consequent optimization strategy in the context of spatially fractionated radiation therapy Open
Purpose Stereotactic core ablative radiation therapy (SCART) delivers a single ablative dose core to the central hypoxic part while keeping low doses to the periphery of the tumor. This study evaluated the dosimetric impacts of various SCA…
View article: Gradient-Based Radiomics Analysis for Outcome Prediction in Personalized Ultra-Fractionated Stereotactic Adaptive Radiotherapy (PULSAR)
Gradient-Based Radiomics Analysis for Outcome Prediction in Personalized Ultra-Fractionated Stereotactic Adaptive Radiotherapy (PULSAR) Open
View article: Targeting EZH2 to mitigate immune checkpoint resistance in ARID1A-deficient triple-negative breast cancer
Targeting EZH2 to mitigate immune checkpoint resistance in ARID1A-deficient triple-negative breast cancer Open
Immune checkpoint inhibitors (ICIs) have shown promise in treating triple-negative breast cancer (TNBC), but resistance to these therapies remains a significant challenge. AT-rich interactive domain 1A (ARID1A), a component of the SWItch/S…
View article: LNE-Blocking: An Efficient Framework for Contamination Mitigation Evaluation on Large Language Models
LNE-Blocking: An Efficient Framework for Contamination Mitigation Evaluation on Large Language Models Open
View article: Enhancing the color and astringency of red wines through white grape seeds addition: Repurposing wine production byproducts
Enhancing the color and astringency of red wines through white grape seeds addition: Repurposing wine production byproducts Open
The clear juice fermentation technique for white wines suggests that white grape seeds, rich in flavan-3-ols and proanthocyanidins, are not effectively utilized in the winemaking process. This study incorporated 'Gewürztraminer' grape seed…
View article: Evolution of Aroma Profiles in Vitis vinifera L. Marselan and Merlot from Grapes to Wines and Difference between Varieties
Evolution of Aroma Profiles in Vitis vinifera L. Marselan and Merlot from Grapes to Wines and Difference between Varieties Open
The fermentation process has a significant impact on the aromatic profile of wines, particularly in relation to the difference in fermentation matrix caused by grape varieties. This study investigates the leaching and evolution patterns of…
View article: Optimization of Observational Bionic Underwater Vehicle Based on TRIZ Theory
Optimization of Observational Bionic Underwater Vehicle Based on TRIZ Theory Open
This paper applies the Theory of Inventive Problem Solving (TRIZ) to address challenges in observation-type biomimetic underwater robots. Traditional underwater robots impact the environment, while biomimetic robots lack flexibility and co…
View article: Factors influencing early recurrence of atrial fibrillation among elderly patients following radiofrequency catheter ablation and the impact of different antiarrhythmic regimens
Factors influencing early recurrence of atrial fibrillation among elderly patients following radiofrequency catheter ablation and the impact of different antiarrhythmic regimens Open
Background Patients with atrial fibrillation (AF) who undergo radiofrequency catheter ablation (RFCA) necessitate the administration of antiarrhythmic drugs to prevent early recurrence. The clinical outcomes among these patients may be inf…
View article: Numerical Simulation and Bench Test of Crawler-Type Cotton Time-Delay Hole-Forming Device Based on RecurDyn-EDEM Coupling
Numerical Simulation and Bench Test of Crawler-Type Cotton Time-Delay Hole-Forming Device Based on RecurDyn-EDEM Coupling Open
Addressing the significant challenge in high-speed cotton dibbling operations in Xinjiang—specifically, the duck bill’s ("Duck bill" is a type of duck-billed bunch planting mechanism or component). shortened opening duration lead…
View article: Dosimetric characterization for GRID collimator‐based spatially fractionated radiation therapy: Dosimetric parameter acquisition and machine interchangeability investigation
