Explanipedia

Lessons Learned: Quality Analysis of Optical Coherence Tomography in Neuromyelitis Optica Open

Hayder Salih, Sara Samadzadeh, Charlotte Bereuter, Seyedamirhosein Motamedi, Claudia Chien , et al. · 2025

Introduction Optical coherence tomography (OCT)‐derived retina measurements are markers for neuroaxonal visual pathway status. High‐quality OCT scans are essential for reliable measurements, but their acquisition is particularly challengin…

3621 Paediatric versus adult-onset neuromyelitis optica spectrum disorder: a multi-centre study Open

Pakeeran Siriratnam, Saif Huda, Paul G. Sanfilippo, Vilija Jokubaitis, Anneke van der Walt , et al. · 2025

Ambiguitas Leksikal dalam buku Anak -anak Amelia Bedelia Karya Herman Parish Open

Saif Huda, Nia Kurniati, Ni Made Widisanti Swetasurya · 2025

This study aims to identify words that contain lexical ambiguity, explore their meanings, and classify them in the children’s book Amelia Bedelia by Herman Parish. The data were collected from the Amelia Bedelia Chapter Books series, which…

Significant Visual Field Defects Persist Despite Excellent Visual Acuity Following Optic Neuritis in Myelin-Oligodendrocyte Glycoprotein Associated Disease Open

Saif Huda, Aviv Fineberg, Chiara Rocchi, Omer Bialer, Ainat Klein , et al. · 2025

Unemployment, work hour reduction, and income loss: An international, multicentered, cross-sectional study of neuromyelitis optica spectrum disorder Open

Andrew Siyoon Ham, Isabella Gomez Hjerthen, De‐Cai Tian, Hongfei Gu, Lu Wen , et al. · 2025

Objectives: To assess loss of employment, work hours, and wages of people with aquaporin-4 antibody-positive or double-seronegative/antibody status unknown neuromyelitis optica spectrum disorder (NMOSD) internationally. Methods: An investi…

Rituximab as First‐Line Compared to Escalation Immunotherapy Is Associated With Lower Disability Accumulation in Aquaporin‐4‐IgG‐Positive Neuromyelitis Optica Spectrum Disorder: A Multicenter Cohort Study From Germany and the United Kingdom Open

Daniel Engels, Chiara Rocchi, Mirasol Forcadela, Pakeeran Siriratnam, Marius Ringelstein , et al. · 2025

Background Aquaporin‐4‐IgG‐positive neuromyelitis optica spectrum disorder (AQP4‐IgG+ NMOSD) can cause significant disability after a single attack. Long‐term immunotherapy reduces disability accumulation, but the choice of first‐line ther…

Comorbidities Are Associated With Unfavorable Outcome in Aquaporin‐4 Antibody Positive Neuromyelitis Optica Spectrum Disorders and Myelin Oligodendrocyte Glycoprotein Antibody‐Associated Disease: Exploratory Study From the CROCTINO Cohort Open

Sara Samadzadeh, Frederike Cosima Oertel, Hayder Salih, Ting‐Yi Lin, Seyedamirhosein Motamedi , et al. · 2025

Background Comorbidities occur in aquaporin‐4 antibody‐positive neuromyelitis optica spectrum disorder (AQP4‐NMOSD), myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD), and double seronegative NMOSD (DN‐NMOSD), potenti…

A Descritive Study of Adolescent Lifestyle and Cardiovascular Disease Risk in Senior High School Open

Wayunah Wayunah, Saif Huda, Muhammad Saefulloh · 2025

Introduction: Common adolescent behaviors such as consuming fast food, high-sugar beverages, lack of physical activity, and excessive screen time are major contributing factors to the emergence of CVD among youth. Early detection of risk f…

A first report of progressive multifocal leukoencephalopathy in childhood-onset NMOSD Open

Pakeeran Siriratnam, Simon Gosling, Maneesh Bhojak, Michael J. Griffiths, Rachel Kneen , et al. · 2025

Background: Progressive multifocal leukoencephalopathy (PML) has not been reported in pediatric neuromyelitis optica spectrum disorder (NMOSD) and rarely described in children. Objectives: To report a case of PML in childhood-onset NMOSD. …

Progression independent of relapse activity and relapse-associated worsening in seronegative NMOSD: an international cohort study Open

Pakeeran Siriratnam, Saif Huda, Anneke van der Walt, Paul G. Sanfilippo, Sifat Sharmin , et al. · 2025

