Jian Huang
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View article: Causal inference and risk prediction of gestational diabetes mellitus based on case–control study and Mendel randomization
Causal inference and risk prediction of gestational diabetes mellitus based on case–control study and Mendel randomization Open
Aims To evaluate the causal determinants and their risk predictive efficacy of gestational diabetes mellitus (GDM) in Chinese population. Methods Genotyping data for candidate genetic variants were collected from 554 cases of GDM and 641 p…
View article: Large-Scale T Cell Receptor Repertoire Profiling Unveils Tumor-Specific Signals for Diagnosing Indeterminate Pulmonary Nodules
Large-Scale T Cell Receptor Repertoire Profiling Unveils Tumor-Specific Signals for Diagnosing Indeterminate Pulmonary Nodules Open
Indeterminate pulmonary nodules (IPNs) are increasingly detected due to rising health awareness and widespread lung cancer screening, yet distinguishing benign from malignant nodules remains a critical challenge. Emerging evidence suggests…
View article: Runx1 drives cardiac fibrosis and heart failure through epigenetic activation of myofibroblasts in pressure overload-induced cardiac remodeling
Runx1 drives cardiac fibrosis and heart failure through epigenetic activation of myofibroblasts in pressure overload-induced cardiac remodeling Open
Runx1 plays a pivotal role in cardiac fibroblast activation and fibrosis, likely through epigenetic regulation of Postn expression, thereby driving heart failure progression. Targeting Runx1 may represent a promising therapeutic strategy f…
View article: Enhancing polyreactivity prediction of preclinical antibodies through fine-tuned protein language models
Enhancing polyreactivity prediction of preclinical antibodies through fine-tuned protein language models Open
View article: Guide the design of lactic acid bacteria synthesis community through computational metabolic interaction experimental pipeline
Guide the design of lactic acid bacteria synthesis community through computational metabolic interaction experimental pipeline Open
Understanding whether ecological assembly principles can inform synthetic microbial community construction remains a critical challenge in fermented food research, hindered by the complexity of natural ecosystems. Here, we integrate top-do…
View article: Optimization of fused deposition modeling process parameters based on grey relational analysis
Optimization of fused deposition modeling process parameters based on grey relational analysis Open
Fused Deposition Modeling has been extensively utilized in industrial component fabrication due to its cost-effectiveness and operational simplicity. Current research predominantly focuses on analyzing the influence of process parameters o…
View article: Interpretable machine learning-guided single-cell mapping deciphers multi-lineage pancreatic dysregulation in type 2 diabetes
Interpretable machine learning-guided single-cell mapping deciphers multi-lineage pancreatic dysregulation in type 2 diabetes Open
View article: Genetic variants in HLA-DQA1/DQB1 genes modulate the risk of gestational diabetes mellitus in a southern Chinese population
Genetic variants in HLA-DQA1/DQB1 genes modulate the risk of gestational diabetes mellitus in a southern Chinese population Open
Background Gestational diabetes mellitus (GDM) is an endocrine disorder that occurs easily in women during pregnancy. HLA-DQA1/DQB1 genes play a crucial role in the regulation of the human immune and endocrine systems, potentially influenc…
View article: Ancient genomes in Southwest China revealed genetic interactions among diverse populations in the historical period
Ancient genomes in Southwest China revealed genetic interactions among diverse populations in the historical period Open
These findings underscore the complexity of genetic interactions and population movements during the historical period, providing new insights into the genetic landscape and ethnic formation processes in Southwest China.
View article: Intravesical Disitamab Vedotin (RC48) for HER2‐Expressing High‐Risk Non‐Muscle‐Invasive Bladder Cancer: A Single‐Arm, Dose–Escalation Phase I Trial Study
Intravesical Disitamab Vedotin (RC48) for HER2‐Expressing High‐Risk Non‐Muscle‐Invasive Bladder Cancer: A Single‐Arm, Dose–Escalation Phase I Trial Study Open
HER2 expression is correlated with diminished efficacy of Bacillus Calmette–Guérin (BCG) instillation in high‐risk non‐muscle‐invasive bladder cancer (HR‐NMIBC). The development of effective intravesical treatments for HER2‐expressing HR‐N…
View article: scRiskCell: A single‐cell framework for quantifying islet risk cells and their adaptive dynamics in type 2 diabetes
scRiskCell: A single‐cell framework for quantifying islet risk cells and their adaptive dynamics in type 2 diabetes Open
scRiskCell is an interpretable intelligent computational framework that leverages nearly 500,000 islet cell expression profiles from 106 donors across different continuous disease states. By calculating the intrinsic relationship between d…
View article: 715 | LOW‐INTENSITY FOCUSED ULTRASOUND ENHANCES CD20 ANTIBODY DELIVERY ACROSS BBB IN CNS LYMPHOMA
715 | LOW‐INTENSITY FOCUSED ULTRASOUND ENHANCES CD20 ANTIBODY DELIVERY ACROSS BBB IN CNS LYMPHOMA Open
View article: A comprehensive antigen-antibody complex database unlocking insights into interaction interface
A comprehensive antigen-antibody complex database unlocking insights into interaction interface Open
Antibodies are critical components of the vertebrate immune system and possess a wide array of biomedical applications. Elucidating the complex interactions between antibodies and antigens is an important step in drug development. However,…
View article: Author response: A comprehensive antigen-antibody complex database unlocking insights into interaction interface
Author response: A comprehensive antigen-antibody complex database unlocking insights into interaction interface Open
View article: Author response: AACDB: Antigen-Antibody Complex Database — a Comprehensive Database Unlocking Insights into Interaction Interface
Author response: AACDB: Antigen-Antibody Complex Database — a Comprehensive Database Unlocking Insights into Interaction Interface Open
View article: AACDB: Antigen-Antibody Complex Database — a Comprehensive Database Unlocking Insights into Interaction Interface