Dosimetric characterization for GRID collimator‐based spatially fractionated radiation therapy: Dosimetric parameter acquisition and machine interchangeability investigation Open
Purpose The purpose of this study is to characterize the dosimetric properties of a commercial brass GRID collimator for high energy photon beams including 15 and 10 MV. Then, the difference in dosimetric parameters of GRID beams among dif…
View article: Hard-Thresholding Meets Evolution Strategies in Reinforcement Learning
Hard-Thresholding Meets Evolution Strategies in Reinforcement Learning Open
Evolution Strategies (ES) have emerged as a competitive alternative for model-free reinforcement learning, showcasing exemplary performance in tasks like Mujoco and Atari. Notably, they shine in scenarios with imperfect reward functions, m…
View article: Obtaining Lower Query Complexities Through Lightweight Zeroth-Order Proximal Gradient Algorithms
Obtaining Lower Query Complexities Through Lightweight Zeroth-Order Proximal Gradient Algorithms Open
Zeroth-order (ZO) optimization is one key technique for machine learning problems where gradient calculation is expensive or impossible. Several variance, reduced ZO proximal algorithms have been proposed to speed up ZO optimization for no…
View article: Effects of Phenolic Evolution on Color Characteristics of Single-Cultivar Vitis vinifera L. Marselan and Merlot Wines during Vinification and Aging
Effects of Phenolic Evolution on Color Characteristics of Single-Cultivar Vitis vinifera L. Marselan and Merlot Wines during Vinification and Aging Open
The loss of red hue in dry red wine has been a persistent issue for wine enterprises in western China. We investigated the changes in anthocyanins and non-anthocyanin phenols during the industrial-scale fermentation and one-year bottle agi…
View article: Intraoperative radiation therapy with 50 kV x‐rays: A multi‐institutional review
Intraoperative radiation therapy with 50 kV x‐rays: A multi‐institutional review Open
This report covers clinical implementation of a low kV intraoperative radiation therapy (IORT) program with the INTRABEAM® System (Carl Zeiss Meditec AG, Jena, Germany). Based on collective user experience from eight institutions, we discu…
View article: Overview and Recommendations for Prospective Multi-institutional Spatially Fractionated Radiation Therapy Clinical Trials
Overview and Recommendations for Prospective Multi-institutional Spatially Fractionated Radiation Therapy Clinical Trials Open
View article: Immune Priming with Spatially Fractionated Radiation Therapy
Immune Priming with Spatially Fractionated Radiation Therapy Open
View article: CTNI-22. A PHASE 0/2 ‘TRIGGER’ TRIAL OF NIRAPARIB IN PATIENTS WITH NEWLY-DIAGNOSED GLIOBLASTOMA
CTNI-22. A PHASE 0/2 ‘TRIGGER’ TRIAL OF NIRAPARIB IN PATIENTS WITH NEWLY-DIAGNOSED GLIOBLASTOMA Open
BACKGROUND Poly (ADP-ribose) polymerase (PARP) mediates DNA damage response; niraparib is an investigational PARP1/2-selective inhibitor. This Phase 0 study evaluates newly-diagnosed glioblastoma (GBM) tumor pharmacokinetics (PK) and pharm…
View article: Hippocampal sparing radiation therapy for brain metastases: treatment techniques and clinical implementation
Hippocampal sparing radiation therapy for brain metastases: treatment techniques and clinical implementation Open
High doses of radiation to the hippocampus have been correlated with increased cognitive decline following radiation therapy for brain metastases. To mitigate these effects, a variety of hippocampal sparing techniques have been implemented…
View article: Practice Patterns of Spatially Fractionated Radiation Therapy: A Clinical Practice Survey
Practice Patterns of Spatially Fractionated Radiation Therapy: A Clinical Practice Survey Open
View article: Treating Cylindrically Populated Endometrial Cancers With High Dose Rate Vaginal Cuff Brachytherapy: Should We Use a MulTi-Channel or Single-Channel Cylinder?