Is a Benign Disease Course Possible in Untreated AQP4‐IgG NMOSD? Open

Pakeeran Siriratnam, Chiara Rocchi, Emily Gibbons, Patricia J. Kelly, Samantha Linaker , et al. · 2025

Background Most patients with aquaporin‐4 antibody‐positive neuromyelitis optica spectrum disorder (AQP4‐IgG NMOSD) require life‐long immunosuppression to prevent relapses. Patients who are untreated or undergo de‐escalation of therapy typ…

Opposing Influences of Optic Neuritis and Transverse Myelitis on the Future Location of Relapses in MOG Antibody–Associated Disease Open

Daniel Lordelo San Martin, Marcos Baruch Portela Filho, Chiara Rocchi, Shahd Hamid, Saif Huda · 2025

Background Studies in MS and NMOSD have shown that relapses can frequently occur in the same location as the first attack. Factors associated with this outcome in MOGAD are unclear. Objective The objective of this study was to investigate …

Edukasi Dan Penerapan Terapi Latihan Dengan Keluhan Nyeri Pinggang Pada Lansia Di Rumah Sakit Umum Paru Dungus Madiun Open

Saif Huda, Safun Rahmanto · 2025

Manusia akan mengalami masa tua dimana masa tua atau lanjut usia merupakan tahap akhir dari siklus hidup manusia yang termasuk bagian dari proses alamiah kehidupan yang tidak dapat dihindarkan dan akan dialami oleh setiap individu. Pada us…

Employment, work hours, and wages in adults with myelin oligodendrocyte glycoprotein antibody disease: An international cohort study Open

Andrew Siyoon Ham, Isabella Gomez Hjerthen, Akshatha Sudhir, Lekha Pandit, Y Muralidhar Reddy , et al. · 2024

Objectives: The objectives were to understand the employment impacts of myelin oligodendrocyte glycoprotein–associated antibody disease (MOGAD) on adults in an international cohort by determining lost employment, work hours, and wages. Bac…

Characterizing mortality in patients with AQP4‐Ab+ neuromyelitis optica spectrum disorder Open

Anna Francis, Emily Gibbons, Jeffrey Yu, Karissa Johnston, Hannah Rochon , et al. · 2024

Neuromyelitis optica spectrum disorder is an autoimmune disease, causing severe disability due to relapses, but recent mortality data are limited. Among 396 patients seropositive for anti‐aquaporin‐4 antibody from 2014 to 2020 in the Unite…

A retrospective multicenter study on clinical and serological parameters in patients with MuSK myasthenia gravis with and without general immunosuppression Open

Inga Koneczny, Marina Mané-Damas, Shenghua Zong, Sander de Haas, Saif Huda , et al. · 2024

Introduction Muscle-specific kinase (MuSK)- myasthenia gravis (MG) is caused by pathogenic autoantibodies against MuSK that correlate with disease severity and are predominantly of the IgG4 subclass. The first-line treatment for MuSK-MG is…

Impact of rituximab treatment regime on time to relapse in aquaporin-4 antibody positive neuromyelitis optica spectrum disorder Open

Moneeb Nasir, Luke Hone, Emma Tallantyre, Patricia A. Kelly, Maria Isabel Leite , et al. · 2024

Risks and outcomes of pregnancy in neuromyelitis optica spectrum disorder: A comprehensive review Open

Pakeeran Siriratnam, Saif Huda, Helmut Butzkueven, Anneke van der Walt, Vilija Jokubaitis , et al. · 2023

Neuromyelitis optica spectrum disorder (NMOSD) is a rare central nervous system autoimmune disease. Aquaporin-4 antibody (AQP4-IgG) is present in over 75% of cases and criteria also exist for the diagnosis of seronegative NMOSD. AQP4-IgG N…

Timing of MOG-IgG Testing Is Key to 2023 MOGAD Diagnostic Criteria Open

Mirasol Forcadela, Chiara Rocchi, Daniel Lordelo San Martin, Emily Gibbons, D. Wells , et al. · 2023

The 2023 MOGAD diagnostic criteria were highly sensitive and specific and closely align with historically established cases of MOGAD. However, because additional supportive features are stipulated for patients with a low-positive MOG-IgG r…

A comprehensive review of the advances in neuromyelitis optica spectrum disorder Open

Pakeeran Siriratnam, Saif Huda, Helmut Butzkueven, Anneke van der Walt, Vilija Jokubaitis , et al. · 2023

