Huaying Wang
YOU?
Author Swipe
View article: A multicenter, prospective, non-interventional drug intensive monitoring study of olaparib in a large real-world Chinese patient cohort with ovarian cancer (DIM-OC)
A multicenter, prospective, non-interventional drug intensive monitoring study of olaparib in a large real-world Chinese patient cohort with ovarian cancer (DIM-OC) Open
Background Ovarian cancer (OC) is a highly lethal gynecological cancer. Olaparib maintenance therapy was effective and well-tolerated in pivotal RCTs. However, nationwide real-world safety information is limited in China. This multicenter,…
View article: Prognostic factors and optimal management approaches for stage IB uterine leiomyosarcoma: a retrospective analysis
Prognostic factors and optimal management approaches for stage IB uterine leiomyosarcoma: a retrospective analysis Open
Age >48 years, postmenopausal status, larger tumor size, higher Ki-67, and lymphadenectomy predicted poor DFS but not OS in stage IB uLMS. Ovarian preservation is safe. Adjuvant chemotherapy with different regimens showed no significant su…
View article: Emerging role of the TCA cycle and its metabolites in lung disease
Emerging role of the TCA cycle and its metabolites in lung disease Open
The TCA cycle is a central pathway for oxidative phosphorylation in eukaryotic mitochondria, plays a role in energy production and biosynthesis, and can alter cellular function in a variety of ways. As our understanding of the TCA cycle ha…
View article: Managing severe dermatitis and grade 4 pneumonitis in a patient with non‑small‑cell lung cancer following pembrolizumab treatment: A case report
Managing severe dermatitis and grade 4 pneumonitis in a patient with non‑small‑cell lung cancer following pembrolizumab treatment: A case report Open
Inhibitors of the programmed death receptor 1 (PD-1) or its ligand PD-L1 are widely used in cancer treatment. Despite their efficacy, these immunotherapies can induce adverse effects, particularly dermatitis and pneumonitis. However, the p…
View article: Deep cervical stromal invasion predicts poor prognosis in patients with stage II endometrioid endometrial cancer: a two-centered retrospective study
Deep cervical stromal invasion predicts poor prognosis in patients with stage II endometrioid endometrial cancer: a two-centered retrospective study Open
Objective To evaluate the impact of depth of cervical stromal invasion (CSI) on the prognosis of International Federation of Gynecology and Obstetrics (FIGO) stage II endometrioid endometrial cancer (EEC). Methods Patients with FIGO stage …
View article: Corynoxine suppresses lung adenocarcinoma proliferation and metastasis via inhibiting PI3K/AKT pathway and suppressing Cyclooxygenase-2 expression
Corynoxine suppresses lung adenocarcinoma proliferation and metastasis via inhibiting PI3K/AKT pathway and suppressing Cyclooxygenase-2 expression Open
Background Lung adenocarcinoma (LUAD) is the most common lung cancer subtype, and the prognosis of affected patients is generally poor. The traditional Chinese medicine Uncaria rhychophaylla has been reported to exhibit anti-lung cancer pr…
View article: Clinical application of FIGO 2023 staging system of endometrial cancer in a Chinese cohort
Clinical application of FIGO 2023 staging system of endometrial cancer in a Chinese cohort Open
Objective The International Federation of Gynecology and Obstetrics (FIGO) 2023 staging system for endometrial cancer (EC) was released with incorporating histology, lympho-vascular space invasion, and molecular classification together. Ou…
View article: Disulfidptosis-related lncRNAs signature predicting prognosis and immunotherapy effect in lung adenocarcinoma
Disulfidptosis-related lncRNAs signature predicting prognosis and immunotherapy effect in lung adenocarcinoma Open
The prognostic model of DRGs-lncRNAs constructed in this study has certain accuracy and reliability in predicting the survival prognosis of LUAD patients, and provides clues for the interaction between disulfidptosis and LUAD immunotherapy.
View article: Clinical application of FIGO 2023 staging system of endometrial cancer in a Chinese cohort
Clinical application of FIGO 2023 staging system of endometrial cancer in a Chinese cohort Open
Objective: The International Federation of Gynecology and Obstetrics (FIGO) 2023 staging system represents a refined classification with a comprehensive and improved prognostic significance for endometrial cancer (EC). Our objective is to …
View article: Identification and validation of ferroptosis-related gene SLC2A1 as a novel prognostic biomarker in AKI
Identification and validation of ferroptosis-related gene SLC2A1 as a novel prognostic biomarker in AKI Open
In summary, our study not only identifies SLC2A1 as diagnostic biomarker for AKI, but also sheds light on the role of it in AKI progression, providing novel insights for the clinical diagnosis and treatment of AKI.
View article: Real‐world outcomes of niraparib treatment in patients with ovarian cancer: a multicenter non‐interventional study in China
Real‐world outcomes of niraparib treatment in patients with ovarian cancer: a multicenter non‐interventional study in China Open
Dear Editor, Ovarian cancer remains the deadliest among all gynecological cancers. Although most patients at advanced stage respond to initial treatment, the majority experience recurrence [1]. It was estimated that 55,342 new cases and 37…
View article: Efficacy and safety of apatinib in patients with recurrent uterine malignancy: a prospective, single-center, single-arm, phase 2 study
Efficacy and safety of apatinib in patients with recurrent uterine malignancy: a prospective, single-center, single-arm, phase 2 study Open
To our knowledge, this is the first prospective study assessing the efficacy and safety of apatinib in patients with uterine malignancy. The results suggested that apatinib might be a potential treatment option for these patients.
