Explanipedia

CLEP-GAN: an innovative approach to subject-independent ECG reconstruction from PPG signals Open

Xiaoyan Li, Faisal Habib, Arvind Gupta, Huaxiong Huang · 2025

Background Reconstructing ECG signals from PPG measurements is a critical task for non-invasive cardiac monitoring. While several public ECG–PPG datasets exist, they lack the diversity found in image datasets, and the data collection proce…

Glymphatic Clearance in the Optic Nerve: A Multidomain Electro-Osmostic Model Open

Shanfeng Xiao, Huaxiong Huang, Zilong Song, Shixin Xu · 2025

Effective metabolic waste clearance and maintaining ionic homeostasis are essential for the health and normal function of the central nervous system (CNS). To understand its mechanism and the role of fluid flow, we develop a multidomain el…

Pump-driven droplet electrohydrodynamics: deformation, pinch-off and recoalescence Open

Yuzhe Qin, Huaxiong Huang, Zilong Song, Shixin Xu · 2025

We investigate pump-driven droplet electrohydrodynamics with an emphasis on deformation, pinch-off, and recoalescence. A thermodynamically consistent phase-field framework is developed that couples Nernst--Planck--Poisson electrodiffusion …

Proper Orthogonal Decomposition-based Model-Order Reduction for Smoothed Particle Hydrodynamics Simulation -- Mass-Spring-Damper System Open

Zilong Song, Kirk Fraser, Huaxiong Huang · 2025

Model Order Reduction (MOR) based on Proper Orthogonal Decomposition (POD) and Smooth Particle Hydrodynamics (SPH) has proven effective in various applications. Most MOR methods utilizing POD are implemented within a pure Eulerian framewor…

Potassium Clearance in Optic Nerve: A Multidomain Model Open

Shanfeng Xiao, Huaxiong Huang, Bob Eisenberg, Zilong Song, Shixin Xu · 2025

Background: Ion and water transport in the central nervous system (CNS) is governed by tightly coupled mechanisms involving electrodiffusion, osmotic pressure, and fluid convection. Disruptions to these processes are implicated in patholog…

Beyond Single-Channel: Multichannel Signal Imaging for PPG-to-ECG Reconstruction with Vision Transformers Open

Xiaoyan Li, Shixin Xu, Faisal Habib, Arvind Gupta, Huaxiong Huang · 2025

Reconstructing ECG from PPG is a promising yet challenging task. While recent advancements in generative models have significantly improved ECG reconstruction, accurately capturing fine-grained waveform features remains a key challenge. To…

Theory and Application of Linear Regression Model in Financial Market Forecasting Open

Huaxiong Huang · 2025

Linear regression model in the theoretical basis and practical application in the financial markets was discussed by this article, the article first introduces basic principle of linear regression models and assumptions, such as least squa…

CLEP-GAN: An Innovative Approach to Subject-Independent ECG Reconstruction from PPG Signals Open

Xiaoyan Li, Shixin Xu, Faisal Habib, Neda Aminnejad, Arvind Gupta , et al. · 2025

This study addresses the challenge of reconstructing unseen ECG signals from PPG signals, a critical task for non-invasive cardiac monitoring. While numerous public ECG-PPG datasets are available, they lack the diversity seen in image data…

Predicting the onset of chronic kidney disease (CKD) for diabetic patients with aggregated longitudinal EMR data Open

Neda Aminnejad, Michelle Greiver, Huaxiong Huang · 2025

Chronic kidney disease (CKD) affects over 13% of the population, totaling more than 800 million individuals worldwide. Timely identification and intervention are crucial to delay CKD progression and improve patient outcomes. This research …

Beyond Single-Channel: Multichannel Signal Imaging for Ppg-to-Ecg Reconstruction with Vision Transformers Open

Xiaoyan Li, Shixin Xu, Faisal Habib, Arvind Gupta, Huaxiong Huang · 2025

Multidomain Model for Optic Nerve Potassium Clearance: Roles of Glial Cells and Perivascular Spaces Open

Shanfeng Xiao, Huaxiong Huang, Bob Eisenberg, Zilong Song, Shixin Xu · 2024

The accumulation of potassium in the extracellular space surrounding nerve cells is a fundamental aspect of biophysics that has garnered significant attention in recent research. This phenomenon holds implications for various neurological …

VSG-GAN: A high-fidelity image synthesis method with semantic manipulation in retinal fundus image Open

Junjie Liu, Shixin Xu, Ping He, Sirong Wu, Xi Luo , et al. · 2024

In recent years, advancements in retinal image analysis, driven by machine learning and deep learning techniques, have enhanced disease detection and diagnosis through automated feature extraction. However, challenges persist, including li…

CGMD simulation of interaction between hemagglutinin fusion peptides and lipid bilayer membranes Open

Naveen Viadya, Huaxiong Huang, Shu Takagi · 2024

A multi-domain model for microcirculation in optic nerve: blood flow and oxygen transport Open

Zilong Song, Shixin Xu, Bob Eisenberg, Huaxiong Huang · 2024

Microcirculation of blood and oxygen transport play important roles in biological function of optic nerve and are directly affected by damages or pathologies. This work develops a multi-domain model for optic nerve, that includes important…

Proper Orthogonal Decomposition-Based Model-Order Reduction for Smoothed Particle Hydrodynamics Simulation Open

Lidong Fang, Zilong Song, Kirk Fraser, Faisal Habib, Christopher Drummond , et al. · 2024

