Hubertus Jarry
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View article: Effect of dihydrotestosterone, 17-β-estrogen, genistein and equol on remodeling and morphology of bone in osteoporotic male rats during bone healing
Effect of dihydrotestosterone, 17-β-estrogen, genistein and equol on remodeling and morphology of bone in osteoporotic male rats during bone healing Open
We conclude from our results that healing of cortical bone defects in a rat model of male osteoporosis are mainly influenced by the estrogen pathway. Nevertheless, effects via purely androgenic mechanisms can also be demonstrated. The role…
View article: Issue Information
Issue Information Open
They go through the journal's standard peerreview process and will be accepted or rejected based on their own merit. Rapid CommunicationsManuscripts intended for Rapid Communication must present new fi ndings of suffi cient importance to j…
View article: Testosterone metabolites inhibit proliferation of castration- and therapy-resistant prostate cancer
Testosterone metabolites inhibit proliferation of castration- and therapy-resistant prostate cancer Open
Novel treatments for castration-resistant prostate cancer (CRPC) such as abiraterone acetate (AA) or enzalutamide effectively target the androgen pathway to arrest aberrant signalling and cell proliferation. Testosterone is able to inhibit…
View article: Prospects of estrogen receptor β activation in the treatment of castration-resistant prostate cancer
Prospects of estrogen receptor β activation in the treatment of castration-resistant prostate cancer Open
Advanced prostate cancer can develop into castration-resistant prostate cancer (CRPC). This process is mediated either by intratumoral ligand synthesis or by mutations or aberrations of the androgen receptor (AR) or its cofactors. To date,…
View article: Synaptopodin is regulated by aromatase activity
Synaptopodin is regulated by aromatase activity Open
Locally synthesized estradiol plays an important role in synaptic plasticity in the hippocampus. We have previously shown that in hippocampal neurons, activity of the enzyme aromatase, which converts testosterone into estradiol, is reduced…
View article: Role of N-cadherin in proliferation, migration, and invasion of germ cell tumours
Role of N-cadherin in proliferation, migration, and invasion of germ cell tumours Open
Germ cell tumors (GCTs) are the most common malignancies in young men. Most patients with GCT can be cured with cisplatin-based combination chemotherapy, even in metastatic disease. In case of therapy resistance, prognosis is usually poor.…