Neuromyelitis optica spectrum disorder (NMOSD) is a rare relapsing neuroinflammatory autoimmune astrocytopathy, with a predilection for the optic nerves and spinal cord. Most cases are characterised by aquaporin-4-antibody positivity and h…

IgG1-3 MuSK Antibodies Inhibit AChR Cluster Formation, Restored by SHP2 Inhibitor, Despite Normal MuSK, DOK7, or AChR Subunit Phosphorylation Open

Michelangelo Cao, Wei Wei Liu, Susan Maxwell, Saif Huda, Richard Webster , et al. · 2023

MuSK-IgG1-3 is pathogenic but seems to act through a noncanonical pathway. Further studies should throw light on the mechanisms involved at the neuromuscular junction.

Table of Contents Open

Jacque L. Duncan, Wendi Liang, Maureen G. Maguire, Travis C. Porco, Jessica Wong , et al. · 2023

International Delphi Consensus on the Management of AQP4-IgG+ NMOSD Open

Friedemann Paul, Romain Marignier, Jacqueline Palace, Georgina Arrambide, Nasrin Asgari , et al. · 2023

An established consensus method was used to develop statements relevant to the management of AQP4-IgG-seropositive NMOSD. These international statements will be valuable for informing individualized therapeutic decision-making and could fo…

Visual Outcomes Following Plasma Exchange for Optic Neuritis: An International Multicenter Retrospective Analysis of 395 Optic Neuritis Attacks Open

John J. Chen, Eoin P. Flanagan, Sean J. Pittock, Nicole Caroline Stern, Nanthaya Tisavipat , et al. · 2023

Diagnostic value of intereye difference metrics for optic neuritis in aquaporin-4 antibody seropositive neuromyelitis optica spectrum disorders Open

Frederike Cosima Oertel, Hanna Zimmermann, Seyedamirhosein Motamedi, Claudia Chien, Orhan Aktaş , et al. · 2023

Background The novel optic neuritis (ON) diagnostic criteria include intereye differences (IED) of optical coherence tomography (OCT) parameters. IED has proven valuable for ON diagnosis in multiple sclerosis but has not been evaluated in …

Acute Inflammatory Diseases of the Central Nervous System After SARS-CoV-2 Vaccination Open

Anna Francis, Kariem Elhadd, Valentina Camera, Monica Ferreira dos Santos, Chiara Rocchi , et al. · 2022

ChAdOx1S was associated with 12/14 antibody-positive cases, the majority MOGAD. MOGAD patients presented atypically, only 2 with isolated ON (1 after BNT162b2 vaccine) but with frequent ADEM-like brain lesions and LETM. Within the seronega…

Rituximab abrogates aquaporin-4–specific germinal center activity in patients with neuromyelitis optica spectrum disorders Open

Valentina Damato, Jakob Theorell, Adam Al‐Diwani, Anne‐Kathrin Kienzler, Mateusz Makuch , et al. · 2022

Significance By studying paired blood and deep cervical lymph node samples from patients with neuromyelitis optica spectrum disorders, our data provide evidence for a germinal center–based generation of aquaporin-4 antibodies. Frequent ser…

Health utilities and costs for neuromyelitis optica spectrum disorder Open

Dyfrig Hughes, Siobhan Bourke, Angela Jones, Rikesh Bhatt, Saif Huda , et al. · 2022

Association of Maintenance Intravenous Immunoglobulin With Prevention of Relapse in Adult Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease Open

John J. Chen, Saif Huda, Yael Hacohen, Michael Levy, Itay Lotan , et al. · 2022

Results of this retrospective, multicenter, cohort study of adult patients with MOGAD suggest that maintenance IVIG was associated with a reduction in disease relapse. Less frequent and lower dosing of IVIG may be associated with treatment…

N-Methyl-D-Aspartate receptor and myelin oligodendrocyte glycoprotein antibody overlap syndrome with homonymous hemianopia: A case report Open

Omer Ali, Kariem Elhadd, Mirasol Forcadela, Rocchi Chiara, Surjit Lyons-Nandra , et al. · 2022

N-Methyl-D-Aspartate receptor antibody encephalitis (NMDAR-E) is a distinct, often severe and relapsing autoimmune disorder characterised by prominent neuropsychiatric symptoms, seizures, and movement disorders. Myelin oligodendrocyte glyc…

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