AACDB: Antigen-Antibody Complex Database — a Comprehensive Database Unlocking Insights into Interaction Interface Open
Antibodies are critical components of the vertebrate immune system and possess a wide array of biomedical applications. Elucidating the complex interactions between antibodies and antigens is an important step in drug development. However,…
View article: Case report: a critically ill patient with aggressive NK-cell leukemia receiving emergency chemotherapy in the ICU
Case report: a critically ill patient with aggressive NK-cell leukemia receiving emergency chemotherapy in the ICU Open
Aggressive NK-cell leukemia (ANKL) is a scarce mature NK-cell neoplasm frequently associated with Epstein-Barr virus (EBV) infection. We report the case of a 47-year-old male patient who was admitted to the hospital due to recurrent fever,…
View article: Research on atmospheric coherence length detection method based on optical computing lidar
Research on atmospheric coherence length detection method based on optical computing lidar Open
The atmospheric coherence length is an important parameter that reflects the turbulence effects on optical wave transmission through the atmosphere. Real-time acquisition of atmospheric coherence length plays a significant role in various …
View article: Applications of gene pair methods in clinical research: advancing precision medicine
Applications of gene pair methods in clinical research: advancing precision medicine Open
The rapid evolution of high-throughput sequencing technologies has revolutionized biomedical research, producing vast amounts of gene expression data that hold immense potential for biological discovery and clinical applications. Effective…
View article: PlateletBase: A Comprehensive Knowledgebase for Platelet Research and Disease Insights
PlateletBase: A Comprehensive Knowledgebase for Platelet Research and Disease Insights Open
Platelets are vital in many pathophysiological processes, yet there is a lack of a comprehensive resource dedicated specifically to platelet research. To fill this gap, we have developed PlateletBase, a knowledge base aimed at enhancing th…
View article: TCM2COVID in 2024: Enhanced Data on Traditional Chinese Medicine Formulas and Knowledge Graph for COVID-19
TCM2COVID in 2024: Enhanced Data on Traditional Chinese Medicine Formulas and Knowledge Graph for COVID-19 Open
Despite the fact that five years have passed since the outbreak of COVID-19, the coronavirus continues to coexist with our lives, making ongoing attention to COVID-19 important for understanding its transmission mechanisms, optimizing prev…
View article: Regulating carbonaceous mesophase structure by controlling nitrogen-containing aromatics of FCC slurry oil: Insights from MD simulations and experimental studies
Regulating carbonaceous mesophase structure by controlling nitrogen-containing aromatics of FCC slurry oil: Insights from MD simulations and experimental studies Open
View article: Maternal genetic architecture of Guizhou's Hmong-Mien populations via whole mitogenome
Maternal genetic architecture of Guizhou's Hmong-Mien populations via whole mitogenome Open
The Hmong-Mien (HM) language family, majorly distributed across southern China and Southeast Asia, has remained underexplored in population genetics, particularly concerning whole mitogenome studies. In this study, we sequenced the whole m…
View article: From Theophylline to Adenine or preQ<sub>1</sub>: Repurposing a DNA Aptamer Revealed by Crystal Structure Analysis
From Theophylline to Adenine or preQ<sub>1</sub>: Repurposing a DNA Aptamer Revealed by Crystal Structure Analysis Open
Aptamers, which are short, single‐stranded DNA or RNA, are capable of binding to a wide array of targets with exceptional selectivity. Those with high affinity for theophylline have the potential to serve as biosensors, crucial for trackin…
View article: Targeting novel regulated cell death: disulfidptosis in cancer immunotherapy with immune checkpoint inhibitors
Targeting novel regulated cell death: disulfidptosis in cancer immunotherapy with immune checkpoint inhibitors Open
View article: Efficacy and safety of HYYK formula for residual follicle revival in premature ovarian insufficiency: a multicenter, randomized, double-blind, placebo-controlled trial protocol
Efficacy and safety of HYYK formula for residual follicle revival in premature ovarian insufficiency: a multicenter, randomized, double-blind, placebo-controlled trial protocol Open
Chinese Clinical Trials.gov ChiCTR2100049604 Registered on August 6, 2021 ( http://www.chictr.org.cn ).
View article: A comprehensive antigen-antibody complex database unlocking insights into interaction interface
A comprehensive antigen-antibody complex database unlocking insights into interaction interface Open
Antibodies are critical components of the vertebrate immune system and possess a wide array of biomedical applications. Elucidating the complex interactions between antibodies and antigens is an important step in drug development. However,…
View article: Author response: AACDB: Antigen-Antibody Complex Database — a Comprehensive Database Unlocking Insights into Interaction Interface
Author response: AACDB: Antigen-Antibody Complex Database — a Comprehensive Database Unlocking Insights into Interaction Interface Open
View article: AACDB: Antigen-Antibody Complex Database — a Comprehensive Database Unlocking Insights into Interaction Interface
AACDB: Antigen-Antibody Complex Database — a Comprehensive Database Unlocking Insights into Interaction Interface Open
Antibodies play a crucial role in the vertebrate immune system and have diverse biomedical applications. Understanding the intricate interactions between antibodies and antigens is an important step in drug development. However, the comple…
View article: Serum metabolomic profiling for predicting therapeutic response and toxicity in breast cancer neoadjuvant chemotherapy: a retrospective longitudinal study
Serum metabolomic profiling for predicting therapeutic response and toxicity in breast cancer neoadjuvant chemotherapy: a retrospective longitudinal study Open
This study elucidated the dynamic changes in metabolism during NACT treatment, providing a possibility for developing responsive metabolic signatures for personalized NACT treatment.