Proper Orthogonal Decomposition-Based Model-Order Reduction for Smoothed Particle Hydrodynamics Simulation Open

Lidong Fang, Zilong Song, Kirk Fraser, Faisal Habib, Christopher Drummond , et al. · 2024

CLEP-GAN: An Innovative Approach to ECG Reconstruction from PPG Signals Open

Xiaoyan Li, Shixin Xu, Faisal Habib, Neda Aminnejad, Arvind Gupta , et al. · 2023

This study aims to advance the domain of zero-shot ECG reconstruction from PPG signals, addressing the limitations of existing methods that predominantly rely on future reference ECG subsets. We present two pivotal innovations: First, an e…

Mathematical Model for Chemical Reactions in Electrolytes Applied to Cytochrome c Oxidase: An Electro-Osmotic Approach Open

Shixin Xu, Bob Eisenberg, Zilong Song, Huaxiong Huang · 2023

This study introduces a mathematical model for electrolytic chemical reactions, employing an energy variation approach grounded in classical thermodynamics. Our model combines electrostatics and chemical reactions within well-defined energ…

High-throughput single-cell assay for precise measurement of the intrinsic mechanical properties and shape characteristics of red blood cells Open

Qiaodong Wei, Ying Xiong, Yuhang Ma, Deyun Liu, Yunshu Lu , et al. · 2023

A unique high-throughput single-cell microfluidic method for measuring the inherent physical/mechanical properties of RBCs.

Micro-Macro Modeling of Polymeric Fluids and Shear-Induced Microscopic Behaviors Open

Xuelian Bao, Huaxiong Huang, Zilong Song, Shixin Xu · 2023

This article delves into the micro-macro modeling of polymeric fluids, considering various microscopic potential energies, including the classical Hookean potential, as well as newly proposed modified Morse and Elastic-plastic potentials. …

Using advanced convolutional neural network approaches to reveal patient age, gender, and weight based on tongue images Open

Xiaoyan Li, Li Li, Wei Jing, Pengwei Zhang, Volodymyr Turchenko , et al. · 2023

The human tongue has been long believed to be a window to provide important insights into a patient's health in medicine. The present study introduced a novel approach to predict patient age, gender, and weight inferences based on tongue i…

Coupled Chemical Reactions: Effects of Electric Field, Diffusion and Boundary Control Open

Shixin Xu, Bob Eisenberg, Zilong Song, Huaxiong Huang · 2023

Chemical reactions involve the movement of charges, and this work presents a mathematical model for describing chemical reactions in electrolytes. The model is developed using an energy variational method that aligns with classical thermod…

A phase field model for droplets suspended in viscous liquids under the influence of electric fields Open

Yuzhe Qin, Huaxiong Huang, Zilong Song, Shixin Xu · 2023

In this paper, we propose a Poisson-Nernst-Planck-Navier-Stokes-Cahn-Hillard (PNP-NS-CH)model for an electrically charged droplet suspended in a viscous fluid subjected to an external electric field. Our model incorporates spatial variatio…

Multiscale Model for Ion Transport in Cellular Media and Applications in Smooth Muscle Cells Open

Chun Xiao, Yishui Sun, Huaxiong Huang, Zilong Song, Xingye Yue , et al. · 2023

Ion transport in biological tissues is crucial in the study of many biological and pathological problems. Some multi-cellular structures, like the smooth muscles on vessel walls, can be treated as periodic bi-domain structures consisting o…

Cellular Communication Among Smooth Muscle Cells: The Role of Membrane Potential Via Connexins Open

Chun Xiao, Yishui Sun, Huaxiong Huang, Xingye Yue, Tim David , et al. · 2023

Thermodynamically Consistent Micro-Macro Models of Polymeric Fluids Under Simple Shear Flow Open

Xuelian Bao, Huaxiong Huang, Zilong Song, Shixin Xu · 2023

Homogenization theory of ion transportation in multicellular tissue Open

Chun Xiao, Huaxiong Huang, Shixin Xu, Changyuan Yu, Xingye Yue · 2023

The transport of ions in biological tissues plays a crucial role in studying many biological and pathological problems. Certain multi-cellular structures, such as smooth muscles on vessel walls, can be considered as periodic bi-domain stru…

Multi-objective learning and explanation for stroke risk assessment in Shanxi province Open

Jing Ma, Yiyang Sun, Junjie Liu, Huaxiong Huang, Xiaoshuang Zhou , et al. · 2022

Stroke is the leading cause of death in China (Zhou et al. in The Lancet, 2019). A dataset from Shanxi Province is analyzed to predict the risk of patients at four states (low/medium/high/attack) and to estimate transition probabilities be…

Multi-objective learning and explanation for stroke risk assessment in Shanxi province Open

Jing Ma, Yiyang Sun, Junjie Liu, Huaxiong Huang, Xiaoshuang Zhou , et al. · 2022

Stroke is the leading cause of death in China (Zhou et al. The Lancet 2019). A dataset from Shanxi Province is analyzed to predict the risk of patients’ at four states low/medium/high/attack) and to estimate transition probabilities betwee…

Mathematical Model for Chemical Reactions in Electrolyte Applied to Cytochrome $c$ Oxidase: an Electro-osmotic Approach Open

Shixin Xu, Bob Eisenberg, Zilong Song, Huaxiong Huang · 2022

A mathematical model for chemical reactions in electrolytes is developed using an Energy variational method consistent with classical thermodynamics. Electrostatics and chemical reactions are included in properly defined energetic and diss…

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