View article: EP148/#437 Combination of niraparib and anlotinib in patients with recurrent or metastatic endometrial cancer: an open-label, single-arm, two-stage, phase II study
EP148/#437 Combination of niraparib and anlotinib in patients with recurrent or metastatic endometrial cancer: an open-label, single-arm, two-stage, phase II study Open
Objectives Treatment options for patients with recurrent endometrial cancer remain limited with few targeted drugs available for selected patients. Previous studies have shown synergistic antitumor activity of anlotinib, a tyrosine kinase …
View article: Characterization of hotspot exonuclease domain mutations in the DNA polymerase ϵ gene in endometrial cancer
Characterization of hotspot exonuclease domain mutations in the DNA polymerase ϵ gene in endometrial cancer Open
Objective This study was aimed to profile hotspot exonuclease domain mutations (EDMs) of the DNA polymerase ϵ gene ( POLE ) in endometrial cancer (EC) and to investigate the effects of EDMs on tumor cell behavior and catalytic activities o…
View article: Cucumber-Derived Nanovesicles Containing Cucurbitacin B for Non-Small Cell Lung Cancer Therapy
Cucumber-Derived Nanovesicles Containing Cucurbitacin B for Non-Small Cell Lung Cancer Therapy Open
These results demonstrate that CDNVs suppress tumor growth. This study addresses the development of cancer therapeutic drugs using plant-derived nanovesicles that are cost-efficient, simple to produce in high yields, and provide an alterna…
View article: Surgery and Surgery Approach Affect Survival of Patients With Stage I-IIA Small-Cell Lung Cancer: A Study Based SEER Database by Propensity Score Matching Analysis
Surgery and Surgery Approach Affect Survival of Patients With Stage I-IIA Small-Cell Lung Cancer: A Study Based SEER Database by Propensity Score Matching Analysis Open
Purpose The purpose of this study was to observe the significance of surgery and its approach in stage I-IIA (according to 8th American Joint Committee on Cancer Staging Manual) small-cell lung cancer (SCLC) using the Surveillance, Epidemi…
View article: Optical image encryption scheme with extended visual cryptography and non-mechanical ptychographic encoding
Optical image encryption scheme with extended visual cryptography and non-mechanical ptychographic encoding Open
Non-mechanical ptychographic encoding (NPE) transforms the secret information into series of diffractive patterns through a spatial light modulator (SLM), saving the need to fabricate the secret objects. Conventionally, the shares in exten…
View article: Hysteroscopic Curettage Followed by Megestrol Acetate Plus Metformin as a Fertility-Sparing Treatment for Women with Atypical Endometrial Hyperplasia or Well-Differentiated Endometrioid Endometrial Carcinoma
Hysteroscopic Curettage Followed by Megestrol Acetate Plus Metformin as a Fertility-Sparing Treatment for Women with Atypical Endometrial Hyperplasia or Well-Differentiated Endometrioid Endometrial Carcinoma Open
Background: In reproductive-aged women, the incidence of atypical endometrial hyperplasia (AEH) or endometrioid endometrial carcinoma (EEC) is rising globally. The study aimed to investigate the effectiveness of hysteroscopic curettage fol…
View article: Advanced Retinex-Net image enhancement method based on value component processing
Advanced Retinex-Net image enhancement method based on value component processing Open
When capturing images under low-light lighting conditions, the resulting images often suffer low visibility. Such low-visibility images not only affect the visual effect but also cause many difficulties in practical application. Therefore,…
View article: Structured vanadium dioxide metamaterial for tunable broadband terahertz absorption
Structured vanadium dioxide metamaterial for tunable broadband terahertz absorption Open
A tunable broadband terahertz (THz) absorber based on vanadium dioxide (VO 2 ) is proposed, which is composed of a structured VO 2 metamaterial layer, a dielectric layer, and a metal layer. The simulation results show that the peak absorpt…
View article: Exploration of Potential Diagnostic Value of Protein Content in Serum Small Extracellular Vesicles for Early-Stage Epithelial Ovarian Carcinoma
Exploration of Potential Diagnostic Value of Protein Content in Serum Small Extracellular Vesicles for Early-Stage Epithelial Ovarian Carcinoma Open
Epithelial ovarian carcinoma (EOC) is one of the most common gynecologic malignancies with a high mortality rate. Serum biomarkers and imaging approaches are insufficient in identifying EOC patients at an early stage. This study is to set …
View article: Spatiotemporal coherent modulation imaging for dynamic quantitative phase and amplitude microscopy
Spatiotemporal coherent modulation imaging for dynamic quantitative phase and amplitude microscopy Open
The single-shot capability of coherent modulation imaging (CMI) makes it have great potential in the investigation of dynamic processes. Its main disadvantage is the relatively low signal-to-noise ratio (SNR) which affects the spatial reso…