Treating Cylindrically Populated Endometrial Cancers With High Dose Rate Vaginal Cuff Brachytherapy: Should We Use a MulTi-Channel or Single-Channel Cylinder? Open
Purpose: The purpose of this study was to evaluate the dosimetric impact of multiple channels compared to a single channel in high dose rate (HDR) vaginal cuff brachytherapy (VCBT).
Methods and materials: Sample plans of HDR VCBT from bo…
View article: Data from Predicting Outcomes in Cervical Cancer: A Kinetic Model of Tumor Regression during Radiation Therapy
Data from Predicting Outcomes in Cervical Cancer: A Kinetic Model of Tumor Regression during Radiation Therapy Open
Applications of mathematical modeling can improve outcome predictions of cancer therapy. Here we present a kinetic model incorporating effects of radiosensitivity, tumor repopulation, and dead-cell resolving on the analysis of tumor volume…
View article: Free Article from Predicting Outcomes in Cervical Cancer: A Kinetic Model of Tumor Regression during Radiation Therapy
Free Article from Predicting Outcomes in Cervical Cancer: A Kinetic Model of Tumor Regression during Radiation Therapy Open
Free Article from Predicting Outcomes in Cervical Cancer: A Kinetic Model of Tumor Regression during Radiation Therapy
View article: Free Article from Predicting Outcomes in Cervical Cancer: A Kinetic Model of Tumor Regression during Radiation Therapy
Free Article from Predicting Outcomes in Cervical Cancer: A Kinetic Model of Tumor Regression during Radiation Therapy Open
Free Article from Predicting Outcomes in Cervical Cancer: A Kinetic Model of Tumor Regression during Radiation Therapy
View article: Data from Predicting Outcomes in Cervical Cancer: A Kinetic Model of Tumor Regression during Radiation Therapy
Data from Predicting Outcomes in Cervical Cancer: A Kinetic Model of Tumor Regression during Radiation Therapy Open
Applications of mathematical modeling can improve outcome predictions of cancer therapy. Here we present a kinetic model incorporating effects of radiosensitivity, tumor repopulation, and dead-cell resolving on the analysis of tumor volume…
View article: Zeroth-Order Hard-Thresholding: Gradient Error vs. Expansivity
Zeroth-Order Hard-Thresholding: Gradient Error vs. Expansivity Open
$\ell_0$ constrained optimization is prevalent in machine learning, particularly for high-dimensional problems, because it is a fundamental approach to achieve sparse learning. Hard-thresholding gradient descent is a dominant technique to …
View article: An International Consensus on the Design of Prospective Clinical–Translational Trials in Spatially Fractionated Radiation Therapy for Advanced Gynecologic Cancer
An International Consensus on the Design of Prospective Clinical–Translational Trials in Spatially Fractionated Radiation Therapy for Advanced Gynecologic Cancer Open
Despite the unexpectedly high tumor responses and limited treatment-related toxicities observed with SFRT, prospective multi-institutional clinical trials of SFRT are still lacking. High variability of SFRT technologies and methods, unfami…
View article: A Dosimetric Parameter Reference Look-Up Table for GRID Collimator-Based Spatially Fractionated Radiation Therapy
A Dosimetric Parameter Reference Look-Up Table for GRID Collimator-Based Spatially Fractionated Radiation Therapy Open
Computations of heterogeneity dose parameters in GRID therapy remain challenging in many treatment planning systems (TPS). To address this difficulty, we developed reference dose tables for a standard GRID collimator and validate their acc…
View article: An International Consensus on the Design of Prospective Clinical–Translational Trials in Spatially Fractionated Radiation Therapy
An International Consensus on the Design of Prospective Clinical–Translational Trials in Spatially Fractionated Radiation Therapy Open
This consensus provides design guidelines for the development of prospective multi-institutional clinical trials testing SFRT in advanced head and neck cancer and soft-tissue sarcoma through in-advance harmonization of the fundamental clin…